DE69116590T2 - Ergolin-8-carboxamide zum Blockieren von 5HT-Rezeptoren - Google Patents

Ergolin-8-carboxamide zum Blockieren von 5HT-Rezeptoren

Info

Publication number
DE69116590T2
DE69116590T2 DE69116590T DE69116590T DE69116590T2 DE 69116590 T2 DE69116590 T2 DE 69116590T2 DE 69116590 T DE69116590 T DE 69116590T DE 69116590 T DE69116590 T DE 69116590T DE 69116590 T2 DE69116590 T2 DE 69116590T2
Authority
DE
Germany
Prior art keywords
carboxamide
hydroxycyclopentyl
isopropyl
methylergoline
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69116590T
Other languages
German (de)
English (en)
Other versions
DE69116590D1 (de
Inventor
Marlene Lois Cohen
David Wayne Robertson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69116590D1 publication Critical patent/DE69116590D1/de
Application granted granted Critical
Publication of DE69116590T2 publication Critical patent/DE69116590T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Power Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69116590T 1990-04-11 1991-04-09 Ergolin-8-carboxamide zum Blockieren von 5HT-Rezeptoren Expired - Fee Related DE69116590T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/508,324 US5043341A (en) 1990-04-11 1990-04-11 N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides

Publications (2)

Publication Number Publication Date
DE69116590D1 DE69116590D1 (de) 1996-03-07
DE69116590T2 true DE69116590T2 (de) 1996-07-04

Family

ID=24022297

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69116590T Expired - Fee Related DE69116590T2 (de) 1990-04-11 1991-04-09 Ergolin-8-carboxamide zum Blockieren von 5HT-Rezeptoren

Country Status (24)

Country Link
US (1) US5043341A (enExample)
EP (1) EP0452074B1 (enExample)
JP (1) JPH04224578A (enExample)
KR (1) KR0165124B1 (enExample)
CN (1) CN1038937C (enExample)
AT (1) ATE133414T1 (enExample)
AU (1) AU634374B2 (enExample)
CA (1) CA2040170A1 (enExample)
CZ (1) CZ279745B6 (enExample)
DE (1) DE69116590T2 (enExample)
DK (1) DK0452074T3 (enExample)
ES (1) ES2082923T3 (enExample)
FI (1) FI96604C (enExample)
GR (1) GR3019416T3 (enExample)
HU (1) HU206113B (enExample)
IE (1) IE72084B1 (enExample)
IL (1) IL97808A (enExample)
NO (1) NO177709C (enExample)
NZ (1) NZ237753A (enExample)
PT (1) PT97299B (enExample)
RU (2) RU2002746C1 (enExample)
TW (1) TW199859B (enExample)
YU (1) YU47809B (enExample)
ZA (1) ZA912628B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141944A (en) * 1990-04-11 1992-08-25 Eli Lilly And Company N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
JPH0613145U (ja) * 1992-07-23 1994-02-18 日新電機株式会社 基板収納カセット
US5441961A (en) * 1992-08-27 1995-08-15 Eli Lilly And Company Substituted cyclo or bicycloalkylamides of (8β)-6-(substituted) ergolines
US5516943A (en) * 1993-09-14 1996-05-14 Sepracor, Inc. Process for preparing cyclic CIS-1-amino-2-alkanols
US5599985A (en) * 1993-09-14 1997-02-04 Sepracor, Inc. Optically pure 1-amido-2-indanols
AU5317996A (en) * 1995-04-18 1996-11-07 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-ht7 receptor
US5880134A (en) * 1996-03-20 1999-03-09 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor
US6385208B1 (en) * 1998-06-02 2002-05-07 Cisco Technology, Inc. Serial media independent interface
PT2062914E (pt) * 2001-06-08 2014-07-18 Ipsen Pharma Sas Análogos quiméricos de somatostatina-dopamina
DE10212564B4 (de) * 2002-03-12 2007-04-19 Neurobiotec Gmbh 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
JP2005220081A (ja) * 2004-02-06 2005-08-18 Toray Fine Chemicals Co Ltd ｃｉｓ−４−アミノ−１−ベンジル−３−ピロリジノールの製造方法およびピロリジン誘導体
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
WO2014070965A2 (en) 2012-11-01 2014-05-08 Ipsen Pharma S.A.S Somatostatin analogs and dimers thereof
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997470A (en) * 1956-03-05 1961-08-22 Lilly Co Eli Lysergic acid amides
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
ZA884222B (en) * 1987-06-15 1990-02-28 Lilly Co Eli Cycloalkylamides of(8beta)-1-alkyl-6-(substituted)ergolines

Also Published As

Publication number Publication date
PT97299B (pt) 1998-08-31
RU2086551C1 (ru) 1997-08-10
HU206113B (en) 1992-08-28
FI96604C (fi) 1996-07-25
NO177709B (no) 1995-07-31
YU47809B (sr) 1996-01-09
AU7433791A (en) 1991-10-17
FI911713L (fi) 1991-10-12
EP0452074A2 (en) 1991-10-16
GR3019416T3 (en) 1996-06-30
JPH04224578A (ja) 1992-08-13
CN1038937C (zh) 1998-07-01
CZ279745B6 (cs) 1995-06-14
CN1056496A (zh) 1991-11-27
NO177709C (no) 1995-11-08
KR910018381A (ko) 1991-11-30
TW199859B (enExample) 1993-02-11
FI911713A0 (fi) 1991-04-10
CZ99091A3 (en) 1995-03-15
NO911398D0 (no) 1991-04-10
RU2002746C1 (ru) 1993-11-15
ES2082923T3 (es) 1996-04-01
YU64691A (sh) 1994-01-20
IL97808A (en) 1994-12-29
DK0452074T3 (da) 1996-02-19
ZA912628B (en) 1992-12-30
PT97299A (pt) 1992-01-31
EP0452074A3 (en) 1992-03-04
EP0452074B1 (en) 1996-01-24
ATE133414T1 (de) 1996-02-15
CA2040170A1 (en) 1991-10-12
US5043341A (en) 1991-08-27
IE911205A1 (en) 1991-10-23
NO911398L (no) 1991-10-14
IL97808A0 (en) 1992-06-21
KR0165124B1 (ko) 1999-03-20
HUT56841A (en) 1991-10-28
IE72084B1 (en) 1997-03-12
AU634374B2 (en) 1993-02-18
FI96604B (fi) 1996-04-15
DE69116590D1 (de) 1996-03-07
NZ237753A (en) 1993-02-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee