DE602007003375D1 - Verfahren zur herstellung von 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicycloä2.2.2üoctanbromid - Google Patents

Verfahren zur herstellung von 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicycloä2.2.2üoctanbromid

Info

Publication number
DE602007003375D1
DE602007003375D1 DE602007003375T DE602007003375T DE602007003375D1 DE 602007003375 D1 DE602007003375 D1 DE 602007003375D1 DE 602007003375 T DE602007003375 T DE 602007003375T DE 602007003375 T DE602007003375 T DE 602007003375T DE 602007003375 D1 DE602007003375 D1 DE 602007003375D1
Authority
DE
Germany
Prior art keywords
ylacetoxy
dithien
phenoxypropyl
hydroxy
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007003375T
Other languages
English (en)
Inventor
Baque Nuria Busquets
Lorenzo Francesca Pajuelo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37808353&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602007003375(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall SA filed Critical Almirall SA
Publication of DE602007003375D1 publication Critical patent/DE602007003375D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
DE602007003375T 2006-07-21 2007-07-16 Verfahren zur herstellung von 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicycloä2.2.2üoctanbromid Active DE602007003375D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200601951A ES2298049B1 (es) 2006-07-21 2006-07-21 Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
PCT/EP2007/006278 WO2008009397A1 (en) 2006-07-21 2007-07-16 Process for manufacturing 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide

Publications (1)

Publication Number Publication Date
DE602007003375D1 true DE602007003375D1 (de) 2009-12-31

Family

ID=37808353

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007003375T Active DE602007003375D1 (de) 2006-07-21 2007-07-16 Verfahren zur herstellung von 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicycloä2.2.2üoctanbromid

Country Status (37)

Country Link
US (1) US8044205B2 (de)
EP (1) EP2044067B1 (de)
JP (1) JP5279708B2 (de)
KR (1) KR101410198B1 (de)
CN (1) CN101490048B (de)
AR (1) AR061933A1 (de)
AT (1) ATE449096T1 (de)
AU (1) AU2007276395B2 (de)
BR (1) BRPI0711500B1 (de)
CA (1) CA2657679C (de)
CL (1) CL2007002078A1 (de)
CO (1) CO6460740A2 (de)
CY (1) CY1109792T1 (de)
DE (1) DE602007003375D1 (de)
DK (1) DK2044067T3 (de)
EC (1) ECSP099033A (de)
EG (1) EG25727A (de)
ES (2) ES2298049B1 (de)
HK (1) HK1124051A1 (de)
HR (1) HRP20090652T1 (de)
IL (1) IL196324A (de)
ME (1) ME01773B (de)
MX (1) MX2009000573A (de)
MY (1) MY145285A (de)
NO (1) NO20090811L (de)
NZ (1) NZ573170A (de)
PE (1) PE20081307A1 (de)
PL (1) PL2044067T3 (de)
PT (1) PT2044067E (de)
RS (1) RS51264B (de)
RU (1) RU2439070C2 (de)
SI (1) SI2044067T1 (de)
TW (1) TWI363057B (de)
UA (1) UA96453C2 (de)
UY (1) UY30475A1 (de)
WO (1) WO2008009397A1 (de)
ZA (1) ZA200810051B (de)

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* Cited by examiner, † Cited by third party
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ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
CA2608561A1 (en) * 2007-10-29 2009-04-29 Carl Paluszkiewicz Motorcycle wind deflector accessory support
EP2100599A1 (de) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung
EP2100598A1 (de) * 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung
EP2510928A1 (de) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium zur Verbesserung der Schlafqualität bei atemwegserkrankten Patienten
EP2666465A1 (de) * 2012-05-25 2013-11-27 Almirall, S.A. Neuartige Dosierung und Formulierung
CZ306791B6 (cs) * 2013-10-29 2017-07-12 Zentiva, K.S. Průmyslově využitelný způsob přípravy aklidinium bromidu o vysoké čistotě
CN103755699A (zh) * 2014-01-06 2014-04-30 万特制药(海南)有限公司 一种2-羟基-2,2-二噻吩-2-基乙酸-1-氮杂二环[2,2,2]辛-3(r)-基酯制备方法
CN103755698A (zh) * 2014-01-06 2014-04-30 万特制药(海南)有限公司 一锅法制备阿地溴铵的工艺
CZ2014188A3 (cs) 2014-03-26 2015-10-07 Zentiva, K.S. Nové formy aclidinium chloridu a způsob jejich přípravy
CN104478871B (zh) * 2014-12-26 2016-09-07 东华大学 一种胆碱m受体拮抗剂阿地溴铵及其制备方法
PT108370B (pt) * 2015-03-30 2018-10-25 Hovione Farm S A Processo de preparação de brometo de aclidínio
WO2016162878A1 (en) * 2015-04-04 2016-10-13 Harman Finochem Limited An advantageous process for preparing 1-azoniabicyclo[2.2.2]octane,3-[(hydroxydi-2-thienylacetyl)oxy]-1-(3¬phenoxypropyl)-, bromide, (3r)- and its novel crystalline form-i
CZ2015257A3 (cs) 2015-04-16 2016-10-26 Zentiva, K.S. Způsob pro zmenšování velikosti částic bromidu [(3R)-1-(3-fenoxypropyl)chinuklidin-1-ium-3-yl] 2-hydroxy-2,2-bis(2-thienyl)acetátu

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Also Published As

Publication number Publication date
MX2009000573A (es) 2009-01-29
EP2044067A1 (de) 2009-04-08
JP2009544591A (ja) 2009-12-17
CY1109792T1 (el) 2014-09-10
ECSP099033A (es) 2009-02-27
ES2298049B1 (es) 2009-10-20
TW200821307A (en) 2008-05-16
CO6460740A2 (es) 2012-06-15
HRP20090652T1 (hr) 2010-01-31
SI2044067T1 (sl) 2010-03-31
UA96453C2 (uk) 2011-11-10
BRPI0711500B1 (pt) 2014-09-16
US8044205B2 (en) 2011-10-25
AR061933A1 (es) 2008-10-01
CA2657679A1 (en) 2008-01-24
NO20090811L (no) 2009-02-20
HK1124051A1 (en) 2009-07-03
JP5279708B2 (ja) 2013-09-04
RU2009105827A (ru) 2010-08-27
RU2439070C2 (ru) 2012-01-10
ES2336045T3 (es) 2010-04-07
IL196324A0 (en) 2009-09-22
WO2008009397A1 (en) 2008-01-24
PL2044067T3 (pl) 2010-04-30
NZ573170A (en) 2010-12-24
EP2044067B1 (de) 2009-11-18
ATE449096T1 (de) 2009-12-15
AU2007276395B2 (en) 2012-03-08
MY145285A (en) 2012-01-13
IL196324A (en) 2012-12-31
PE20081307A1 (es) 2008-09-17
CN101490048B (zh) 2011-06-29
ME01773B (me) 2010-12-31
BRPI0711500A2 (pt) 2011-11-01
DK2044067T3 (da) 2010-02-01
WO2008009397A8 (en) 2009-01-22
ZA200810051B (en) 2009-11-25
CA2657679C (en) 2014-10-21
ES2298049A1 (es) 2008-05-01
KR101410198B1 (ko) 2014-06-19
RS51264B (sr) 2010-12-31
US20090299042A1 (en) 2009-12-03
KR20090031578A (ko) 2009-03-26
CL2007002078A1 (es) 2008-01-25
EG25727A (en) 2012-06-11
TWI363057B (en) 2012-05-01
CN101490048A (zh) 2009-07-22
UY30475A1 (es) 2008-01-02
PT2044067E (pt) 2009-12-21
AU2007276395A1 (en) 2008-01-24

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