DE69228005D1 - Herstellung von fucosylierten Kohlenhydraten durch enzymatische Fucosylierungs-Synthese der Zuckernukleotide; und in situ Regeneration von GDP-fucose - Google Patents

Herstellung von fucosylierten Kohlenhydraten durch enzymatische Fucosylierungs-Synthese der Zuckernukleotide; und in situ Regeneration von GDP-fucose

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Publication number
DE69228005D1
DE69228005D1 DE69228005T DE69228005T DE69228005D1 DE 69228005 D1 DE69228005 D1 DE 69228005D1 DE 69228005 T DE69228005 T DE 69228005T DE 69228005 T DE69228005 T DE 69228005T DE 69228005 D1 DE69228005 D1 DE 69228005D1
Authority
DE
Germany
Prior art keywords
carbohydrates
production
gdp
fucose
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69228005T
Other languages
English (en)
Other versions
DE69228005T2 (de
Inventor
Chi-Huey Wong
Yoshitaka Ichikawa
Gwo-Jenn Shen
Kun-Chin Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/961,076 external-priority patent/US6319695B1/en
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of DE69228005D1 publication Critical patent/DE69228005D1/de
Application granted granted Critical
Publication of DE69228005T2 publication Critical patent/DE69228005T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE69228005T 1991-10-15 1992-10-15 Herstellung von fucosylierten Kohlenhydraten durch enzymatische Fucosylierungs-Synthese der Zuckernukleotide; und in situ Regeneration von GDP-fucose Expired - Fee Related DE69228005T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77766291A 1991-10-15 1991-10-15
US90126092A 1992-06-19 1992-06-19
US91061292A 1992-07-08 1992-07-08
US07/961,076 US6319695B1 (en) 1991-10-15 1992-10-14 Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
PCT/US1992/008789 WO1993008205A1 (en) 1991-10-15 1992-10-15 Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of gdp-fucose

Publications (2)

Publication Number Publication Date
DE69228005D1 true DE69228005D1 (de) 1999-02-04
DE69228005T2 DE69228005T2 (de) 1999-07-15

Family

ID=27505746

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69228005T Expired - Fee Related DE69228005T2 (de) 1991-10-15 1992-10-15 Herstellung von fucosylierten Kohlenhydraten durch enzymatische Fucosylierungs-Synthese der Zuckernukleotide; und in situ Regeneration von GDP-fucose

Country Status (13)

Country Link
US (2) US6518418B1 (de)
EP (1) EP0642526B1 (de)
JP (1) JPH07500248A (de)
AT (1) ATE174925T1 (de)
AU (1) AU675209B2 (de)
BG (1) BG98713A (de)
CA (1) CA2121365C (de)
DE (1) DE69228005T2 (de)
ES (1) ES2129458T3 (de)
FI (1) FI941732A (de)
RO (1) RO118132B1 (de)
SK (1) SK42594A3 (de)
WO (1) WO1993008205A1 (de)

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ES2129458T3 (es) 1991-10-15 1999-06-16 Scripps Research Inst Produccion de carbohidratos fucosilados por sintesis con fucosilacion enzimatica de nucleotidos de azucares y regeneracion in situ de gdp-fucosa.
IT1268954B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
US6040158A (en) * 1996-09-11 2000-03-21 Yamasa Corporation Process for preparing sugar nucleotide
US6022713A (en) * 1996-11-19 2000-02-08 Yamasa Corporation Process for producing nucleoside 5'-triphosphates and application of the same
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
DE19908712C2 (de) * 1999-03-01 2002-02-07 Forschungszentrum Juelich Gmbh Verfahren zur Herstellung eines ·1··8·F-markierten Glykosylierungsreagenz
CA2723197C (en) * 2008-05-02 2017-09-19 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
US9504702B2 (en) 2010-08-05 2016-11-29 Seattle Genetics, Inc. Methods of inhibition of protein fucosylation in vivo using fucose analogs
US20140057868A1 (en) * 2011-02-21 2014-02-27 Glycom A/S Catalytic hydrogenolysis of a composition of a mixture of oligosaccharide precursors and uses thereof
EP2719767A4 (de) * 2011-06-09 2015-01-21 Sanyo Chemical Ind Ltd Verfahren zur herstellung eines polysaccharids
MX363385B (es) 2012-08-23 2019-03-20 Seattle Genetics Inc Métodos para el tratamiento de enfermedad de células falciformes y otras condiciones inflamatorias.
CN104876977A (zh) * 2013-07-17 2015-09-02 张家港威胜生物医药有限公司 一种制备1-溴-2,3,4,6-四-O-乙酰基-α-D-吡喃葡萄糖的方法
CN108251474A (zh) * 2018-01-15 2018-07-06 山东大学 Abh人血型抗原的合成方法
BR112021003156A2 (pt) 2018-08-23 2021-05-11 Seagen, Inc. composição, anticorpo que se liga ao tigit humano, formulação farmacêutica, polinucleotídeo isolado, vetor, célula hospedeira, métodos para a produção de um anticorpo que se liga ao tigit humano e de anticorpos afucosilados que se ligam a tigit e para o tratamento de um câncer, e, kit.
EP3719135A1 (de) * 2019-04-01 2020-10-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Enzymatisches verfahren zur herstellung von gdp-fucose
CN116261597A (zh) * 2020-08-10 2023-06-13 因比奥斯公司 α-1,3糖基化形式的Fuc-a1,2-Gal-R的产生
CN112915565B (zh) * 2021-03-04 2022-04-08 安徽金禾实业股份有限公司 一种旋转式蔗糖-6-酯连续生产设备及生产方法
CN114990175B (zh) * 2021-10-22 2023-03-31 岩唐生物科技(杭州)有限责任公司 一种岩藻糖衍生物的合成方法
CN113960232B (zh) * 2021-10-28 2024-02-20 苏州大学 一种基于唾液特异性岩藻糖基化结构糖谱及其检测方法和应用
WO2023225102A1 (en) * 2022-05-18 2023-11-23 Glycomine, Inc. Continuous flow methods for producing mannose-1-phosphate, polymorphs of mannose-1-phosphate, and compositions and uses related thereto
US20230407357A1 (en) * 2022-05-20 2023-12-21 Zymtronix Catalytic Systems, Inc. Biomanufacturing of oligosaccharides and derivatives from simple sugar

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GB1544908A (en) * 1975-07-08 1979-04-25 Chembiomed Ltd Artificial oligosaccharide antigenic determinants
US4178210A (en) * 1977-03-07 1979-12-11 Massachusetts Institute Of Technology Accellular synthesis of cephalosporins
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4973679A (en) * 1981-03-27 1990-11-27 University Patents, Inc. Process for oligonucleo tide synthesis using phosphormidite intermediates
FR2509313A1 (fr) * 1981-07-08 1983-01-14 Choay Sa Derives de 3-fucosyl-n-acetyl lactosamine, leur preparation et leurs applications biologiques
DE3220427A1 (de) * 1982-05-29 1983-12-01 Behringwerke Ag, 3550 Marburg Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung
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DE3626915A1 (de) * 1986-08-08 1988-02-11 Hoechst Ag Verfahren zur enzymatischen synthese eines n-acetylneuraminsaeure-haltigen trisaccharids
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SE466403B (sv) 1988-03-24 1992-02-10 Kurt G I Nilsson Saett att syntetisera oligosackarider
US5109126A (en) * 1988-12-06 1992-04-28 Worcester Foundation For Experimental Biology 5'[2'(3')-O-(2,4,6-trinitrophenyl) pyprimidine nucleoside]diphosphate 1-glycosides
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Also Published As

Publication number Publication date
ES2129458T3 (es) 1999-06-16
AU675209B2 (en) 1997-01-30
US6518418B1 (en) 2003-02-11
DE69228005T2 (de) 1999-07-15
JPH07500248A (ja) 1995-01-12
FI941732A0 (fi) 1994-04-14
AU2785492A (en) 1993-05-21
US7335500B2 (en) 2008-02-26
FI941732A (fi) 1994-06-14
BG98713A (bg) 1995-05-31
EP0642526A4 (de) 1996-04-10
CA2121365C (en) 2000-11-28
US20020068331A1 (en) 2002-06-06
SK42594A3 (en) 1994-10-05
ATE174925T1 (de) 1999-01-15
CA2121365A1 (en) 1993-04-29
RO118132B1 (ro) 2003-02-28
EP0642526B1 (de) 1998-12-23
EP0642526A1 (de) 1995-03-15
WO1993008205A1 (en) 1993-04-29

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