DE68929050T2 - 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel - Google Patents

1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel

Info

Publication number
DE68929050T2
DE68929050T2 DE68929050T DE68929050T DE68929050T2 DE 68929050 T2 DE68929050 T2 DE 68929050T2 DE 68929050 T DE68929050 T DE 68929050T DE 68929050 T DE68929050 T DE 68929050T DE 68929050 T2 DE68929050 T2 DE 68929050T2
Authority
DE
Germany
Prior art keywords
morpholino
opt
alkyl
piperidino
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68929050T
Other languages
English (en)
Other versions
DE68929050D1 (de
Inventor
William Lee
J Brown
Edward Grange
Abelardo Martinez
Michael Tracy
Daniel Pollart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Application granted granted Critical
Publication of DE68929050D1 publication Critical patent/DE68929050D1/de
Publication of DE68929050T2 publication Critical patent/DE68929050T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Artificial Fish Reefs (AREA)
DE68929050T 1989-09-18 1989-09-18 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel Expired - Fee Related DE68929050T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/004112 WO1991004028A1 (en) 1989-09-18 1989-09-18 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents

Publications (2)

Publication Number Publication Date
DE68929050D1 DE68929050D1 (de) 1999-09-16
DE68929050T2 true DE68929050T2 (de) 2000-02-03

Family

ID=22215243

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68929050T Expired - Fee Related DE68929050T2 (de) 1989-09-18 1989-09-18 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel

Country Status (10)

Country Link
EP (1) EP0478545B1 (de)
JP (1) JP3034541B2 (de)
KR (1) KR0142858B1 (de)
AT (1) ATE183094T1 (de)
AU (1) AU646794B2 (de)
DE (1) DE68929050T2 (de)
FI (1) FI111008B (de)
HU (2) HU221201B1 (de)
NO (1) NO305905B1 (de)
WO (1) WO1991004028A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672702A (en) * 1995-12-04 1997-09-30 Sanofi Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
NZ521436A (en) * 2002-09-17 2005-07-29 Auckland Uniservices Ltd DNA- targeted benzotriazine 1,4-dioxides and their use in cancer therapy
EP1723125A4 (de) * 2004-03-01 2009-11-18 Auckland Uniservices Ltd Neue 1,2,4-benzotriazin-1,4-dioxide
JP2015500295A (ja) * 2011-12-07 2015-01-05 エスアールアイ インターナショナルＳＲＩ Ｉｎｔｅｒｎａｔｉｏｎａｌ ヒト結核菌を標的とする医薬としてのベンゾトリアジンオキサイド類
JP2015084923A (ja) * 2013-10-30 2015-05-07 テクナード株式会社 衣服用防湿マット
US20200276338A1 (en) * 2017-09-19 2020-09-03 The Governors Of The University Of Alberta Bioreductively-activated compounds, their prodrugs, radiopharmaceuticals, the compositions, and their applications in multimodal theranostic management of hypoxia diseases including cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3079390A (en) * 1958-12-12 1963-02-26 Searle & Co N-substituted 3-amino-1, 2, 4-benzotriazine-1-oxides
BE794742A (fr) * 1972-02-01 1973-07-30 Bayer Ag Nouveaux di-n-oxydes (1,4) de benzo-1,2,4-triazine, leur procede de preparation et leur application comme medicaments et additifs de nutrition
US4001410A (en) 1972-02-01 1977-01-04 Bayer Aktiengesellschaft 3-amino-1,2,4-benzotriazine-1,4-di-n-oxide compositions and method of using same
US3980779A (en) 1972-02-01 1976-09-14 Bayer Aktiengesellschaft 3-Amino-1,2,4-benzotriazine-1,4-di-N-oxide compositions and method of using same
US4027022A (en) * 1972-11-15 1977-05-31 Bayer Aktiengesellschaft Antibacterial benzo-1,2,4-triazines
US3991189A (en) * 1972-11-15 1976-11-09 Bayer Aktiengesellschaft Microbiocidal methods and compositions using substituted 1,2,4-triazine-1,4-di-N-oxide derivatives
IL44058A (en) * 1973-02-02 1978-10-31 Ciba Geigy Ag 3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them
US3957799A (en) 1973-04-04 1976-05-18 E. R. Squibb & Sons, Inc. Sulfur containing amino and imino pyridines
US4022022A (en) * 1976-04-26 1977-05-10 Parker-Hannifin Corporation Hydraulic system and control valve assembly therefor
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
DE2910974A1 (de) 1979-03-21 1981-02-19 Bayer Ag 3-sulfonyl-benzo-1,2,4-triazine und -benzo-1,2,4-triazin-1-oxide, verfahren zu ihrer herstellung sowie ihre verwendung als antimikrobielle mittel
US4371540A (en) 1979-09-14 1983-02-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells
DE3790581B4 (de) * 1986-09-25 2004-12-23 Sri International, Menlo Park Verfahren zur selektiven Vernichtung von hypoxischen Tumorzellen
IE62911B1 (en) * 1988-03-18 1995-03-08 Stanford Res Inst Int 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents

Also Published As

Publication number Publication date
NO305905B1 (no) 1999-08-16
KR0142858B1 (en) 1998-07-15
AU4428489A (en) 1991-04-18
EP0478545B1 (de) 1999-08-11
FI111008B (fi) 2003-05-15
JP3034541B2 (ja) 2000-04-17
ATE183094T1 (de) 1999-08-15
JPH05500499A (ja) 1993-02-04
AU646794B2 (en) 1994-03-10
WO1991004028A1 (en) 1991-04-04
NO920747D0 (no) 1992-02-25
EP0478545A1 (de) 1992-04-08
EP0478545A4 (en) 1992-08-05
NO920747L (no) 1992-02-25
DE68929050D1 (de) 1999-09-16
HU225965B1 (en) 2008-01-28
HU9602225D0 (en) 1996-10-28
FI920712A0 (fi) 1992-02-19
HU221201B1 (en) 2002-08-28
KR927003062A (ko) 1992-12-17

Similar Documents

Publication Publication Date Title
ATE188216T1 (de) Therapeutische mittel für die parkinsonsche krankheit
MX9304647A (es) 7-(sustituido)-9-[(glicilo sustituido)amido]-6-desmetil-6-desoxitetraciclinas y metodo para su produccion.
GR3029408T3 (en) Novel piperidine derivatives, useful as neurokinin receptor antagonists
MX9304756A (es) 9-[(glicilo substituido)amido]-6-desmetil-6-desoxitetraciclinas, metodo para su produccion y composiciones farmaceuticas que las contienen.
DK0707007T3 (da) Amino(thio)etherderivater som CNS-aktive midler
NO995846D0 (no) Oksazolidinon-antibakterielle midler med en tiokarbonylfunksjonalitet
ATE159950T1 (de) N-alkyl-2-substituierte atp-analoge
DK0655442T3 (da) Piperazinderivater som tachykinin-antagonister
TR199902593T2 (xx) �kame edilmi� fenil t�revleri, bunlar�n haz�rlanmas� ve kullan�m�.
IL78969A (en) Amides derived from quinoline,processes for preparation thereof and pharmaceutical compositions containing them
UY25143A1 (es) Procedimiento para la preparacion de inhibidores de proteasas.
FI920023A0 (fi) Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
DE68929050T2 (de) 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel
ATE218126T1 (de) Phenylpiperidin-derivate
AR015233A1 (es) Sulfonamidas, proceso para su preparacion, composiciones farmaceuticas que las comprenden y el uso de las mismas para la fabricacion de medicamentos parael tratamiento de trastornos tromboembolicos.
ES2127762T3 (es) Quinoleinas 2-sustituidas para el tratamiento de las leismaniosis.
MX9303587A (es) Producto para el cuidado de lentes de contacto, para lentes de contacto duros o blandos.
IL108444A0 (en) C2 taxane derivatives and pharmaceutical compositions containing them
FI803356L (fi) Nya azepinoindoler deras framstaellning och dessa innehaollande farmaceutiska foereningar
ATE27452T1 (de) Substituierte o-phenylendiaminderivate.
HUT60629A (en) Process for producing pharmaceutical compositions applicable as radiation sensitizer and selective cytotoxic agent and comprising 1,2,4-benzotriazine oxides as active ingredient
ZA974416B (en) Sulfur-containing heterocyclic bradykinin antagonists, process for their preparation, and their use.
DK0435235T3 (da) Nye isoquinolinderivater og salte deraf
AR248402A1 (es) Procedimiento para la preparacion de 4-/3-(4-oxotiazoldinil)/butinilaminas utiles como medicamentos.
TH28677B (th) ฟาร์เนซิลทรานสเฟอเรสที่ยับยั้งอนุพันธ์ของ 2-ควิโนโลน

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee