DE69233022T2 - Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung - Google Patents
Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung Download PDFInfo
- Publication number
- DE69233022T2 DE69233022T2 DE69233022T DE69233022T DE69233022T2 DE 69233022 T2 DE69233022 T2 DE 69233022T2 DE 69233022 T DE69233022 T DE 69233022T DE 69233022 T DE69233022 T DE 69233022T DE 69233022 T2 DE69233022 T2 DE 69233022T2
- Authority
- DE
- Germany
- Prior art keywords
- bmp
- protein
- fragment
- cell
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78749691A | 1991-11-04 | 1991-11-04 | |
US787496 | 1991-11-04 | ||
US86469292A | 1992-04-07 | 1992-04-07 | |
US864692 | 1992-04-07 | ||
PCT/US1992/009430 WO1993009229A1 (en) | 1991-11-04 | 1992-11-02 | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69233022D1 DE69233022D1 (de) | 2003-05-28 |
DE69233022T2 true DE69233022T2 (de) | 2004-02-12 |
Family
ID=27120657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233022T Expired - Lifetime DE69233022T2 (de) | 1991-11-04 | 1992-11-02 | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
Country Status (9)
Country | Link |
---|---|
US (5) | US5866364A (ja) |
EP (1) | EP0612348B1 (ja) |
JP (2) | JP3504263B2 (ja) |
KR (1) | KR100259827B1 (ja) |
AT (1) | ATE238417T1 (ja) |
AU (1) | AU674500B2 (ja) |
DE (1) | DE69233022T2 (ja) |
MX (1) | MX9206315A (ja) |
WO (1) | WO1993009229A1 (ja) |
Families Citing this family (112)
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US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
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AU7605394A (en) * | 1993-09-03 | 1995-03-22 | Regents Of The University Of California, The | Neural tissue affecting factor and compositions |
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US5399677A (en) * | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
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US5679783A (en) * | 1994-11-22 | 1997-10-21 | The Regents Of The University Of California | DNA encoding a tissue differentiation affecting factor |
US7235527B2 (en) | 1995-04-19 | 2007-06-26 | Biopharm Gesellschaft Zur Biotechnologieschen Entwicklung Von Pharmaka Mbh | Protein and process for producing the same |
US5780436A (en) * | 1995-05-01 | 1998-07-14 | The Regents Of The University Of California | Peptide compositions with growth factor-like activity |
US5661127A (en) * | 1995-05-01 | 1997-08-26 | The Regents Of The University Of California | Peptide compositions with growth factor-like activity |
US6638912B2 (en) | 1995-05-01 | 2003-10-28 | The Regents Of The University Of California | Peptide compositions mimicking TGF-β activity |
US5635372A (en) * | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
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US5674292A (en) | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
US6875429B1 (en) * | 1996-01-10 | 2005-04-05 | University Of Liverpool | Metastasis inducing DNA's |
US5869041A (en) * | 1996-01-12 | 1999-02-09 | The Miriam Hospital | Delivery of bioactive compounds to an organism |
EP0883410B1 (en) * | 1996-02-29 | 2004-08-18 | Bioactive Bone Substitute OY, AB | An osteogenic device and a method for preparing the device |
KR20000064752A (ko) | 1996-03-22 | 2000-11-06 | 더 제네랄 호스피탈 코포레이션 | 중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법 |
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- 1992-11-02 DE DE69233022T patent/DE69233022T2/de not_active Expired - Lifetime
- 1992-11-02 WO PCT/US1992/009430 patent/WO1993009229A1/en active IP Right Grant
- 1992-11-02 AT AT92924237T patent/ATE238417T1/de not_active IP Right Cessation
- 1992-11-02 JP JP50867593A patent/JP3504263B2/ja not_active Expired - Fee Related
- 1992-11-02 EP EP92924237A patent/EP0612348B1/en not_active Expired - Lifetime
- 1992-11-02 AU AU30622/92A patent/AU674500B2/en not_active Expired
- 1992-11-03 MX MX9206315A patent/MX9206315A/es unknown
- 1992-11-27 US US07/989,847 patent/US5866364A/en not_active Expired - Lifetime
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1995
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2001
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2002
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2003
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AU3062292A (en) | 1993-06-07 |
US5866364A (en) | 1999-02-02 |
KR940703914A (ko) | 1994-12-12 |
JP2003125789A (ja) | 2003-05-07 |
US6593109B1 (en) | 2003-07-15 |
US6190880B1 (en) | 2001-02-20 |
KR100259827B1 (ko) | 2000-06-15 |
DE69233022D1 (de) | 2003-05-28 |
WO1993009229A1 (en) | 1993-05-13 |
US20030235888A1 (en) | 2003-12-25 |
ATE238417T1 (de) | 2003-05-15 |
EP0612348A1 (en) | 1994-08-31 |
JPH07500968A (ja) | 1995-02-02 |
EP0612348B1 (en) | 2003-04-23 |
US20090105137A1 (en) | 2009-04-23 |
JP3504263B2 (ja) | 2004-03-08 |
AU674500B2 (en) | 1997-01-02 |
MX9206315A (es) | 1993-05-01 |
US7678885B2 (en) | 2010-03-16 |
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