JPH04224578A - エルゴリン−８−カルボキサミドの改良 - Google Patents

エルゴリン−８−カルボキサミドの改良

Info

Publication number
JPH04224578A
JPH04224578A JP3077638A JP7763891A JPH04224578A JP H04224578 A JPH04224578 A JP H04224578A JP 3077638 A JP3077638 A JP 3077638A JP 7763891 A JP7763891 A JP 7763891A JP H04224578 A JPH04224578 A JP H04224578A
Authority
JP
Japan
Prior art keywords
carboxamide
methylergoline
hydroxycyclopentyl
acid
isopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3077638A
Other languages
English (en)
Japanese (ja)
Inventor
Marlene L Cohen
マーリン・ロイス・コーエン
David W Robertson
デイビッド・ウェイン・ロバートソン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPH04224578A publication Critical patent/JPH04224578A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Power Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP3077638A 1990-04-11 1991-04-10 エルゴリン−８−カルボキサミドの改良 Pending JPH04224578A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/508,324 US5043341A (en) 1990-04-11 1990-04-11 N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
US508,324 1990-04-11

Publications (1)

Publication Number Publication Date
JPH04224578A true JPH04224578A (ja) 1992-08-13

Family

ID=24022297

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3077638A Pending JPH04224578A (ja) 1990-04-11 1991-04-10 エルゴリン−８−カルボキサミドの改良

Country Status (24)

Country Link
US (1) US5043341A (enExample)
EP (1) EP0452074B1 (enExample)
JP (1) JPH04224578A (enExample)
KR (1) KR0165124B1 (enExample)
CN (1) CN1038937C (enExample)
AT (1) ATE133414T1 (enExample)
AU (1) AU634374B2 (enExample)
CA (1) CA2040170A1 (enExample)
CZ (1) CZ279745B6 (enExample)
DE (1) DE69116590T2 (enExample)
DK (1) DK0452074T3 (enExample)
ES (1) ES2082923T3 (enExample)
FI (1) FI96604C (enExample)
GR (1) GR3019416T3 (enExample)
HU (1) HU206113B (enExample)
IE (1) IE72084B1 (enExample)
IL (1) IL97808A (enExample)
NO (1) NO177709C (enExample)
NZ (1) NZ237753A (enExample)
PT (1) PT97299B (enExample)
RU (2) RU2002746C1 (enExample)
TW (1) TW199859B (enExample)
YU (1) YU47809B (enExample)
ZA (1) ZA912628B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0613145U (ja) * 1992-07-23 1994-02-18 日新電機株式会社 基板収納カセット
JP2005220081A (ja) * 2004-02-06 2005-08-18 Toray Fine Chemicals Co Ltd ｃｉｓ−４−アミノ−１−ベンジル−３−ピロリジノールの製造方法およびピロリジン誘導体

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141944A (en) * 1990-04-11 1992-08-25 Eli Lilly And Company N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
US5441961A (en) * 1992-08-27 1995-08-15 Eli Lilly And Company Substituted cyclo or bicycloalkylamides of (8β)-6-(substituted) ergolines
US5516943A (en) * 1993-09-14 1996-05-14 Sepracor, Inc. Process for preparing cyclic CIS-1-amino-2-alkanols
US5599985A (en) * 1993-09-14 1997-02-04 Sepracor, Inc. Optically pure 1-amido-2-indanols
AU5317996A (en) * 1995-04-18 1996-11-07 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-ht7 receptor
US5880134A (en) * 1996-03-20 1999-03-09 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor
US6385208B1 (en) * 1998-06-02 2002-05-07 Cisco Technology, Inc. Serial media independent interface
RU2277539C2 (ru) * 2001-06-08 2006-06-10 Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик С.А.С. Химерные аналоги соматостатина-дофамина
DE10212564B4 (de) * 2002-03-12 2007-04-19 Neurobiotec Gmbh 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
HK1213486A1 (zh) 2012-11-01 2016-07-08 Ipsen Pharma S.A.S. 促生长素抑制素类似物及其二聚体
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997470A (en) * 1956-03-05 1961-08-22 Lilly Co Eli Lysergic acid amides
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
IL86725A (en) * 1987-06-15 1993-01-14 Lilly Co Eli 1-alkyl-n-cycloalkyl- 6-methyl-ergoline-8'- carboxamides, their preparation and pharmaceutical compositions containing them

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0613145U (ja) * 1992-07-23 1994-02-18 日新電機株式会社 基板収納カセット
JP2005220081A (ja) * 2004-02-06 2005-08-18 Toray Fine Chemicals Co Ltd ｃｉｓ−４−アミノ−１−ベンジル−３−ピロリジノールの製造方法およびピロリジン誘導体

Also Published As

Publication number Publication date
IL97808A (en) 1994-12-29
ZA912628B (en) 1992-12-30
NZ237753A (en) 1993-02-25
FI911713L (fi) 1991-10-12
DE69116590T2 (de) 1996-07-04
NO177709B (no) 1995-07-31
YU64691A (sh) 1994-01-20
IE911205A1 (en) 1991-10-23
DE69116590D1 (de) 1996-03-07
GR3019416T3 (en) 1996-06-30
CN1056496A (zh) 1991-11-27
RU2002746C1 (ru) 1993-11-15
ATE133414T1 (de) 1996-02-15
HUT56841A (en) 1991-10-28
NO911398D0 (no) 1991-04-10
AU7433791A (en) 1991-10-17
AU634374B2 (en) 1993-02-18
YU47809B (sr) 1996-01-09
CN1038937C (zh) 1998-07-01
IL97808A0 (en) 1992-06-21
EP0452074A3 (en) 1992-03-04
PT97299A (pt) 1992-01-31
IE72084B1 (en) 1997-03-12
FI911713A0 (fi) 1991-04-10
EP0452074A2 (en) 1991-10-16
CA2040170A1 (en) 1991-10-12
RU2086551C1 (ru) 1997-08-10
HU206113B (en) 1992-08-28
EP0452074B1 (en) 1996-01-24
TW199859B (enExample) 1993-02-11
FI96604C (fi) 1996-07-25
DK0452074T3 (da) 1996-02-19
ES2082923T3 (es) 1996-04-01
US5043341A (en) 1991-08-27
KR910018381A (ko) 1991-11-30
CZ99091A3 (en) 1995-03-15
NO177709C (no) 1995-11-08
PT97299B (pt) 1998-08-31
NO911398L (no) 1991-10-14
KR0165124B1 (ko) 1999-03-20
CZ279745B6 (cs) 1995-06-14
FI96604B (fi) 1996-04-15

Similar Documents

Publication Publication Date Title
JP2756742B2 (ja) Ｎ−アシル−２，３−ベンゾジアゼピン誘導体、その製造法、それを含有する医薬組成物、およびその製造法
JPH04224578A (ja) エルゴリン−８−カルボキサミドの改良
KR20080063760A (ko) 코르티코트로핀-방출 인자 (ｃｒｆ) 수용체 길항제로서유용한 피라졸로[1,5-알파]피리미디닐 유도체
JPWO1998030548A1 (ja) ５−ＨＴ▲下２ｃ▼受容体作用薬及びアミノアルキルインダゾール誘導体
JPS6072891A (ja) ピリミド〔４，５−ｇ〕キノリンおよびその製造中間体
KR19990006912A (ko) 트리사이클릭 피라졸 유도체
DE3880022T2 (de) Cycloalkylamide von (8beta)-1-alkyl-6-(substituierten) ergolinen.
JPH02218682A (ja) エルゴリン誘導体
US5141944A (en) N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
US5441961A (en) Substituted cyclo or bicycloalkylamides of (8β)-6-(substituted) ergolines
EP0657443A1 (en) Optically active carboxamide derivative
KR940004059B1 (ko) 비시클로락탐유도체
JPH0778062B2 (ja) Ｄ−ノル−７−エルゴリン誘導体、その製法、薬剤組成物及び使用
CA1302405C (en) Ergoline derivatives
CY1432A (en) Ergotalkaloids
US4318909A (en) Benzoxazocines
US4835159A (en) Ergoline esters useful as serotonin antagonists
US4626522A (en) Benzoxazocines intermediates
JP2004537556A (ja) 抗精神病活性を有する２−（アミノメチル）−テトラヒドロ−９−オキサ−１，３−ジアザ−シクロペンタ［ａ］ナフタレニル誘導体
GB2067555A (en) Benzoxazocines
HK1016816A (en) Optically active carboxamide derivative
JPH07304745A (ja) アダマンチルエチルカンフィジン誘導体およびその用途
CZ292867B6 (cs) Způsob cyklizace anilinových derivátů

Legal Events

Date Code Title Description
A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20031104