DE60320780D1 - Funktionalisierte nanopartikel und verwendungsverfahren - Google Patents

Funktionalisierte nanopartikel und verwendungsverfahren

Info

Publication number
DE60320780D1
DE60320780D1 DE60320780T DE60320780T DE60320780D1 DE 60320780 D1 DE60320780 D1 DE 60320780D1 DE 60320780 T DE60320780 T DE 60320780T DE 60320780 T DE60320780 T DE 60320780T DE 60320780 D1 DE60320780 D1 DE 60320780D1
Authority
DE
Germany
Prior art keywords
use method
functionalized nanoparticles
nucleic acid
acid molecules
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60320780T
Other languages
German (de)
English (en)
Inventor
Weihong Tan
Jin Shouguang
Xiaojun Zhao
Rovelyn Tapec Dytioco
Timothy James Drake
Lisa Renee Hilliard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
Original Assignee
University of Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida filed Critical University of Florida
Application granted granted Critical
Publication of DE60320780D1 publication Critical patent/DE60320780D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Powder Metallurgy (AREA)
  • Saccharide Compounds (AREA)
  • Silicon Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE60320780T 2002-04-22 2003-04-22 Funktionalisierte nanopartikel und verwendungsverfahren Expired - Lifetime DE60320780D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37512202P 2002-04-22 2002-04-22
US37440502P 2002-04-22 2002-04-22
PCT/US2003/012638 WO2003089906A2 (en) 2002-04-22 2003-04-22 Functionalized nanoparticles and methods of use

Publications (1)

Publication Number Publication Date
DE60320780D1 true DE60320780D1 (de) 2008-06-19

Family

ID=29254555

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60320780T Expired - Lifetime DE60320780D1 (de) 2002-04-22 2003-04-22 Funktionalisierte nanopartikel und verwendungsverfahren

Country Status (10)

Country Link
US (1) US7524630B2 (cg-RX-API-DMAC10.html)
EP (1) EP1499895B1 (cg-RX-API-DMAC10.html)
JP (1) JP4381826B2 (cg-RX-API-DMAC10.html)
CN (1) CN100419426C (cg-RX-API-DMAC10.html)
AT (1) ATE394674T1 (cg-RX-API-DMAC10.html)
AU (1) AU2003234196A1 (cg-RX-API-DMAC10.html)
CA (1) CA2482611A1 (cg-RX-API-DMAC10.html)
DE (1) DE60320780D1 (cg-RX-API-DMAC10.html)
RU (1) RU2004133894A (cg-RX-API-DMAC10.html)
WO (1) WO2003089906A2 (cg-RX-API-DMAC10.html)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
CN1312479C (zh) * 2003-08-08 2007-04-25 清华大学 一种纳米荧光磁粒及其制备方法
EP1680443B9 (en) 2003-11-05 2014-09-03 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides and uses thereof
US7906345B2 (en) * 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
US7462452B2 (en) * 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
AU2005250464B2 (en) * 2004-06-01 2010-10-07 The Penn State Research Foundation Unagglomerated core/shell nanocomposite particles
MXPA06013506A (es) * 2004-06-04 2007-03-01 Basf Ag Metodo para marcar materiales.
EP1787124A2 (en) 2004-06-23 2007-05-23 The University Of Texas System Methods and compositions for the detection of biological molecules using a two particle complex
US7405002B2 (en) * 2004-08-04 2008-07-29 Agency For Science, Technology And Research Coated water-soluble nanoparticles comprising semiconductor core and silica coating
US7534489B2 (en) * 2004-09-24 2009-05-19 Agency For Science, Technology And Research Coated composites of magnetic material and quantum dots
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
KR100613189B1 (ko) 2004-11-15 2006-08-21 미지테크주식회사 은 나노 합성 섬유 및 그 제조방법
KR100624447B1 (ko) 2004-11-25 2006-09-18 삼성전자주식회사 은 나노 입자를 이용한 핵산의 정제 방법
US7699979B2 (en) * 2005-01-07 2010-04-20 Board Of Trustees Of The University Of Arkansas Separation system and efficient capture of contaminants using magnetic nanoparticles
US20060217893A1 (en) * 2005-01-07 2006-09-28 Yanbin Li Method for detecting an unknown contaminant concentration in a substance
US20080135490A1 (en) * 2005-01-07 2008-06-12 Board Of Trustees Of The University Of Arkansas Quantum dot biolabeling and immunomagnetic separation for detection of contaminants
US20070055013A1 (en) * 2005-02-21 2007-03-08 Noriho Kamiya Substrate and method of immobilizing protein
CA2599975C (en) * 2005-03-03 2013-07-30 University Of North Dakota Surfaces coated with target-induced fluorescent compounds for detection of target elements
CN1861628B (zh) * 2005-05-11 2010-05-05 上海师范大学 一种分离中药蛋白质的方法
KR101111747B1 (ko) * 2005-05-16 2012-06-12 삼성엘이디 주식회사 혼합 나노 입자 및 이를 이용한 전자소자
DE502006008765D1 (de) 2005-06-23 2011-03-03 Siemens Healthcare Diagnostics Magnetpartikel mit einer geschlossenen, ultradünnen silikaschicht, verfahren zu deren herstellung und verwendung
US20110097277A1 (en) 2005-08-25 2011-04-28 University Of Washington Particles coated with zwitterionic polymers
AU2006288048A1 (en) * 2005-09-08 2007-03-15 Biterials Co., Ltd. Magnetic nanoparticle having fluorescent and preparation method thereof and use thereof
US8906609B1 (en) 2005-09-26 2014-12-09 Arrowhead Center, Inc. Label-free biomolecule sensor based on surface charge modulated ionic conductance
EP1931593A4 (en) * 2005-10-07 2009-04-22 Univ Florida MULTIPLE COMPONENT NANOPARTICLES FOR MULTIPLEX SIGNALING AND OPTICAL CODING
CN100441677C (zh) * 2005-10-20 2008-12-10 上海师范大学 免疫磁性纳米粒子细菌分离器及其制法和应用
KR100886084B1 (ko) * 2005-12-06 2009-02-26 주식회사 엘지화학 코어-쉘 형태의 나노입자 및 그 제조방법
US20090317802A1 (en) * 2005-12-09 2009-12-24 Bhatia Sangeeta N Compositions and Methods to Monitor RNA Delivery to Cells
WO2007075456A2 (en) * 2005-12-15 2007-07-05 University Of Florida Research Foundation, Inc. Colorimetric light switching probe for ultrasensitive detection of target compounds
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
CN100371713C (zh) * 2006-01-13 2008-02-27 东南大学 金或银纳米粒子的表面功能化及比色检测生物分子的方法
JP4670659B2 (ja) * 2006-01-25 2011-04-13 住友電気工業株式会社 蛍光標識金属粉末、ならびに該蛍光標識金属粉末を含有する異方導電膜、実装品
FR2898519B1 (fr) * 2006-03-20 2009-01-09 Commissariat Energie Atomique Nanoparticules notamment a structure coeur coquilles, enrobees
WO2008105773A2 (en) 2006-03-31 2008-09-04 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
US8367113B2 (en) 2006-05-15 2013-02-05 Massachusetts Institute Of Technology Polymers for functional particles
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
EP1889810A1 (en) * 2006-08-10 2008-02-20 HeiQ Materials AG Method for producing nanoparticle loaded powders using flame spray pyrolysis and applications thereof
US20100120016A1 (en) * 2006-09-01 2010-05-13 Yanbin Li Methods and systems for detection of contaminants
CN1987454B (zh) * 2006-10-31 2011-01-12 成都夸常医学工业有限公司 含定向纳米结构功能化区的纳米结构组成及其制备和应用方法
US20100303723A1 (en) * 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
US20110189101A1 (en) * 2006-12-01 2011-08-04 National University Corporation Shimane University Fluorescent labeling agent and fluorescent labeling method
WO2008073856A2 (en) * 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
CA2674632A1 (en) 2006-12-29 2008-07-10 University Of Washington Dual-functional nonfouling surfaces and materials
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US9217129B2 (en) * 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
US20090074828A1 (en) 2007-04-04 2009-03-19 Massachusetts Institute Of Technology Poly(amino acid) targeting moieties
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
US20080255460A1 (en) * 2007-04-13 2008-10-16 Ethicon Endo-Surgery, Inc. Nanoparticle tissue based identification and illumination
CN101663581A (zh) * 2007-04-19 2010-03-03 3M创新有限公司 水分散性二氧化硅纳米颗粒在连接生物分子方面的用途
US8597959B2 (en) * 2007-04-19 2013-12-03 3M Innovative Properties Company Methods of use of solid support material for binding biomolecules
JP4981510B2 (ja) * 2007-04-27 2012-07-25 古河電気工業株式会社 逆ミセル分散系を用いてなるシリカナノ粒子の製造方法、該方法により得られたシリカナノ粒子、及びそれを用いた標識試薬
DE102007020220B3 (de) 2007-04-28 2008-11-13 Forschungszentrum Karlsruhe Gmbh Verfahren zur magnetisch unterstützten Extraktion
US20080269086A1 (en) * 2007-04-30 2008-10-30 Atanu Adhvaryu Functionalized nanosphere lubricants
US20090215643A1 (en) * 2007-07-26 2009-08-27 Cellay, Llc Highly Visible Chromosome-Specific Probes and Related Methods
EP2025364A1 (en) * 2007-08-13 2009-02-18 Procter & Gamble International Operations SA. Compositions comprising dye-loaded particles
EP2062946B1 (en) * 2007-08-13 2012-06-06 Procter & Gamble International Operations SA Dye-loaded particles
EP2025720B1 (en) * 2007-08-13 2010-12-08 Procter & Gamble International Operations SA Spray-drying process for the manufacture of dye-loaded particles
JP5192752B2 (ja) * 2007-08-15 2013-05-08 古河電気工業株式会社 逆ミセル分散系を用いてなるシリカナノ粒子の製造方法、該方法により得られたシリカナノ粒子、及びそれを用いた標識試薬
US20090047222A1 (en) * 2007-08-15 2009-02-19 Ben Gu Color Stable Peroxide Containing Dentifrice Formulations With Dye Encapsulated Silica Shell Nanoparticles
MX2010003642A (es) 2007-10-12 2010-08-09 Massachusetts Inst Technology Nanotecnologia de vacuna.
US9533006B2 (en) 2007-11-19 2017-01-03 University Of Washington Marine coatings
PL2271938T3 (pl) 2008-04-11 2014-07-31 Univ Texas Sposób i urządzenie do wzmacniania elektrogenerowanej chemiluminescencji nanocząsteczek
AU2009244904B2 (en) 2008-05-08 2014-04-17 Board Of Regents Of The University Of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
JP2009275006A (ja) * 2008-05-16 2009-11-26 Univ Of Tokyo 低酸素環境測定用試薬
EP2356139A4 (en) * 2008-07-23 2013-01-09 Harvard College LIGURE COMBINED POLYPEPTIDES
US8999661B2 (en) * 2008-07-30 2015-04-07 Dana-Farber Cancer Institute, Inc. Compositions for detecting cell death and methods of use thereof
CN102203126A (zh) * 2008-09-22 2011-09-28 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8512417B2 (en) 2008-11-14 2013-08-20 Dune Sciences, Inc. Functionalized nanoparticles and methods of forming and using same
US10080578B2 (en) 2008-12-16 2018-09-25 Nico Corporation Tissue removal device with adjustable delivery sleeve for neurosurgical and spinal surgery applications
CN101444503B (zh) * 2008-12-31 2011-02-02 江苏大学 一种水飞蓟宾高效长效制剂及其制法
CN101439025B (zh) * 2008-12-31 2011-05-11 江苏大学 一种水飞蓟素高效长效制剂及其制法
EP2376100B1 (en) 2009-01-14 2017-10-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8961825B2 (en) 2009-04-15 2015-02-24 Cornell University Fluorescent silica nanoparticles through silica densification
WO2010138193A2 (en) 2009-05-27 2010-12-02 Selecta Biosciences, Inc. Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents
US20120142111A1 (en) * 2009-06-15 2012-06-07 Tour James M Nanomaterial-containing signaling compositions for assay of flowing liquid streams and geological formations and methods for use thereof
US9377449B2 (en) 2009-06-15 2016-06-28 William Marsh Rice University Nanocomposite oil sensors for downhole hydrocarbon detection
WO2011008260A2 (en) 2009-07-13 2011-01-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2934401C (en) 2009-11-02 2017-01-10 Pulse Therapeutics, Inc. Magnetomotive stator system and methods for wireless control of magnetic rotors
EP2496267A4 (en) 2009-11-06 2016-02-17 Univ Washington Ct Commerciali ZWITTERIONIC POLYMER BIOKON JUGATES AND CORRESPONDING METHODS
CN102192986B (zh) * 2010-03-19 2014-06-11 成都盛泰尔生物医药科技有限公司 一种心肌肌钙蛋白i的检测试剂
JP5503382B2 (ja) * 2010-04-05 2014-05-28 古河電気工業株式会社 イムノクロマトグラフィー用複合粒子
US20120015344A1 (en) * 2010-05-14 2012-01-19 1. Board of Trustees of MICHIGAN STATE UNIVERSITY Methods, compositions, and apparatus for the detection of viral strains
CN107029223A (zh) 2010-05-26 2017-08-11 西莱克塔生物科技公司 合成纳米载体联合疫苗
WO2012016186A1 (en) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Macrocyclic kinase inhibitors and uses thereof
US9121065B2 (en) 2010-08-09 2015-09-01 The Trustees Of The University Of Pennsylvania Nanoparticle-oligonucleotide hybrid structures and methods of use thereof
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
CA2814040C (en) 2010-10-08 2021-03-23 Joshua Michael Donaldson A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use
US8962804B2 (en) 2010-10-08 2015-02-24 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
WO2012158196A2 (en) 2010-11-05 2012-11-22 Massachusetts Institute Of Technology Core-shell magnetic particles and related methods
GB201019434D0 (en) * 2010-11-17 2010-12-29 Isis Innovation Sonosensitive nanoparticles
EP2677316A4 (en) * 2011-02-15 2014-05-14 Kyowa Medex Co Ltd STREPTAVIDINE-RELATED MAGNETIC PARTICLES AND METHOD FOR THE PRODUCTION THEREOF
JPWO2012111687A1 (ja) * 2011-02-15 2014-07-07 協和メデックス株式会社 ストレプトアビジン結合磁性粒子の製造方法
WO2012111686A1 (ja) * 2011-02-15 2012-08-23 協和メデックス株式会社 ストレプトアビジン結合磁性粒子の製造方法
US8916696B2 (en) 2011-06-12 2014-12-23 City Of Hope Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
WO2012174423A1 (en) 2011-06-17 2012-12-20 President And Fellows Of Harvard College Stabilized polypeptides as regulators of rab gtpase function
CA2843853A1 (en) 2011-07-01 2013-01-10 President And Fellows Of Harvard College Macrocyclic insulin-degrading enzyme (ide) inhibitors and uses thereof
JP2014521687A (ja) 2011-07-29 2014-08-28 セレクタ バイオサイエンシーズ インコーポレーテッド 体液性および細胞傷害性ｔリンパ球（ｃｔｌ）免疫応答を生成する合成ナノキャリア
DK2760471T3 (en) 2011-09-30 2017-05-08 Dana Farber Cancer Inst Inc THERAPEUTIC PEPTIDES
KR102276792B1 (ko) 2011-10-10 2021-07-15 시티 오브 호프 메디토프와 메디토프-결합 항체 및 이들의 용도
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
WO2013102211A2 (en) 2011-12-29 2013-07-04 Walensky Loren D Stabilized antiviral fusion helices
KR20130084091A (ko) 2012-01-16 2013-07-24 삼성전자주식회사 화상형성장치
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
SG11201404728VA (en) * 2012-02-10 2014-09-26 Lockheed Corp Nanoparticle paste formulations and methods for production and use thereof
US9428553B2 (en) 2012-02-10 2016-08-30 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CN102618257B (zh) * 2012-03-09 2014-01-29 浙江大学 一种上转换荧光纳米材料的表面包覆方法
AU2013246419A1 (en) 2012-04-10 2014-10-30 City Of Hope RNA aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells
EP2849657B1 (en) 2012-05-15 2018-08-29 Pulse Therapeutics, Inc. Magnetic-based systems for manipulation of magnetic particles
US9883878B2 (en) 2012-05-15 2018-02-06 Pulse Therapeutics, Inc. Magnetic-based systems and methods for manipulation of magnetic particles
CN102786030B (zh) * 2012-07-06 2014-03-12 江苏大学 一种通过溶剂处理制备多肽纳米薄膜的方法
KR101543583B1 (ko) 2012-08-24 2015-08-11 단국대학교 산학협력단 생체 분자 분석용 미소 입자 및 키트와 생체 분자 분석용 미소 입자의 제조 방법
CA3113959A1 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
WO2014055564A1 (en) 2012-10-01 2014-04-10 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
WO2014065753A1 (en) * 2012-10-23 2014-05-01 Dso National Laboratories Direct visual detection of nucleic acid using gold nanoparticles
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
WO2014107449A1 (en) * 2013-01-01 2014-07-10 The Trustees Of Columbia University In The City Of New York Molecule structure probe methods, devices, and systems
WO2014116813A1 (en) * 2013-01-25 2014-07-31 Douglas Scientific Silica-based biological material isolation
WO2014130488A1 (en) * 2013-02-19 2014-08-28 University Of Massachusetts Functionalized nanoparticles for medical treatments
EP3782638A1 (en) 2013-03-13 2021-02-24 President and Fellows of Harvard College Stapled and stitched polypeptides and uses thereof
WO2014144148A1 (en) 2013-03-15 2014-09-18 Dana-Farber Cancer Institute, Inc. Stabilized sos1 peptides
WO2014151369A2 (en) 2013-03-15 2014-09-25 Dana-Farber Cancer Institute, Inc. Stabilized ezh2 peptides
CA2906775A1 (en) 2013-03-15 2014-09-18 Dana-Farber Cancer Institute, Inc. Bh4 stabilized peptides and uses thereof
WO2014144791A2 (en) 2013-03-15 2014-09-18 Dana-Farber Cancer Institute, Inc. Therapeutic peptides
WO2014201370A1 (en) 2013-06-14 2014-12-18 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
US9409148B2 (en) 2013-08-08 2016-08-09 Uchicago Argonne, Llc Compositions and methods for direct capture of organic materials from process streams
KR101660399B1 (ko) * 2013-08-23 2016-09-28 주식회사 메디센서 금 나노 입자를 포함하는 형광 입자 및 그 제조방법
WO2015034469A2 (en) * 2013-09-03 2015-03-12 Aneeve Nanotechnologies, Llc A process for cleaning carbon nanotubes and other nanostructured films
PT3049116T (pt) * 2013-09-23 2019-04-03 Rensselaer Polytech Inst Distribuição genética mediada por nanopartículas, edição genómica e modificação direcionada a ligantes em várias populações celulares
WO2015048527A1 (en) 2013-09-27 2015-04-02 Tufts University Optically transparent silk hydrogels
WO2015054125A1 (en) 2013-10-08 2015-04-16 Trustees Of Tufts College Tunable covalently crosslinked hydrogels and methods of making the same
US9675953B2 (en) * 2013-10-09 2017-06-13 Nanocomposix, Inc. Encapsulated particles
US10513802B2 (en) 2013-11-08 2019-12-24 Tufts University Peptide-based nanofibrillar materials
MX371187B (es) 2013-12-06 2020-01-22 Dana Farber Cancer Inst Inc Péptidos terapéuticos.
CN113349707A (zh) * 2013-12-31 2021-09-07 纪念斯隆-凯特琳癌症中心 用于荧光源实时多通道成像的系统、方法和设备
EP3116903A2 (en) 2014-03-14 2017-01-18 Dana-Farber Cancer Institute, Inc. Vaccine compositions and methods for restoring nkg2d pathway function against cancers
JP6156229B2 (ja) * 2014-03-31 2017-07-05 株式会社Ｊｖｃケンウッド 粒子の製造方法
CN114805527A (zh) 2014-05-21 2022-07-29 哈佛大学的校长及成员们 Ras抑制肽和其用途
WO2015177933A1 (ja) * 2014-05-23 2015-11-26 株式会社島津製作所 磁性体粒子の操作方法および磁性体粒子操作用デバイス
JP6734011B2 (ja) * 2014-06-06 2020-08-05 古河電気工業株式会社 生体分子検出用試験キット、及びこれを用いた生体分子の検出方法、並びにこれらに用いられる生体分子検出用試験片及び生体分子検出用標識試薬
US12655467B2 (en) 2014-08-08 2026-06-16 Quantum-Si Incorporated Methods for nucleic acid sequencing
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
JP2018503595A (ja) 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその製剤
CN106999587B (zh) 2014-10-02 2023-09-29 希望之城公司 多价中间表位，中间表位结合抗体及其用途
JP6182520B2 (ja) * 2014-12-01 2017-08-16 三洋化成工業株式会社 磁性シリカ粒子、該磁性シリカ粒子を用いた測定対象物質測定方法及び測定対象物質測定用試薬
FR3031063B1 (fr) * 2014-12-30 2017-02-10 Biomerieux Sa Complexe multicouches, procede de fabrication et utilisation du complexe
WO2016145281A1 (en) 2015-03-12 2016-09-15 Tufts University Shape memory silk materials
EP3270945A4 (en) 2015-03-18 2018-09-05 Massachusetts Institute of Technology Selective mcl-1 binding peptides
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2016172631A2 (en) 2015-04-24 2016-10-27 President And Fellows Of Harvard College Substrate selective inhibitors of insulin-degrading enzyme (ide) and uses thereof
KR101646610B1 (ko) 2015-05-28 2016-08-09 (주)바이오니아 생체 물질 정제용 고활성 실리카 자성나노입자 및 이의 제조 방법
JP6772195B2 (ja) * 2015-06-26 2020-10-21 コニカ ミノルタ ラボラトリー ユー．エス．エー．，インコーポレイテッド 迅速かつ高感度なバクテリア検出
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP3328438B1 (en) 2015-07-28 2026-07-15 Trustees Of Tufts College Polypeptide monoliths
CA2993785A1 (en) 2015-08-03 2017-02-09 Advanced Endovascular Therapeutics Novel coatings for medical devices
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
WO2017059338A1 (en) 2015-10-02 2017-04-06 Cornell University Enzyme-responsive peptide nanofiber compositions and uses thereof
US11833272B2 (en) 2015-12-17 2023-12-05 Trustees Of Tufts College Silk-fibroin hydrogels, methods of forming, and uses thereof
US11198715B2 (en) 2016-07-22 2021-12-14 Massachusetts Institute Of Technology Selective Bfl-1 peptides
WO2018026853A1 (en) 2016-08-01 2018-02-08 Trustees Of Tufts College Biomimetic mechanical tension driven fabrication of nanofibrillar architecture
ES2935622T3 (es) 2016-08-26 2023-03-08 Dana Farber Cancer Inst Inc Polipéptidos y miméticos de bcl-w para el tratamiento o la prevención de la neuropatía periférica y la pérdida auditiva inducidas por la quimioterapia
US10369167B2 (en) 2016-11-01 2019-08-06 City Of Hope Continuously expressed therapeutic RNAs for targeted protein binding and methods for their use
RU2019121801A (ru) 2016-12-14 2021-01-15 Лигандал, Инк. Композиции и способы для доставки полезной нагрузки в виде нуклеиновой кислоты и/или белка
AU2018359609B2 (en) * 2017-10-31 2023-01-05 F. Hoffmann-La Roche Ag Improved magnetic particles and uses thereof
US20200385776A1 (en) * 2017-12-19 2020-12-10 3M Innovative Properties Company Compositions and methods to detect microorgnaisms
WO2019168654A2 (en) 2018-02-09 2019-09-06 President And Fellows Of Harvard College Dna-templated macrocycle library
US11918315B2 (en) 2018-05-03 2024-03-05 Pulse Therapeutics, Inc. Determination of structure and traversal of occlusions using magnetic particles
WO2020060975A1 (en) 2018-09-17 2020-03-26 Massachusetts Institute Of Technology Peptides selective for bcl-2 family proteins
EP3861337B1 (en) 2018-10-01 2024-01-24 Kemira Oyj A method for determining concentration of polyelectrolytes and phosphonates
CN109444406A (zh) * 2018-11-09 2019-03-08 深圳市众循精准医学研究院 定量检测标志物cyfra21-1的试纸条及其制备方法和检测方法
CN109521194B (zh) * 2018-11-30 2023-03-31 暨南大学 DNA免疫吸附剂在制备抗ds-DNA抗体检测试剂中的应用
CN110878336B (zh) * 2019-11-18 2022-06-14 大连理工大学 一种基于Fe3O4@C纳米颗粒的miRNA光学传感检测方法
WO2022067351A1 (en) * 2020-09-28 2022-03-31 University Of Florida Research Foundation Compositions including magnetic nanoparticles and methods of using and making the same
US12552834B2 (en) 2021-01-25 2026-02-17 Massachusetts Institute Of Technology Selective MENA binding peptides
US12171443B1 (en) 2021-03-09 2024-12-24 Pulse Therapeutics, Inc. Magnetically controlled flow generation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4297337A (en) * 1979-04-13 1981-10-27 Corning Glass Works Solid-phase immunoassays using magnetic glass
US4661408A (en) * 1986-03-18 1987-04-28 E.I. Du Pont De Nemours And Company Coated chromium dioxide particles
US5091206A (en) * 1987-10-26 1992-02-25 Baxter Diagnostics Inc. Process for producing magnetically responsive polymer particles and application thereof
DE69527877T2 (de) * 1994-04-29 2003-04-30 Seradyn, Inc. Mikropartikel-Immunoassayreagentien, empfindliche und spezifische Immunoassayreagentien und Immunoassaymethode
DE69636553T2 (de) * 1995-07-07 2007-05-31 Toyo Boseki K.K. Nukleinsäuren bindender magnetischer Träger und Verfahren für die Nukleinsäureisolierung unter dessen Verwendung
AU7685498A (en) * 1997-05-14 1998-12-08 Weixin Tang Fully-coated, uniform-sized metallic particles
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6251303B1 (en) * 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
DE10046508A1 (de) * 1999-09-14 2001-04-05 Tridelta Bio Medical Gmbh Magnetische Nanoteilchen mit biochemischer Wikrsamkeit und Verfahren zu ihrer Herstellung sowie ihre Verwendung
EP1276904B1 (en) * 2000-03-22 2013-08-28 Life Technologies Corporation Methods of using semiconductor nanocrystals in bead-based nucleic acid assays
US6548264B1 (en) * 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles

Also Published As

Publication number Publication date
JP4381826B2 (ja) 2009-12-09
ATE394674T1 (de) 2008-05-15
HK1075698A1 (en) 2005-12-23
JP2005523027A (ja) 2005-08-04
EP1499895B1 (en) 2008-05-07
US7524630B2 (en) 2009-04-28
AU2003234196A8 (en) 2003-11-03
WO2003089906A2 (en) 2003-10-30
CN100419426C (zh) 2008-09-17
RU2004133894A (ru) 2005-04-20
CN1662815A (zh) 2005-08-31
EP1499895A2 (en) 2005-01-26
AU2003234196A1 (en) 2003-11-03
EP1499895A4 (en) 2005-08-10
WO2003089906A3 (en) 2004-01-22
US20040067503A1 (en) 2004-04-08
CA2482611A1 (en) 2003-10-30

Similar Documents

Publication Publication Date Title
ATE394674T1 (de) Funktionalisierte nanopartikel und verwendungsverfahren
WO2004092331A3 (en) Composition and method for nucleic acid sequencing
MY136437A (en) Methods and apparatus for nucleic acid sequencing by signal stretching and data intergration
DE60322880D1 (de) Einfache katalytische dna-biosensoren für ionen auf grundlage von farbveränderungen
ATE330038T1 (de) Nukleinsäure-biosensor
EP2474632A3 (en) Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
WO2004058990A3 (en) Genetic polymorphisms associated with stenosis, methods of detection and uses thereof
DK2725107T3 (da) DNA-sekventering med ikke-fluorescerende nukleotidreversible terminatorer og ddNTP'er modificeret med spaltbart mærke og nukleinsyre omfattende inosin med reversible terminatorer
EP2521796A4 (en) DNA SEQUENCING METHODS AND DETECTORS AND SYSTEMS FOR THEIR IMPLEMENTATION
WO2001092572A1 (en) Kit and method for determining hla type
GEP20125384B (en) Representations of nucleotide sequences
ATE551349T1 (de) Methode unter verwendung von reversibel blockierten markierungsoligonukleotiden
WO2004081186A3 (en) Single nucleotide polymorphisms associated with stenosis, methods of detection and uses thereof
NZ600183A (en) Method for efficient exon (44) skipping in duchenne muscular dystrophy and associated means
EP2366803A3 (en) Compositions and methods for detecting west nile virus
EP1784512A4 (en) ELECTROCATALYTIC NUCLEIC ACID HYBRIDIZATION DETECTION
ATE505562T1 (de) Doppel-oligonukleotid- nukleinsäurenachweisverfahren
Song et al. Trypsin-amplified aerolysin nanopore amplified sandwich assay for attomolar nucleic acid and single bacteria detection
WO2005087953A8 (en) Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
Li et al. Efficient detection of secondary structure folded nucleic acids related to Alzheimer's disease based on junction probes
DE602005009693D1 (de) 2"-nitrobenzyl-modifizierte ribonukleotide
Zhang et al. Entropy-driven catalytic G-quadruple cycle amplification integrated with ligases for label-free detection of single nucleotide polymorphisms
EP3040423A3 (en) Microrna and uses thereof
Mi et al. Multiplexed RNA imaging and in situ profiling in living cells
ATE445715T1 (de) Elektrokatalytischer nukleinsäurehybridisierungsnachweis

Legal Events

Date Code Title Description
8364 No opposition during term of opposition