KR0165124B1 - 개선된 에르골린-8-카복스아미드 - Google Patents

개선된 에르골린-8-카복스아미드 Download PDF

Info

Publication number
KR0165124B1
KR0165124B1 KR1019910005643A KR910005643A KR0165124B1 KR 0165124 B1 KR0165124 B1 KR 0165124B1 KR 1019910005643 A KR1019910005643 A KR 1019910005643A KR 910005643 A KR910005643 A KR 910005643A KR 0165124 B1 KR0165124 B1 KR 0165124B1
Authority
KR
South Korea
Prior art keywords
compounds
carboxamide
hydroxycyclopentyl
methylergoline
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019910005643A
Other languages
English (en)
Korean (ko)
Other versions
KR910018381A (ko
Inventor
로이스 코헨 말렌
웨인 로버트슨 데이비드
Original Assignee
리로이 휘테커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 리로이 휘테커, 일라이 릴리 앤드 캄파니 filed Critical 리로이 휘테커
Publication of KR910018381A publication Critical patent/KR910018381A/ko
Application granted granted Critical
Publication of KR0165124B1 publication Critical patent/KR0165124B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Power Engineering (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1019910005643A 1990-04-11 1991-04-09 개선된 에르골린-8-카복스아미드 Expired - Fee Related KR0165124B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7/508,324 1990-04-11
US07/508,324 1990-04-11
US07/508,324 US5043341A (en) 1990-04-11 1990-04-11 N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides

Publications (2)

Publication Number Publication Date
KR910018381A KR910018381A (ko) 1991-11-30
KR0165124B1 true KR0165124B1 (ko) 1999-03-20

Family

ID=24022297

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910005643A Expired - Fee Related KR0165124B1 (ko) 1990-04-11 1991-04-09 개선된 에르골린-8-카복스아미드

Country Status (24)

Country Link
US (1) US5043341A (enExample)
EP (1) EP0452074B1 (enExample)
JP (1) JPH04224578A (enExample)
KR (1) KR0165124B1 (enExample)
CN (1) CN1038937C (enExample)
AT (1) ATE133414T1 (enExample)
AU (1) AU634374B2 (enExample)
CA (1) CA2040170A1 (enExample)
CZ (1) CZ279745B6 (enExample)
DE (1) DE69116590T2 (enExample)
DK (1) DK0452074T3 (enExample)
ES (1) ES2082923T3 (enExample)
FI (1) FI96604C (enExample)
GR (1) GR3019416T3 (enExample)
HU (1) HU206113B (enExample)
IE (1) IE72084B1 (enExample)
IL (1) IL97808A (enExample)
NO (1) NO177709C (enExample)
NZ (1) NZ237753A (enExample)
PT (1) PT97299B (enExample)
RU (2) RU2002746C1 (enExample)
TW (1) TW199859B (enExample)
YU (1) YU47809B (enExample)
ZA (1) ZA912628B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141944A (en) * 1990-04-11 1992-08-25 Eli Lilly And Company N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
JPH0613145U (ja) * 1992-07-23 1994-02-18 日新電機株式会社 基板収納カセット
US5441961A (en) * 1992-08-27 1995-08-15 Eli Lilly And Company Substituted cyclo or bicycloalkylamides of (8β)-6-(substituted) ergolines
US5599985A (en) * 1993-09-14 1997-02-04 Sepracor, Inc. Optically pure 1-amido-2-indanols
US5516943A (en) * 1993-09-14 1996-05-14 Sepracor, Inc. Process for preparing cyclic CIS-1-amino-2-alkanols
WO1996032944A1 (en) * 1995-04-18 1996-10-24 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-ht7 receptor
US5880134A (en) * 1996-03-20 1999-03-09 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor
US6385208B1 (en) * 1998-06-02 2002-05-07 Cisco Technology, Inc. Serial media independent interface
PT1401863E (pt) * 2001-06-08 2009-07-23 Ipsen Pharma Análogos quiméricos da somatostatina-dopamina
DE10212564B4 (de) * 2002-03-12 2007-04-19 Neurobiotec Gmbh 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
JP2005220081A (ja) * 2004-02-06 2005-08-18 Toray Fine Chemicals Co Ltd ｃｉｓ−４−アミノ−１−ベンジル−３−ピロリジノールの製造方法およびピロリジン誘導体
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
US9777039B2 (en) 2012-11-01 2017-10-03 Ipsen Pharma S.A.S. Somatostatin analogs and dimers thereof
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997470A (en) * 1956-03-05 1961-08-22 Lilly Co Eli Lysergic acid amides
IL86725A (en) * 1987-06-15 1993-01-14 Lilly Co Eli 1-alkyl-n-cycloalkyl- 6-methyl-ergoline-8'- carboxamides, their preparation and pharmaceutical compositions containing them
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines

Also Published As

Publication number Publication date
IL97808A0 (en) 1992-06-21
FI96604C (fi) 1996-07-25
CN1056496A (zh) 1991-11-27
DE69116590D1 (de) 1996-03-07
RU2086551C1 (ru) 1997-08-10
DK0452074T3 (da) 1996-02-19
FI911713L (fi) 1991-10-12
NO177709B (no) 1995-07-31
IL97808A (en) 1994-12-29
NO177709C (no) 1995-11-08
PT97299B (pt) 1998-08-31
EP0452074A2 (en) 1991-10-16
YU47809B (sr) 1996-01-09
CZ99091A3 (en) 1995-03-15
TW199859B (enExample) 1993-02-11
NO911398L (no) 1991-10-14
HUT56841A (en) 1991-10-28
FI911713A0 (fi) 1991-04-10
ATE133414T1 (de) 1996-02-15
NZ237753A (en) 1993-02-25
GR3019416T3 (en) 1996-06-30
JPH04224578A (ja) 1992-08-13
AU634374B2 (en) 1993-02-18
US5043341A (en) 1991-08-27
NO911398D0 (no) 1991-04-10
PT97299A (pt) 1992-01-31
IE911205A1 (en) 1991-10-23
EP0452074B1 (en) 1996-01-24
KR910018381A (ko) 1991-11-30
HU206113B (en) 1992-08-28
EP0452074A3 (en) 1992-03-04
YU64691A (sh) 1994-01-20
ES2082923T3 (es) 1996-04-01
FI96604B (fi) 1996-04-15
CN1038937C (zh) 1998-07-01
RU2002746C1 (ru) 1993-11-15
CZ279745B6 (cs) 1995-06-14
AU7433791A (en) 1991-10-17
CA2040170A1 (en) 1991-10-12
ZA912628B (en) 1992-12-30
IE72084B1 (en) 1997-03-12
DE69116590T2 (de) 1996-07-04

Similar Documents

Publication Publication Date Title
KR0165124B1 (ko) 개선된 에르골린-8-카복스아미드
EP0296748B1 (en) Cycloalkylamides of (8beta)-1-alkyl-6-(substituted) ergolines
US5141944A (en) N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
US4931447A (en) Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
JPH02218682A (ja) エルゴリン誘導体
US5441961A (en) Substituted cyclo or bicycloalkylamides of (8β)-6-(substituted) ergolines
KR890000813B1 (ko) 에르고트 5's-(2r-부틸)펩티드 알카로이드의 제조방법
CA1302405C (en) Ergoline derivatives
RU2155748C2 (ru) Производные циклогексадиена, смесь их изомеров или отдельные изомеры и их соли и фармацевтическая композиция с избирательным модулирующим действием на зависимые от кальция калиевые канальцы высокой проводимости
US4835159A (en) Ergoline esters useful as serotonin antagonists
JPH0778062B2 (ja) Ｄ−ノル−７−エルゴリン誘導体、その製法、薬剤組成物及び使用
HU191795B (en) Process for producing pyrrolizidine derivatives
CZ216892A3 (en) 3,4-dehydropiperidine derivatives, process of their preparation and pharmaceutical compositions in which said derivatives are comprised
BG64736B1 (bg) КРИСТАЛНИ ФОРМИ НА 1S-[1АЛФА(2S* ,3R*), 9АЛФА]-6,10-ДИОКСО-N-(2-ЕТОКСИ-5-ОКСО-ТЕТРАХИДРО-3-ФУРАНИЛ)-9- [[(1-ИЗОХИНОЛИЛ) КАРБОНИЛ]АМИНО]ОКТАХИДРО-6H-ПИРИДАЗИНО[1,2-а][1,2] ДИАЗЕПИН-1-КАРБОКСАМИД
EP0411494A2 (en) Ergoline derivatives having dopaminergic activity

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20010917

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20010917

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000