CN1038937C - 麦角灵－8－甲酰胺衍生物的制备方法 - Google Patents

麦角灵－8－甲酰胺衍生物的制备方法 Download PDF

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Publication number
CN1038937C
CN1038937C CN91103069A CN91103069A CN1038937C CN 1038937 C CN1038937 C CN 1038937C CN 91103069 A CN91103069 A CN 91103069A CN 91103069 A CN91103069 A CN 91103069A CN 1038937 C CN1038937 C CN 1038937C
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CN
China
Prior art keywords
preparation
acid
ergoline
methylergoline
isopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN91103069A
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English (en)
Chinese (zh)
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CN1056496A (zh
Inventor
马林·L·科恩
戴维·W·罗伯特逊
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Eli Lilly and Co
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Eli Lilly and Co
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Publication of CN1056496A publication Critical patent/CN1056496A/zh
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Publication of CN1038937C publication Critical patent/CN1038937C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Power Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN91103069A 1990-04-11 1991-04-10 麦角灵－8－甲酰胺衍生物的制备方法 Expired - Fee Related CN1038937C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/508,324 US5043341A (en) 1990-04-11 1990-04-11 N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
US508,324 1990-04-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN97119578A Division CN1186663A (zh) 1990-04-11 1997-09-30 含麦角灵－8－甲酰胺衍生物的药物制剂的制备方法

Publications (2)

Publication Number Publication Date
CN1056496A CN1056496A (zh) 1991-11-27
CN1038937C true CN1038937C (zh) 1998-07-01

Family

ID=24022297

Family Applications (1)

Application Number Title Priority Date Filing Date
CN91103069A Expired - Fee Related CN1038937C (zh) 1990-04-11 1991-04-10 麦角灵－8－甲酰胺衍生物的制备方法

Country Status (24)

Country Link
US (1) US5043341A (enExample)
EP (1) EP0452074B1 (enExample)
JP (1) JPH04224578A (enExample)
KR (1) KR0165124B1 (enExample)
CN (1) CN1038937C (enExample)
AT (1) ATE133414T1 (enExample)
AU (1) AU634374B2 (enExample)
CA (1) CA2040170A1 (enExample)
CZ (1) CZ279745B6 (enExample)
DE (1) DE69116590T2 (enExample)
DK (1) DK0452074T3 (enExample)
ES (1) ES2082923T3 (enExample)
FI (1) FI96604C (enExample)
GR (1) GR3019416T3 (enExample)
HU (1) HU206113B (enExample)
IE (1) IE72084B1 (enExample)
IL (1) IL97808A (enExample)
NO (1) NO177709C (enExample)
NZ (1) NZ237753A (enExample)
PT (1) PT97299B (enExample)
RU (2) RU2002746C1 (enExample)
TW (1) TW199859B (enExample)
YU (1) YU47809B (enExample)
ZA (1) ZA912628B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141944A (en) * 1990-04-11 1992-08-25 Eli Lilly And Company N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
JPH0613145U (ja) * 1992-07-23 1994-02-18 日新電機株式会社 基板収納カセット
US5441961A (en) * 1992-08-27 1995-08-15 Eli Lilly And Company Substituted cyclo or bicycloalkylamides of (8β)-6-(substituted) ergolines
US5516943A (en) * 1993-09-14 1996-05-14 Sepracor, Inc. Process for preparing cyclic CIS-1-amino-2-alkanols
US5599985A (en) * 1993-09-14 1997-02-04 Sepracor, Inc. Optically pure 1-amido-2-indanols
JPH11503757A (ja) * 1995-04-18 1999-03-30 イーライ・リリー・アンド・カンパニー ５−ｈｔ▲下７▼レセプターにおいて生理学的および病理学的機能を生じるエルゴリン化合物の使用方法
US5880134A (en) * 1996-03-20 1999-03-09 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor
US6385208B1 (en) * 1998-06-02 2002-05-07 Cisco Technology, Inc. Serial media independent interface
IL158922A0 (en) * 2001-06-08 2004-05-12 Sod Conseils Rech Applic Somatostatin-dopamine chimeric analogs
DE10212564B4 (de) * 2002-03-12 2007-04-19 Neurobiotec Gmbh 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
JP2005220081A (ja) * 2004-02-06 2005-08-18 Toray Fine Chemicals Co Ltd ｃｉｓ−４−アミノ−１−ベンジル−３−ピロリジノールの製造方法およびピロリジン誘導体
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
CN104768565B (zh) 2012-11-01 2017-04-26 益普生制药股份有限公司 促生长素抑制素类似物及其二聚体
HK1215170A1 (zh) 2012-11-14 2016-08-19 The Johns Hopkins University 治療精神分裂症的方法和組合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296748A1 (en) * 1987-06-15 1988-12-28 Eli Lilly And Company Cycloalkylamides of (8Beta)-1-alkyl-6-(substituted) ergolines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997470A (en) * 1956-03-05 1961-08-22 Lilly Co Eli Lysergic acid amides
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296748A1 (en) * 1987-06-15 1988-12-28 Eli Lilly And Company Cycloalkylamides of (8Beta)-1-alkyl-6-(substituted) ergolines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNCL OF MEDIAIND CHENUIFHG 1990.2.1 J.W.HISNER ET AF 8BETA-6-MEEHTERGO HIREAMIDRDERIVAFIWES AS SEROFOMIM EFFEE *

Also Published As

Publication number Publication date
EP0452074B1 (en) 1996-01-24
NO177709C (no) 1995-11-08
NO177709B (no) 1995-07-31
EP0452074A2 (en) 1991-10-16
DE69116590T2 (de) 1996-07-04
KR910018381A (ko) 1991-11-30
NO911398D0 (no) 1991-04-10
DK0452074T3 (da) 1996-02-19
CA2040170A1 (en) 1991-10-12
FI96604B (fi) 1996-04-15
EP0452074A3 (en) 1992-03-04
GR3019416T3 (en) 1996-06-30
CN1056496A (zh) 1991-11-27
RU2086551C1 (ru) 1997-08-10
IE72084B1 (en) 1997-03-12
AU7433791A (en) 1991-10-17
HUT56841A (en) 1991-10-28
IE911205A1 (en) 1991-10-23
ATE133414T1 (de) 1996-02-15
NZ237753A (en) 1993-02-25
JPH04224578A (ja) 1992-08-13
US5043341A (en) 1991-08-27
NO911398L (no) 1991-10-14
HU206113B (en) 1992-08-28
RU2002746C1 (ru) 1993-11-15
YU47809B (sr) 1996-01-09
PT97299A (pt) 1992-01-31
YU64691A (sh) 1994-01-20
DE69116590D1 (de) 1996-03-07
ES2082923T3 (es) 1996-04-01
IL97808A (en) 1994-12-29
IL97808A0 (en) 1992-06-21
TW199859B (enExample) 1993-02-11
ZA912628B (en) 1992-12-30
PT97299B (pt) 1998-08-31
FI911713A0 (fi) 1991-04-10
KR0165124B1 (ko) 1999-03-20
FI96604C (fi) 1996-07-25
CZ99091A3 (en) 1995-03-15
AU634374B2 (en) 1993-02-18
CZ279745B6 (cs) 1995-06-14
FI911713L (fi) 1991-10-12

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C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee