DE60213826T8 - Entwicklung neuer molekularer funktionen - Google Patents
Entwicklung neuer molekularer funktionen Download PDFInfo
- Publication number
- DE60213826T8 DE60213826T8 DE60213826T DE60213826T DE60213826T8 DE 60213826 T8 DE60213826 T8 DE 60213826T8 DE 60213826 T DE60213826 T DE 60213826T DE 60213826 T DE60213826 T DE 60213826T DE 60213826 T8 DE60213826 T8 DE 60213826T8
- Authority
- DE
- Germany
- Prior art keywords
- molecules
- amplification
- natural
- nucleic acid
- selection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003321 amplification Effects 0.000 abstract 3
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 229920001222 biopolymer Polymers 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Steroid Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27708101P | 2001-03-19 | 2001-03-19 | |
US27709401P | 2001-03-19 | 2001-03-19 | |
US277081P | 2001-03-19 | ||
US277094P | 2001-03-19 | ||
US30669101P | 2001-07-20 | 2001-07-20 | |
US306691P | 2001-07-20 | ||
US101030 | 2002-03-19 | ||
US10/101,030 US7070928B2 (en) | 2001-03-19 | 2002-03-19 | Evolving new molecular function |
EP02753671.3A EP1423400B2 (de) | 2001-03-19 | 2002-03-19 | Entwicklung neuer molekularer funktionen |
PCT/US2002/008546 WO2002074929A2 (en) | 2001-03-19 | 2002-03-19 | Evolving new molecular function |
Publications (4)
Publication Number | Publication Date |
---|---|
DE60213826D1 DE60213826D1 (de) | 2006-09-21 |
DE60213826T2 DE60213826T2 (de) | 2007-03-29 |
DE60213826T8 true DE60213826T8 (de) | 2007-08-30 |
DE60213826T3 DE60213826T3 (de) | 2013-10-17 |
Family
ID=27493169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60213826T Expired - Lifetime DE60213826T3 (de) | 2001-03-19 | 2002-03-19 | Entwicklung neuer molekularer funktionen |
Country Status (12)
Country | Link |
---|---|
US (7) | US7070928B2 (de) |
EP (3) | EP1832567A3 (de) |
JP (4) | JP4128453B2 (de) |
AT (1) | ATE335754T1 (de) |
AU (2) | AU2002306777C1 (de) |
CA (1) | CA2441820C (de) |
DE (1) | DE60213826T3 (de) |
DK (1) | DK1423400T4 (de) |
ES (1) | ES2271306T5 (de) |
IL (4) | IL158000A0 (de) |
PT (1) | PT1423400E (de) |
WO (1) | WO2002074929A2 (de) |
Families Citing this family (121)
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US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
PT1423400E (pt) * | 2001-03-19 | 2006-12-29 | Harvard College | Evolução de nova função molecular |
WO2002102820A1 (en) | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Nucleoside derivatives for library preparation |
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US7491494B2 (en) * | 2002-08-19 | 2009-02-17 | President And Fellows Of Harvard College | Evolving new molecular function |
WO2004024929A2 (en) * | 2002-09-12 | 2004-03-25 | Nuevolution A/S | Proximity-aided synthesis of templated molecules |
EP1545762A2 (de) * | 2002-09-27 | 2005-06-29 | Carlsberg A/S | Räumlich kodierte polymermatrix |
AU2011226815B2 (en) * | 2002-10-30 | 2014-09-25 | Nuevolution A/S | Enzymatic encoding |
CN106337046B (zh) * | 2002-10-30 | 2021-03-23 | 纽韦卢森公司 | 合成双功能复合物的方法 |
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EP2175019A3 (de) | 2002-12-19 | 2011-04-06 | Nuevolution A/S | Durch Quasizufallsstrukturen und Funktionen geführte Synthesemethoden |
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