DE69323447T2 - Trockenes analytisches Element zum Nachweis der sauren Prostataphosphatase - Google Patents
Trockenes analytisches Element zum Nachweis der sauren ProstataphosphataseInfo
- Publication number
- DE69323447T2 DE69323447T2 DE69323447T DE69323447T DE69323447T2 DE 69323447 T2 DE69323447 T2 DE 69323447T2 DE 69323447 T DE69323447 T DE 69323447T DE 69323447 T DE69323447 T DE 69323447T DE 69323447 T2 DE69323447 T2 DE 69323447T2
- Authority
- DE
- Germany
- Prior art keywords
- salt
- acid phosphatase
- substrate
- phosphate ester
- prostatic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 title description 8
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 title description 8
- 210000002307 prostate Anatomy 0.000 title description 5
- 230000002378 acidificating effect Effects 0.000 title description 3
- 239000000758 substrate Substances 0.000 claims abstract description 28
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 23
- 239000010452 phosphate Substances 0.000 claims abstract description 23
- 239000012954 diazonium Substances 0.000 claims abstract description 21
- 125000003831 tetrazolyl group Chemical group 0.000 claims abstract description 16
- 102100035703 Prostatic acid phosphatase Human genes 0.000 claims abstract description 15
- 108010043671 prostatic acid phosphatase Proteins 0.000 claims abstract description 15
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 125000003118 aryl group Chemical group 0.000 claims abstract description 14
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- 239000007795 chemical reaction product Substances 0.000 claims abstract description 11
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- 238000003892 spreading Methods 0.000 claims abstract description 9
- 230000007480 spreading Effects 0.000 claims abstract description 9
- -1 aryl phosphate ester Chemical class 0.000 claims description 34
- 239000003153 chemical reaction reagent Substances 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 150000001768 cations Chemical class 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 150000001989 diazonium salts Chemical class 0.000 claims description 8
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- 229910052736 halogen Inorganic materials 0.000 claims description 3
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- 239000001257 hydrogen Substances 0.000 claims description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
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- 108010051457 Acid Phosphatase Proteins 0.000 claims description 2
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- 125000002252 acyl group Chemical group 0.000 claims description 2
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract description 7
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
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- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 2
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- ANAZDOWEOOFEET-UHFFFAOYSA-N (4-hydroxyphenyl) [4-(3-oxo-1h-2-benzofuran-1-yl)phenyl] hydrogen phosphate Chemical compound C1=CC(O)=CC=C1OP(O)(=O)OC1=CC=C(C2C3=CC=CC=C3C(=O)O2)C=C1 ANAZDOWEOOFEET-UHFFFAOYSA-N 0.000 description 1
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- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- KJCVRFUGPWSIIH-UHFFFAOYSA-N 1-naphthol Chemical compound C1=CC=C2C(O)=CC=CC2=C1 KJCVRFUGPWSIIH-UHFFFAOYSA-N 0.000 description 1
- JTNGEYANGCBZLK-UHFFFAOYSA-N 1h-indol-3-yl dihydrogen phosphate Chemical compound C1=CC=C2C(OP(O)(=O)O)=CNC2=C1 JTNGEYANGCBZLK-UHFFFAOYSA-N 0.000 description 1
- QZTKDVCDBIDYMD-UHFFFAOYSA-N 2,2'-[(2-amino-2-oxoethyl)imino]diacetic acid Chemical compound NC(=O)CN(CC(O)=O)CC(O)=O QZTKDVCDBIDYMD-UHFFFAOYSA-N 0.000 description 1
- SGPKEYSZPHMVNI-UHFFFAOYSA-N 2-bromo-1-(2-hydroxyphenyl)ethanone Chemical compound OC1=CC=CC=C1C(=O)CBr SGPKEYSZPHMVNI-UHFFFAOYSA-N 0.000 description 1
