HRP20090652T1 - Postupak proizvodnje 3(r)-(2-hidroksi-2,2-ditien-2-ilacetoksi)-1-(3-fenoksipropil)-1-azoniabiciklo[2.2.2]oktan bromida - Google Patents
Postupak proizvodnje 3(r)-(2-hidroksi-2,2-ditien-2-ilacetoksi)-1-(3-fenoksipropil)-1-azoniabiciklo[2.2.2]oktan bromida Download PDFInfo
- Publication number
- HRP20090652T1 HRP20090652T1 HR20090652T HRP20090652T HRP20090652T1 HR P20090652 T1 HRP20090652 T1 HR P20090652T1 HR 20090652 T HR20090652 T HR 20090652T HR P20090652 T HRP20090652 T HR P20090652T HR P20090652 T1 HRP20090652 T1 HR P20090652T1
- Authority
- HR
- Croatia
- Prior art keywords
- dithien
- hydroxy
- solvent
- phenoxypropyl
- azabicyclo
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 14
- XLAKJQPTOJHYDR-QTQXQZBYSA-M aclidinium bromide Chemical compound [Br-].C([C@@H](C(CC1)CC2)OC(=O)C(O)(C=3SC=CC=3)C=3SC=CC=3)[N+]21CCCOC1=CC=CC=C1 XLAKJQPTOJHYDR-QTQXQZBYSA-M 0.000 title claims abstract 3
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- 239000002904 solvent Substances 0.000 claims abstract 7
- GYDFTKNRHZMENP-ZDUSSCGKSA-N [(3r)-1-azabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate Chemical compound O([C@@H]1C2CCN(CC2)C1)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 GYDFTKNRHZMENP-ZDUSSCGKSA-N 0.000 claims abstract 4
- NIDWUZTTXGJFNN-UHFFFAOYSA-N 3-bromopropoxybenzene Chemical compound BrCCCOC1=CC=CC=C1 NIDWUZTTXGJFNN-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000011877 solvent mixture Substances 0.000 claims abstract 3
- 238000009835 boiling Methods 0.000 claims abstract 2
- 150000004292 cyclic ethers Chemical class 0.000 claims abstract 2
- 150000002576 ketones Chemical class 0.000 claims abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- FVEJUHUCFCAYRP-UHFFFAOYSA-N 2-hydroxy-2,2-dithiophen-2-ylacetic acid Chemical compound C=1C=CSC=1C(O)(C(=O)O)C1=CC=CS1 FVEJUHUCFCAYRP-UHFFFAOYSA-N 0.000 claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200601951A ES2298049B1 (es) | 2006-07-21 | 2006-07-21 | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
| PCT/EP2007/006278 WO2008009397A1 (en) | 2006-07-21 | 2007-07-16 | Process for manufacturing 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090652T1 true HRP20090652T1 (hr) | 2010-01-31 |
Family
ID=37808353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090652T HRP20090652T1 (hr) | 2006-07-21 | 2009-12-08 | Postupak proizvodnje 3(r)-(2-hidroksi-2,2-ditien-2-ilacetoksi)-1-(3-fenoksipropil)-1-azoniabiciklo[2.2.2]oktan bromida |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US8044205B2 (de) |
| EP (1) | EP2044067B1 (de) |
| JP (1) | JP5279708B2 (de) |
| KR (1) | KR101410198B1 (de) |
| CN (1) | CN101490048B (de) |
| AR (1) | AR061933A1 (de) |
| AT (1) | ATE449096T1 (de) |
| AU (1) | AU2007276395B2 (de) |
| BR (1) | BRPI0711500B1 (de) |
| CA (1) | CA2657679C (de) |
| CL (1) | CL2007002078A1 (de) |
| CO (1) | CO6460740A2 (de) |
| CY (1) | CY1109792T1 (de) |
| DE (1) | DE602007003375D1 (de) |
| DK (1) | DK2044067T3 (de) |
| EC (1) | ECSP099033A (de) |
| EG (1) | EG25727A (de) |
| ES (2) | ES2298049B1 (de) |
| HK (1) | HK1124051A1 (de) |
| HR (1) | HRP20090652T1 (de) |
| IL (1) | IL196324A (de) |
| ME (1) | ME01773B (de) |
| MX (1) | MX2009000573A (de) |
| MY (1) | MY145285A (de) |
| NO (1) | NO20090811L (de) |
| NZ (1) | NZ573170A (de) |
| PE (1) | PE20081307A1 (de) |
| PL (1) | PL2044067T3 (de) |
| PT (1) | PT2044067E (de) |
| RS (1) | RS51264B (de) |
| RU (1) | RU2439070C2 (de) |
| SI (1) | SI2044067T1 (de) |
| TW (1) | TWI363057B (de) |
| UA (1) | UA96453C2 (de) |
| UY (1) | UY30475A1 (de) |
| WO (1) | WO2008009397A1 (de) |
| ZA (1) | ZA200810051B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| CA2608561A1 (en) * | 2007-10-29 | 2009-04-29 | Carl Paluszkiewicz | Motorcycle wind deflector accessory support |
| EP2100599A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
| EP2100598A1 (de) * | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
| EP2510928A1 (de) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium zur Verbesserung der Schlafqualität bei atemwegserkrankten Patienten |
| EP2666465A1 (de) | 2012-05-25 | 2013-11-27 | Almirall, S.A. | Neuartige Dosierung und Formulierung |
| CZ306791B6 (cs) | 2013-10-29 | 2017-07-12 | Zentiva, K.S. | Průmyslově využitelný způsob přípravy aklidinium bromidu o vysoké čistotě |
| CN103755698A (zh) * | 2014-01-06 | 2014-04-30 | 万特制药(海南)有限公司 | 一锅法制备阿地溴铵的工艺 |
