GB2203151A - 1,2,4, benzotriazine oxides as radio sensitizers and selective cytotoxic agents - Google Patents
1,2,4, benzotriazine oxides as radio sensitizers and selective cytotoxic agentsInfo
- Publication number
- GB2203151A GB2203151A GB08810634A GB8810634A GB2203151A GB 2203151 A GB2203151 A GB 2203151A GB 08810634 A GB08810634 A GB 08810634A GB 8810634 A GB8810634 A GB 8810634A GB 2203151 A GB2203151 A GB 2203151A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrocarbyl
- independently
- nhr
- alkoxy
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of formula (I), wherein when X is OH, OR or NR2, n is 0 or 1, and when X is NH2 or NHR, n is 0, where each R is independently an alkyl of 1-4 carbon atoms or a morpholino moiety and may further be substituted with hydroxy, alkoxy, amino or halogeno substituents, Y<1> and Y<2> are independently either H, halogeno, hydrocarbyl (1-14C) including cyclic and unsaturated hydrocarbyl, optionally substituted with 1 or 2 substituents selected from the group consisting of halogeno, hydroxy, epoxy, alkoxy, alkylthio, amino (including morpholino), acyloxy, acylamido and their thio analogs, carboxy, alkoxycarbonyl, carbamyl or alkylcarbamyl, and wherein the hydrocarbyl can optionally be interrupted by a single ether (-O-) linkage, or wherein Y<1> or Y<2> are independently either NHR', O(CO)R', NH(CO)R', O(SO)R', or O(POR')R' in which R' is a hydrocarbyl optionally substituted as defined above; and wherein when X is NH2 and n is 1, Y<1> and Y<2> are independently either H, saturated or unsaturated hydrocarbyl of between about 7 and 14 carbon atoms, unsaturated hydrocarbyl of betweeen about 1 and 6 carbon atoms, either hydrocarbyl substituents being unsubstituted or substituted with halogen, hydroxy, epoxy, alkoxy, alkylthio, amino, morpholino, acyloxy, acylamide and their thio analogs, and where the hydrocarbyl can be optionally interrupted by a single ether linkage, or wherein Y<1> or Y<2> are independently either NHR', O(CO)R', NH(CO)R', O(SO)R', or O(POR)R', in which R' is a hydrocarbyl optionally substituted as defined above. Compounds within the purview of the formula and related compounds are useful in killing hypoxic tumor cells and as radiosensitizing agents.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91190686A | 1986-09-25 | 1986-09-25 | |
PCT/US1987/001412 WO1988002366A1 (en) | 1986-09-25 | 1987-06-16 | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8810634D0 GB8810634D0 (en) | 1988-07-06 |
GB2203151A true GB2203151A (en) | 1988-10-12 |
GB2203151B GB2203151B (en) | 1991-05-29 |
Family
ID=25431084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8810634A Expired - Lifetime GB2203151B (en) | 1986-09-25 | 1987-06-16 | 1,2,4-benzotriazine oxides as radiosensitisers and selective cytotoxic agents |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP2668232B2 (en) |
CA (1) | CA1338445C (en) |
DE (2) | DE3790581B4 (en) |
GB (1) | GB2203151B (en) |
WO (1) | WO1988002366A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5175287A (en) * | 1986-09-25 | 1992-12-29 | S R I International | Process for preparing 1,2,4-benzotriazine oxides |
US5624925A (en) | 1986-09-25 | 1997-04-29 | Sri International | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
IE62911B1 (en) * | 1988-03-18 | 1995-03-08 | Stanford Res Inst Int | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
GR1000941B (en) * | 1989-03-17 | 1993-03-16 | Stanford Res Inst Int | Method for preparing 1,2,4-benzotriazine oxides |
ATE183094T1 (en) * | 1989-09-18 | 1999-08-15 | Stanford Res Inst Int | 1,2,4-BENZOTRIAZINE OXIDES AS RADIO-SENSITIVE AND SELECTIVE CYTOTOXIC AGENTS |
US5672702A (en) * | 1995-12-04 | 1997-09-30 | Sanofi | Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide |
JP2015500295A (en) * | 2011-12-07 | 2015-01-05 | エスアールアイ インターナショナルSRI International | Benzotriazine oxides as drugs targeting Mycobacterium tuberculosis |
JP6654899B2 (en) | 2013-12-26 | 2020-02-26 | 東亞合成株式会社 | Method for promoting calreticulin expression and synthetic peptide used in the method |
JP6872713B2 (en) | 2015-05-29 | 2021-05-19 | 東亞合成株式会社 | Synthetic peptides that increase the radiosensitivity of tumor cells and their use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2489352A (en) * | 1946-04-10 | 1949-11-29 | Merck & Co Inc | Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1 |
US2489359A (en) * | 1947-01-10 | 1949-11-29 | Merck & Co Inc | Benzotriazines |
CH487171A (en) * | 1963-10-22 | 1970-03-15 | Siegfried Ag | Process for the preparation of therapeutically active 1,2-dihydro-1,2,4-benzotriazines |
DE1809390A1 (en) * | 1968-11-16 | 1970-06-11 | Bayer Ag | Phosphorus, phosphonic or thionophosphorus (- phosphonic) acid esters and process for their production |
IL44058A (en) * | 1973-02-02 | 1978-10-31 | Ciba Geigy Ag | 3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them |
DE2538179C2 (en) * | 1975-08-27 | 1986-05-28 | Bayer Ag, 5090 Leverkusen | 3-alkoxy-benzo-1,2,4-triazines, process for their preparation and their use as fungicides |
DE2740887A1 (en) * | 1977-09-10 | 1979-03-22 | Bayer Ag | AGENTS FOR CONTROLLING PLANT BACTERIOS |
-
1987
- 1987-06-16 DE DE3790581A patent/DE3790581B4/en not_active Expired - Lifetime
- 1987-06-16 WO PCT/US1987/001412 patent/WO1988002366A1/en active Application Filing
- 1987-06-16 DE DE19873790581 patent/DE3790581T1/de active Pending
- 1987-06-16 GB GB8810634A patent/GB2203151B/en not_active Expired - Lifetime
- 1987-06-16 JP JP62504083A patent/JP2668232B2/en not_active Expired - Lifetime
- 1987-06-30 CA CA000540932A patent/CA1338445C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2668232B2 (en) | 1997-10-27 |
CA1338445C (en) | 1996-07-09 |
GB2203151B (en) | 1991-05-29 |
JPH01500826A (en) | 1989-03-23 |
WO1988002366A1 (en) | 1988-04-07 |
GB8810634D0 (en) | 1988-07-06 |
DE3790581B4 (en) | 2004-12-23 |
DE3790581T1 (en) | 1988-08-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE20 | Patent expired after termination of 20 years |
Effective date: 20070615 |