ATE183094T1 - 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel - Google Patents
1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittelInfo
- Publication number
- ATE183094T1 ATE183094T1 AT89911346T AT89911346T ATE183094T1 AT E183094 T1 ATE183094 T1 AT E183094T1 AT 89911346 T AT89911346 T AT 89911346T AT 89911346 T AT89911346 T AT 89911346T AT E183094 T1 ATE183094 T1 AT E183094T1
- Authority
- AT
- Austria
- Prior art keywords
- morpholino
- opt
- alkyl
- piperidino
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Artificial Fish Reefs (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1989/004112 WO1991004028A1 (en) | 1989-09-18 | 1989-09-18 | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE183094T1 true ATE183094T1 (de) | 1999-08-15 |
Family
ID=22215243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89911346T ATE183094T1 (de) | 1989-09-18 | 1989-09-18 | 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0478545B1 (de) |
JP (1) | JP3034541B2 (de) |
KR (1) | KR0142858B1 (de) |
AT (1) | ATE183094T1 (de) |
AU (1) | AU646794B2 (de) |
DE (1) | DE68929050T2 (de) |
FI (1) | FI111008B (de) |
HU (2) | HU225965B1 (de) |
NO (1) | NO305905B1 (de) |
WO (1) | WO1991004028A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672702A (en) * | 1995-12-04 | 1997-09-30 | Sanofi | Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide |
IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
NZ521436A (en) * | 2002-09-17 | 2005-07-29 | Auckland Uniservices Ltd | DNA- targeted benzotriazine 1,4-dioxides and their use in cancer therapy |
EP1723125A4 (de) * | 2004-03-01 | 2009-11-18 | Auckland Uniservices Ltd | Neue 1,2,4-benzotriazin-1,4-dioxide |
EP2800744A4 (de) * | 2011-12-07 | 2015-06-03 | Sri Internat Inc | Benzotriazinoxide als arzneimittel gegen mycobacterium tuberculosis |
JP2015084923A (ja) * | 2013-10-30 | 2015-05-07 | テクナード株式会社 | 衣服用防湿マット |
CN111372940A (zh) * | 2017-09-19 | 2020-07-03 | 阿尔伯塔大学理事会 | 生物还原活化的化合物、其前药、放射性药物、组合物及其在包括癌症在内的低氧疾病的多模式治疗控制中的应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3079390A (en) | 1958-12-12 | 1963-02-26 | Searle & Co | N-substituted 3-amino-1, 2, 4-benzotriazine-1-oxides |
BE794742A (fr) * | 1972-02-01 | 1973-07-30 | Bayer Ag | Nouveaux di-n-oxydes (1,4) de benzo-1,2,4-triazine, leur procede de preparation et leur application comme medicaments et additifs de nutrition |
US3980779A (en) | 1972-02-01 | 1976-09-14 | Bayer Aktiengesellschaft | 3-Amino-1,2,4-benzotriazine-1,4-di-N-oxide compositions and method of using same |
US4001410A (en) | 1972-02-01 | 1977-01-04 | Bayer Aktiengesellschaft | 3-amino-1,2,4-benzotriazine-1,4-di-n-oxide compositions and method of using same |
US4027022A (en) | 1972-11-15 | 1977-05-31 | Bayer Aktiengesellschaft | Antibacterial benzo-1,2,4-triazines |
US3991189A (en) | 1972-11-15 | 1976-11-09 | Bayer Aktiengesellschaft | Microbiocidal methods and compositions using substituted 1,2,4-triazine-1,4-di-N-oxide derivatives |
IL44058A (en) | 1973-02-02 | 1978-10-31 | Ciba Geigy Ag | 3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them |
US3957799A (en) | 1973-04-04 | 1976-05-18 | E. R. Squibb & Sons, Inc. | Sulfur containing amino and imino pyridines |
US4022022A (en) * | 1976-04-26 | 1977-05-10 | Parker-Hannifin Corporation | Hydraulic system and control valve assembly therefor |
US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
DE2910974A1 (de) | 1979-03-21 | 1981-02-19 | Bayer Ag | 3-sulfonyl-benzo-1,2,4-triazine und -benzo-1,2,4-triazin-1-oxide, verfahren zu ihrer herstellung sowie ihre verwendung als antimikrobielle mittel |
US4371540A (en) | 1979-09-14 | 1983-02-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells |
JP2668232B2 (ja) | 1986-09-25 | 1997-10-27 | エス・アール・アイ・インターナシヨナル | 放射線増感剤及び選択性細胞毒性剤としての1,2,4―ベンゾトリアジンオキシド |
IE62911B1 (en) | 1988-03-18 | 1995-03-08 | Stanford Res Inst Int | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
-
1989
- 1989-09-18 DE DE68929050T patent/DE68929050T2/de not_active Expired - Fee Related
- 1989-09-18 AT AT89911346T patent/ATE183094T1/de not_active IP Right Cessation
- 1989-09-18 AU AU44284/89A patent/AU646794B2/en not_active Ceased
- 1989-09-18 HU HU9602225A patent/HU225965B1/hu unknown
- 1989-09-18 EP EP89911346A patent/EP0478545B1/de not_active Expired - Lifetime
- 1989-09-18 WO PCT/US1989/004112 patent/WO1991004028A1/en active IP Right Grant
- 1989-09-18 JP JP01510665A patent/JP3034541B2/ja not_active Expired - Fee Related
- 1989-09-18 HU HU9200873A patent/HU221201B1/hu unknown
-
1992
- 1992-02-19 FI FI920712A patent/FI111008B/fi not_active IP Right Cessation
- 1992-02-25 NO NO920747A patent/NO305905B1/no not_active IP Right Cessation
- 1992-03-16 KR KR92700595A patent/KR0142858B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU225965B1 (en) | 2008-01-28 |
KR0142858B1 (en) | 1998-07-15 |
JPH05500499A (ja) | 1993-02-04 |
KR927003062A (ko) | 1992-12-17 |
WO1991004028A1 (en) | 1991-04-04 |
FI920712A0 (fi) | 1992-02-19 |
EP0478545A4 (en) | 1992-08-05 |
HU9602225D0 (en) | 1996-10-28 |
JP3034541B2 (ja) | 2000-04-17 |
NO920747L (no) | 1992-02-25 |
HU221201B1 (en) | 2002-08-28 |
NO920747D0 (no) | 1992-02-25 |
EP0478545B1 (de) | 1999-08-11 |
DE68929050D1 (de) | 1999-09-16 |
NO305905B1 (no) | 1999-08-16 |
DE68929050T2 (de) | 2000-02-03 |
EP0478545A1 (de) | 1992-04-08 |
FI111008B (fi) | 2003-05-15 |
AU4428489A (en) | 1991-04-18 |
AU646794B2 (en) | 1994-03-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REN | Ceased due to non-payment of the annual fee |