UY30475A1 - Procedimientos para fabricar bromuro de 3(r)-(2-hidroxi-2,2-dietien-2-ilaxetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo[2.2.2]octano. - Google Patents

Procedimientos para fabricar bromuro de 3(r)-(2-hidroxi-2,2-dietien-2-ilaxetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo[2.2.2]octano.

Info

Publication number
UY30475A1
UY30475A1 UY30475A UY30475A UY30475A1 UY 30475 A1 UY30475 A1 UY 30475A1 UY 30475 A UY30475 A UY 30475A UY 30475 A UY30475 A UY 30475A UY 30475 A1 UY30475 A1 UY 30475A1
Authority
UY
Uruguay
Prior art keywords
bromide
phenoxipropil
ilaxetoxi
dietien
azoniabiciclo
Prior art date
Application number
UY30475A
Other languages
English (en)
Inventor
Francesca Pajuelo Lorenzo
Nuria Busquets Baque
Original Assignee
Almirall Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37808353&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY30475(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall Lab filed Critical Almirall Lab
Publication of UY30475A1 publication Critical patent/UY30475A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La invencinn consiste en un procedimiento que comprende llevar a cabo la reaccinn de cuaternarizacinn entre el rster 1-azabiciclo[2.2.2]oct-3(R)elico del rcido 2-hidroxi-2,2-ditien-2-ilacctico y el bromuro de 3-fenoxipropilo en un disolvente o mezcla de disolventes que tiene(n) un punto de ebullicnn de 50 a 210sC y que se selecciona(n) del grupo consistente en cetonas y cteres ceclicos. Se prefiere el uso de un unico disolvente. El procedimiento de la presente invencinn permite disminuir el tiempo de reaccinn y la cantidad de disolventes y reaccionantes de alquilacinn utilizados, al mismo tiempo que se aumenta el rendimiento y que se mantiene el nivel de impurezas.
UY30475A 2006-07-21 2007-07-09 Procedimientos para fabricar bromuro de 3(r)-(2-hidroxi-2,2-dietien-2-ilaxetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo[2.2.2]octano. UY30475A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200601951A ES2298049B1 (es) 2006-07-21 2006-07-21 Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.

Publications (1)

Publication Number Publication Date
UY30475A1 true UY30475A1 (es) 2008-01-02

Family

ID=37808353

Family Applications (1)

Application Number Title Priority Date Filing Date
UY30475A UY30475A1 (es) 2006-07-21 2007-07-09 Procedimientos para fabricar bromuro de 3(r)-(2-hidroxi-2,2-dietien-2-ilaxetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo[2.2.2]octano.

Country Status (37)

Country Link
US (1) US8044205B2 (es)
EP (1) EP2044067B1 (es)
JP (1) JP5279708B2 (es)
KR (1) KR101410198B1 (es)
CN (1) CN101490048B (es)
AR (1) AR061933A1 (es)
AT (1) ATE449096T1 (es)
AU (1) AU2007276395B2 (es)
BR (1) BRPI0711500B1 (es)
CA (1) CA2657679C (es)
CL (1) CL2007002078A1 (es)
CO (1) CO6460740A2 (es)
CY (1) CY1109792T1 (es)
DE (1) DE602007003375D1 (es)
DK (1) DK2044067T3 (es)
EC (1) ECSP099033A (es)
EG (1) EG25727A (es)
ES (2) ES2298049B1 (es)
HK (1) HK1124051A1 (es)
HR (1) HRP20090652T1 (es)
IL (1) IL196324A (es)
ME (1) ME01773B (es)
MX (1) MX2009000573A (es)
MY (1) MY145285A (es)
NO (1) NO20090811L (es)
NZ (1) NZ573170A (es)
PE (1) PE20081307A1 (es)
PL (1) PL2044067T3 (es)
PT (1) PT2044067E (es)
RS (1) RS51264B (es)
RU (1) RU2439070C2 (es)
SI (1) SI2044067T1 (es)
TW (1) TWI363057B (es)
UA (1) UA96453C2 (es)
UY (1) UY30475A1 (es)
WO (1) WO2008009397A1 (es)
ZA (1) ZA200810051B (es)

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CN103755699A (zh) * 2014-01-06 2014-04-30 万特制药(海南)有限公司 一种2-羟基-2,2-二噻吩-2-基乙酸-1-氮杂二环[2,2,2]辛-3(r)-基酯制备方法
CN103755698A (zh) * 2014-01-06 2014-04-30 万特制药(海南)有限公司 一锅法制备阿地溴铵的工艺
CZ2014188A3 (cs) 2014-03-26 2015-10-07 Zentiva, K.S. Nové formy aclidinium chloridu a způsob jejich přípravy
CN104478871B (zh) * 2014-12-26 2016-09-07 东华大学 一种胆碱m受体拮抗剂阿地溴铵及其制备方法
PT108370B (pt) * 2015-03-30 2018-10-25 Hovione Farm S A Processo de preparação de brometo de aclidínio
WO2016162878A1 (en) * 2015-04-04 2016-10-13 Harman Finochem Limited An advantageous process for preparing 1-azoniabicyclo[2.2.2]octane,3-[(hydroxydi-2-thienylacetyl)oxy]-1-(3¬phenoxypropyl)-, bromide, (3r)- and its novel crystalline form-i
CZ2015257A3 (cs) 2015-04-16 2016-10-26 Zentiva, K.S. Způsob pro zmenšování velikosti částic bromidu [(3R)-1-(3-fenoxypropyl)chinuklidin-1-ium-3-yl] 2-hydroxy-2,2-bis(2-thienyl)acetátu

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Also Published As

Publication number Publication date
ATE449096T1 (de) 2009-12-15
CL2007002078A1 (es) 2008-01-25
JP2009544591A (ja) 2009-12-17
ES2298049B1 (es) 2009-10-20
JP5279708B2 (ja) 2013-09-04
KR101410198B1 (ko) 2014-06-19
AU2007276395A1 (en) 2008-01-24
TWI363057B (en) 2012-05-01
EG25727A (en) 2012-06-11
EP2044067B1 (en) 2009-11-18
IL196324A (en) 2012-12-31
ZA200810051B (en) 2009-11-25
NZ573170A (en) 2010-12-24
RU2439070C2 (ru) 2012-01-10
CA2657679A1 (en) 2008-01-24
BRPI0711500A2 (pt) 2011-11-01
ME01773B (me) 2010-12-31
CN101490048A (zh) 2009-07-22
AR061933A1 (es) 2008-10-01
RU2009105827A (ru) 2010-08-27
CA2657679C (en) 2014-10-21
DK2044067T3 (da) 2010-02-01
AU2007276395B2 (en) 2012-03-08
PT2044067E (pt) 2009-12-21
RS51264B (sr) 2010-12-31
DE602007003375D1 (de) 2009-12-31
HRP20090652T1 (hr) 2010-01-31
CO6460740A2 (es) 2012-06-15
MX2009000573A (es) 2009-01-29
PL2044067T3 (pl) 2010-04-30
CN101490048B (zh) 2011-06-29
TW200821307A (en) 2008-05-16
UA96453C2 (uk) 2011-11-10
US8044205B2 (en) 2011-10-25
WO2008009397A8 (en) 2009-01-22
HK1124051A1 (en) 2009-07-03
ES2336045T3 (es) 2010-04-07
CY1109792T1 (el) 2014-09-10
KR20090031578A (ko) 2009-03-26
IL196324A0 (en) 2009-09-22
EP2044067A1 (en) 2009-04-08
ES2298049A1 (es) 2008-05-01
NO20090811L (no) 2009-02-20
US20090299042A1 (en) 2009-12-03
BRPI0711500B1 (pt) 2014-09-16
ECSP099033A (es) 2009-02-27
PE20081307A1 (es) 2008-09-17
MY145285A (en) 2012-01-13
SI2044067T1 (sl) 2010-03-31
WO2008009397A1 (en) 2008-01-24

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