NO981361L - Syntetiske flervalente sLEX inneholdende polyaktosaminer og anvendelse derav - Google Patents

Syntetiske flervalente sLEX inneholdende polyaktosaminer og anvendelse derav

Info

Publication number
NO981361L
NO981361L NO981361A NO981361A NO981361L NO 981361 L NO981361 L NO 981361L NO 981361 A NO981361 A NO 981361A NO 981361 A NO981361 A NO 981361A NO 981361 L NO981361 L NO 981361L
Authority
NO
Norway
Prior art keywords
polyactosamines
relates
constructs
synthetic polyvalent
slex
Prior art date
Application number
NO981361A
Other languages
English (en)
Other versions
NO981361D0 (no
Inventor
Ossi Renkonen
Risto Renkonen
Original Assignee
Glycim Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycim Oy filed Critical Glycim Oy
Publication of NO981361D0 publication Critical patent/NO981361D0/no
Publication of NO981361L publication Critical patent/NO981361L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Den foreliggende oppfinnelse vedrører nye blandinger og deres anvendelse ved behandling av inflammatoriske responser. Spesifikt angår oppfinnelsen nye syntetiske oligosakkarid-konstruksjoner og deres anvendelse til å blokkere lymfocyttbinding til tilsvarende oligosakkarider på endoteloverflaten, og således redusere eller på annen måte forbedre en uønsket inflammatorisk respons. Oppfinnelsen angår dessuten anvendelsen av slike konstruksjoner ved andre sykdomstilstanderselektinbinding, så som bakterieinfeksjoner og metastatisk kreft.
NO981361A 1995-09-29 1998-03-25 Syntetiske flervalente sLEX inneholdende polyaktosaminer og anvendelse derav NO981361L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US462395P 1995-09-29 1995-09-29
US786795P 1995-12-01 1995-12-01
PCT/FI1996/000513 WO1997012892A1 (en) 1995-09-29 1996-09-27 SYNTHETIC MULTIVALENT sLEX CONTAINING POLYLACTOSAMINES AND METHODS FOR USE

Publications (2)

Publication Number Publication Date
NO981361D0 NO981361D0 (no) 1998-03-25
NO981361L true NO981361L (no) 1998-05-26

Family

ID=26673254

Family Applications (1)

Application Number Title Priority Date Filing Date
NO981361A NO981361L (no) 1995-09-29 1998-03-25 Syntetiske flervalente sLEX inneholdende polyaktosaminer og anvendelse derav

Country Status (11)

Country Link
US (1) US5965544A (no)
EP (1) EP0874861A1 (no)
JP (1) JP2000507993A (no)
AU (1) AU713078B2 (no)
CA (1) CA2231073A1 (no)
CZ (1) CZ89098A3 (no)
HU (1) HUP9900058A2 (no)
NO (1) NO981361L (no)
PL (1) PL325873A1 (no)
SK (1) SK39498A3 (no)
WO (1) WO1997012892A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204431B1 (en) 1994-03-09 2001-03-20 Abbott Laboratories Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
US6841543B1 (en) * 1996-01-31 2005-01-11 President And Fellows Of Harvard College Methods of inhibiting production of T helper type 2 cytokines in human immune cells
JP4179567B2 (ja) * 1996-07-23 2008-11-12 生化学工業株式会社 新規ラクトサミンオリゴ糖およびその製造方法
EP1015464A2 (en) * 1997-09-05 2000-07-05 Glycim Oy SYNTHETIC DIVALENT sLex CONTAINING POLYLACTOSAMINES AND METHODS FOR USE
US7018637B2 (en) * 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
SE9904581D0 (sv) * 1999-12-15 1999-12-15 A & Science Invest Ab A novel helicobacter pylori-binding substance and use thereof
AU2001261534A1 (en) * 2000-05-11 2001-11-20 The Burnham Institute The meca-79 antigen and related methods
DK1522590T3 (da) * 2000-06-28 2009-12-21 Glycofi Inc Fremgangsmåde til fremstilling af modificerede glykoproteiner
WO2002016438A2 (en) * 2000-08-22 2002-02-28 National Research Council Of Canada Synthesis of complex carbohydrates
US20050026866A1 (en) * 2002-08-02 2005-02-03 Pawelek John M. Agents and methods for treatment of disease by oligosaccharide targeting agents

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079353A (en) * 1987-12-02 1992-01-07 Chembiomed, Ltd. Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
AU8007791A (en) * 1990-06-15 1992-01-07 Cytel Corporation Intercellular adhesion mediators
US5211937A (en) * 1990-07-30 1993-05-18 Glycomed Incorporated Method of determining a site of inflammation utilizing elam-1 ligands
US5352670A (en) * 1991-06-10 1994-10-04 Alberta Research Council Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
WO1992022565A1 (en) * 1991-06-10 1992-12-23 Alberta Research Council Modified sialyl lewisx compounds
EP0627442A4 (en) * 1992-01-31 1995-01-11 Nippon Shinyaku Co Ltd DERIVATIVE OF A LEWIS TYPE SUGAR CHAIN.
JPH0686684A (ja) * 1992-05-26 1994-03-29 Monsanto Co シアロ抱合体の合成
US5591835A (en) * 1992-06-29 1997-01-07 Glycomed Incorporated Substituted lactose derivatives
US5426178A (en) * 1993-03-31 1995-06-20 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Synthesis of anti-inflammatory compounds, and novel trisaccharides useful in the synthesis of anti-inflammatory compounds
WO1994025047A1 (en) * 1993-05-03 1994-11-10 Genentech, Inc. Inhibition of leukocyte adhesion
US5374541A (en) * 1993-05-04 1994-12-20 The Scripps Research Institute Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides
US5409817A (en) * 1993-05-04 1995-04-25 Cytel, Inc. Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides
AU687408B2 (en) * 1993-05-14 1998-02-26 Cytel Corporation Sialyl LeX-analogues as inhibitors of cellular adhesion and methods for their preparation
WO1995001361A1 (fr) * 1993-07-02 1995-01-12 Nippon Shinyaku Co., Ltd. Derive de galactosylmoranoline
US5559103A (en) * 1993-07-21 1996-09-24 Cytel Corporation Bivalent sialyl X saccharides
WO1995006057A1 (fr) * 1993-08-23 1995-03-02 Nippon Shinyaku Co., Ltd. Derive de galactosylmoraniline
EP0671409A3 (de) * 1994-03-11 1996-06-12 Hoechst Ag Malonsäurederivate mit antiadhäsiven Eigenschaften.
HUT77345A (hu) * 1994-04-29 1998-03-30 Texas Biotechnology Corporation E-szelektin, P-szelektin vagy L-szelektin szialil-Lewis x-hez vagy szialil-Lewis a-hoz kapcsolódását gátló mannopiranoziloxi-bifenil származékok és ezeket tartalmazó gyógyszerkészítmények

Also Published As

Publication number Publication date
CA2231073A1 (en) 1997-04-10
NO981361D0 (no) 1998-03-25
SK39498A3 (en) 1999-01-11
WO1997012892A1 (en) 1997-04-10
HUP9900058A2 (hu) 1999-04-28
AU713078B2 (en) 1999-11-25
EP0874861A1 (en) 1998-11-04
CZ89098A3 (cs) 1998-09-16
AU7087296A (en) 1997-04-28
PL325873A1 (en) 1998-08-17
JP2000507993A (ja) 2000-06-27
US5965544A (en) 1999-10-12

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