NO20064134L - Modifiserte bouganinproteiner, cytotoksiner og fremgangsmater og anvendelser derav - Google Patents
Modifiserte bouganinproteiner, cytotoksiner og fremgangsmater og anvendelser deravInfo
- Publication number
- NO20064134L NO20064134L NO20064134A NO20064134A NO20064134L NO 20064134 L NO20064134 L NO 20064134L NO 20064134 A NO20064134 A NO 20064134A NO 20064134 A NO20064134 A NO 20064134A NO 20064134 L NO20064134 L NO 20064134L
- Authority
- NO
- Norway
- Prior art keywords
- bouganin
- cytotoxins
- modified
- methods
- cell epitope
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 231100000599 cytotoxic agent Toxicity 0.000 title abstract 3
- 239000002619 cytotoxin Substances 0.000 title abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000000593 degrading effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
- A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Botany (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
SAMMENDRAG Oppfinnelsen tilveiebringer modifiserte former av bouganinprotein som har biologisk aktivitet og en redusert tilbøyelighet til å aktivere humane T-celler ammenlignet med umodifisert bouganinprotein. Oppfinnelsen tilveiebringer også T- celle epitop-peptider av bouganin og modifiserte T-celle epitop-peptider av bouganin om har en redusert tilbøyelighet til å aktivere humane T-celler sammenlignet med umodifisert T-celle epitoppeptid. Oppfinnelsen tilveiebringer også cytotoksiner som omfatter en ligand som binder til kreftceller bundet til de modifiserte bouganinproteinene. Også gitt er fremgangsmåter for å hemme eller nedbryte mammalske kreftceller ved anvendelse av cytotoksinene ifølge oppfinnelsen og farmasøytiske blandinger for behandling av human kreft.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55458004P | 2004-03-19 | 2004-03-19 | |
US63057104P | 2004-11-26 | 2004-11-26 | |
PCT/CA2005/000410 WO2005090579A1 (en) | 2004-03-19 | 2005-03-18 | Modified bouganin proteins, cytotoxins and methods and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20064134L true NO20064134L (no) | 2006-11-08 |
NO338293B1 NO338293B1 (no) | 2016-08-08 |
Family
ID=34993709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20064134A NO338293B1 (no) | 2004-03-19 | 2006-09-13 | Modifiserte bouganinproteiner, cytotoksiner samt anvendelse derav, og fremgangsmåte for fremstilling av et farmasøytikum, samt nukleinsyremolekyl og et T-celle epitope peptid |
Country Status (18)
Country | Link |
---|---|
US (4) | US7339031B2 (no) |
EP (1) | EP1737961B1 (no) |
JP (1) | JP5025460B2 (no) |
KR (1) | KR101165867B1 (no) |
AU (1) | AU2005224942B2 (no) |
BR (1) | BRPI0508670B1 (no) |
CA (1) | CA2560278C (no) |
DK (1) | DK1737961T3 (no) |
EA (1) | EA010803B1 (no) |
ES (1) | ES2424643T3 (no) |
HK (1) | HK1102306A1 (no) |
IL (1) | IL177922A (no) |
MX (1) | MXPA06010716A (no) |
NO (1) | NO338293B1 (no) |
NZ (1) | NZ550339A (no) |
PL (1) | PL1737961T3 (no) |
PT (1) | PT1737961E (no) |
WO (1) | WO2005090579A1 (no) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE033533T2 (en) | 2003-04-30 | 2017-12-28 | Universität Zuerich | A method of treating cancer using immunotoxin |
CA2569788C (en) | 2004-06-10 | 2014-03-18 | Viventia Biotech Inc. | Tumor specific antibody |
KR101385886B1 (ko) | 2005-02-03 | 2014-04-24 | 안티토페 리미티드 | 인간 항체들과 단백질들 |
CN104072611A (zh) * | 2005-12-21 | 2014-10-01 | 维文蒂阿生物公司 | 与癌症相关的新抗原 |
CN101389791A (zh) * | 2005-12-23 | 2009-03-18 | 维文蒂阿生物技术股份有限公司 | 融合蛋白文库的产生和筛选方法及其应用 |
CA2668017A1 (en) * | 2006-10-30 | 2008-05-08 | Viventia Biotech Inc. | Improved conjugates |
EP2423222B2 (en) * | 2007-01-30 | 2020-07-29 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
US8263744B2 (en) | 2007-04-19 | 2012-09-11 | Viventia Biotechnologies Inc. | Binding proteins that bind to EpCAM linked to an effector molecule |
EP2167528B1 (en) | 2007-06-21 | 2018-01-10 | Angelica Therapeutics, INC. | Modified toxins |
CA2700815A1 (en) | 2007-09-27 | 2009-04-02 | Viventia Biotech Inc. | Optimized nucleic acid sequences for the expression of vb4-845 |
WO2009110944A1 (en) | 2008-02-29 | 2009-09-11 | Angelica Therapeutics, Inc. | Modified toxins |
US8932586B2 (en) | 2011-09-06 | 2015-01-13 | Intrexon Corporation | Modified forms of Pseudomonas exotoxin A |
WO2014127211A1 (en) * | 2013-02-15 | 2014-08-21 | Research Development Foundation | Deimmunized gelonin molecules and therapies |
EP2968450A4 (en) | 2013-03-15 | 2016-10-26 | Angelica Therapeutics Inc | MODIFIED TOXINS |
KR20160006697A (ko) * | 2013-04-12 | 2016-01-19 | 비벤티아 바이오 인코포레이티드 | 간세포 암종을 검출 및 치료하기 위한 조성물 및 방법 |
KR102068519B1 (ko) | 2013-07-01 | 2020-01-21 | 삼성전자주식회사 | 저장 장치, 그것의 쓰기 방법 및 읽기 방법 |
WO2015048901A1 (en) | 2013-10-02 | 2015-04-09 | Viventia Bio Inc. | Anti-epcam antibodies and methods of use |
US20160060358A1 (en) * | 2014-08-28 | 2016-03-03 | California Institute Of Technology | Induction of antigen-specific tolerance |
US10583198B2 (en) | 2015-03-12 | 2020-03-10 | Viventia Bio Inc. | Dosing strategies for targeting EPCAM positive bladder cancer |
CN108513547A (zh) | 2015-03-12 | 2018-09-07 | 维文蒂亚生物公司 | 用于epcam阳性膀胱癌的治疗方法 |
WO2016187571A2 (en) * | 2015-05-20 | 2016-11-24 | Viventia Bio Inc. | Her2 immunotoxins and methods of using the same |
CN111405911A (zh) | 2017-10-10 | 2020-07-10 | 梅迪塞纳医疗股份有限公司 | 用于治疗中枢神经系统(cns)肿瘤的il-4融合制剂 |
CA3108797A1 (en) * | 2018-08-10 | 2020-02-13 | Sanford Burnham Prebys Medical Discovery Institute | Binding molecules to tumor associated macrophages and methods of use |
JP7124034B2 (ja) * | 2020-11-05 | 2022-08-23 | 株式会社天柳 | 嚥下困難者用食品組成物の製造方法 |
JP7488928B1 (ja) | 2023-03-01 | 2024-05-22 | 積水フーラー株式会社 | ホットメルト接着剤 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6680295B1 (en) * | 1994-09-22 | 2004-01-20 | The Administrators Of The Tulane Educational Fund | Method and pharmaceutical composition for prevention and treatment of brain damage |
US6121416A (en) * | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
WO1998055623A1 (en) * | 1997-06-06 | 1998-12-10 | Tanox Pharma B.V. | Type-1 ribosome-inactivating protein |
ATE211394T1 (de) * | 1997-06-20 | 2002-01-15 | Tanox Pharma B V | Anti-cd40l immunotoxine zur behandlung von krankheiten |
WO2000034317A2 (en) | 1998-12-08 | 2000-06-15 | Biovation Limited | Method for reducing immunogenicity of proteins |
EP1998266A3 (en) * | 2001-02-19 | 2009-02-11 | Merck Patent GmbH | Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity |
WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
WO2003104803A2 (en) | 2002-06-11 | 2003-12-18 | Merck Patent Gmbh | Method for mapping and eliminating t-cell epitopes |
MXPA04012210A (es) | 2002-06-11 | 2005-02-25 | Merck Patent Gmbh | Birodina i modificada con inmunogenicidad reducida. |
CA2424255A1 (en) * | 2003-03-26 | 2004-09-26 | Claudio Di Paolo | Immunotoxins |
US7696322B2 (en) * | 2003-07-28 | 2010-04-13 | Catalent Pharma Solutions, Inc. | Fusion antibodies |
CA2569788C (en) | 2004-06-10 | 2014-03-18 | Viventia Biotech Inc. | Tumor specific antibody |
NZ556055A (en) * | 2004-12-21 | 2009-12-24 | Viventia Biotech Inc | Cancer specific antibody and cell surface proteins |
KR101385886B1 (ko) * | 2005-02-03 | 2014-04-24 | 안티토페 리미티드 | 인간 항체들과 단백질들 |
-
2005
- 2005-03-18 PT PT57289837T patent/PT1737961E/pt unknown
- 2005-03-18 PL PL05728983T patent/PL1737961T3/pl unknown
- 2005-03-18 EA EA200601738A patent/EA010803B1/ru not_active IP Right Cessation
- 2005-03-18 CA CA2560278A patent/CA2560278C/en active Active
- 2005-03-18 NZ NZ550339A patent/NZ550339A/en not_active IP Right Cessation
- 2005-03-18 DK DK05728983.7T patent/DK1737961T3/da active
- 2005-03-18 BR BRPI0508670-1A patent/BRPI0508670B1/pt active IP Right Grant
- 2005-03-18 AU AU2005224942A patent/AU2005224942B2/en active Active
- 2005-03-18 EP EP05728983.7A patent/EP1737961B1/en active Active
- 2005-03-18 ES ES05728983T patent/ES2424643T3/es active Active
- 2005-03-18 KR KR1020067021711A patent/KR101165867B1/ko active IP Right Grant
- 2005-03-18 JP JP2007503165A patent/JP5025460B2/ja active Active
- 2005-03-18 WO PCT/CA2005/000410 patent/WO2005090579A1/en active Application Filing
- 2005-03-18 US US11/084,080 patent/US7339031B2/en active Active
- 2005-03-18 MX MXPA06010716A patent/MXPA06010716A/es active IP Right Grant
-
2006
- 2006-09-06 IL IL177922A patent/IL177922A/en active IP Right Grant
- 2006-09-13 NO NO20064134A patent/NO338293B1/no unknown
-
2007
- 2007-09-27 HK HK07110463.0A patent/HK1102306A1/xx unknown
-
2008
- 2008-01-09 US US11/971,660 patent/US7750136B2/en active Active
-
2010
- 2010-05-21 US US12/784,820 patent/US8716234B2/en active Active
-
2014
- 2014-04-01 US US14/242,181 patent/US20150018526A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080219994A1 (en) | 2008-09-11 |
IL177922A0 (en) | 2006-12-31 |
NZ550339A (en) | 2009-11-27 |
PL1737961T3 (pl) | 2013-12-31 |
US20150018526A1 (en) | 2015-01-15 |
AU2005224942A1 (en) | 2005-09-29 |
DK1737961T3 (da) | 2013-08-05 |
EA200601738A1 (ru) | 2007-04-27 |
PT1737961E (pt) | 2013-08-26 |
EA010803B1 (ru) | 2008-12-30 |
US20050238642A1 (en) | 2005-10-27 |
MXPA06010716A (es) | 2007-02-21 |
JP5025460B2 (ja) | 2012-09-12 |
WO2005090579A1 (en) | 2005-09-29 |
EP1737961A1 (en) | 2007-01-03 |
ES2424643T3 (es) | 2013-10-07 |
HK1102306A1 (en) | 2007-11-16 |
BRPI0508670B1 (pt) | 2023-01-24 |
IL177922A (en) | 2011-06-30 |
CA2560278A1 (en) | 2005-09-29 |
US7339031B2 (en) | 2008-03-04 |
NO338293B1 (no) | 2016-08-08 |
KR20070000494A (ko) | 2007-01-02 |
CA2560278C (en) | 2012-11-20 |
EP1737961A4 (en) | 2008-12-17 |
US20100254964A1 (en) | 2010-10-07 |
US8716234B2 (en) | 2014-05-06 |
JP2008500811A (ja) | 2008-01-17 |
BRPI0508670A (pt) | 2007-08-14 |
US7750136B2 (en) | 2010-07-06 |
AU2005224942B2 (en) | 2011-08-11 |
EP1737961B1 (en) | 2013-05-08 |
KR101165867B1 (ko) | 2012-07-13 |
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