ES2129458T3 - Produccion de carbohidratos fucosilados por sintesis con fucosilacion enzimatica de nucleotidos de azucares y regeneracion in situ de gdp-fucosa. - Google Patents
Produccion de carbohidratos fucosilados por sintesis con fucosilacion enzimatica de nucleotidos de azucares y regeneracion in situ de gdp-fucosa.Info
- Publication number
- ES2129458T3 ES2129458T3 ES92921939T ES92921939T ES2129458T3 ES 2129458 T3 ES2129458 T3 ES 2129458T3 ES 92921939 T ES92921939 T ES 92921939T ES 92921939 T ES92921939 T ES 92921939T ES 2129458 T3 ES2129458 T3 ES 2129458T3
- Authority
- ES
- Spain
- Prior art keywords
- carbohydrates
- enzymatic
- production
- fucosilation
- fucosilated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A METODOS DE PRODUCCION ENZIMATICA DE CARBOHIDRATOS, ESPECIALMENTE CARBOHIDRATOS FUCOSILATADOS. TAMBIEN SE ANALIZAN SINTESIS PERFECCIONADAS DE 1 DE GLICOSILO, USANDO MEDIOS QUIMICOS Y ENZIMATICOS. LOS GLICOSIDOS FOSFORILATADOS SE USAN DESPUES PARA OBTENER NUCLEOTIDOS DE AZUCAR, QUE SON, A SU VEZ, USADOS COMO AZUCARES DONANTES PARA GLICOSILACION DE CARBOHIDRATOS ACEPTORES. ESPECIALMENTE PREFERENTE AQUI ES EL USO DE UN METODO DESCRITO PARA FUCOSILACION.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77766291A | 1991-10-15 | 1991-10-15 | |
US90126092A | 1992-06-19 | 1992-06-19 | |
US91061292A | 1992-07-08 | 1992-07-08 | |
US07/961,076 US6319695B1 (en) | 1991-10-15 | 1992-10-14 | Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2129458T3 true ES2129458T3 (es) | 1999-06-16 |
Family
ID=27505746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92921939T Expired - Lifetime ES2129458T3 (es) | 1991-10-15 | 1992-10-15 | Produccion de carbohidratos fucosilados por sintesis con fucosilacion enzimatica de nucleotidos de azucares y regeneracion in situ de gdp-fucosa. |
Country Status (13)
Country | Link |
---|---|
US (2) | US6518418B1 (es) |
EP (1) | EP0642526B1 (es) |
JP (1) | JPH07500248A (es) |
AT (1) | ATE174925T1 (es) |
AU (1) | AU675209B2 (es) |
BG (1) | BG98713A (es) |
CA (1) | CA2121365C (es) |
DE (1) | DE69228005T2 (es) |
ES (1) | ES2129458T3 (es) |
FI (1) | FI941732A (es) |
RO (1) | RO118132B1 (es) |
SK (1) | SK42594A3 (es) |
WO (1) | WO1993008205A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK42594A3 (en) | 1991-10-15 | 1994-10-05 | Scripps Research Inst | Method of production of fucosylated carbohydrates |
IT1268954B1 (it) * | 1994-03-11 | 1997-03-18 | Fidia Advanced Biopolymers Srl | Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche |
AU4032297A (en) * | 1996-09-11 | 1998-04-02 | Yamasa Corporation | Process for preparing sugar nucleotide |
WO1998022614A1 (fr) * | 1996-11-19 | 1998-05-28 | Yamasa Corporation | Procede pour produire des nucleosides 5'-triphosphates et utilisation desdits nucleosides |
US6274725B1 (en) * | 1998-06-02 | 2001-08-14 | Isis Pharmaceuticals, Inc. | Activators for oligonucleotide synthesis |
DE19908712C2 (de) * | 1999-03-01 | 2002-02-07 | Forschungszentrum Juelich Gmbh | Verfahren zur Herstellung eines ·1··8·F-markierten Glykosylierungsreagenz |
CN102076865B (zh) | 2008-05-02 | 2016-03-16 | 西雅图基因公司 | 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物 |
MX356671B (es) | 2010-08-05 | 2018-06-08 | Seattle Genetics Inc | Métodos para inhibir fucosilación de proteína in vivo utilizando análogos de fucosa. |
EP2678347A4 (en) * | 2011-02-21 | 2014-10-08 | Glycom As | CATALYTIC HYDROGENOLYSIS OF A COMPOSITION FROM A MIXTURE OF OLIGOSACCHARIDE PROBLEMS AND APPLICATIONS THEREOF |
KR101577127B1 (ko) * | 2011-06-09 | 2015-12-11 | 산요가세이고교 가부시키가이샤 | 다당의 제조 방법 |
CA2882725C (en) | 2012-08-23 | 2021-03-09 | Regents Of The University Of Minnesota | Treatment of sickle cell disease and inflammatory conditions |
CN104876977A (zh) * | 2013-07-17 | 2015-09-02 | 张家港威胜生物医药有限公司 | 一种制备1-溴-2,3,4,6-四-O-乙酰基-α-D-吡喃葡萄糖的方法 |
CN108251474A (zh) * | 2018-01-15 | 2018-07-06 | 山东大学 | Abh人血型抗原的合成方法 |
KR20210057053A (ko) | 2018-08-23 | 2021-05-20 | 씨젠 인크. | 항-tigit 항체 |
EP3719135A1 (en) * | 2019-04-01 | 2020-10-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Enzymatic method for preparation of gdp-fucose |
CN116249781A (zh) * | 2020-08-10 | 2023-06-09 | 因比奥斯公司 | 在细胞中的含有GlcNAc的生物产品的产生 |
CN112915565B (zh) * | 2021-03-04 | 2022-04-08 | 安徽金禾实业股份有限公司 | 一种旋转式蔗糖-6-酯连续生产设备及生产方法 |
CN114990175B (zh) * | 2021-10-22 | 2023-03-31 | 岩唐生物科技(杭州)有限责任公司 | 一种岩藻糖衍生物的合成方法 |
CN113960232B (zh) * | 2021-10-28 | 2024-02-20 | 苏州大学 | 一种基于唾液特异性岩藻糖基化结构糖谱及其检测方法和应用 |
WO2023225102A1 (en) * | 2022-05-18 | 2023-11-23 | Glycomine, Inc. | Continuous flow methods for producing mannose-1-phosphate, polymorphs of mannose-1-phosphate, and compositions and uses related thereto |
WO2023225364A1 (en) * | 2022-05-20 | 2023-11-23 | Zymtronix Catalytic Systems, Inc. | Biomanufacturing of oligosaccharides and derivatives from simple sugars |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1544908A (en) * | 1975-07-08 | 1979-04-25 | Chembiomed Ltd | Artificial oligosaccharide antigenic determinants |
US4178210A (en) * | 1977-03-07 | 1979-12-11 | Massachusetts Institute Of Technology | Accellular synthesis of cephalosporins |
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4973679A (en) * | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
FR2509313A1 (fr) * | 1981-07-08 | 1983-01-14 | Choay Sa | Derives de 3-fucosyl-n-acetyl lactosamine, leur preparation et leurs applications biologiques |
DE3220427A1 (de) * | 1982-05-29 | 1983-12-01 | Behringwerke Ag, 3550 Marburg | Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung |
US4770994A (en) * | 1982-07-30 | 1988-09-13 | Abbott Laboratories | Determination of carbohydrate acceptors |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
EP0263533A3 (en) * | 1983-03-01 | 1990-05-30 | C.R.C. Compagnia di Ricerca Chimica S.p.A. | A method for preparing the cytidine monophosphate of 5-acetamido-3,5-dideoxy-d-glycero-d-galactononulosaminic acid |
JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
US4925796A (en) * | 1986-03-07 | 1990-05-15 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
DE3626915A1 (de) * | 1986-08-08 | 1988-02-11 | Hoechst Ag | Verfahren zur enzymatischen synthese eines n-acetylneuraminsaeure-haltigen trisaccharids |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5079353A (en) * | 1987-12-02 | 1992-01-07 | Chembiomed, Ltd. | Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation |
US5344870A (en) | 1987-12-02 | 1994-09-06 | Alberta Research Council | Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation |
SE466403B (sv) | 1988-03-24 | 1992-02-10 | Kurt G I Nilsson | Saett att syntetisera oligosackarider |
US5109126A (en) * | 1988-12-06 | 1992-04-28 | Worcester Foundation For Experimental Biology | 5'[2'(3')-O-(2,4,6-trinitrophenyl) pyprimidine nucleoside]diphosphate 1-glycosides |
WO1991016449A1 (en) | 1990-04-16 | 1991-10-31 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
AU668505B2 (en) * | 1991-03-18 | 1996-05-09 | Scripps Research Institute, The | Oligosaccharide enzyme substrates and inhibitors: methods and compositions |
US5278299A (en) | 1991-03-18 | 1994-01-11 | Scripps Clinic And Research Foundation | Method and composition for synthesizing sialylated glycosyl compounds |
TW213952B (es) | 1991-04-09 | 1993-10-01 | Hoechst Ag | |
US5352670A (en) | 1991-06-10 | 1994-10-04 | Alberta Research Council | Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides |
SK42594A3 (en) | 1991-10-15 | 1994-10-05 | Scripps Research Inst | Method of production of fucosylated carbohydrates |
US5220008A (en) | 1991-11-22 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Oligosaccharide inhibitors for influenza virus |
-
1992
- 1992-10-15 SK SK425-94A patent/SK42594A3/sk unknown
- 1992-10-15 DE DE69228005T patent/DE69228005T2/de not_active Expired - Fee Related
- 1992-10-15 CA CA002121365A patent/CA2121365C/en not_active Expired - Fee Related
- 1992-10-15 RO RO94-00636A patent/RO118132B1/ro unknown
- 1992-10-15 ES ES92921939T patent/ES2129458T3/es not_active Expired - Lifetime
- 1992-10-15 AU AU27854/92A patent/AU675209B2/en not_active Ceased
- 1992-10-15 EP EP92921939A patent/EP0642526B1/en not_active Expired - Lifetime
- 1992-10-15 JP JP5507791A patent/JPH07500248A/ja active Pending
- 1992-10-15 WO PCT/US1992/008789 patent/WO1993008205A1/en not_active Application Discontinuation
- 1992-10-15 AT AT92921939T patent/ATE174925T1/de not_active IP Right Cessation
- 1992-12-10 US US07/991,182 patent/US6518418B1/en not_active Expired - Fee Related
-
1994
- 1994-04-13 BG BG98713A patent/BG98713A/bg unknown
- 1994-04-14 FI FI941732A patent/FI941732A/fi unknown
-
2001
- 2001-11-19 US US09/992,680 patent/US7335500B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FI941732A (fi) | 1994-06-14 |
DE69228005T2 (de) | 1999-07-15 |
US6518418B1 (en) | 2003-02-11 |
BG98713A (bg) | 1995-05-31 |
AU675209B2 (en) | 1997-01-30 |
EP0642526B1 (en) | 1998-12-23 |
EP0642526A1 (en) | 1995-03-15 |
CA2121365A1 (en) | 1993-04-29 |
FI941732A0 (fi) | 1994-04-14 |
ATE174925T1 (de) | 1999-01-15 |
EP0642526A4 (en) | 1996-04-10 |
US7335500B2 (en) | 2008-02-26 |
WO1993008205A1 (en) | 1993-04-29 |
CA2121365C (en) | 2000-11-28 |
DE69228005D1 (de) | 1999-02-04 |
US20020068331A1 (en) | 2002-06-06 |
AU2785492A (en) | 1993-05-21 |
RO118132B1 (ro) | 2003-02-28 |
JPH07500248A (ja) | 1995-01-12 |
SK42594A3 (en) | 1994-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2129458T3 (es) | Produccion de carbohidratos fucosilados por sintesis con fucosilacion enzimatica de nucleotidos de azucares y regeneracion in situ de gdp-fucosa. | |
HU9401072D0 (en) | Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of gdp-fucose | |
SE8505842L (sv) | Sett att syntetisera glykosidiska bindningar | |
DE69217491D1 (de) | Verfahren zur enzymatischen herstellung von alpha-sialylierten oligosaccharid-glykosiden | |
DE69232138D1 (de) | Methode zur isolation von glykosyltransferasen | |
DE69524092D1 (de) | Fraktionierungsverfahren für saccharose enthaltende lösungen | |
NZ337701A (en) | Process for processing sucrose into glucose and fructose | |
MX172793B (es) | Procedimiento para sintetizar derivados de sacarosa mediante reaccion regio selectiva | |
NO960177L (no) | Fremgangsmåte for fremstilling av sakaridsammensetninger | |
ATE177790T1 (de) | Methode zur enzymatischen synthese von kohlenhydraten | |
SE9301677D0 (sv) | Syntesmetod | |
Percy et al. | Acceptor specificity of cellobiose phosphorylase from Cellvibrio gilvus: synthesis of three branched trisaccharides | |
AU580686B2 (en) | Isolation of unreduced oligosaccharides | |
GB1331389A (en) | Sucrose/starch sweeteners | |
RU94026248A (ru) | Способы получения фукозилированных углеводов за счет ферментативного фукозилирования нуклеотидов сахаров с регенерацией gdp фукозы in situ, реакционная система in vitro, способ получения гликозил-1 или 2-фосфита, защищенный фосфитильный моносахарид, способ галоидгидратирования, гликозилгалоидгидрины | |
WO2000014264A8 (en) | Method for the production of sialylated oligosaccharides | |
ES2164885T3 (es) | Procedimiento para la gactosilacion enzimatica de mono- y oligo-sacaridos. | |
SE8602971D0 (sv) | Low calorie bulking agent, method for production thereof, and use thereof | |
NO941346L (no) | Fremstilling av fucosylerte karboydrater ved enzymatisk fucosyleringssyntese av sukkernukleotider; samt regenerering in situ av GDP-fucose | |
Tariq et al. | Synthesis and structural analysis of disaccharides of 4-O-β-d-glucopyranosyl-d-glucosamine and 4-Od-β-glucopyranosyl-2-deoxy-d-glucose | |
WO1999009180A3 (de) | Verfahren zur enzymatischen herstellung von guanosindiphosphat-6-desoxyhexosen und deren verwendung zur herstellung von oligosacchariden | |
RU92016371A (ru) | Композиции сахаридов, способы их устройства для их синтеза | |
EP0730033A3 (en) | Method of producing glycosphingolipid | |
Chiba et al. | Enzymatic Synthesis of a New Disaccharide, 6-O-α-Glucopyranosyl-2-deoxy-D-glucose, by Transglucosylation of Schizosaccharomyces pombe α-Glucosidase | |
WO2024050533A3 (en) | Compositions and methods for producing rebaudioside m |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 642526 Country of ref document: ES |