FI920712A0 - 1,2,4-benzotriazinoxider som radiosensibilisatorer och selektiva cytotoxiska medel. - Google Patents
1,2,4-benzotriazinoxider som radiosensibilisatorer och selektiva cytotoxiska medel.Info
- Publication number
- FI920712A0 FI920712A0 FI920712A FI920712A FI920712A0 FI 920712 A0 FI920712 A0 FI 920712A0 FI 920712 A FI920712 A FI 920712A FI 920712 A FI920712 A FI 920712A FI 920712 A0 FI920712 A0 FI 920712A0
- Authority
- FI
- Finland
- Prior art keywords
- morpholino
- opt
- alkyl
- piperidino
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Artificial Fish Reefs (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8904112 | 1989-09-18 | ||
PCT/US1989/004112 WO1991004028A1 (en) | 1989-09-18 | 1989-09-18 | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
FI920712 | 1992-02-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
FI920712A0 true FI920712A0 (fi) | 1992-02-19 |
FI111008B FI111008B (fi) | 2003-05-15 |
Family
ID=22215243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI920712A FI111008B (fi) | 1989-09-18 | 1992-02-19 | Menetelmä farmaseuttisesti hyödyllisten 1,2,4-bentsotriatsiini-1,4-dioksidien valmistamiseksi |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0478545B1 (fi) |
JP (1) | JP3034541B2 (fi) |
KR (1) | KR0142858B1 (fi) |
AT (1) | ATE183094T1 (fi) |
AU (1) | AU646794B2 (fi) |
DE (1) | DE68929050T2 (fi) |
FI (1) | FI111008B (fi) |
HU (2) | HU221201B1 (fi) |
NO (1) | NO305905B1 (fi) |
WO (1) | WO1991004028A1 (fi) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672702A (en) * | 1995-12-04 | 1997-09-30 | Sanofi | Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide |
EP1490090A4 (en) | 2002-02-22 | 2006-09-20 | New River Pharmaceuticals Inc | SYSTEMS FOR DELIVERING ACTIVE AGENTS AND METHODS FOR PROTECTING AND DELIVERING ACTIVE AGENTS |
NZ521436A (en) * | 2002-09-17 | 2005-07-29 | Auckland Uniservices Ltd | DNA- targeted benzotriazine 1,4-dioxides and their use in cancer therapy |
EP1723125A4 (en) | 2004-03-01 | 2009-11-18 | Auckland Uniservices Ltd | 1,2,4-benzotriazine-1,4-dioxides |
JP2015500295A (ja) * | 2011-12-07 | 2015-01-05 | エスアールアイ インターナショナルSRI International | ヒト結核菌を標的とする医薬としてのベンゾトリアジンオキサイド類 |
JP2015084923A (ja) * | 2013-10-30 | 2015-05-07 | テクナード株式会社 | 衣服用防湿マット |
CN111372940A (zh) * | 2017-09-19 | 2020-07-03 | 阿尔伯塔大学理事会 | 生物还原活化的化合物、其前药、放射性药物、组合物及其在包括癌症在内的低氧疾病的多模式治疗控制中的应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3079390A (en) | 1958-12-12 | 1963-02-26 | Searle & Co | N-substituted 3-amino-1, 2, 4-benzotriazine-1-oxides |
BE794742A (fr) | 1972-02-01 | 1973-07-30 | Bayer Ag | Nouveaux di-n-oxydes (1,4) de benzo-1,2,4-triazine, leur procede de preparation et leur application comme medicaments et additifs de nutrition |
US3980779A (en) | 1972-02-01 | 1976-09-14 | Bayer Aktiengesellschaft | 3-Amino-1,2,4-benzotriazine-1,4-di-N-oxide compositions and method of using same |
US4001410A (en) | 1972-02-01 | 1977-01-04 | Bayer Aktiengesellschaft | 3-amino-1,2,4-benzotriazine-1,4-di-n-oxide compositions and method of using same |
US3991189A (en) | 1972-11-15 | 1976-11-09 | Bayer Aktiengesellschaft | Microbiocidal methods and compositions using substituted 1,2,4-triazine-1,4-di-N-oxide derivatives |
US4027022A (en) | 1972-11-15 | 1977-05-31 | Bayer Aktiengesellschaft | Antibacterial benzo-1,2,4-triazines |
IL44058A (en) | 1973-02-02 | 1978-10-31 | Ciba Geigy Ag | 3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them |
US3957799A (en) | 1973-04-04 | 1976-05-18 | E. R. Squibb & Sons, Inc. | Sulfur containing amino and imino pyridines |
US4022022A (en) * | 1976-04-26 | 1977-05-10 | Parker-Hannifin Corporation | Hydraulic system and control valve assembly therefor |
US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
DE2910974A1 (de) | 1979-03-21 | 1981-02-19 | Bayer Ag | 3-sulfonyl-benzo-1,2,4-triazine und -benzo-1,2,4-triazin-1-oxide, verfahren zu ihrer herstellung sowie ihre verwendung als antimikrobielle mittel |
US4371540A (en) | 1979-09-14 | 1983-02-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells |
GB2203151B (en) | 1986-09-25 | 1991-05-29 | Stanford Res Inst Int | 1,2,4-benzotriazine oxides as radiosensitisers and selective cytotoxic agents |
IE62911B1 (en) | 1988-03-18 | 1995-03-08 | Stanford Res Inst Int | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
-
1989
- 1989-09-18 AU AU44284/89A patent/AU646794B2/en not_active Ceased
- 1989-09-18 JP JP01510665A patent/JP3034541B2/ja not_active Expired - Fee Related
- 1989-09-18 WO PCT/US1989/004112 patent/WO1991004028A1/en active IP Right Grant
- 1989-09-18 EP EP89911346A patent/EP0478545B1/en not_active Expired - Lifetime
- 1989-09-18 DE DE68929050T patent/DE68929050T2/de not_active Expired - Fee Related
- 1989-09-18 HU HU9200873A patent/HU221201B1/hu unknown
- 1989-09-18 HU HU9602225A patent/HU225965B1/hu unknown
- 1989-09-18 AT AT89911346T patent/ATE183094T1/de not_active IP Right Cessation
-
1992
- 1992-02-19 FI FI920712A patent/FI111008B/fi not_active IP Right Cessation
- 1992-02-25 NO NO920747A patent/NO305905B1/no not_active IP Right Cessation
- 1992-03-16 KR KR92700595A patent/KR0142858B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE68929050T2 (de) | 2000-02-03 |
DE68929050D1 (de) | 1999-09-16 |
KR0142858B1 (en) | 1998-07-15 |
HU225965B1 (en) | 2008-01-28 |
NO920747L (no) | 1992-02-25 |
KR927003062A (ko) | 1992-12-17 |
JPH05500499A (ja) | 1993-02-04 |
JP3034541B2 (ja) | 2000-04-17 |
AU646794B2 (en) | 1994-03-10 |
EP0478545A4 (en) | 1992-08-05 |
EP0478545A1 (en) | 1992-04-08 |
ATE183094T1 (de) | 1999-08-15 |
NO920747D0 (no) | 1992-02-25 |
WO1991004028A1 (en) | 1991-04-04 |
NO305905B1 (no) | 1999-08-16 |
EP0478545B1 (en) | 1999-08-11 |
HU9602225D0 (en) | 1996-10-28 |
HU221201B1 (en) | 2002-08-28 |
FI111008B (fi) | 2003-05-15 |
AU4428489A (en) | 1991-04-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |