DE68929050D1 - 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel - Google Patents

1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel

Info

Publication number
DE68929050D1
DE68929050D1 DE68929050T DE68929050T DE68929050D1 DE 68929050 D1 DE68929050 D1 DE 68929050D1 DE 68929050 T DE68929050 T DE 68929050T DE 68929050 T DE68929050 T DE 68929050T DE 68929050 D1 DE68929050 D1 DE 68929050D1
Authority
DE
Germany
Prior art keywords
morpholino
opt
alkyl
piperidino
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68929050T
Other languages
English (en)
Other versions
DE68929050T2 (de
Inventor
William Lee
J Brown
Edward Grange
Abelardo Martinez
Michael Tracy
Daniel Pollart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Application granted granted Critical
Publication of DE68929050D1 publication Critical patent/DE68929050D1/de
Publication of DE68929050T2 publication Critical patent/DE68929050T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Artificial Fish Reefs (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE68929050T 1989-09-18 1989-09-18 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel Expired - Fee Related DE68929050T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/004112 WO1991004028A1 (en) 1989-09-18 1989-09-18 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents

Publications (2)

Publication Number Publication Date
DE68929050D1 true DE68929050D1 (de) 1999-09-16
DE68929050T2 DE68929050T2 (de) 2000-02-03

Family

ID=22215243

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68929050T Expired - Fee Related DE68929050T2 (de) 1989-09-18 1989-09-18 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel

Country Status (10)

Country Link
EP (1) EP0478545B1 (de)
JP (1) JP3034541B2 (de)
KR (1) KR0142858B1 (de)
AT (1) ATE183094T1 (de)
AU (1) AU646794B2 (de)
DE (1) DE68929050T2 (de)
FI (1) FI111008B (de)
HU (2) HU221201B1 (de)
NO (1) NO305905B1 (de)
WO (1) WO1991004028A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672702A (en) * 1995-12-04 1997-09-30 Sanofi Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide
EP1490090A4 (de) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc Wirkstoff-abgabesystem und verfahren zum schutz und zur verabreichung von wirkstoffen
NZ521436A (en) * 2002-09-17 2005-07-29 Auckland Uniservices Ltd DNA- targeted benzotriazine 1,4-dioxides and their use in cancer therapy
EP1723125A4 (de) 2004-03-01 2009-11-18 Auckland Uniservices Ltd Neue 1,2,4-benzotriazin-1,4-dioxide
JP2015500295A (ja) * 2011-12-07 2015-01-05 エスアールアイ インターナショナルＳＲＩ Ｉｎｔｅｒｎａｔｉｏｎａｌ ヒト結核菌を標的とする医薬としてのベンゾトリアジンオキサイド類
JP2015084923A (ja) * 2013-10-30 2015-05-07 テクナード株式会社 衣服用防湿マット
CN111372940A (zh) * 2017-09-19 2020-07-03 阿尔伯塔大学理事会 生物还原活化的化合物、其前药、放射性药物、组合物及其在包括癌症在内的低氧疾病的多模式治疗控制中的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3079390A (en) 1958-12-12 1963-02-26 Searle & Co N-substituted 3-amino-1, 2, 4-benzotriazine-1-oxides
BE794742A (fr) 1972-02-01 1973-07-30 Bayer Ag Nouveaux di-n-oxydes (1,4) de benzo-1,2,4-triazine, leur procede de preparation et leur application comme medicaments et additifs de nutrition
US3980779A (en) 1972-02-01 1976-09-14 Bayer Aktiengesellschaft 3-Amino-1,2,4-benzotriazine-1,4-di-N-oxide compositions and method of using same
US4001410A (en) 1972-02-01 1977-01-04 Bayer Aktiengesellschaft 3-amino-1,2,4-benzotriazine-1,4-di-n-oxide compositions and method of using same
US3991189A (en) 1972-11-15 1976-11-09 Bayer Aktiengesellschaft Microbiocidal methods and compositions using substituted 1,2,4-triazine-1,4-di-N-oxide derivatives
US4027022A (en) 1972-11-15 1977-05-31 Bayer Aktiengesellschaft Antibacterial benzo-1,2,4-triazines
IL44058A (en) 1973-02-02 1978-10-31 Ciba Geigy Ag 3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them
US3957799A (en) 1973-04-04 1976-05-18 E. R. Squibb & Sons, Inc. Sulfur containing amino and imino pyridines
US4022022A (en) * 1976-04-26 1977-05-10 Parker-Hannifin Corporation Hydraulic system and control valve assembly therefor
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
DE2910974A1 (de) 1979-03-21 1981-02-19 Bayer Ag 3-sulfonyl-benzo-1,2,4-triazine und -benzo-1,2,4-triazin-1-oxide, verfahren zu ihrer herstellung sowie ihre verwendung als antimikrobielle mittel
US4371540A (en) 1979-09-14 1983-02-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells
GB2203151B (en) 1986-09-25 1991-05-29 Stanford Res Inst Int 1,2,4-benzotriazine oxides as radiosensitisers and selective cytotoxic agents
IE62911B1 (en) 1988-03-18 1995-03-08 Stanford Res Inst Int 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents

Also Published As

Publication number Publication date
DE68929050T2 (de) 2000-02-03
KR0142858B1 (en) 1998-07-15
FI920712A0 (fi) 1992-02-19
HU225965B1 (en) 2008-01-28
NO920747L (no) 1992-02-25
KR927003062A (ko) 1992-12-17
JPH05500499A (ja) 1993-02-04
JP3034541B2 (ja) 2000-04-17
AU646794B2 (en) 1994-03-10
EP0478545A4 (en) 1992-08-05
EP0478545A1 (de) 1992-04-08
ATE183094T1 (de) 1999-08-15
NO920747D0 (no) 1992-02-25
WO1991004028A1 (en) 1991-04-04
NO305905B1 (no) 1999-08-16
EP0478545B1 (de) 1999-08-11
HU9602225D0 (en) 1996-10-28
HU221201B1 (en) 2002-08-28
FI111008B (fi) 2003-05-15
AU4428489A (en) 1991-04-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee