DE60128218D1 - METHODEN ZUR MODELIERUNG DIE FUNKTION VON POLYPEPTID GalNAc TRANSFERASEN UND ZURSCREENING SUBSTANZEN DAFÜR - Google Patents

METHODEN ZUR MODELIERUNG DIE FUNKTION VON POLYPEPTID GalNAc TRANSFERASEN UND ZURSCREENING SUBSTANZEN DAFÜR

Info

Publication number
DE60128218D1
DE60128218D1 DE60128218T DE60128218T DE60128218D1 DE 60128218 D1 DE60128218 D1 DE 60128218D1 DE 60128218 T DE60128218 T DE 60128218T DE 60128218 T DE60128218 T DE 60128218T DE 60128218 D1 DE60128218 D1 DE 60128218D1
Authority
DE
Germany
Prior art keywords
galnac
lectin domains
transferases
functions
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60128218T
Other languages
English (en)
Inventor
Henrik Clausen
Helle Hassan
Celso Albuquerque Reis
Eric Paul Bennett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlycoZym ApS
Original Assignee
GlycoZym ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlycoZym ApS filed Critical GlycoZym ApS
Application granted granted Critical
Publication of DE60128218D1 publication Critical patent/DE60128218D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91091—Glycosyltransferases (2.4)
    • G01N2333/91097—Hexosyltransferases (general) (2.4.1)
    • G01N2333/91102—Hexosyltransferases (general) (2.4.1) with definite EC number (2.4.1.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
DE60128218T 2000-05-11 2001-05-10 METHODEN ZUR MODELIERUNG DIE FUNKTION VON POLYPEPTID GalNAc TRANSFERASEN UND ZURSCREENING SUBSTANZEN DAFÜR Expired - Lifetime DE60128218D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20333100P 2000-05-11 2000-05-11
PCT/DK2001/000328 WO2001085215A2 (en) 2000-05-11 2001-05-10 METHODS OF MODULATING FUNCTIONS OF POLYPEPTIDE GalNAc TRANSFERASES AND OF SCREENING SUBSTANCES THEREFOR, PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH AGENTS

Publications (1)

Publication Number Publication Date
DE60128218D1 true DE60128218D1 (de) 2007-06-14

Family

ID=22753535

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60128218T Expired - Lifetime DE60128218D1 (de) 2000-05-11 2001-05-10 METHODEN ZUR MODELIERUNG DIE FUNKTION VON POLYPEPTID GalNAc TRANSFERASEN UND ZURSCREENING SUBSTANZEN DAFÜR

Country Status (5)

Country Link
EP (1) EP1282725B1 (de)
AT (1) ATE361375T1 (de)
AU (1) AU2001258234A1 (de)
DE (1) DE60128218D1 (de)
WO (1) WO2001085215A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7338932B2 (en) 2000-05-11 2008-03-04 Glycozym Aps Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
AU2003275952A1 (en) * 2002-11-08 2004-06-07 Glycozym Aps Inactivated ga1 - nac - transferases, methods for inhibitors of such transferases and their use
US7888048B2 (en) * 2004-06-21 2011-02-15 Exelixis, Inc. P4HAS as modifiers of the IGFR pathway and methods of use
CA2977261A1 (en) 2006-10-04 2008-04-10 Kobenhavns Universitet Generation of a cancer-specific immune response toward muc1 and cancer specific muc1 antibodies
WO2011024412A1 (en) * 2009-08-25 2011-03-03 Oncotherapy Science, Inc. Gene and polypeptide relating to breast cancer
WO2014024820A1 (ja) * 2012-08-06 2014-02-13 塩野義製薬株式会社 新規慢性腎臓病治療用医薬組成物及び新規慢性腎臓病治療薬のスクリーニング方法
GB201406767D0 (en) 2014-04-15 2014-05-28 Cancer Rec Tech Ltd Humanized anti-Tn-MUC1 antibodies anf their conjugates
US11058675B2 (en) 2018-03-29 2021-07-13 Carnegie Mellon University Cell-based screening and compounds that modulate GaINAc-transferases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268364A (en) * 1991-12-12 1993-12-07 The Biomembrane Institute Method for inhibiting selectin-dependent adhesion of leukocytes and platelets by O-glycosylation modification
HUP0003418A2 (hu) * 1997-09-05 2001-02-28 Glycim Oy Szintetikus, kétértékű, sLex-tartalmú polilaktózaminok és eljárás előállításukra
MXPA00012237A (es) * 1998-06-10 2002-11-15 Glycodesign Inc Biblioteca de compuestos combinatorios derigidos y ensayos de alto rendimiento para seleccionar los mismos.

Also Published As

Publication number Publication date
WO2001085215A3 (en) 2002-06-27
ATE361375T1 (de) 2007-05-15
AU2001258234A1 (en) 2001-11-20
WO2001085215A9 (en) 2002-01-24
EP1282725A2 (de) 2003-02-12
WO2001085215A2 (en) 2001-11-15
EP1282725B1 (de) 2007-05-02

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