HUP9900058A2 - Polilaktózaminokat tartalmazó szintetikus multivalens sLEX és eljárások az alkalmazására - Google Patents
Polilaktózaminokat tartalmazó szintetikus multivalens sLEX és eljárások az alkalmazásáraInfo
- Publication number
- HUP9900058A2 HUP9900058A2 HU9900058A HUP9900058A HUP9900058A2 HU P9900058 A2 HUP9900058 A2 HU P9900058A2 HU 9900058 A HU9900058 A HU 9900058A HU P9900058 A HUP9900058 A HU P9900058A HU P9900058 A2 HUP9900058 A2 HU P9900058A2
- Authority
- HU
- Hungary
- Prior art keywords
- primordial
- subject
- methods
- structures
- new synthetic
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001720 carbohydrates Chemical group 0.000 abstract 2
- LAQPKDLYOBZWBT-NYLDSJSYSA-N (2s,4s,5r,6r)-5-acetamido-2-{[(2s,3r,4s,5s,6r)-2-{[(2r,3r,4r,5r)-5-acetamido-1,2-dihydroxy-6-oxo-4-{[(2s,3s,4r,5s,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-6-[(1r,2r)-1,2,3-trihydrox Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]([C@@H](NC(C)=O)C=O)[C@@H]([C@H](O)CO)O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 LAQPKDLYOBZWBT-NYLDSJSYSA-N 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 102000003800 Selectins Human genes 0.000 abstract 1
- 108090000184 Selectins Proteins 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
Abstract
A találmány új készítményekre és ezek alkalmazására vőnatkőzikgyűlladásős válaszők kezelésében. Közelebbről a találmány tárgyát újszintetikűs őligőszacharidszerkezetek, különösen többszörösen sLex-ettartalmaz pőli(N-acetil-laktózaminők) képezik, és alkalmazásűk amegfelelő őligőszacharidőkhőz történő limfőcitakötődés blőkkőlására azendőteliális felszínen, és ezáltal a nemkívánt gyűlladásős válaszőkcsökkentésére vagy más módőn javítására. A találmány tővábbá az ilyenszerkezetek szelektinkötődéssel jellemezhető, egyéb betegségiállapőtőkban történő felhasználására is vőnatkőzik, mint példáűlbakteriális fertőzések és tűmőrmetasztázisők. A találmány tárgyát képezik tővábbá az új szintetikűs őligőszacharidőkelőállítására szőlgáló enzimes eljárásők is. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US462395P | 1995-09-29 | 1995-09-29 | |
| US786795P | 1995-12-01 | 1995-12-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP9900058A2 true HUP9900058A2 (hu) | 1999-04-28 |
Family
ID=26673254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900058A HUP9900058A2 (hu) | 1995-09-29 | 1996-09-27 | Polilaktózaminokat tartalmazó szintetikus multivalens sLEX és eljárások az alkalmazására |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5965544A (hu) |
| EP (1) | EP0874861A1 (hu) |
| JP (1) | JP2000507993A (hu) |
| AU (1) | AU713078B2 (hu) |
| CA (1) | CA2231073A1 (hu) |
| CZ (1) | CZ89098A3 (hu) |
| HU (1) | HUP9900058A2 (hu) |
| NO (1) | NO981361L (hu) |
| PL (1) | PL325873A1 (hu) |
| SK (1) | SK39498A3 (hu) |
| WO (1) | WO1997012892A1 (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204431B1 (en) | 1994-03-09 | 2001-03-20 | Abbott Laboratories | Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk |
| US6841543B1 (en) * | 1996-01-31 | 2005-01-11 | President And Fellows Of Harvard College | Methods of inhibiting production of T helper type 2 cytokines in human immune cells |
| EP0926154B1 (en) * | 1996-07-23 | 2010-01-27 | Seikagaku Corporation | Novel lactosamine oligosaccharides and process for the preparation thereof |
| JP2001515912A (ja) | 1997-09-05 | 2001-09-25 | グリシム オサケ ユキチュア | 合成二価ｓＬｅｘ含有ポリラクトサミン類および使用法 |
