CN101538224A - 制备黄嘌呤磷酸二酯酶v抑制剂及其前体的方法 - Google Patents

制备黄嘌呤磷酸二酯酶v抑制剂及其前体的方法 Download PDF

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Publication number
CN101538224A
CN101538224A CNA2009101321189A CN200910132118A CN101538224A CN 101538224 A CN101538224 A CN 101538224A CN A2009101321189 A CNA2009101321189 A CN A2009101321189A CN 200910132118 A CN200910132118 A CN 200910132118A CN 101538224 A CN101538224 A CN 101538224A
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CN
China
Prior art keywords
compound
alkyl
group
reaction
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2009101321189A
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English (en)
Chinese (zh)
Inventor
V·H·达哈努卡
H·N·阮
C·A·奥尔
F·张
I·A·扎维亚洛夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
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Schering Corp
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Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN101538224A publication Critical patent/CN101538224A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/12—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNA2009101321189A 2002-05-31 2003-05-30 制备黄嘌呤磷酸二酯酶v抑制剂及其前体的方法 Pending CN101538224A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38447802P 2002-05-31 2002-05-31
US60/384478 2002-05-31

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB038124971A Division CN100497336C (zh) 2002-05-31 2003-05-30 制备黄嘌呤磷酸二酯酶v抑制剂及其前体的方法

Publications (1)

Publication Number Publication Date
CN101538224A true CN101538224A (zh) 2009-09-23

Family

ID=29712039

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CNA2009101321189A Pending CN101538224A (zh) 2002-05-31 2003-05-30 制备黄嘌呤磷酸二酯酶v抑制剂及其前体的方法
CNB038124971A Expired - Fee Related CN100497336C (zh) 2002-05-31 2003-05-30 制备黄嘌呤磷酸二酯酶v抑制剂及其前体的方法

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CNB038124971A Expired - Fee Related CN100497336C (zh) 2002-05-31 2003-05-30 制备黄嘌呤磷酸二酯酶v抑制剂及其前体的方法

Country Status (16)

Country Link
US (2) US7074923B2 (https=)
EP (1) EP1509525B9 (https=)
JP (1) JP2005529934A (https=)
CN (2) CN101538224A (https=)
AR (1) AR040232A1 (https=)
AT (1) ATE336494T1 (https=)
AU (1) AU2003238822A1 (https=)
CA (1) CA2483923A1 (https=)
CY (1) CY1105774T1 (https=)
DE (1) DE60307628T2 (https=)
DK (1) DK1509525T5 (https=)
ES (1) ES2270047T3 (https=)
MX (1) MXPA04011862A (https=)
PT (1) PT1509525E (https=)
WO (1) WO2003101992A1 (https=)
ZA (1) ZA200408719B (https=)

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KR20240090632A (ko) 2009-11-27 2024-06-21 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
CA3070513C (en) 2010-05-05 2023-01-03 Boehringer Ingelheim International Gmbh A dpp-4 inhibitor for use in treatment of skin-alterations or necrosis
KR20130093012A (ko) 2010-06-24 2013-08-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
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Also Published As

Publication number Publication date
AU2003238822A1 (en) 2003-12-19
US7786301B2 (en) 2010-08-31
EP1509525B9 (en) 2007-10-31
DK1509525T3 (da) 2006-12-11
ZA200408719B (en) 2005-11-15
US20030232987A1 (en) 2003-12-18
CN1668618A (zh) 2005-09-14
MXPA04011862A (es) 2005-03-31
ES2270047T3 (es) 2007-04-01
EP1509525B1 (en) 2006-08-16
CN100497336C (zh) 2009-06-10
DE60307628T2 (de) 2007-08-09
US7074923B2 (en) 2006-07-11
PT1509525E (pt) 2006-12-29
US20060205943A1 (en) 2006-09-14
CA2483923A1 (en) 2003-12-11
EP1509525A1 (en) 2005-03-02
CY1105774T1 (el) 2011-02-02
DK1509525T5 (da) 2007-07-30
HK1068139A1 (en) 2005-04-22
WO2003101992A1 (en) 2003-12-11
AR040232A1 (es) 2005-03-23
JP2005529934A (ja) 2005-10-06
DE60307628D1 (de) 2006-09-28
ATE336494T1 (de) 2006-09-15

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