PT95781A - Novo processo para a preparacao e isolamento directo de captopril - Google Patents

Novo processo para a preparacao e isolamento directo de captopril

Info

Publication number
PT95781A
PT95781A PT95781A PT9578190A PT95781A PT 95781 A PT95781 A PT 95781A PT 95781 A PT95781 A PT 95781A PT 9578190 A PT9578190 A PT 9578190A PT 95781 A PT95781 A PT 95781A
Authority
PT
Portugal
Prior art keywords
substrate
captopril
direct isolation
alkali metal
metal hydroxide
Prior art date
Application number
PT95781A
Other languages
English (en)
Other versions
PT95781B (pt
Inventor
Neal G Anderson
David A Lust
Barbara J Bennett
Alan F Feldman
Robert E Polomski
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23714462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT95781(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of PT95781A publication Critical patent/PT95781A/pt
Publication of PT95781B publication Critical patent/PT95781B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pyrrole Compounds (AREA)
  • Semiconductor Lasers (AREA)
PT95781A 1989-11-06 1990-11-05 Novo processo para a preparacao e isolamento directo de captopril PT95781B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/432,028 US5026873A (en) 1989-11-06 1989-11-06 Process for direct isolation of captopril

Publications (2)

Publication Number Publication Date
PT95781A true PT95781A (pt) 1991-09-13
PT95781B PT95781B (pt) 1997-11-28

Family

ID=23714462

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95781A PT95781B (pt) 1989-11-06 1990-11-05 Novo processo para a preparacao e isolamento directo de captopril

Country Status (29)

Country Link
US (1) US5026873A (pt)
EP (1) EP0427435B1 (pt)
JP (1) JPH03169856A (pt)
KR (1) KR0163956B1 (pt)
CN (1) CN1028169C (pt)
AT (1) ATE119148T1 (pt)
AU (1) AU635341B2 (pt)
CA (1) CA2027377A1 (pt)
CY (1) CY1852A (pt)
CZ (1) CZ277714B6 (pt)
DE (1) DE69017355T2 (pt)
DK (1) DK0427435T3 (pt)
EG (1) EG18964A (pt)
ES (1) ES2068349T3 (pt)
FI (1) FI98814C (pt)
HK (1) HK109895A (pt)
HU (1) HU208525B (pt)
IE (1) IE67284B1 (pt)
IL (1) IL96018A (pt)
MX (1) MX166721B (pt)
MY (1) MY106445A (pt)
NO (1) NO904796L (pt)
NZ (1) NZ235958A (pt)
PH (1) PH26962A (pt)
PL (1) PL287642A1 (pt)
PT (1) PT95781B (pt)
RU (1) RU2001909C1 (pt)
SK (1) SK278604B6 (pt)
ZA (1) ZA908523B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208954B (en) * 1990-09-21 1994-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn
US5387697A (en) * 1994-06-13 1995-02-07 Merck & Co., Inc. Process for the preparation of 1-[3-acetylthio-2(s)-methylpropanoyl]-l-proline
JP3980684B2 (ja) * 1996-10-11 2007-09-26 株式会社カネカ 高品質カプトプリルの簡便な製造方法
CN107652215A (zh) * 2017-09-19 2018-02-02 重庆西南制药二厂有限责任公司 一种卡托普利的制备方法
CN110146624B (zh) * 2019-06-14 2022-02-22 湖南汉森制药股份有限公司 一种卡托普利有关物质的检测方法
CN110950792A (zh) * 2019-12-11 2020-04-03 华中药业股份有限公司 一种卡托普利的改进制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4241076A (en) * 1978-02-21 1980-12-23 E. R. Squibb & Sons, Inc. Halogenated substituted mercaptoacylamino acids
NL7809120A (nl) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw Werkwijze voor de bereiding van proline-derivaten.
US4297282A (en) * 1979-03-02 1981-10-27 Sumitomo Chemical Company, Limited Resolution of mercaptopropionic acids
HU184082B (en) * 1979-12-29 1984-06-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid
US4332726A (en) * 1980-08-25 1982-06-01 E. R. Squibb & Sons, Inc. Purification of mercaptoacyl amino acids
JPS58124764A (ja) * 1982-01-20 1983-07-25 Kanegafuchi Chem Ind Co Ltd 光学活性チオ−ル化合物の製造法
KR870001570B1 (ko) * 1984-12-19 1987-09-04 보령제약 주식회사 피롤리딘 유도체의 제조방법
IL91581A (en) * 1988-09-13 1993-07-08 Sepracor Inc Methods for preparing optically active captopril and its analogues

Also Published As

Publication number Publication date
IE903759A1 (en) 1991-05-08
IE67284B1 (en) 1996-03-20
EP0427435B1 (en) 1995-03-01
NO904796D0 (no) 1990-11-05
KR0163956B1 (ko) 1998-12-01
ES2068349T3 (es) 1995-04-16
EP0427435A1 (en) 1991-05-15
RU2001909C1 (ru) 1993-10-30
AU6397790A (en) 1991-05-09
MY106445A (en) 1995-05-30
FI98814B (fi) 1997-05-15
CS540590A3 (en) 1992-11-18
ZA908523B (en) 1991-08-28
US5026873A (en) 1991-06-25
DK0427435T3 (da) 1995-03-27
HUT55754A (en) 1991-06-28
PH26962A (en) 1992-12-28
ATE119148T1 (de) 1995-03-15
KR910009657A (ko) 1991-06-28
PL287642A1 (en) 1991-05-20
CN1028169C (zh) 1995-04-12
IL96018A0 (en) 1991-07-18
MX166721B (es) 1993-01-29
CN1051908A (zh) 1991-06-05
PT95781B (pt) 1997-11-28
FI98814C (fi) 1997-08-25
DE69017355T2 (de) 1995-06-29
CZ277714B6 (en) 1993-03-17
SK278604B6 (en) 1997-11-05
CA2027377A1 (en) 1991-05-07
JPH03169856A (ja) 1991-07-23
HU907031D0 (en) 1991-05-28
IL96018A (en) 1996-05-14
FI905467A0 (fi) 1990-11-05
HK109895A (en) 1995-07-14
NO904796L (no) 1991-05-07
AU635341B2 (en) 1993-03-18
DE69017355D1 (de) 1995-04-06
NZ235958A (en) 1993-01-27
HU208525B (en) 1993-11-29
EG18964A (en) 1994-09-29
CY1852A (en) 1996-03-08

Similar Documents

Publication Publication Date Title
BR8703170A (pt) Processo para preparacao de(2,2)-paraciclofano e derivados deste
PT952148E (pt) Derivados de acido ciclobutil-ariloxiarilsulfonilamino-hidroxamico
BR8703169A (pt) Processo para preparacao de(2,2)-paraciclofano e derivados deste
PT99134A (pt) Processo para a preparacao de derivados da piperazina
PT95781A (pt) Novo processo para a preparacao e isolamento directo de captopril
ATE69604T1 (de) Verfahren zur herstellung von 1-hydroxy-2pyridonen.
BR9002873A (pt) Composicao aquosa de condicionamento de cabelo e processo para aperfeicoar a elasticidade do cabelo
PT95978A (pt) Processo para de novos derivados do 6-aril-5,6-dihidroimidazo/2,l-b/-tiazol comefeito imuno-estimulante
PT84819B (pt) Processo para a preparacao de compostos 2-piridil-penem
PT89098A (pt) Processo para a preparacao de derivados de guanina
DE69005984D1 (de) 2-Hydroxy-3-phenoxypropylaminoverbindungen.
BR9303402A (pt) Processo para o tratamento de um sistema aquoso e composicao adequada para ser adicionada a um sistema aquoso
GR3001947T3 (en) Process for preparing isothiazolones
HUT53528A (en) Process for production of having antiviral effectg, well suluable in water stabil cristallic salts of 2',3' dideozoxiinozin- monohidrat, 2',3'-didezoxi-2'3'-didohydrotimidin monohydrate and 2',3' didezoxi-2'-fluor-inosine-hemihydrate and medical compositions containing these salts
BR8705168A (pt) Processo para a preparacao de 2,3,5,6-tetracloropiridina
ES551363A0 (es) Procedimiento para fabricar carbonato de sodio anhidro denso
BR8205560A (pt) Processo para preparacao de um acido hidroxi-amino-organossulfonico n-acilado,em particular de um acido hidroxi-amino-arilsulfonico n-acilado
BR0016170A (pt) Processo para preparação de tienopirimidinas
TH18762A (th) กรรมวิธีสำหรับเตรียมเกลือไอเซไธโอเนทเอสเทอร์
GB1048907A (en) Penicillins
FR2352069A1 (fr) Procede de phosphatation de metaux
ES8300106A1 (es) Procedimiento para preparar compuesto de 2-(2-imidazolin-2-il)-piridina y quinolina.
GEP19971039B (en) Method for production of acrylic acid

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910403

FG3A Patent granted, date of granting

Effective date: 19970804

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20100204