| US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| SE9904581D0 (sv) * | 1999-12-15 | 1999-12-15 | A & Science Invest Ab | A novel helicobacter pylori-binding substance and use thereof |
| AU2001261534A1 (en) * | 2000-05-11 | 2001-11-20 | The Burnham Institute | The meca-79 antigen and related methods |
| WO2002000879A2 (en) * | 2000-06-28 | 2002-01-03 | Glycofi, Inc. | Methods for producing modified glycoproteins |
| AU2001287422A1 (en) * | 2000-08-22 | 2002-03-04 | National Research Council Of Canada | Synthesis of complex carbohydrates |
| US20050026866A1 (en) * | 2002-08-02 | 2005-02-03 | Pawelek John M. | Agents and methods for treatment of disease by oligosaccharide targeting agents |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5079353A (en) * | 1987-12-02 | 1992-01-07 | Chembiomed, Ltd. | Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation |
| AU8007791A (en) * | 1990-06-15 | 1992-01-07 | Cytel Corporation | Intercellular adhesion mediators |
| US5211937A (en) * | 1990-07-30 | 1993-05-18 | Glycomed Incorporated | Method of determining a site of inflammation utilizing elam-1 ligands |
| US5352670A (en) * | 1991-06-10 | 1994-10-04 | Alberta Research Council | Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides |
| CA2110797C (en) * | 1991-06-10 | 2001-02-20 | Andre P. Venot | Modified sialyl lewis x compounds |
| WO1993015098A1 (en) * | 1992-01-31 | 1993-08-05 | Nippon Shinyaku Co., Ltd. | Lewis-type sugar chain derivative |
| JPH0686684A (ja) * | 1992-05-26 | 1994-03-29 | Monsanto Co | シアロ抱合体の合成 |
| US5591835A (en) * | 1992-06-29 | 1997-01-07 | Glycomed Incorporated | Substituted lactose derivatives |
| US5426178A (en) * | 1993-03-31 | 1995-06-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis of anti-inflammatory compounds, and novel trisaccharides useful in the synthesis of anti-inflammatory compounds |
| EP0697880B1 (en) * | 1993-05-03 | 2001-08-22 | Genentech, Inc. | Inhibition of leukocyte adhesion |
| US5409817A (en) * | 1993-05-04 | 1995-04-25 | Cytel, Inc. | Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides |
| US5374541A (en) * | 1993-05-04 | 1994-12-20 | The Scripps Research Institute | Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides |
| EP0698031A4 (en) * | 1993-05-14 | 1997-07-09 | Cytel Corp | SIALYL LEx ANALOGS AS INHIBITORS OF CELLULAR ADHESION |
| AU7083594A (en) * | 1993-07-02 | 1995-01-24 | Nippon Shinyaku Co. Ltd. | Galactosylmoranoline derivative |
| US5559103A (en) * | 1993-07-21 | 1996-09-24 | Cytel Corporation | Bivalent sialyl X saccharides |
| AU7467394A (en) * | 1993-08-23 | 1995-03-21 | Nippon Shinyaku Co. Ltd. | Galactosylmoranoline derivative |
| EP0671409A3 (de) * | 1994-03-11 | 1996-06-12 | Hoechst Ag | Malonsäurederivate mit antiadhäsiven Eigenschaften. |
| HUT77345A (hu) * | 1994-04-29 | 1998-03-30 | Texas Biotechnology Corporation | E-szelektin, P-szelektin vagy L-szelektin szialil-Lewis x-hez vagy szialil-Lewis a-hoz kapcsolódását gátló mannopiranoziloxi-bifenil származékok és ezeket tartalmazó gyógyszerkészítmények |
-
1996
- 1996-09-27 CA CA002231073A patent/CA2231073A1/en not_active Abandoned
- 1996-09-27 CZ CZ98890A patent/CZ89098A3/cs unknown
- 1996-09-27 WO PCT/FI1996/000513 patent/WO1997012892A1/en not_active Application Discontinuation
- 1996-09-27 EP EP96931833A patent/EP0874861A1/en not_active Withdrawn
- 1996-09-27 PL PL96325873A patent/PL325873A1/xx unknown
- 1996-09-27 JP JP9513991A patent/JP2000507993A/ja active Pending
- 1996-09-27 SK SK394-98A patent/SK39498A3/sk unknown
- 1996-09-27 HU HU9900058A patent/HUP9900058A2/hu unknown
- 1996-09-27 US US08/722,573 patent/US5965544A/en not_active Expired - Fee Related
- 1996-09-27 AU AU70872/96A patent/AU713078B2/en not_active Ceased
-
1998
- 1998-03-25 NO NO981361A patent/NO981361L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL325873A1 (en) | 1998-08-17 |
| JP2000507993A (ja) | 2000-06-27 |
| CA2231073A1 (en) | 1997-04-10 |
| NO981361D0 (no) | 1998-03-25 |
| AU7087296A (en) | 1997-04-28 |
| CZ89098A3 (cs) | 1998-09-16 |
| WO1997012892A1 (en) | 1997-04-10 |
| SK39498A3 (en) | 1999-01-11 |
| US5965544A (en) | 1999-10-12 |
| AU713078B2 (en) | 1999-11-25 |
| EP0874861A1 (en) | 1998-11-04 |
| NO981361L (no) | 1998-05-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IT8721005A0 (it) | Metodo per la preservazione difogli trapiantabili di epitelio coltivato in vitro vitale. | |
| BG102708A (en) | 4-aminopyrimidine derivatives, medicamentous preparations containing them, their application and method for their preparation | |
| ATE146360T1 (de) | Gonadotropin enthaltende gefriergetrocknete troepfen | |
| DK1053256T3 (da) | Antistoffer mod Dødsreceptor 4 (DR4) og anvendelser deraf | |
| HUP9900058A2 (hu) | Polilaktózaminokat tartalmazó szintetikus multivalens sLEX és eljárások az alkalmazására | |
| DE3884622D1 (de) | Schmiermittelzubereitung zur behandlung von rheuma. | |
| BG46598A3 (en) | Method for preparation of alpha- heterocyclic substituted tolunitriles | |
| ATE82681T1 (de) | 2',3'-dideoxy-3'-fluorothymidin und verwandte verbindungen zur behandlung von adenovirusinfektionen. | |
| BR9607679B8 (pt) | Uso de bicarbornato de potássio, composição farmacêutica, e, processo para tratar esofagite de refluxo, gastrite, dispepsia ou ulceração péptica. | |
| ES498476A0 (es) | Procedimiento de preparacion de arn ribosomales bacterianos | |
| BR8806217A (pt) | Derivados de 2,2-difluorciclopropiletano,processo para sua preparacao,composicoes praguicidas e aplicacao | |
| CA2351947A1 (en) | Hyperforin as cytostatic agent and hyperforin ointment or cream as application form | |
| IT1229991B (it) | Miglioramenti nella,o relativi alla produzione di semi ibridi | |
| WO1999012944A3 (en) | SYNTHETIC DIVALENT sLex CONTAINING POLYLACTOSAMINES AND METHODS FOR USE | |
| NO920143D0 (no) | Substituerte 2-imidazoliner og fremstilling og anvendelsederav | |
| ES2153090T3 (es) | Conjugado inmunoenzimatico, su procedimiento de preparacion y sus aplicaciones. | |
| EP0361490A3 (en) | Sulfated oligosaccharides and derivatives thereof | |
| HUP9801439A2 (hu) | Béta-D-Galakotpiranozil-D-xilózok alkalmazása bél laktáz kimutatására alkalmas készítmények és oldatok előállításánál, valamint eljárás a vegyületek előállítására | |
| ES2163001T3 (es) | Nuevos derivados de borneol, procedimiento para su preparacion y su utilizacion farmaceutica. | |
| IT8447751A0 (it) | Composizione contenente polisaccaride per legare proteine specifiche, metodo per ottenerla e procedimento nonche' corredo di saggio che la impiegano | |
| DE69323191D1 (de) | Wasserlösliche retinoide | |
| DE60003074D1 (de) | Fusidinsäure-derivate | |
| FR2811572B1 (fr) | Utilisation de cyclodextrines polysulfatees pour le traitement de l'arthrose | |
| BG40817A3 (en) | Method for preparation of macrolidic antibiotics | |
| IT8721559A0 (it) | Catalizzatore di deidrogenazione, procedimento per la sua preparazione e suo uso nella produzione di oleofine lineari da paraffine lineari. |