ATE361375T1 - Methoden zur modelierung die funktion von polypeptid galnac transferasen und zurscreening substanzen dafür - Google Patents
Methoden zur modelierung die funktion von polypeptid galnac transferasen und zurscreening substanzen dafürInfo
- Publication number
- ATE361375T1 ATE361375T1 AT01931464T AT01931464T ATE361375T1 AT E361375 T1 ATE361375 T1 AT E361375T1 AT 01931464 T AT01931464 T AT 01931464T AT 01931464 T AT01931464 T AT 01931464T AT E361375 T1 ATE361375 T1 AT E361375T1
- Authority
- AT
- Austria
- Prior art keywords
- galnac
- lectin domains
- transferases
- functions
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91091—Glycosyltransferases (2.4)
- G01N2333/91097—Hexosyltransferases (general) (2.4.1)
- G01N2333/91102—Hexosyltransferases (general) (2.4.1) with definite EC number (2.4.1.-)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20333100P | 2000-05-11 | 2000-05-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE361375T1 true ATE361375T1 (de) | 2007-05-15 |
Family
ID=22753535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01931464T ATE361375T1 (de) | 2000-05-11 | 2001-05-10 | Methoden zur modelierung die funktion von polypeptid galnac transferasen und zurscreening substanzen dafür |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1282725B1 (de) |
AT (1) | ATE361375T1 (de) |
AU (1) | AU2001258234A1 (de) |
DE (1) | DE60128218D1 (de) |
WO (1) | WO2001085215A2 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7338932B2 (en) | 2000-05-11 | 2008-03-04 | Glycozym Aps | Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments |
DE60314658D1 (de) * | 2002-11-08 | 2007-08-09 | Glycozym Aps | Verfahren zur identifizierung von die funktionen von polypeptid-galnac-transferasen modulierenden agentien, solche agentien umfassende pharmazeutische zusammensetzungen und verwendung solcher agentien zur herstellung von arzneimitteln |
US20090142272A1 (en) * | 2004-06-21 | 2009-06-04 | Exelixis, Inc. | Pfks as modifiers of the igfr pathway and methods of use |
CA2977261A1 (en) | 2006-10-04 | 2008-04-10 | Kobenhavns Universitet | Generation of a cancer-specific immune response toward muc1 and cancer specific muc1 antibodies |
US20120214174A1 (en) * | 2009-08-25 | 2012-08-23 | Oncotherapy Science, Inc. | Gene and polypeptide relating to breast cancer |
WO2014024820A1 (ja) * | 2012-08-06 | 2014-02-13 | 塩野義製薬株式会社 | 新規慢性腎臓病治療用医薬組成物及び新規慢性腎臓病治療薬のスクリーニング方法 |
GB201406767D0 (en) | 2014-04-15 | 2014-05-28 | Cancer Rec Tech Ltd | Humanized anti-Tn-MUC1 antibodies anf their conjugates |
US11058675B2 (en) | 2018-03-29 | 2021-07-13 | Carnegie Mellon University | Cell-based screening and compounds that modulate GaINAc-transferases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5268364A (en) * | 1991-12-12 | 1993-12-07 | The Biomembrane Institute | Method for inhibiting selectin-dependent adhesion of leukocytes and platelets by O-glycosylation modification |
PL339773A1 (en) * | 1997-09-05 | 2001-01-02 | Glycim Oy | Synthetic bivalent polylactose amines containing slex and method of using them |
JP2002517474A (ja) * | 1998-06-10 | 2002-06-18 | グリコデザイン インコーポレイテッド | 定方向のコンビナトリアル化合物ライブラリおよびそれをスクリーニングするための高スループットアッセイ |
-
2001
- 2001-05-10 AU AU2001258234A patent/AU2001258234A1/en not_active Abandoned
- 2001-05-10 DE DE60128218T patent/DE60128218D1/de not_active Expired - Lifetime
- 2001-05-10 AT AT01931464T patent/ATE361375T1/de not_active IP Right Cessation
- 2001-05-10 EP EP01931464A patent/EP1282725B1/de not_active Expired - Lifetime
- 2001-05-10 WO PCT/DK2001/000328 patent/WO2001085215A2/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE60128218D1 (de) | 2007-06-14 |
EP1282725B1 (de) | 2007-05-02 |
EP1282725A2 (de) | 2003-02-12 |
AU2001258234A1 (en) | 2001-11-20 |
WO2001085215A9 (en) | 2002-01-24 |
WO2001085215A3 (en) | 2002-06-27 |
WO2001085215A2 (en) | 2001-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |