DE60307628T2 - Verfahren zur herstellung von xanthin phosphodiesterase v inhibitoren und deren vorstufen - Google Patents

Verfahren zur herstellung von xanthin phosphodiesterase v inhibitoren und deren vorstufen Download PDF

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Publication number
DE60307628T2
DE60307628T2 DE60307628T DE60307628T DE60307628T2 DE 60307628 T2 DE60307628 T2 DE 60307628T2 DE 60307628 T DE60307628 T DE 60307628T DE 60307628 T DE60307628 T DE 60307628T DE 60307628 T2 DE60307628 T2 DE 60307628T2
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Germany
Prior art keywords
compound
alkyl
group
reacting
base
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE60307628T
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German (de)
English (en)
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DE60307628D1 (de
Inventor
H. Vilas Edison DAHANUKAR
N. Hoa Dayton NGUYEN
A. Cecilia Clark ORR
Fucheng Edison ZHANG
A. Ilia East Windsor ZAVIALOV
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Merck Sharp and Dohme LLC
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Schering Corp
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Publication of DE60307628D1 publication Critical patent/DE60307628D1/de
Publication of DE60307628T2 publication Critical patent/DE60307628T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/12—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60307628T 2002-05-31 2003-05-30 Verfahren zur herstellung von xanthin phosphodiesterase v inhibitoren und deren vorstufen Expired - Lifetime DE60307628T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38447802P 2002-05-31 2002-05-31
US384478P 2002-05-31
PCT/US2003/017042 WO2003101992A1 (en) 2002-05-31 2003-05-30 Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof

Publications (2)

Publication Number Publication Date
DE60307628D1 DE60307628D1 (de) 2006-09-28
DE60307628T2 true DE60307628T2 (de) 2007-08-09

Family

ID=29712039

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60307628T Expired - Lifetime DE60307628T2 (de) 2002-05-31 2003-05-30 Verfahren zur herstellung von xanthin phosphodiesterase v inhibitoren und deren vorstufen

Country Status (16)

Country Link
US (2) US7074923B2 (https=)
EP (1) EP1509525B9 (https=)
JP (1) JP2005529934A (https=)
CN (2) CN101538224A (https=)
AR (1) AR040232A1 (https=)
AT (1) ATE336494T1 (https=)
AU (1) AU2003238822A1 (https=)
CA (1) CA2483923A1 (https=)
CY (1) CY1105774T1 (https=)
DE (1) DE60307628T2 (https=)
DK (1) DK1509525T5 (https=)
ES (1) ES2270047T3 (https=)
MX (1) MXPA04011862A (https=)
PT (1) PT1509525E (https=)
WO (1) WO2003101992A1 (https=)
ZA (1) ZA200408719B (https=)

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DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
KR101452915B1 (ko) * 2006-05-04 2014-10-21 베링거 인겔하임 인터내셔날 게엠베하 다형태
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
JP2010500326A (ja) * 2006-08-08 2010-01-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病の治療のためのｄｐｐ−ｉｖ阻害剤としてのピロロ［３，２−ｄ］ピリミジン
BRPI0815405A2 (pt) * 2007-08-17 2015-02-03 Boehringer Ingelheim Int Compostos derivados de purina, processo para a preparação de uma composição farmacêutica e uso dos mesmos
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
UA119131C2 (uk) * 2008-08-15 2019-05-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх Похідні пурину для застосування при лікуванні пов'язаних із fab захворювань
CA2736421A1 (en) 2008-09-10 2010-03-18 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
JP2012512848A (ja) 2008-12-23 2012-06-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 有機化合物の塩の形態
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
KR20240090632A (ko) 2009-11-27 2024-06-21 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
CA3070513C (en) 2010-05-05 2023-01-03 Boehringer Ingelheim International Gmbh A dpp-4 inhibitor for use in treatment of skin-alterations or necrosis
KR20130093012A (ko) 2010-06-24 2013-08-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
DK2731947T3 (en) 2011-07-15 2019-04-23 Boehringer Ingelheim Int SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
WO2013171167A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013171166A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp-4 inhibitor for use in the treatment of sirs and/or sepsis
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
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Also Published As

Publication number Publication date
AU2003238822A1 (en) 2003-12-19
US7786301B2 (en) 2010-08-31
EP1509525B9 (en) 2007-10-31
DK1509525T3 (da) 2006-12-11
ZA200408719B (en) 2005-11-15
US20030232987A1 (en) 2003-12-18
CN1668618A (zh) 2005-09-14
MXPA04011862A (es) 2005-03-31
ES2270047T3 (es) 2007-04-01
EP1509525B1 (en) 2006-08-16
CN100497336C (zh) 2009-06-10
US7074923B2 (en) 2006-07-11
PT1509525E (pt) 2006-12-29
US20060205943A1 (en) 2006-09-14
CN101538224A (zh) 2009-09-23
CA2483923A1 (en) 2003-12-11
EP1509525A1 (en) 2005-03-02
CY1105774T1 (el) 2011-02-02
DK1509525T5 (da) 2007-07-30
HK1068139A1 (en) 2005-04-22
WO2003101992A1 (en) 2003-12-11
AR040232A1 (es) 2005-03-23
JP2005529934A (ja) 2005-10-06
DE60307628D1 (de) 2006-09-28
ATE336494T1 (de) 2006-09-15

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