NO20001091L - Syntetisk divalent sLex inneholdende polylaktosaminer og fremgangsmåter for anvendelse - Google Patents
Syntetisk divalent sLex inneholdende polylaktosaminer og fremgangsmåter for anvendelseInfo
- Publication number
- NO20001091L NO20001091L NO20001091A NO20001091A NO20001091L NO 20001091 L NO20001091 L NO 20001091L NO 20001091 A NO20001091 A NO 20001091A NO 20001091 A NO20001091 A NO 20001091A NO 20001091 L NO20001091 L NO 20001091L
- Authority
- NO
- Norway
- Prior art keywords
- methods
- directed
- constructs
- polylactosamines
- synthetic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Communicable Diseases (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Det er beskrevet den foreliggende oppfinnelse som er rettet på nye sammensetninger og deres anvendelse til behandling av inflammatoriske responser. Spesifikt er oppfinnelsen rettet på nye syntetiske oligosakkarid-konstrukter og deres anvendelse til å blokkere lymfocyttbinding til tilsvarende oligosakkarider på endoteloverflaten, og således redusere eller på annen måte forbedre en uønsket inflammatorisk respons. Oppfinnelsen er videre rettet på anvendelse av slike konstrukter i andre sykdommer,selektinbinding, såsom bakterielle infeksjoner og metastatiske kreftformer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5766097P | 1997-09-05 | 1997-09-05 | |
PCT/FI1998/000688 WO1999012944A2 (en) | 1997-09-05 | 1998-09-04 | SYNTHETIC DIVALENT sLex CONTAINING POLYLACTOSAMINES AND METHODS FOR USE |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20001091L true NO20001091L (no) | 2000-03-02 |
NO20001091D0 NO20001091D0 (no) | 2000-03-02 |
Family
ID=22011973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20001091A NO20001091D0 (no) | 1997-09-05 | 2000-03-02 | Syntetisk divalent sLex inneholdende polylaktosaminer og fremgangsmõter for anvendelse |
Country Status (10)
Country | Link |
---|---|
US (1) | US6191271B1 (no) |
EP (1) | EP1015464A2 (no) |
JP (1) | JP2001515912A (no) |
AU (1) | AU9073998A (no) |
CA (1) | CA2302470A1 (no) |
HU (1) | HUP0003418A2 (no) |
NO (1) | NO20001091D0 (no) |
PL (1) | PL339773A1 (no) |
SK (1) | SK2812000A3 (no) |
WO (1) | WO1999012944A2 (no) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7338932B2 (en) | 2000-05-11 | 2008-03-04 | Glycozym Aps | Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments |
ATE361375T1 (de) * | 2000-05-11 | 2007-05-15 | Glycozym Aps | Methoden zur modelierung die funktion von polypeptid galnac transferasen und zurscreening substanzen dafür |
AU7684201A (en) * | 2000-06-28 | 2002-01-08 | Glycofi Inc | Methods for producing modified glycoproteins |
WO2002089819A1 (en) * | 2001-05-07 | 2002-11-14 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Glycoconjugates and uses thereof |
US20050203578A1 (en) * | 2001-08-15 | 2005-09-15 | Weiner Michael L. | Process and apparatus for treating biological organisms |
JP4934802B2 (ja) * | 2005-05-30 | 2012-05-23 | 国立大学法人信州大学 | リンパ系の細胞接着物質、リンパ系薬物輸送材およびそれを含有する薬剤 |
PL3116887T3 (pl) | 2014-03-13 | 2021-09-06 | Universität Basel | Ligandy węglowodanowe, które wiążą się z przeciwciałami igm przeciwko glikoproteinie związanej z mieliną |
