EG25727A - Process for manufacturing 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-L-(3-phenoxypropyl)-L-azoniabicyclo[2.2.2]octane bromide - Google Patents

Process for manufacturing 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-L-(3-phenoxypropyl)-L-azoniabicyclo[2.2.2]octane bromide

Info

Publication number
EG25727A
EG25727A EG2009010072A EG2009010072A EG25727A EG 25727 A EG25727 A EG 25727A EG 2009010072 A EG2009010072 A EG 2009010072A EG 2009010072 A EG2009010072 A EG 2009010072A EG 25727 A EG25727 A EG 25727A
Authority
EG
Egypt
Prior art keywords
ylacetoxy
dithien
azoniabicyclo
phenoxypropyl
hydroxy
Prior art date
Application number
EG2009010072A
Other languages
English (en)
Inventor
Baque Nuria Busquets
Lorenzo Francesca Pajuelo
Original Assignee
Almirall Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37808353&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EG25727(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall Lab filed Critical Almirall Lab
Application granted granted Critical
Publication of EG25727A publication Critical patent/EG25727A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EG2009010072A 2006-07-21 2009-01-18 Process for manufacturing 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-L-(3-phenoxypropyl)-L-azoniabicyclo[2.2.2]octane bromide EG25727A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200601951A ES2298049B1 (es) 2006-07-21 2006-07-21 Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
PCT/EP2007/006278 WO2008009397A1 (en) 2006-07-21 2007-07-16 Process for manufacturing 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide

Publications (1)

Publication Number Publication Date
EG25727A true EG25727A (en) 2012-06-11

Family

ID=37808353

Family Applications (1)

Application Number Title Priority Date Filing Date
EG2009010072A EG25727A (en) 2006-07-21 2009-01-18 Process for manufacturing 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-L-(3-phenoxypropyl)-L-azoniabicyclo[2.2.2]octane bromide

Country Status (37)

Country Link
US (1) US8044205B2 (es)
EP (1) EP2044067B1 (es)
JP (1) JP5279708B2 (es)
KR (1) KR101410198B1 (es)
CN (1) CN101490048B (es)
AR (1) AR061933A1 (es)
AT (1) ATE449096T1 (es)
AU (1) AU2007276395B2 (es)
BR (1) BRPI0711500B1 (es)
CA (1) CA2657679C (es)
CL (1) CL2007002078A1 (es)
CO (1) CO6460740A2 (es)
CY (1) CY1109792T1 (es)
DE (1) DE602007003375D1 (es)
DK (1) DK2044067T3 (es)
EC (1) ECSP099033A (es)
EG (1) EG25727A (es)
ES (2) ES2298049B1 (es)
HK (1) HK1124051A1 (es)
HR (1) HRP20090652T1 (es)
IL (1) IL196324A (es)
ME (1) ME01773B (es)
MX (1) MX2009000573A (es)
MY (1) MY145285A (es)
NO (1) NO20090811L (es)
NZ (1) NZ573170A (es)
PE (1) PE20081307A1 (es)
PL (1) PL2044067T3 (es)
PT (1) PT2044067E (es)
RS (1) RS51264B (es)
RU (1) RU2439070C2 (es)
SI (1) SI2044067T1 (es)
TW (1) TWI363057B (es)
UA (1) UA96453C2 (es)
UY (1) UY30475A1 (es)
WO (1) WO2008009397A1 (es)
ZA (1) ZA200810051B (es)

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EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
EP2666465A1 (en) * 2012-05-25 2013-11-27 Almirall, S.A. Novel dosage and formulation
CZ306791B6 (cs) * 2013-10-29 2017-07-12 Zentiva, K.S. Průmyslově využitelný způsob přípravy aklidinium bromidu o vysoké čistotě
CN103755699A (zh) * 2014-01-06 2014-04-30 万特制药(海南)有限公司 一种2-羟基-2,2-二噻吩-2-基乙酸-1-氮杂二环[2,2,2]辛-3(r)-基酯制备方法
CN103755698A (zh) * 2014-01-06 2014-04-30 万特制药(海南)有限公司 一锅法制备阿地溴铵的工艺
CZ2014188A3 (cs) 2014-03-26 2015-10-07 Zentiva, K.S. Nové formy aclidinium chloridu a způsob jejich přípravy
CN104478871B (zh) * 2014-12-26 2016-09-07 东华大学 一种胆碱m受体拮抗剂阿地溴铵及其制备方法
PT108370B (pt) * 2015-03-30 2018-10-25 Hovione Farm S A Processo de preparação de brometo de aclidínio
WO2016162878A1 (en) * 2015-04-04 2016-10-13 Harman Finochem Limited An advantageous process for preparing 1-azoniabicyclo[2.2.2]octane,3-[(hydroxydi-2-thienylacetyl)oxy]-1-(3¬phenoxypropyl)-, bromide, (3r)- and its novel crystalline form-i
CZ2015257A3 (cs) 2015-04-16 2016-10-26 Zentiva, K.S. Způsob pro zmenšování velikosti částic bromidu [(3R)-1-(3-fenoxypropyl)chinuklidin-1-ium-3-yl] 2-hydroxy-2,2-bis(2-thienyl)acetátu

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Also Published As

Publication number Publication date
ATE449096T1 (de) 2009-12-15
CL2007002078A1 (es) 2008-01-25
JP2009544591A (ja) 2009-12-17
ES2298049B1 (es) 2009-10-20
JP5279708B2 (ja) 2013-09-04
KR101410198B1 (ko) 2014-06-19
AU2007276395A1 (en) 2008-01-24
TWI363057B (en) 2012-05-01
EP2044067B1 (en) 2009-11-18
IL196324A (en) 2012-12-31
ZA200810051B (en) 2009-11-25
UY30475A1 (es) 2008-01-02
NZ573170A (en) 2010-12-24
RU2439070C2 (ru) 2012-01-10
CA2657679A1 (en) 2008-01-24
BRPI0711500A2 (pt) 2011-11-01
ME01773B (me) 2010-12-31
CN101490048A (zh) 2009-07-22
AR061933A1 (es) 2008-10-01
RU2009105827A (ru) 2010-08-27
CA2657679C (en) 2014-10-21
DK2044067T3 (da) 2010-02-01
AU2007276395B2 (en) 2012-03-08
PT2044067E (pt) 2009-12-21
RS51264B (sr) 2010-12-31
DE602007003375D1 (de) 2009-12-31
HRP20090652T1 (hr) 2010-01-31
CO6460740A2 (es) 2012-06-15
MX2009000573A (es) 2009-01-29
PL2044067T3 (pl) 2010-04-30
CN101490048B (zh) 2011-06-29
TW200821307A (en) 2008-05-16
UA96453C2 (uk) 2011-11-10
US8044205B2 (en) 2011-10-25
WO2008009397A8 (en) 2009-01-22
HK1124051A1 (en) 2009-07-03
ES2336045T3 (es) 2010-04-07
CY1109792T1 (el) 2014-09-10
KR20090031578A (ko) 2009-03-26
IL196324A0 (en) 2009-09-22
EP2044067A1 (en) 2009-04-08
ES2298049A1 (es) 2008-05-01
NO20090811L (no) 2009-02-20
US20090299042A1 (en) 2009-12-03
BRPI0711500B1 (pt) 2014-09-16
ECSP099033A (es) 2009-02-27
PE20081307A1 (es) 2008-09-17
MY145285A (en) 2012-01-13
SI2044067T1 (sl) 2010-03-31
WO2008009397A1 (en) 2008-01-24

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