DE69028967D1 - Cyclosporin- Derivate - Google Patents

Cyclosporin- Derivate

Info

Publication number
DE69028967D1
DE69028967D1 DE69028967T DE69028967T DE69028967D1 DE 69028967 D1 DE69028967 D1 DE 69028967D1 DE 69028967 T DE69028967 T DE 69028967T DE 69028967 T DE69028967 T DE 69028967T DE 69028967 D1 DE69028967 D1 DE 69028967D1
Authority
DE
Germany
Prior art keywords
cyclosporin derivatives
ser
ciclosporin
derivatives
immunosuppressants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69028967T
Other languages
English (en)
Other versions
DE69028967T2 (de
Inventor
Marcel Karl Eberle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Sandoz Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG, Sandoz Patent GmbH filed Critical Sandoz AG
Application granted granted Critical
Publication of DE69028967D1 publication Critical patent/DE69028967D1/de
Publication of DE69028967T2 publication Critical patent/DE69028967T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69028967T 1989-07-24 1990-07-23 Cyclosporin- Derivate Expired - Fee Related DE69028967T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898916901A GB8916901D0 (en) 1989-07-24 1989-07-24 Improvements in or relating to organic compounds

Publications (2)

Publication Number Publication Date
DE69028967D1 true DE69028967D1 (de) 1996-11-28
DE69028967T2 DE69028967T2 (de) 1997-05-15

Family

ID=10660543

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69028967T Expired - Fee Related DE69028967T2 (de) 1989-07-24 1990-07-23 Cyclosporin- Derivate

Country Status (23)

Country Link
EP (1) EP0414632B1 (de)
JP (1) JPH0730113B2 (de)
KR (1) KR100201174B1 (de)
AT (1) ATE144536T1 (de)
AU (1) AU631667B2 (de)
CA (1) CA2021788C (de)
CZ (1) CZ411691A3 (de)
DE (1) DE69028967T2 (de)
DK (1) DK0414632T3 (de)
ES (1) ES2092500T3 (de)
FI (1) FI94355C (de)
GB (1) GB8916901D0 (de)
GR (1) GR3021667T3 (de)
HK (1) HK1004268A1 (de)
HU (1) HU206127B (de)
IE (1) IE902669A1 (de)
IL (1) IL95154A (de)
MY (1) MY105942A (de)
NZ (1) NZ234613A (de)
PT (1) PT94790B (de)
SA (1) SA91110205B1 (de)
SK (1) SK411691A3 (de)
ZA (1) ZA905823B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
GB9204466D0 (en) * 1992-03-02 1992-04-15 Sandoz Ltd Improvements in or relating to organic compounds
US5482850A (en) * 1993-10-29 1996-01-09 New England Biolabs, Inc. Method for identifying anti-parasitic compounds
WO1997011092A1 (fr) * 1994-04-07 1997-03-27 Nippon Shinyaku Co., Ltd. Derives de phosphates de cyclosporine et composition medicinale
US7807211B2 (en) 1999-09-03 2010-10-05 Advanced Cardiovascular Systems, Inc. Thermal treatment of an implantable medical device
US6790228B2 (en) 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
KR100681670B1 (ko) * 2001-02-14 2007-02-09 주식회사 엘지생활건강 [감마 히드록시 엔- 메틸-엘-루신9]사이클로스포린 에이를유효성분으로 하는 모발 성장 촉진제
KR100465012B1 (ko) * 2001-05-11 2005-01-13 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
US7141648B2 (en) 2001-10-19 2006-11-28 Isotechnika Inc. Synthesis of cyclosporin analogs
KR100865211B1 (ko) * 2001-10-26 2008-10-23 주식회사 엘지생활건강 비면역 [감마 히드록시 엔-메틸 엘-루신4] 사이클로스포린 유도체를 유효성분으로 하는 항암 화학요법 기인 탈모증상 억제제
US6987090B2 (en) 2002-05-09 2006-01-17 Lg Household & Health Care Ltd. Use of 3-position cyclosporin derivatives for hair growth
KR100439467B1 (ko) * 2002-11-13 2004-07-09 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
US20050118344A1 (en) 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
FR2873585B1 (fr) * 2004-07-27 2006-11-17 Aventis Pharma Sa Nouvelles formulations galeniques de principes actifs
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
WO2013074608A1 (en) * 2011-11-15 2013-05-23 Allergan, Inc. Cyclosporine a form 2 and method of making same
WO2020037530A1 (en) 2018-08-22 2020-02-27 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Crystalline form of compound and uses thereof in medicine

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (de) 1975-11-04 1979-12-28 Sandoz Ag
DE2819094A1 (de) 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
SE448386B (sv) 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en) 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
DE3167014D1 (en) 1980-02-14 1984-12-13 Sandoz Ag A method for the total synthesis of cyclosporins and novel cyclosporins
DE3260468D1 (en) 1981-01-09 1984-09-06 Sandoz Ag Novel cyclosporins
CH667274A5 (de) 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
CY1915A (en) 1984-10-04 1985-09-27 Sandoz Ag Cyclosporins
US4798823A (en) 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
ES2059558T3 (es) * 1987-06-17 1994-11-16 Sandoz Ag Ciclosporins y su uso como productos farmaceuticos.
GB2206119B (en) 1987-06-22 1990-10-31 Merck & Co Inc A new cyclosporin derivative with modified "8-amino acid"
GB8717299D0 (en) 1987-07-22 1987-08-26 Nat Res Dev Peptides
GB8717300D0 (en) 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
GB2207678A (en) 1987-08-03 1989-02-08 Merck & Co Inc Novel immunosuppressive fluorinated cyclosporin analogs
HU205010B (en) 1987-09-15 1992-03-30 Sandoz Ag Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
KR0148748B1 (ko) 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물

Also Published As

Publication number Publication date
FI94355B (fi) 1995-05-15
DK0414632T3 (da) 1996-11-25
PT94790B (pt) 1997-04-30
PT94790A (pt) 1991-03-20
NZ234613A (en) 1992-09-25
HK1004268A1 (en) 1998-11-20
AU5972790A (en) 1991-01-24
SK411691A3 (en) 1995-07-11
EP0414632B1 (de) 1996-10-23
SA91110205B1 (ar) 2004-08-07
HU206127B (en) 1992-08-28
KR910002902A (ko) 1991-02-26
EP0414632A3 (en) 1991-09-11
GB8916901D0 (en) 1989-09-06
AU631667B2 (en) 1992-12-03
HUT54714A (en) 1991-03-28
IL95154A0 (en) 1991-06-10
JPH0730113B2 (ja) 1995-04-05
GR3021667T3 (en) 1997-02-28
ATE144536T1 (de) 1996-11-15
EP0414632A2 (de) 1991-02-27
CA2021788A1 (en) 1991-01-25
CA2021788C (en) 2001-02-13
MY105942A (en) 1995-02-28
ES2092500T3 (es) 1996-12-01
DE69028967T2 (de) 1997-05-15
FI903706A0 (fi) 1990-07-23
IE902669A1 (en) 1991-02-27
KR100201174B1 (ko) 1999-06-15
FI94355C (fi) 1995-08-25
ZA905823B (en) 1992-03-25
IL95154A (en) 1995-03-30
JPH03218396A (ja) 1991-09-25
CZ411691A3 (cs) 1998-06-17
HU904224D0 (en) 1990-12-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

8339 Ceased/non-payment of the annual fee