US11091591B2 (en) | 2015-09-16 | 2021-08-17 | Universität Basel | Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5079353A (en) | 1987-12-02 | 1992-01-07 | Chembiomed, Ltd. | Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation |
WO1991019501A1 (en) | 1990-06-15 | 1991-12-26 | Cytel Corporation | Intercellular adhesion mediators |
US5211937A (en) | 1990-07-30 | 1993-05-18 | Glycomed Incorporated | Method of determining a site of inflammation utilizing elam-1 ligands |
CA2110797C (en) | 1991-06-10 | 2001-02-20 | Andre P. Venot | Modified sialyl lewis x compounds |
US5352670A (en) | 1991-06-10 | 1994-10-04 | Alberta Research Council | Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides |
CA2129140A1 (en) | 1992-01-31 | 1993-08-05 | Akira Hasegawa | Lewis-type sugar chain derivative |
JPH0686684A (ja) | 1992-05-26 | 1994-03-29 | Monsanto Co | シアロ抱合体の合成 |
US5426178A (en) | 1993-03-31 | 1995-06-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis of anti-inflammatory compounds, and novel trisaccharides useful in the synthesis of anti-inflammatory compounds |
US5374541A (en) | 1993-05-04 | 1994-12-20 | The Scripps Research Institute | Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides |
US5409817A (en) | 1993-05-04 | 1995-04-25 | Cytel, Inc. | Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides |
WO1994026760A1 (en) | 1993-05-14 | 1994-11-24 | Cytel Corporation | SIALYL Lex ANALOGUES AS INHIBITORS OF CELLULAR ADHESION |
WO1995001361A1 (fr) | 1993-07-02 | 1995-01-12 | Nippon Shinyaku Co., Ltd. | Derive de galactosylmoranoline |
US5559103A (en) | 1993-07-21 | 1996-09-24 | Cytel Corporation | Bivalent sialyl X saccharides |
WO1995006057A1 (fr) | 1993-08-23 | 1995-03-02 | Nippon Shinyaku Co., Ltd. | Derive de galactosylmoraniline |
HUT77345A (hu) | 1994-04-29 | 1998-03-30 | Texas Biotechnology Corporation | E-szelektin, P-szelektin vagy L-szelektin szialil-Lewis x-hez vagy szialil-Lewis a-hoz kapcsolódását gátló mannopiranoziloxi-bifenil származékok és ezeket tartalmazó gyógyszerkészítmények |
SK39498A3 (en) | 1995-09-29 | 1999-01-11 | Glycim Oy | Synthetic multivalent slex containing polylactosamines and methods for use |
-
1998
- 1998-09-04 CA CA002302470A patent/CA2302470A1/en not_active Abandoned
- 1998-09-04 JP JP2000510750A patent/JP2001515912A/ja active Pending
- 1998-09-04 PL PL98339773A patent/PL339773A1/xx unknown
- 1998-09-04 HU HU0003418A patent/HUP0003418A2/hu unknown
- 1998-09-04 SK SK281-2000A patent/SK2812000A3/sk unknown
- 1998-09-04 EP EP98942706A patent/EP1015464A2/en not_active Withdrawn
- 1998-09-04 US US09/148,076 patent/US6191271B1/en not_active Expired - Fee Related
- 1998-09-04 AU AU90739/98A patent/AU9073998A/en not_active Abandoned
- 1998-09-04 WO PCT/FI1998/000688 patent/WO1999012944A2/en not_active Application Discontinuation
-
2000
- 2000-03-02 NO NO20001091A patent/NO20001091D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999012944A3 (en) | 1999-08-26 |
CA2302470A1 (en) | 1999-03-18 |
AU9073998A (en) | 1999-03-29 |
WO1999012944A2 (en) | 1999-03-18 |
PL339773A1 (en) | 2001-01-02 |
SK2812000A3 (en) | 2001-03-12 |
HUP0003418A2 (hu) | 2001-02-28 |
EP1015464A2 (en) | 2000-07-05 |
US6191271B1 (en) | 2001-02-20 |
JP2001515912A (ja) | 2001-09-25 |
NO20001091D0 (no) | 2000-03-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |