ES2100346T3 - Un procedimiento para la sintesis enzimatica de un glicosido oligosacarido alfa-sializado. - Google Patents

Un procedimiento para la sintesis enzimatica de un glicosido oligosacarido alfa-sializado.

Info

Publication number
ES2100346T3
ES2100346T3 ES92911544T ES92911544T ES2100346T3 ES 2100346 T3 ES2100346 T3 ES 2100346T3 ES 92911544 T ES92911544 T ES 92911544T ES 92911544 T ES92911544 T ES 92911544T ES 2100346 T3 ES2100346 T3 ES 2100346T3
Authority
ES
Spain
Prior art keywords
alpha
enzymatic synthesis
sialized
procedure
oligosaccharide glycoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92911544T
Other languages
English (en)
Inventor
Andre P Venot
Frank M Unger
Mohammed A Kashem
Paul Bird
M Abdul Mazid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycomed Inc
Original Assignee
Glycomed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomed Inc filed Critical Glycomed Inc
Application granted granted Critical
Publication of ES2100346T3 publication Critical patent/ES2100346T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

SE PRESENTAN METODOS PARA LA SINTESIS ENZIMATICA DE GLICOSIDOS DE OLIGOSACARIDOS ALFA-SILILADOS. ESPECIFICAMENTE, EN LOS METODOS PRESENTADOS, LA SILIL TRANSFERASA SE ACTIVA PARA TRANSFERIR UN ANALOGOS DEL ACIDO SIALICO, EMPLEADO COMO SUBDERIVADO DEL NUCLEOTIDO CMP, EN UN GLICOSIDO DE OLIGOSACARIDO. EL ANALOGO DEL ACIDO SIALICO Y EL OLIGOSACARIDO EMPLEADOS EN ESTE METODOS SE SELECCIONAN PARA QUE SEAN COMPATIBLES CON LA SIALIL TRANSFERASA USADA.
ES92911544T 1991-06-10 1992-06-09 Un procedimiento para la sintesis enzimatica de un glicosido oligosacarido alfa-sializado. Expired - Lifetime ES2100346T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71416191A 1991-06-10 1991-06-10
US07/771,007 US5352670A (en) 1991-06-10 1991-10-02 Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides

Publications (1)

Publication Number Publication Date
ES2100346T3 true ES2100346T3 (es) 1997-06-16

Family

ID=27109106

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92911544T Expired - Lifetime ES2100346T3 (es) 1991-06-10 1992-06-09 Un procedimiento para la sintesis enzimatica de un glicosido oligosacarido alfa-sializado.

Country Status (8)

Country Link
US (1) US5352670A (es)
EP (1) EP0589933B1 (es)
JP (1) JPH06509703A (es)
AT (1) ATE148920T1 (es)
CA (1) CA2110386C (es)
DE (1) DE69217491T2 (es)
ES (1) ES2100346T3 (es)
WO (1) WO1992022661A1 (es)

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DE69217491D1 (de) 1997-03-27
US5352670A (en) 1994-10-04
CA2110386A1 (en) 1992-12-23
CA2110386C (en) 2000-04-25
EP0589933A1 (en) 1994-04-06
JPH06509703A (ja) 1994-11-02
EP0589933B1 (en) 1997-02-12
ATE148920T1 (de) 1997-02-15
DE69217491T2 (de) 1997-10-02

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