DE60209721T2 - Oxazolo- und furopyrimidine und deren verwendung als medikamente gegen tumore - Google Patents
Oxazolo- und furopyrimidine und deren verwendung als medikamente gegen tumore Download PDFInfo
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- DE60209721T2 DE60209721T2 DE60209721T DE60209721T DE60209721T2 DE 60209721 T2 DE60209721 T2 DE 60209721T2 DE 60209721 T DE60209721 T DE 60209721T DE 60209721 T DE60209721 T DE 60209721T DE 60209721 T2 DE60209721 T2 DE 60209721T2
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- 239000003814 drug Substances 0.000 title description 9
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- 125000000217 alkyl group Chemical group 0.000 claims description 77
- 150000003839 salts Chemical class 0.000 claims description 72
- -1 phenyl- Chemical group 0.000 claims description 67
- 229910052757 nitrogen Inorganic materials 0.000 claims description 58
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 48
- 229910052739 hydrogen Inorganic materials 0.000 claims description 47
- 125000003118 aryl group Chemical group 0.000 claims description 45
- 239000001257 hydrogen Substances 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 42
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- 229910052736 halogen Inorganic materials 0.000 claims description 27
- 150000002367 halogens Chemical class 0.000 claims description 27
- 125000000623 heterocyclic group Chemical group 0.000 claims description 27
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 26
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 15
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH873012001 | 2001-05-14 | ||
| CH8732001 | 2001-05-14 | ||
| PCT/EP2002/005241 WO2002092603A1 (en) | 2001-05-14 | 2002-05-13 | Oxazolo-and furopyrimidines and their use in medicaments against tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60209721D1 DE60209721D1 (de) | 2006-05-04 |
| DE60209721T2 true DE60209721T2 (de) | 2006-09-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60209721T Expired - Lifetime DE60209721T2 (de) | 2001-05-14 | 2002-05-13 | Oxazolo- und furopyrimidine und deren verwendung als medikamente gegen tumore |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7294633B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1390371B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP4155827B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN100378107C (cg-RX-API-DMAC10.html) |
| AT (1) | ATE319718T1 (cg-RX-API-DMAC10.html) |
| BR (1) | BR0209645A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2449188A1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE60209721T2 (cg-RX-API-DMAC10.html) |
| DK (1) | DK1390371T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2259707T3 (cg-RX-API-DMAC10.html) |
| PT (1) | PT1390371E (cg-RX-API-DMAC10.html) |
| WO (1) | WO2002092603A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1689753A4 (en) * | 2003-12-04 | 2010-07-07 | Glaxosmithkline Llc | NEW CHEMICAL COMPOUNDS |
| KR20050091462A (ko) * | 2004-03-12 | 2005-09-15 | 한국과학기술연구원 | 푸로피리미딘 화합물 및 이를 포함하는 ｄｄｒ2 티로신키나아제 활성 저해제 |
| JPWO2005095419A1 (ja) * | 2004-04-01 | 2008-02-21 | 武田薬品工業株式会社 | チアゾロピリミジン誘導体 |
| EP1874769B1 (de) | 2005-04-25 | 2011-09-14 | Merck Patent GmbH | Neuartige aza-heterozyklen als kinase-inhibitoren |
| DE102005061170A1 (de) | 2005-12-21 | 2007-07-05 | Bayer Healthcare Ag | Neue, acyclisch substituierte Furopyrimidin-Derivate und ihre Verwendung |
| DE102005061171A1 (de) | 2005-12-21 | 2007-07-05 | Bayer Healthcare Ag | Neue, cyclisch substituierte Furopyrimidin-Derivate und ihre Verwendung |
| EP3219319A1 (en) * | 2006-06-22 | 2017-09-20 | Nippon Chemiphar Co., Ltd. | Agent for overcoming resistance to anti-cancer agent |
| DE102007019691A1 (de) | 2007-04-26 | 2008-10-30 | Bayer Healthcare Ag | Verwendung von acyclisch substituierten Furopyrimidin-Derivaten zur Behandlung der pulmonalen arteriellen Hypertonie |
| DE102007019690A1 (de) | 2007-04-26 | 2008-10-30 | Bayer Healthcare Ag | Verwendung von cyclisch substituierten Furopyrimidin-Derivaten zur Behandlung der pulmonalen arteriellen Hypertonie |
| DE102007027799A1 (de) | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte Furopyrimidine und ihre Verwendung |
| DE102007027800A1 (de) | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung |
| RU2345996C1 (ru) * | 2007-07-17 | 2009-02-10 | Андрей Александрович Иващенко | Аннелированные азагетероциклические амиды, включающие пиримидиновый фрагмент, способ их получения и применения |
| EP2318415B1 (en) * | 2008-07-15 | 2013-02-20 | Sanofi | Oxazolopyrimidines as edg-1 receptor agonists |
| UY32240A (es) | 2008-11-14 | 2010-06-30 | Boeringer Ingelheim Kg | Nuevas 2,4-diaminopirimidinas, sus sales farmacéuticamente aceptables, composiciones conteniéndolas y aplicaciones. |
| CN101899057A (zh) * | 2010-07-21 | 2010-12-01 | 中国药科大学 | 嘧啶并噁唑衍生物的一种制备方法及其在医学上的用途 |
| US8907093B2 (en) * | 2011-07-07 | 2014-12-09 | Sanofi | Carboxylic acid derivatives having an oxazolo[4,5-c]pyridine ring |
| US8580816B2 (en) * | 2011-07-07 | 2013-11-12 | Sanofi | Carboxylic acid derivatives having an oxazolo[5,4-b]pyridine ring |
| CN103087077B (zh) * | 2011-11-03 | 2016-05-18 | 上海希迈医药科技有限公司 | 噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用 |
| CN103360407B (zh) * | 2012-04-10 | 2016-06-22 | 上海希迈医药科技有限公司 | 一种噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用 |
| WO2015162518A1 (en) | 2014-04-25 | 2015-10-29 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| CN104650111A (zh) * | 2015-01-14 | 2015-05-27 | 中国药科大学 | 芳基脲及芳基酰胺取代的噁唑并嘧啶类化合物及其制备和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5137879A (en) | 1990-03-30 | 1992-08-11 | Dowelanco | Furopyrimidin-4-imine derivatives |
| US5227387A (en) * | 1991-09-03 | 1993-07-13 | Dowelanco | Quinoline nematicidal method |
| ES2109796T3 (es) | 1994-05-03 | 1998-01-16 | Ciba Geigy Ag | Derivados de pirrolopirimidilo con efecto antiproliferante. |
| JPH1184248A (ja) * | 1997-09-12 | 1999-03-26 | Nikon Corp | 反射屈折縮小光学系 |
| KR100600550B1 (ko) * | 2000-10-20 | 2006-07-13 | 에자이 가부시키가이샤 | 질소 함유 방향환 유도체 |
-
2002
- 2002-05-13 CA CA002449188A patent/CA2449188A1/en not_active Abandoned
- 2002-05-13 BR BR0209645-5A patent/BR0209645A/pt not_active IP Right Cessation
- 2002-05-13 AT AT02740590T patent/ATE319718T1/de active
- 2002-05-13 ES ES02740590T patent/ES2259707T3/es not_active Expired - Lifetime
- 2002-05-13 DE DE60209721T patent/DE60209721T2/de not_active Expired - Lifetime
- 2002-05-13 EP EP02740590A patent/EP1390371B1/en not_active Expired - Lifetime
- 2002-05-13 CN CNB028100026A patent/CN100378107C/zh not_active Expired - Fee Related
- 2002-05-13 WO PCT/EP2002/005241 patent/WO2002092603A1/en not_active Ceased
- 2002-05-13 DK DK02740590T patent/DK1390371T3/da active
- 2002-05-13 JP JP2002589487A patent/JP4155827B2/ja not_active Expired - Fee Related
- 2002-05-13 US US10/476,818 patent/US7294633B2/en not_active Expired - Fee Related
- 2002-05-13 PT PT02740590T patent/PT1390371E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20040152892A1 (en) | 2004-08-05 |
| CN1509291A (zh) | 2004-06-30 |
| ES2259707T3 (es) | 2006-10-16 |
| DK1390371T3 (da) | 2006-06-19 |
| WO2002092603A1 (en) | 2002-11-21 |
| JP4155827B2 (ja) | 2008-09-24 |
| BR0209645A (pt) | 2004-07-06 |
| EP1390371B1 (en) | 2006-03-08 |
| PT1390371E (pt) | 2006-07-31 |
| DE60209721D1 (de) | 2006-05-04 |
| JP2005508855A (ja) | 2005-04-07 |
| CA2449188A1 (en) | 2002-11-21 |
| US7294633B2 (en) | 2007-11-13 |
| ATE319718T1 (de) | 2006-03-15 |
| EP1390371A1 (en) | 2004-02-25 |
| CN100378107C (zh) | 2008-04-02 |
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