- XZKIHKMTEMTJQX-UHFFFAOYSA-N 4-Nitrophenyl Phosphate Chemical compound OP(O)(=O)OC1=CC=C([N+]([O-])=O)C=C1 XZKIHKMTEMTJQX-UHFFFAOYSA-N 0.000 description 1
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- 238000010998 test method Methods 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- DBPYGJOORSXBMI-UHFFFAOYSA-N trinaphthalen-1-yl phosphate Chemical compound C1=CC=C2C(OP(OC=3C4=CC=CC=C4C=CC=3)(OC=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 DBPYGJOORSXBMI-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/30—Naphthol derivatives, e.g. alpha-naphthyl-esters, i.e. alpha-NE, beta-naphthyl-esters, i.e. beta-NE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/70—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases the product, e.g. phenol, naphthol being diazotised in situ, e.g. with Fast Red
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/886,263 US5981206A (en) | 1992-05-20 | 1992-05-20 | Dry analytical element and method for the detection of prostatic acid phosphatase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69323447D1 DE69323447D1 (de) | 1999-03-25 |
| DE69323447T2 true DE69323447T2 (de) | 1999-08-05 |
Family
ID=25388729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69323447T Expired - Lifetime DE69323447T2 (de) | 1992-05-20 | 1993-05-12 | Trockenes analytisches Element zum Nachweis der sauren Prostataphosphatase |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5981206A (da) |
| EP (1) | EP0574056B1 (da) |
| JP (1) | JP2889788B2 (da) |
| AT (1) | ATE176686T1 (da) |
| DE (1) | DE69323447T2 (da) |
| DK (1) | DK0574056T3 (da) |
| SG (1) | SG55077A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9615435D0 (en) * | 1996-07-23 | 1996-09-04 | Andaris Ltd | Spray-dried product and its therapeutic use |
| WO2002027012A1 (fr) * | 2000-09-28 | 2002-04-04 | Arkray, Inc. | Procede de production de produits de degradation de proteines |
| US6764856B2 (en) * | 2002-05-02 | 2004-07-20 | Bradley Jay Holmes | Semen detection system and method |
| US20090170147A1 (en) * | 2007-12-26 | 2009-07-02 | Stephen Patrick Ashburn | Forensic test kit and method for the detection of semen |
| US20100124760A1 (en) * | 2008-11-14 | 2010-05-20 | Stephen Patrick Ashburn | Zinc Test Strip and Method for the Detection of Semen |
| US8137956B2 (en) * | 2008-11-14 | 2012-03-20 | Stephen Patrick Ashburn | Forensic test strip and method for the detection of semen |
| CN103406689A (zh) * | 2013-07-13 | 2013-11-27 | 北京工业大学 | 一种wc颗粒增强镍基mig耐磨堆焊药芯焊丝 |
| US11460409B1 (en) * | 2017-05-05 | 2022-10-04 | Vision Diagnostics, Inc. | Methods and reagents useful for verification of the integrity of a urine sample and the detection of counterfeit urine |
| US11493497B1 (en) | 2018-12-20 | 2022-11-08 | Vision Diagnostics, Inc. | Assays and methods for diagnosing substance use disorder |
| KR102700522B1 (ko) * | 2021-04-16 | 2024-08-30 | 한소 주식회사 | 유해산 검출용 변색성 조성물 및 이의 제조 방법 |
| CN114457141B (zh) * | 2022-02-16 | 2024-05-24 | 北京九强生物技术股份有限公司 | 前列腺酸性磷酸酶的定量检测试剂盒 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3002893A (en) * | 1958-11-13 | 1961-10-03 | Warner Lambert Pharmaceutical | Method for the determination of serum acid phosphatase and diagnostic preparation therefor |
| US3410756A (en) * | 1966-05-27 | 1968-11-12 | Army Usa | Naphthyl esters as fluorogenic substrates for enzymes |
| US3595756A (en) * | 1968-11-26 | 1971-07-27 | Smith Kline French Lab | Laboratory reagent for assay of alkaline phosphatase |
| US3823071A (en) * | 1970-12-21 | 1974-07-09 | Worthington Biochem Corp | Prostatic acid phosphatase determination |
| DE2115748C3 (de) * | 1971-03-31 | 1981-07-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Bestimmung der sauren Phosphatase |
| US3992158A (en) * | 1973-08-16 | 1976-11-16 | Eastman Kodak Company | Integral analytical element |
| US3905872A (en) * | 1973-12-14 | 1975-09-16 | American Cyanamid Co | Alkaline phosphatase test material |
| US4042335A (en) * | 1975-07-23 | 1977-08-16 | Eastman Kodak Company | Integral element for analysis of liquids |
| US4206280A (en) * | 1975-12-24 | 1980-06-03 | Hoffmann-La Roche Inc. | Determination of acid phosphatase |
| US4162194A (en) * | 1976-02-13 | 1979-07-24 | Beckman Instruments, Inc. | Kinetic assay for acid phosphotase and composition therefore |
| IT1167728B (it) * | 1981-03-31 | 1987-05-13 | Sclavo Inst Sieroterapeut | Composizione adatta alla determinazione della fosfatasi acida prostatica e metodo impiegante la stessa |
| WO1983003254A1 (en) * | 1982-03-11 | 1983-09-29 | Arthur Babson | Stabilization of diazonium salt solutions |
| US4510239A (en) * | 1982-08-09 | 1985-04-09 | Beckman Instruments, Inc. | Double antibody immunoassays of enzymes such as prostatic acid phosphatase |
| JPS5963198A (ja) * | 1982-10-01 | 1984-04-10 | Toyo Jozo Co Ltd | 酵素を用いる定量法 |
| US4555484A (en) * | 1983-07-25 | 1985-11-26 | Eastman Kodak Company | Analytical element and method for alkaline phosphatase assay |
| DE3413118A1 (de) * | 1984-04-06 | 1985-10-24 | Miles Laboratories, Inc., Elkhart, Ind. | Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme |
| US4547460A (en) * | 1984-04-16 | 1985-10-15 | Eastman Kodak Company | Multizone analytical element and method for analyte determination |
| JPS61110058A (ja) * | 1984-11-02 | 1986-05-28 | Fuji Photo Film Co Ltd | アルカリ性ホスフアタ−ゼ活性測定用一体型多層分析要素 |
| JPH0672883B2 (ja) * | 1985-06-19 | 1994-09-14 | コニカ株式会社 | 分析素子 |
| US4868106A (en) * | 1985-10-17 | 1989-09-19 | Konishiroku Photo Industry Co., Ltd. | Analytical element and method for determining a component in a test sample |
| JPS62138198A (ja) * | 1985-12-10 | 1987-06-20 | Fuji Photo Film Co Ltd | 自己顕色性基質を含む乾式液体分析要素 |
| US4806470A (en) * | 1986-08-25 | 1989-02-21 | Eastman Kodak Company | Analytical element and method for theophylline determination having increased alkaline phosphatase isoenzyme |
| JPS6388000A (ja) * | 1986-09-30 | 1988-04-19 | Fuji Photo Film Co Ltd | 酸性ホスフアタ−ゼ活性分析要素 |
| US4983512A (en) * | 1987-04-14 | 1991-01-08 | Toyo Boseki Kabushiki Kaisha | Reagent for determination of acid phosphatase |
| US4892817A (en) * | 1987-09-21 | 1990-01-09 | Biogenex Laboratories | Stable phosphatase substrate composition |
| JP2678609B2 (ja) * | 1988-02-01 | 1997-11-17 | 和光純薬工業株式会社 | 新規な２−クロルニトロフェニルリン酸塩及びこれを用いるホスファターゼ活性測定法 |
| JPH0833393B2 (ja) * | 1988-03-14 | 1996-03-29 | 富士写真フイルム株式会社 | 乾式分析要素 |
| JP2577431B2 (ja) * | 1988-04-06 | 1997-01-29 | 帝国臓器製薬株式会社 | 前立腺酸性ホスフアターゼの測定方法 |
| EP0363688B1 (en) * | 1988-09-19 | 1994-01-05 | Nitto Boseki Co., Ltd. | Novel phosphoric acid derivatives and a method for determination of acid phosphatase activity using the same |
| WO1990010084A1 (en) * | 1989-02-23 | 1990-09-07 | Iatron Laboratories, Inc. | Substrate for enzymatic activity determination and method and reagent for determining enzymatic activity using said substrate |
| JPH086480B2 (ja) * | 1989-08-30 | 1996-01-24 | 伊藤忠商事株式会社 | 駐輪設備の無人ゲート装置 |
-
1992
- 1992-05-20 US US07/886,263 patent/US5981206A/en not_active Expired - Lifetime
-
1993
- 1993-05-12 EP EP93201362A patent/EP0574056B1/en not_active Expired - Lifetime
- 1993-05-12 AT AT93201362T patent/ATE176686T1/de not_active IP Right Cessation
- 1993-05-12 SG SG1996004936A patent/SG55077A1/en unknown
- 1993-05-12 DK DK93201362T patent/DK0574056T3/da active
- 1993-05-12 DE DE69323447T patent/DE69323447T2/de not_active Expired - Lifetime
- 1993-05-18 JP JP5115512A patent/JP2889788B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69323447D1 (de) | 1999-03-25 |
| EP0574056A1 (en) | 1993-12-15 |
| JPH0646896A (ja) | 1994-02-22 |
| SG55077A1 (en) | 1998-12-21 |
| JP2889788B2 (ja) | 1999-05-10 |
| EP0574056B1 (en) | 1999-02-10 |
| US5981206A (en) | 1999-11-09 |
| ATE176686T1 (de) | 1999-02-15 |
| DK0574056T3 (da) | 1999-09-20 |
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Legal Events
| Date | Code | Title | Description |
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| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN |