CY1109792T1 - Μεθοδος για την παρασκευη βρωμιουχου 3(r)-(2-υδροξυ-2,2-διθειενο-2-υλακετοξυ)-1-(3-φαινοξυπροπυλο)-1 - αζονιαδικυκλο [2.2.2] οκτανιου - Google Patents
Μεθοδος για την παρασκευη βρωμιουχου 3(r)-(2-υδροξυ-2,2-διθειενο-2-υλακετοξυ)-1-(3-φαινοξυπροπυλο)-1 - αζονιαδικυκλο [2.2.2] οκτανιουInfo
- Publication number
- CY1109792T1 CY1109792T1 CY20101100117T CY101100117T CY1109792T1 CY 1109792 T1 CY1109792 T1 CY 1109792T1 CY 20101100117 T CY20101100117 T CY 20101100117T CY 101100117 T CY101100117 T CY 101100117T CY 1109792 T1 CY1109792 T1 CY 1109792T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hydroxy
- preparation
- ylaketoxy
- phenoxypypyl
- dytheneo
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- NIDWUZTTXGJFNN-UHFFFAOYSA-N 3-bromopropoxybenzene Chemical compound BrCCCOC1=CC=CC=C1 NIDWUZTTXGJFNN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- XLAKJQPTOJHYDR-QTQXQZBYSA-M aclidinium bromide Chemical compound [Br-].C([C@@H](C(CC1)CC2)OC(=O)C(O)(C=3SC=CC=3)C=3SC=CC=3)[N+]21CCCOC1=CC=CC=C1 XLAKJQPTOJHYDR-QTQXQZBYSA-M 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 150000004292 cyclic ethers Chemical class 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Αυτή η εφεύρεση αφορά σε μια μέθοδο για την παρασκευή βρωμιούχου 3(R) - (2-υδροξυ-2,2-διθειενο-2-υλακετοξυ) -1- (3-φαινοξυπροπυλο) -1-αζονιαδικυκλο[2.2.2] οκτανίου μέσω της αντίδρασης 1-αζαδικυκλο[2.2.2]-οκτ-3(R)υλεστέρα του 2-υδροξυ-2,2-διθειεvo-2-υλοξικού οξέος και 3-φαινοξυπροπυλο βρωμιδίου, στην οποία η αντίδραση λαμβάνει χώρα σε έναν διαλύτη ή σε μίγματα διαλυτών που έχουν σημείο βρασμού μεταξύ 50 και 210°C και επιλέγονται από την ομάδα που αποτελείται από κετόνες και κυκλικούς αιθέρες.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200601951A ES2298049B1 (es) | 2006-07-21 | 2006-07-21 | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
| EP07786080A EP2044067B1 (en) | 2006-07-21 | 2007-07-16 | Process for manufacturing 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3- phenoxypropyl)-1 -azoniabicyclo[2.2.2]octane bromide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109792T1 true CY1109792T1 (el) | 2014-09-10 |
Family
ID=37808353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100117T CY1109792T1 (el) | 2006-07-21 | 2010-02-05 | Μεθοδος για την παρασκευη βρωμιουχου 3(r)-(2-υδροξυ-2,2-διθειενο-2-υλακετοξυ)-1-(3-φαινοξυπροπυλο)-1 - αζονιαδικυκλο [2.2.2] οκτανιου |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US8044205B2 (el) |
| EP (1) | EP2044067B1 (el) |
| JP (1) | JP5279708B2 (el) |
| KR (1) | KR101410198B1 (el) |
| CN (1) | CN101490048B (el) |
| AR (1) | AR061933A1 (el) |
| AT (1) | ATE449096T1 (el) |
| AU (1) | AU2007276395B2 (el) |
| BR (1) | BRPI0711500B1 (el) |
| CA (1) | CA2657679C (el) |
| CL (1) | CL2007002078A1 (el) |
| CO (1) | CO6460740A2 (el) |
| CY (1) | CY1109792T1 (el) |
| DE (1) | DE602007003375D1 (el) |
| DK (1) | DK2044067T3 (el) |
| EC (1) | ECSP099033A (el) |
| EG (1) | EG25727A (el) |
| ES (2) | ES2298049B1 (el) |
| HK (1) | HK1124051A1 (el) |
| HR (1) | HRP20090652T1 (el) |
| IL (1) | IL196324A (el) |
| ME (1) | ME01773B (el) |
| MX (1) | MX2009000573A (el) |
| MY (1) | MY145285A (el) |
| NO (1) | NO20090811L (el) |
| NZ (1) | NZ573170A (el) |
| PE (1) | PE20081307A1 (el) |
| PL (1) | PL2044067T3 (el) |
| PT (1) | PT2044067E (el) |
| RS (1) | RS51264B (el) |
| RU (1) | RU2439070C2 (el) |
| SI (1) | SI2044067T1 (el) |
| TW (1) | TWI363057B (el) |
| UA (1) | UA96453C2 (el) |
| UY (1) | UY30475A1 (el) |
| WO (1) | WO2008009397A1 (el) |
| ZA (1) | ZA200810051B (el) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| CA2608561A1 (en) * | 2007-10-29 | 2009-04-29 | Carl Paluszkiewicz | Motorcycle wind deflector accessory support |
| EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
| EP2666465A1 (en) | 2012-05-25 | 2013-11-27 | Almirall, S.A. | Novel dosage and formulation |
| CZ306791B6 (cs) * | 2013-10-29 | 2017-07-12 | Zentiva, K.S. | Průmyslově využitelný způsob přípravy aklidinium bromidu o vysoké čistotě |
| CN103755698A (zh) * | 2014-01-06 | 2014-04-30 | 万特制药(海南)有限公司 | 一锅法制备阿地溴铵的工艺 |
| CN103755699A (zh) * | 2014-01-06 | 2014-04-30 | 万特制药(海南)有限公司 | 一种2-羟基-2,2-二噻吩-2-基乙酸-1-氮杂二环[2,2,2]辛-3(r)-基酯制备方法 |
| CZ2014188A3 (cs) | 2014-03-26 | 2015-10-07 | Zentiva, K.S. | Nové formy aclidinium chloridu a způsob jejich přípravy |
| CN104478871B (zh) * | 2014-12-26 | 2016-09-07 | 东华大学 | 一种胆碱m受体拮抗剂阿地溴铵及其制备方法 |
| PT108370B (pt) * | 2015-03-30 | 2018-10-25 | Hovione Farm S A | Processo de preparação de brometo de aclidínio |
| WO2016162878A1 (en) * | 2015-04-04 | 2016-10-13 | Harman Finochem Limited | An advantageous process for preparing 1-azoniabicyclo[2.2.2]octane,3-[(hydroxydi-2-thienylacetyl)oxy]-1-(3¬phenoxypropyl)-, bromide, (3r)- and its novel crystalline form-i |
| CZ2015257A3 (cs) | 2015-04-16 | 2016-10-26 | Zentiva, K.S. | Způsob pro zmenšování velikosti částic bromidu [(3R)-1-(3-fenoxypropyl)chinuklidin-1-ium-3-yl] 2-hydroxy-2,2-bis(2-thienyl)acetátu |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1219606A (en) | 1968-07-15 | 1971-01-20 | Rech S Et D Applic Scient Soge | Quinuclidinol derivatives and preparation thereof |
| FR2414044A1 (fr) | 1978-01-10 | 1979-08-03 | Pharmindustrie | Nouveaux derives d'aza-1 bicyclo(2,2,2) octane, utilisables comme medicaments |
| FR2539135B1 (fr) | 1983-01-11 | 1986-02-28 | Essilor Int | Hydrogels de polyurethane et procede de fabrication |
| GB8334494D0 (en) | 1983-12-24 | 1984-02-01 | Tanabe Seiyaku Co | Carbostyril derivatives |
| US4675326A (en) | 1985-05-08 | 1987-06-23 | Gabriel Amitai | Bisquaternary antidotes |
| US4843074A (en) | 1988-05-17 | 1989-06-27 | Marion Laboratories, Inc. | 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts |
| DE3931041C2 (de) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| US5610163A (en) | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
| GB8923590D0 (en) | 1989-10-19 | 1989-12-06 | Pfizer Ltd | Antimuscarinic bronchodilators |
| US5201308A (en) | 1990-02-14 | 1993-04-13 | Newhouse Michael T | Powder inhaler |
| US5091528A (en) | 1990-09-12 | 1992-02-25 | Allergan, Inc. | 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents |
| DE4108393A1 (de) | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln |
| DE4239402A1 (de) | 1992-11-24 | 1994-05-26 | Bayer Ag | Pulverinhalator |
| AU685225B2 (en) | 1994-02-10 | 1998-01-15 | Yamanouchi Pharmaceutical Co., Ltd. | Novel carbamate derivative and medicinal composition containing the same |
| NO2005012I1 (no) * | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
| ATE297773T1 (de) | 1995-04-14 | 2005-07-15 | Smithkline Beecham Corp | Dosierinhalator für salmeterol |
| FR2756739B1 (fr) | 1996-12-05 | 2000-04-28 | Astra Ab | Nouvelle formulation de budesonide |
| EP1087750B1 (en) | 1998-06-18 | 2003-11-12 | Boehringer Ingelheim Pharmaceuticals Inc. | Pharmaceutical formulations for aerosols with two or more active substances |
| DE59904648D1 (de) | 1998-08-04 | 2003-04-24 | Jago Res Ag Muttenz | Medizinische aerosolformulierungen |
| GB9902689D0 (en) | 1999-02-08 | 1999-03-31 | Novartis Ag | Organic compounds |
| DE19921693A1 (de) | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| US7214687B2 (en) | 1999-07-14 | 2007-05-08 | Almirall Ag | Quinuclidine derivatives and medicinal compositions containing the same |
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| FR2803378B1 (fr) | 1999-12-29 | 2004-03-19 | Valeo Climatisation | Echangeur de chaleur a tubes a plusieurs canaux, en particulier pour vehicule automobile |
| GB0009605D0 (en) | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Medicaments |
| GB0009606D0 (en) | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Therapeutic combinations |
| GB0009583D0 (en) | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Respiratory formulations |
| GB0009592D0 (en) | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Respiratory combinations |
| US20020183292A1 (en) | 2000-10-31 | 2002-12-05 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and corticosteroids |
| US20020193393A1 (en) | 2001-03-07 | 2002-12-19 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
| US20030158196A1 (en) | 2002-02-16 | 2003-08-21 | Boehringer Ingelheim Pharma Gmbh Co. Kg | Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors |
| US20020151541A1 (en) | 2000-10-31 | 2002-10-17 | Michel Pairet | Pharmaceutical compositions containing tiotropium salts and antihistamines and their use |
| US6620438B2 (en) | 2001-03-08 | 2003-09-16 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics and NK1-receptor antagonists |
| US7776315B2 (en) | 2000-10-31 | 2010-08-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
| US6608054B2 (en) | 2001-03-20 | 2003-08-19 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics and endothelin antagonists |
| CA2436540C (en) | 2000-10-31 | 2008-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and corticosteroids |
| US20020137764A1 (en) | 2000-10-31 | 2002-09-26 | Karin Drechsel | Inhalable formulation of a solution containing a tiotropium salt |
| US20020122773A1 (en) | 2000-12-20 | 2002-09-05 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and dopamine agonists |
| DE10062712A1 (de) | 2000-12-15 | 2002-06-20 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden |
| DE10056104A1 (de) | 2000-11-13 | 2002-05-23 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols |
| US20020193392A1 (en) | 2000-11-13 | 2002-12-19 | Christel Schmelzer | Pharmaceutical compositions based on tiotropium salts of salts of salmeterol |
| US20100310477A1 (en) | 2000-11-28 | 2010-12-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Pharmaceutical compositions based on anticholingerics and additional active ingredients |
| SI1345937T1 (sl) * | 2000-12-22 | 2006-02-28 | Almirall Prodesfarma Ag | Derivati kinulidinkarbamata in njihova uporaba kot M3 antagonisti |
| CA2433128C (en) | 2000-12-28 | 2010-05-25 | Almirall Prodesfarma Ag | Novel quinuclidine derivatives and medicinal compositions containing the same |
| US20020179087A1 (en) | 2001-02-01 | 2002-12-05 | Karl-Heinz Bozung | Pharmaceutical compositions containing an oxitropium salt and a betamimetic |
| DE10104367A1 (de) | 2001-02-01 | 2002-08-08 | Boehringer Ingelheim Pharma | Betamimetika enthaltende Arzneimittelkompositionen mit geringeren Nebenwirkungen |
| US20020189610A1 (en) | 2001-02-01 | 2002-12-19 | Karl-Heinz Bozung | Pharmaceutical compositions containing an ipratropium salt and a betamimetic |
| DE10104370A1 (de) | 2001-02-01 | 2002-08-08 | Boehringer Ingelheim Pharma | Arzneimittelkompositionen mit geringeren Nebenwirkungen |
| US20030018019A1 (en) | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| DE10130371A1 (de) | 2001-06-23 | 2003-01-02 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika |
| ES2206021B1 (es) | 2002-04-16 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirrolidinio. |
| ES2195785B1 (es) | 2002-05-16 | 2005-03-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| ES2204295B1 (es) * | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
| ES2211315B1 (es) | 2002-11-12 | 2005-10-16 | Almirall Prodesfarma, S.A. | Nuevos compuestos triciclicos. |
| ES2211344B1 (es) | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| US20050026886A1 (en) | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a PDE IV inhibitor |
| US20050026887A1 (en) | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a steroid |
| US20050026948A1 (en) | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a betamimetic |
| JP2007500150A (ja) | 2003-07-29 | 2007-01-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗コリン作用薬とステロイドとの併用剤及び吸入により呼吸障害を治療するためのその使用 |
| US20050025718A1 (en) | 2003-07-31 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a betamimetic |
| ES2232306B1 (es) | 2003-11-10 | 2006-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| ES2239546B1 (es) | 2004-03-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos esteres de quinuclidina cuaternizados. |
| ES2257152B1 (es) | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
-
2006
- 2006-07-21 ES ES200601951A patent/ES2298049B1/es not_active Withdrawn - After Issue
-
2007
- 2007-07-09 UY UY30475A patent/UY30475A1/es unknown
- 2007-07-16 NZ NZ573170A patent/NZ573170A/en unknown
- 2007-07-16 AU AU2007276395A patent/AU2007276395B2/en active Active
- 2007-07-16 UA UAA200901336A patent/UA96453C2/uk unknown
- 2007-07-16 US US12/374,185 patent/US8044205B2/en active Active
- 2007-07-16 RS RSP-2010/0009A patent/RS51264B/sr unknown
- 2007-07-16 JP JP2009519845A patent/JP5279708B2/ja active Active
- 2007-07-16 DE DE602007003375T patent/DE602007003375D1/de active Active
- 2007-07-16 MY MYPI20090241A patent/MY145285A/en unknown
- 2007-07-16 SI SI200730159T patent/SI2044067T1/sl unknown
- 2007-07-16 RU RU2009105827/04A patent/RU2439070C2/ru active
- 2007-07-16 EP EP07786080A patent/EP2044067B1/en active Active
- 2007-07-16 ES ES07786080T patent/ES2336045T3/es active Active
- 2007-07-16 PT PT07786080T patent/PT2044067E/pt unknown
- 2007-07-16 MX MX2009000573A patent/MX2009000573A/es active IP Right Grant
- 2007-07-16 KR KR1020097001067A patent/KR101410198B1/ko active IP Right Grant
- 2007-07-16 CN CN2007800274230A patent/CN101490048B/zh active Active
- 2007-07-16 PL PL07786080T patent/PL2044067T3/pl unknown
- 2007-07-16 BR BRPI0711500-8A patent/BRPI0711500B1/pt active IP Right Grant
- 2007-07-16 WO PCT/EP2007/006278 patent/WO2008009397A1/en active Application Filing
- 2007-07-16 CA CA2657679A patent/CA2657679C/en active Active
- 2007-07-16 ME MEP-2010-9A patent/ME01773B/me unknown
- 2007-07-16 DK DK07786080.7T patent/DK2044067T3/da active
- 2007-07-16 AT AT07786080T patent/ATE449096T1/de active
- 2007-07-17 CL CL2007002078A patent/CL2007002078A1/es unknown
- 2007-07-18 PE PE2007000929A patent/PE20081307A1/es not_active Application Discontinuation
- 2007-07-19 AR ARP070103217A patent/AR061933A1/es unknown
- 2007-07-20 TW TW096126654A patent/TWI363057B/zh active
-
2008
- 2008-11-26 ZA ZA200810051A patent/ZA200810051B/xx unknown
-
2009
- 2009-01-01 IL IL196324A patent/IL196324A/en active IP Right Grant
- 2009-01-06 EC EC2009009033A patent/ECSP099033A/es unknown
- 2009-01-18 EG EG2009010072A patent/EG25727A/xx active
- 2009-01-21 CO CO09004925A patent/CO6460740A2/es active IP Right Grant
- 2009-02-20 NO NO20090811A patent/NO20090811L/no not_active Application Discontinuation
- 2009-04-20 HK HK09103625.8A patent/HK1124051A1/xx unknown
- 2009-12-08 HR HR20090652T patent/HRP20090652T1/hr unknown
-
2010
- 2010-02-05 CY CY20101100117T patent/CY1109792T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1109792T1 (el) | Μεθοδος για την παρασκευη βρωμιουχου 3(r)-(2-υδροξυ-2,2-διθειενο-2-υλακετοξυ)-1-(3-φαινοξυπροπυλο)-1 - αζονιαδικυκλο [2.2.2] οκτανιου | |
| EA201500156A2 (ru) | Доставка антител посредством модульного домена распознавания | |
| ATE430153T1 (de) | Verfahren zur verminderung von alpha, beta- ungesättigten ketonen in opioidzusammensetzungen | |
| DE602004029724D1 (de) | Verfahren zur Herstellung von organischen Verbindungen aus Glycerol, stammend aus nachwachsenden Rohstoffen | |
| EA201001774A1 (ru) | Конденсированные азотсодержащие гетероциклы и содержащие их композиции в качестве ингибиторов киназы | |
| DE502005009384D1 (de) | Verfahren zur herstellung von sterilen suspensionen oder lyophilisaten schwerlöslicher basischer peptidkomplexe, diese enthaltende pharmazeutische for | |
| EA200602210A1 (ru) | Связывающие молекулы, способные нейтрализовать вирус бешенства, и их применение | |
| ATE455776T1 (de) | Nikotinische alpha-7-rezeptorliganden gegen erkrankungen des zns | |
| EA201201650A1 (ru) | Связывающие молекулы человека, имеющие убивающую активность против стафилококков, и их применения | |
| DE602008005928D1 (de) | 1h-indol-3-carbonsäure-chinuclidin-4-ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit | |
| ATE431426T1 (de) | Verfahren zur identifizierung von lrrk2 interagierenden molekülen und zur reinigung von lrrk2 | |
| HK1135096A1 (en) | Process for preparing 6-phenoxypyrimidin-4-ol derivatives in the presence of a quinuclidine or a n-methyl pyrrolidine derivative | |
| ATE541902T1 (de) | Oberflächenbehandlungsverfahren für nanopartikel | |
| DE502005007702D1 (de) | Verfahren zur herstellung von terrylen-3,4:11,12-t | |
| DE502007002353D1 (de) | Verfahren zur herstellung von cyclischen ketonen | |
| DE602006017011D1 (de) | Verfahren zur Herstellung von Mannich Kondensationsprodukte zur Verwendung als Chelatbildner | |
| ATE511517T1 (de) | Vom cd4-rezeptor abgeleitete peptide und verfahren zur herstellung davon | |
| ATE542810T1 (de) | Verfahren zur herstellung von 3,5-di-omikron-acyl-2-fluor-2-c-methyl-d-ribono gamma-lacton | |
| DE602004014264D1 (de) | Verfahren zur herstellung von olanzapin | |
| DE112007000952A5 (de) | Verfahren zur Herstellung von Wasserstoffreichen Silanen, sowie neue chemische Verbindungen | |
| DE602007010926D1 (de) | Neues verfahren zur herstellung von ammoniumsalzen von esomeprazol | |
| ATE456572T1 (de) | Verfahren zum herstellen von lysobactin-derivaten | |
| ATE534639T1 (de) | Verfahren zur lösung von citalopram | |
| CY1116707T1 (el) | Παραγωγα αμινοδιυδροθειαζινης ως αναστολεις bace για την αγωγη της νοσου του alzheimer | |
| TH127395B (th) | วิธีสังเคราะห์สำหรับสารประกอบ สไพโร-ออกซินโดล |