| CN103755699A (zh) * | 2014-01-06 | 2014-04-30 | 万特制药(海南)有限公司 | 一种2-羟基-2,2-二噻吩-2-基乙酸-1-氮杂二环[2,2,2]辛-3(r)-基酯制备方法 |
| CZ2014188A3 (cs) | 2014-03-26 | 2015-10-07 | Zentiva, K.S. | Nové formy aclidinium chloridu a způsob jejich přípravy |
| CN104478871B (zh) * | 2014-12-26 | 2016-09-07 | 东华大学 | 一种胆碱m受体拮抗剂阿地溴铵及其制备方法 |
| PT108370B (pt) * | 2015-03-30 | 2018-10-25 | Hovione Farm S A | Processo de preparação de brometo de aclidínio |
| WO2016162878A1 (en) * | 2015-04-04 | 2016-10-13 | Harman Finochem Limited | An advantageous process for preparing 1-azoniabicyclo[2.2.2]octane,3-[(hydroxydi-2-thienylacetyl)oxy]-1-(3¬phenoxypropyl)-, bromide, (3r)- and its novel crystalline form-i |
| CZ2015257A3 (cs) | 2015-04-16 | 2016-10-26 | Zentiva, K.S. | Způsob pro zmenšování velikosti částic bromidu [(3R)-1-(3-fenoxypropyl)chinuklidin-1-ium-3-yl] 2-hydroxy-2,2-bis(2-thienyl)acetátu |
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| FR2539135B1 (fr) | 1983-01-11 | 1986-02-28 | Essilor Int | Hydrogels de polyurethane et procede de fabrication |
| GB8334494D0 (en) | 1983-12-24 | 1984-02-01 | Tanabe Seiyaku Co | Carbostyril derivatives |
| US4675326A (en) | 1985-05-08 | 1987-06-23 | Gabriel Amitai | Bisquaternary antidotes |
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| DE3931041C2 (de) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| US5610163A (en) | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
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| US20020193392A1 (en) | 2000-11-13 | 2002-12-19 | Christel Schmelzer | Pharmaceutical compositions based on tiotropium salts of salts of salmeterol |
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| EP2100598A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
| EP2100599A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
-
2006
- 2006-07-21 ES ES200601951A patent/ES2298049B1/es not_active Withdrawn - After Issue
-
2007
- 2007-07-09 UY UY30475A patent/UY30475A1/es unknown
- 2007-07-16 CN CN2007800274230A patent/CN101490048B/zh active Active
- 2007-07-16 ME MEP-2010-9A patent/ME01773B/me unknown
- 2007-07-16 MX MX2009000573A patent/MX2009000573A/es active IP Right Grant
- 2007-07-16 JP JP2009519845A patent/JP5279708B2/ja active Active
- 2007-07-16 ES ES07786080T patent/ES2336045T3/es active Active
- 2007-07-16 KR KR1020097001067A patent/KR101410198B1/ko active IP Right Grant
- 2007-07-16 AT AT07786080T patent/ATE449096T1/de active
- 2007-07-16 RU RU2009105827/04A patent/RU2439070C2/ru active
- 2007-07-16 UA UAA200901336A patent/UA96453C2/uk unknown
- 2007-07-16 CA CA2657679A patent/CA2657679C/en active Active
- 2007-07-16 MY MYPI20090241A patent/MY145285A/en unknown
- 2007-07-16 SI SI200730159T patent/SI2044067T1/sl unknown
- 2007-07-16 BR BRPI0711500-8A patent/BRPI0711500B1/pt active IP Right Grant
- 2007-07-16 WO PCT/EP2007/006278 patent/WO2008009397A1/en active Application Filing
- 2007-07-16 NZ NZ573170A patent/NZ573170A/en unknown
- 2007-07-16 PT PT07786080T patent/PT2044067E/pt unknown
- 2007-07-16 EP EP07786080A patent/EP2044067B1/de active Active
- 2007-07-16 AU AU2007276395A patent/AU2007276395B2/en active Active
- 2007-07-16 US US12/374,185 patent/US8044205B2/en active Active
- 2007-07-16 PL PL07786080T patent/PL2044067T3/pl unknown
- 2007-07-16 DE DE602007003375T patent/DE602007003375D1/de active Active
- 2007-07-16 DK DK07786080.7T patent/DK2044067T3/da active
- 2007-07-16 RS RSP-2010/0009A patent/RS51264B/sr unknown
- 2007-07-17 CL CL2007002078A patent/CL2007002078A1/es unknown
- 2007-07-18 PE PE2007000929A patent/PE20081307A1/es not_active Application Discontinuation
- 2007-07-19 AR ARP070103217A patent/AR061933A1/es unknown
- 2007-07-20 TW TW096126654A patent/TWI363057B/zh active
-
2008
- 2008-11-26 ZA ZA200810051A patent/ZA200810051B/xx unknown
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2009
- 2009-01-01 IL IL196324A patent/IL196324A/en active IP Right Grant
- 2009-01-06 EC EC2009009033A patent/ECSP099033A/es unknown
- 2009-01-18 EG EG2009010072A patent/EG25727A/xx active
- 2009-01-21 CO CO09004925A patent/CO6460740A2/es active IP Right Grant
- 2009-02-20 NO NO20090811A patent/NO20090811L/no not_active Application Discontinuation
- 2009-04-20 HK HK09103625.8A patent/HK1124051A1/xx unknown
- 2009-12-08 HR HR20090652T patent/HRP20090652T1/hr unknown
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2010
- 2010-02-05 CY CY20101100117T patent/CY1109792T1/el unknown
Also Published As
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