ZA912628B - Ergoline-8-carboxyamides - Google Patents
Ergoline-8-carboxyamidesInfo
- Publication number
- ZA912628B ZA912628B ZA912628A ZA912628A ZA912628B ZA 912628 B ZA912628 B ZA 912628B ZA 912628 A ZA912628 A ZA 912628A ZA 912628 A ZA912628 A ZA 912628A ZA 912628 B ZA912628 B ZA 912628B
- Authority
- ZA
- South Africa
- Prior art keywords
- carboxyamides
- ergoline
- provides
- disorders
- methylergoline
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- IMSDOBUYDTVEHN-DOVRCZIGSA-N (6ar,10ar)-n-(2-hydroxycyclopentyl)-7-methyl-4-propan-2-yl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-carboxamide Chemical class C([C@H]1[C@H](N(C2)C)CC3=CN(C=4C=CC=C1C3=4)C(C)C)C2C(=O)NC1CCCC1O IMSDOBUYDTVEHN-DOVRCZIGSA-N 0.000 abstract 1
- 102000056834 5-HT2 Serotonin Receptors Human genes 0.000 abstract 1
- 108091005479 5-HT2 receptors Proteins 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000027559 Appetite disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 206010047163 Vasospasm Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Power Engineering (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/508,324 US5043341A (en) | 1990-04-11 | 1990-04-11 | N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA912628B true ZA912628B (en) | 1992-12-30 |
Family
ID=24022297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA912628A ZA912628B (en) | 1990-04-11 | 1991-04-09 | Ergoline-8-carboxyamides |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5043341A (enExample) |
| EP (1) | EP0452074B1 (enExample) |
| JP (1) | JPH04224578A (enExample) |
| KR (1) | KR0165124B1 (enExample) |
| CN (1) | CN1038937C (enExample) |
| AT (1) | ATE133414T1 (enExample) |
| AU (1) | AU634374B2 (enExample) |
| CA (1) | CA2040170A1 (enExample) |
| CZ (1) | CZ279745B6 (enExample) |
| DE (1) | DE69116590T2 (enExample) |
| DK (1) | DK0452074T3 (enExample) |
| ES (1) | ES2082923T3 (enExample) |
| FI (1) | FI96604C (enExample) |
| GR (1) | GR3019416T3 (enExample) |
| HU (1) | HU206113B (enExample) |
| IE (1) | IE72084B1 (enExample) |
| IL (1) | IL97808A (enExample) |
| NO (1) | NO177709C (enExample) |
| NZ (1) | NZ237753A (enExample) |
| PT (1) | PT97299B (enExample) |
| RU (2) | RU2002746C1 (enExample) |
| TW (1) | TW199859B (enExample) |
| YU (1) | YU47809B (enExample) |
| ZA (1) | ZA912628B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5141944A (en) * | 1990-04-11 | 1992-08-25 | Eli Lilly And Company | N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides |
| JPH0613145U (ja) * | 1992-07-23 | 1994-02-18 | 日新電機株式会社 | 基板収納カセット |
| US5441961A (en) * | 1992-08-27 | 1995-08-15 | Eli Lilly And Company | Substituted cyclo or bicycloalkylamides of (8β)-6-(substituted) ergolines |
| US5599985A (en) * | 1993-09-14 | 1997-02-04 | Sepracor, Inc. | Optically pure 1-amido-2-indanols |
| US5516943A (en) * | 1993-09-14 | 1996-05-14 | Sepracor, Inc. | Process for preparing cyclic CIS-1-amino-2-alkanols |
| WO1996032944A1 (en) * | 1995-04-18 | 1996-10-24 | Eli Lilly And Company | Method for using ergoline compounds to effect physiological and pathological functions at the 5-ht7 receptor |
| US5880134A (en) * | 1996-03-20 | 1999-03-09 | Eli Lilly And Company | Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor |
| US6385208B1 (en) * | 1998-06-02 | 2002-05-07 | Cisco Technology, Inc. | Serial media independent interface |
| PT1401863E (pt) * | 2001-06-08 | 2009-07-23 | Ipsen Pharma | Análogos quiméricos da somatostatina-dopamina |
| DE10212564B4 (de) * | 2002-03-12 | 2007-04-19 | Neurobiotec Gmbh | 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne |
| GB0306604D0 (en) * | 2003-03-21 | 2003-04-30 | Curidium Ltd | Second medical use |
| JP2005220081A (ja) * | 2004-02-06 | 2005-08-18 | Toray Fine Chemicals Co Ltd | ｃｉｓ−４−アミノ−１−ベンジル−３−ピロリジノールの製造方法およびピロリジン誘導体 |
| TWI523863B (zh) | 2012-11-01 | 2016-03-01 | 艾普森藥品公司 | 體抑素－多巴胺嵌合體類似物 |
| US9777039B2 (en) | 2012-11-01 | 2017-10-03 | Ipsen Pharma S.A.S. | Somatostatin analogs and dimers thereof |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2997470A (en) * | 1956-03-05 | 1961-08-22 | Lilly Co Eli | Lysergic acid amides |
| IL86725A (en) * | 1987-06-15 | 1993-01-14 | Lilly Co Eli | 1-alkyl-n-cycloalkyl- 6-methyl-ergoline-8'- carboxamides, their preparation and pharmaceutical compositions containing them |
| US4931447A (en) * | 1987-06-15 | 1990-06-05 | Eli Lilly And Company | Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines |
-
1990
- 1990-04-11 US US07/508,324 patent/US5043341A/en not_active Expired - Fee Related
-
1991
- 1991-04-09 AT AT91303088T patent/ATE133414T1/de not_active IP Right Cessation
- 1991-04-09 TW TW080102652A patent/TW199859B/zh active
- 1991-04-09 DK DK91303088.8T patent/DK0452074T3/da active
- 1991-04-09 EP EP91303088A patent/EP0452074B1/en not_active Expired - Lifetime
- 1991-04-09 PT PT97299A patent/PT97299B/pt not_active IP Right Cessation
- 1991-04-09 DE DE69116590T patent/DE69116590T2/de not_active Expired - Fee Related
- 1991-04-09 IL IL9780891A patent/IL97808A/en not_active IP Right Cessation
- 1991-04-09 ES ES91303088T patent/ES2082923T3/es not_active Expired - Lifetime
- 1991-04-09 KR KR1019910005643A patent/KR0165124B1/ko not_active Expired - Fee Related
- 1991-04-09 CZ CS91990A patent/CZ279745B6/cs not_active IP Right Cessation
- 1991-04-09 ZA ZA912628A patent/ZA912628B/xx unknown
- 1991-04-09 NZ NZ237753A patent/NZ237753A/xx unknown
- 1991-04-10 CN CN91103069A patent/CN1038937C/zh not_active Expired - Fee Related
- 1991-04-10 YU YU64691A patent/YU47809B/sh unknown
- 1991-04-10 AU AU74337/91A patent/AU634374B2/en not_active Ceased
- 1991-04-10 FI FI911713A patent/FI96604C/fi active
- 1991-04-10 HU HU911165A patent/HU206113B/hu not_active IP Right Cessation
- 1991-04-10 RU SU914895120A patent/RU2002746C1/ru active
- 1991-04-10 JP JP3077638A patent/JPH04224578A/ja active Pending
- 1991-04-10 IE IE120591A patent/IE72084B1/en not_active IP Right Cessation
- 1991-04-10 NO NO911398A patent/NO177709C/no not_active IP Right Cessation
- 1991-04-10 CA CA002040170A patent/CA2040170A1/en not_active Abandoned
-
1992
- 1992-04-20 RU SU925011387A patent/RU2086551C1/ru active
-
1996
- 1996-03-26 GR GR960400796T patent/GR3019416T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA912628B (en) | Ergoline-8-carboxyamides | |
| MY131298A (en) | 5-heteroyl indole derivatives | |
| DE69129009D1 (de) | Indole Derivate als Serotonin-Antagonisten | |
| PT901374E (pt) | Tetra-hidropteridinas e piridilpiperazinas para o tratamento de disturbios neurologicos | |
| ES2194960T3 (es) | N-(2-sustituido-3-(2-aminoetil)-1h-indol-5-il)-amidas como nuevos agonistas de 5-ht1f. | |
| ES2188095T3 (es) | Carboxamidas heterociclicas. | |
| EP0776201A4 (en) | PREPARATION AND METHOD FOR TREATING ANXIETIES | |
| DE69919436D1 (de) | N-Acyl und N-Aroyl Aralkylamide | |
| WO2000006083A3 (en) | Sulfonamide derivatives | |
| MY127686A (en) | Monofluoroalkyl derivatives | |
| EA200000561A1 (ru) | Триазиновые соединения для лечения расстройств цнс | |
| MY119686A (en) | Sequential distillation process for removing tetrahydroazepine from aminocapronitrile and/or hexamethylenediamine | |
| DE69828414D1 (de) | Mukosale zytotoxische t-lymphozytenantwort | |
| DK0571457T3 (da) | Iloprost med virkning overfor cerebral malaria. | |
| PL331407A1 (en) | Method of treating bipolar disorders | |
| FR2773596B1 (fr) | Embase de fixation de piece | |
| ATE149047T1 (de) | Schienenbefestigungsanordnung | |
| TR199802324T2 (xx) | Penis ereksiyon fonksiyonu bozukluğu tedavisi için alfa bloke ajanlarının ve özellikle de moksisilit ve/veya türevlerinin balanik transmukoza rotası üzerinden kullanımı. | |
| EA200001105A1 (ru) | 10-камфорсульфонат пароксетина для лечения нарушений цнс | |
| FR2818747B1 (fr) | Procede de criblage base sur l'interaction siah-numb | |
| MXPA03003926A (es) | Amidas de alquinilo y sus aplicaciones terapeuticas. | |
| FI943637A0 (fi) | Aryylialkoksifenoksi-imidatsoliiniyhdisteitä | |
| EA199900429A1 (ru) | Синтез бензо[f]хинолинонов | |
| ITPS920010U1 (it) | Gruppo generatore di vibrazioni | |
| SE9201162L (sv) | Bullerskydd, särskilt för järnvägar och spårvägar |