DE69217491D1 - Verfahren zur enzymatischen herstellung von alpha-sialylierten oligosaccharid-glykosiden - Google Patents

Verfahren zur enzymatischen herstellung von alpha-sialylierten oligosaccharid-glykosiden

Info

Publication number
DE69217491D1
DE69217491D1 DE69217491T DE69217491T DE69217491D1 DE 69217491 D1 DE69217491 D1 DE 69217491D1 DE 69217491 T DE69217491 T DE 69217491T DE 69217491 T DE69217491 T DE 69217491T DE 69217491 D1 DE69217491 D1 DE 69217491D1
Authority
DE
Germany
Prior art keywords
alpha
sialylated oligosaccharide
enzymatic production
employed
oligosaccharide glycosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69217491T
Other languages
English (en)
Other versions
DE69217491T2 (de
Inventor
Andre Venot
Frank Unger
Mohammed Kashem
Paul Bird
M Mazid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycomed Inc
Original Assignee
Glycomed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomed Inc filed Critical Glycomed Inc
Publication of DE69217491D1 publication Critical patent/DE69217491D1/de
Application granted granted Critical
Publication of DE69217491T2 publication Critical patent/DE69217491T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE69217491T 1991-06-10 1992-06-09 Verfahren zur enzymatischen herstellung von alpha-sialylierten oligosaccharid-glykosiden Expired - Fee Related DE69217491T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71416191A 1991-06-10 1991-06-10
US07/771,007 US5352670A (en) 1991-06-10 1991-10-02 Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
PCT/CA1992/000243 WO1992022661A1 (en) 1991-06-10 1992-06-09 Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides

Publications (2)

Publication Number Publication Date
DE69217491D1 true DE69217491D1 (de) 1997-03-27
DE69217491T2 DE69217491T2 (de) 1997-10-02

Family

ID=27109106

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69217491T Expired - Fee Related DE69217491T2 (de) 1991-06-10 1992-06-09 Verfahren zur enzymatischen herstellung von alpha-sialylierten oligosaccharid-glykosiden

Country Status (8)

Country Link
US (1) US5352670A (de)
EP (1) EP0589933B1 (de)
JP (1) JPH06509703A (de)
AT (1) ATE148920T1 (de)
CA (1) CA2110386C (de)
DE (1) DE69217491T2 (de)
ES (1) ES2100346T3 (de)
WO (1) WO1992022661A1 (de)

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US5352670A (en) 1994-10-04
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CA2110386C (en) 2000-04-25
JPH06509703A (ja) 1994-11-02
EP0589933B1 (de) 1997-02-12
ATE148920T1 (de) 1997-02-15
ES2100346T3 (es) 1997-06-16
WO1992022661A1 (en) 1992-12-23
DE69217491T2 (de) 1997-10-02

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