DE69017355D1 - Prozess zur direkten Isolierung von Captopril. - Google Patents

Prozess zur direkten Isolierung von Captopril.

Info

Publication number
DE69017355D1
DE69017355D1 DE69017355T DE69017355T DE69017355D1 DE 69017355 D1 DE69017355 D1 DE 69017355D1 DE 69017355 T DE69017355 T DE 69017355T DE 69017355 T DE69017355 T DE 69017355T DE 69017355 D1 DE69017355 D1 DE 69017355D1
Authority
DE
Germany
Prior art keywords
substrate
captopril
alkali metal
metal hydroxide
direct isolation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69017355T
Other languages
English (en)
Other versions
DE69017355T2 (de
Inventor
Neal G Anderson
Alan F Feldman
David A Lust
Robert E Polomski
Barbara J Bennett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23714462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69017355(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of DE69017355D1 publication Critical patent/DE69017355D1/de
Publication of DE69017355T2 publication Critical patent/DE69017355T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Semiconductor Lasers (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69017355T 1989-11-06 1990-10-29 Prozess zur direkten Isolierung von Captopril. Expired - Fee Related DE69017355T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/432,028 US5026873A (en) 1989-11-06 1989-11-06 Process for direct isolation of captopril

Publications (2)

Publication Number Publication Date
DE69017355D1 true DE69017355D1 (de) 1995-04-06
DE69017355T2 DE69017355T2 (de) 1995-06-29

Family

ID=23714462

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69017355T Expired - Fee Related DE69017355T2 (de) 1989-11-06 1990-10-29 Prozess zur direkten Isolierung von Captopril.

Country Status (29)

Country Link
US (1) US5026873A (de)
EP (1) EP0427435B1 (de)
JP (1) JPH03169856A (de)
KR (1) KR0163956B1 (de)
CN (1) CN1028169C (de)
AT (1) ATE119148T1 (de)
AU (1) AU635341B2 (de)
CA (1) CA2027377A1 (de)
CY (1) CY1852A (de)
CZ (1) CZ277714B6 (de)
DE (1) DE69017355T2 (de)
DK (1) DK0427435T3 (de)
EG (1) EG18964A (de)
ES (1) ES2068349T3 (de)
FI (1) FI98814C (de)
HK (1) HK109895A (de)
HU (1) HU208525B (de)
IE (1) IE67284B1 (de)
IL (1) IL96018A (de)
MX (1) MX166721B (de)
MY (1) MY106445A (de)
NO (1) NO904796L (de)
NZ (1) NZ235958A (de)
PH (1) PH26962A (de)
PL (1) PL287642A1 (de)
PT (1) PT95781B (de)
RU (1) RU2001909C1 (de)
SK (1) SK278604B6 (de)
ZA (1) ZA908523B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208954B (en) * 1990-09-21 1994-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn
US5387697A (en) * 1994-06-13 1995-02-07 Merck & Co., Inc. Process for the preparation of 1-[3-acetylthio-2(s)-methylpropanoyl]-l-proline
JP3980684B2 (ja) * 1996-10-11 2007-09-26 株式会社カネカ 高品質カプトプリルの簡便な製造方法
CN107652215A (zh) * 2017-09-19 2018-02-02 重庆西南制药二厂有限责任公司 一种卡托普利的制备方法
CN110146624B (zh) * 2019-06-14 2022-02-22 湖南汉森制药股份有限公司 一种卡托普利有关物质的检测方法
CN110950792A (zh) * 2019-12-11 2020-04-03 华中药业股份有限公司 一种卡托普利的改进制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4241076A (en) * 1978-02-21 1980-12-23 E. R. Squibb & Sons, Inc. Halogenated substituted mercaptoacylamino acids
NL7809120A (nl) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw Werkwijze voor de bereiding van proline-derivaten.
US4297282A (en) * 1979-03-02 1981-10-27 Sumitomo Chemical Company, Limited Resolution of mercaptopropionic acids
HU184082B (en) * 1979-12-29 1984-06-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid
US4332726A (en) * 1980-08-25 1982-06-01 E. R. Squibb & Sons, Inc. Purification of mercaptoacyl amino acids
JPS58124764A (ja) * 1982-01-20 1983-07-25 Kanegafuchi Chem Ind Co Ltd 光学活性チオ−ル化合物の製造法
KR870001570B1 (ko) * 1984-12-19 1987-09-04 보령제약 주식회사 피롤리딘 유도체의 제조방법
IL91581A (en) * 1988-09-13 1993-07-08 Sepracor Inc Methods for preparing optically active captopril and its analogues

Also Published As

Publication number Publication date
EP0427435B1 (de) 1995-03-01
CN1051908A (zh) 1991-06-05
NO904796L (no) 1991-05-07
MY106445A (en) 1995-05-30
FI98814B (fi) 1997-05-15
EP0427435A1 (de) 1991-05-15
PT95781B (pt) 1997-11-28
PL287642A1 (en) 1991-05-20
US5026873A (en) 1991-06-25
DK0427435T3 (da) 1995-03-27
PH26962A (en) 1992-12-28
ES2068349T3 (es) 1995-04-16
AU6397790A (en) 1991-05-09
IL96018A0 (en) 1991-07-18
EG18964A (en) 1994-09-29
FI98814C (fi) 1997-08-25
CZ277714B6 (en) 1993-03-17
HU208525B (en) 1993-11-29
CY1852A (en) 1996-03-08
HK109895A (en) 1995-07-14
HUT55754A (en) 1991-06-28
ZA908523B (en) 1991-08-28
IL96018A (en) 1996-05-14
CA2027377A1 (en) 1991-05-07
DE69017355T2 (de) 1995-06-29
RU2001909C1 (ru) 1993-10-30
JPH03169856A (ja) 1991-07-23
NZ235958A (en) 1993-01-27
FI905467A0 (fi) 1990-11-05
MX166721B (es) 1993-01-29
AU635341B2 (en) 1993-03-18
IE67284B1 (en) 1996-03-20
CS540590A3 (en) 1992-11-18
IE903759A1 (en) 1991-05-08
PT95781A (pt) 1991-09-13
HU907031D0 (en) 1991-05-28
SK278604B6 (en) 1997-11-05
ATE119148T1 (de) 1995-03-15
KR0163956B1 (ko) 1998-12-01
NO904796D0 (no) 1990-11-05
KR910009657A (ko) 1991-06-28
CN1028169C (zh) 1995-04-12

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings
8339 Ceased/non-payment of the annual fee