DE602006018634D1 - Transformierte Hefezellen UND VERFAHREN ZUR HERSTELLUNG VON FREMDPROTEIN - Google Patents
Transformierte Hefezellen UND VERFAHREN ZUR HERSTELLUNG VON FREMDPROTEINInfo
- Publication number
- DE602006018634D1 DE602006018634D1 DE602006018634T DE602006018634T DE602006018634D1 DE 602006018634 D1 DE602006018634 D1 DE 602006018634D1 DE 602006018634 T DE602006018634 T DE 602006018634T DE 602006018634 T DE602006018634 T DE 602006018634T DE 602006018634 D1 DE602006018634 D1 DE 602006018634D1
- Authority
- DE
- Germany
- Prior art keywords
- yeast cells
- foreign protein
- transformed yeast
- producing foreign
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 210000005253 yeast cell Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005225638 | 2005-08-03 | ||
JP2006160347 | 2006-06-08 | ||
PCT/JP2006/315173 WO2007015470A1 (ja) | 2005-08-03 | 2006-07-31 | 酵母宿主、形質転換体および異種タンパク質の製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006018634D1 true DE602006018634D1 (de) | 2011-01-13 |
Family
ID=37708750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006018634T Active DE602006018634D1 (de) | 2005-08-03 | 2006-07-31 | Transformierte Hefezellen UND VERFAHREN ZUR HERSTELLUNG VON FREMDPROTEIN |
Country Status (6)
Country | Link |
---|---|
US (2) | US8329448B2 (de) |
EP (2) | EP2182060B1 (de) |
JP (2) | JP5131457B2 (de) |
CA (1) | CA2617832A1 (de) |
DE (1) | DE602006018634D1 (de) |
WO (1) | WO2007015470A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2182060B1 (de) * | 2005-08-03 | 2012-10-24 | Asahi Glass Company, Limited | Transformierte Hefezellen und Verfahren zur Herstellung von Fremdprotein |
US20090253173A1 (en) * | 2008-04-08 | 2009-10-08 | Danisco Us Inc., Genencor Division | Filamentous fungi with inactivated protease genes for altered protein production |
WO2010058616A1 (ja) * | 2008-11-18 | 2010-05-27 | アサヒビール株式会社 | グルタミン酸高含有酵母の製造方法 |
WO2010087344A1 (ja) | 2009-01-27 | 2010-08-05 | 旭硝子株式会社 | シゾサッカロミセス・ポンベの形質転換方法および形質転換体、ならびに異種蛋白質の製造方法 |
US20110306139A1 (en) * | 2009-02-27 | 2011-12-15 | Novozymes A/S | Mutant Cells Suitable For Recombinant Polypeptide Production |
JP5772594B2 (ja) | 2009-08-21 | 2015-09-02 | 旭硝子株式会社 | 形質転換体およびその製造方法、ならびに乳酸の製造方法 |
EP2494050A4 (de) * | 2009-10-30 | 2013-10-30 | Merck Sharp & Dohme | In glycoengineerter pichia pastoris hergestellter granulozytenkolonienstimulierender faktor |
CN103180442A (zh) | 2010-11-05 | 2013-06-26 | 旭硝子株式会社 | 裂殖酵母属酵母的转化体及其制造方法 |
EP2703484A4 (de) | 2011-03-24 | 2014-12-31 | Asahi Glass Co Ltd | Transformant aus hefe der art schizosaccharomyces, herstellungsverfahren dafür, verfahren zur herstellung von beta-glucosidase und verfahren zur zersetzung von zellulose |
WO2013048661A1 (en) | 2011-09-30 | 2013-04-04 | Codexis, Inc. | Fungal proteases |
SG11201403818XA (en) | 2012-01-05 | 2014-08-28 | Novartis Ag | Protease deficient filamentous fungal cells and methods of use thereof |
JP6064915B2 (ja) | 2012-01-23 | 2017-01-25 | 旭硝子株式会社 | 発現ベクターおよび蛋白質の製造方法 |
WO2013174927A1 (en) | 2012-05-23 | 2013-11-28 | Novartis International Pharmaceutical Limited | Production of fucosylated glycoproteins |
JP6206408B2 (ja) | 2012-08-20 | 2017-10-04 | 旭硝子株式会社 | シゾサッカロミセス・ポンベ変異体の形質転換体、およびクローニングベクター |
JP2016523552A (ja) | 2013-07-10 | 2016-08-12 | ノバルティス アーゲー | 多重プロテアーゼ欠損糸状菌細胞及びその使用方法 |
ES2719828T3 (es) | 2013-11-22 | 2019-07-16 | Jmtc Enzyme Corp | Transformante y procedimiento para la producción del mismo, y procedimiento para la producción de ácido láctico |
CN108064266A (zh) | 2014-07-21 | 2018-05-22 | 格利科斯芬兰公司 | 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备 |
JP2018011511A (ja) * | 2014-11-26 | 2018-01-25 | 旭硝子株式会社 | 3−ヒドロキシプロピオン酸の製造方法、および形質転換体 |
CN109153985B (zh) * | 2016-01-12 | 2022-02-22 | Agc株式会社 | 转化体、以及转铁蛋白的制造方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE248925T1 (de) * | 1988-01-05 | 2003-09-15 | Roche Diagnostics Gmbh | Verfahren zur herstellung von proteinen oder proteinhaltigen genprodukten |
JP2776085B2 (ja) | 1990-09-14 | 1998-07-16 | 旭硝子株式会社 | ベクター |
JP3689920B2 (ja) | 1993-10-05 | 2005-08-31 | 旭硝子株式会社 | マルチクローニングベクター、発現ベクター、および異種蛋白質の生産 |
EP0773296B1 (de) * | 1995-02-03 | 2006-09-13 | Asahi Glass Company Ltd. | Gen für ein sekretionssignal und dieses enthaltender vektor |
AU7112796A (en) * | 1995-09-27 | 1997-04-17 | Chiron Corporation | Method of making a protease deficient host |
ATE313620T1 (de) * | 1996-09-19 | 2006-01-15 | Novozymes As | Wirtszellen und methoden für die produktion von proteinen |
MX9605082A (es) * | 1996-10-24 | 1998-04-30 | Univ Autonoma De Nuevo Leon | Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano. |
JPH10215867A (ja) | 1997-02-04 | 1998-08-18 | Asahi Glass Co Ltd | タンパク質誘導体、該タンパク質をコードする遺伝子および該タンパク質の製造法 |
JPH10234375A (ja) | 1997-02-28 | 1998-09-08 | Asahi Glass Co Ltd | マルチクローニングベクター |
JP3968618B2 (ja) | 1997-10-31 | 2007-08-29 | 旭硝子株式会社 | シゾサッカロミセス・ポンベで使用可能な誘導プロモータ、誘導発現ベクター、およびそれらの利用 |
JP2000136199A (ja) | 1998-10-29 | 2000-05-16 | Asahi Glass Co Ltd | シゾサッカロミセス・ポンベで使用可能なシグナルペプチド、分泌型発現ベクター、およびそれらを用いたタンパク質生産方法 |
JP4305998B2 (ja) | 1999-03-18 | 2009-07-29 | 旭硝子株式会社 | シゾサッカロミセス・ポンベの形質転換方法 |
KR100386836B1 (ko) * | 2000-08-31 | 2003-06-09 | 동국제약 주식회사 | 재조합 인체 부갑상선 호르몬을 생산하는 형질전환효모 및재조합 인체 부갑상선 호르몬의 생산방법 |
GB0030038D0 (en) * | 2000-12-08 | 2001-01-24 | Univ Warwick | Yeast-based assay |
DE60222404T2 (de) * | 2001-05-29 | 2008-06-19 | Asahi Glass Co., Ltd. | Verfahren zur konstruktion eines wirts und verfahren zur herstellung eines fremdproteins |
JP2006109701A (ja) | 2003-04-10 | 2006-04-27 | Asahi Glass Co Ltd | 酵母宿主、形質転換体および異種タンパク質の製造方法 |
EP2182060B1 (de) * | 2005-08-03 | 2012-10-24 | Asahi Glass Company, Limited | Transformierte Hefezellen und Verfahren zur Herstellung von Fremdprotein |
-
2006
- 2006-07-31 EP EP10000311A patent/EP2182060B1/de active Active
- 2006-07-31 EP EP06782051A patent/EP1930428B1/de active Active
- 2006-07-31 DE DE602006018634T patent/DE602006018634D1/de active Active
- 2006-07-31 CA CA002617832A patent/CA2617832A1/en not_active Abandoned
- 2006-07-31 WO PCT/JP2006/315173 patent/WO2007015470A1/ja active Application Filing
- 2006-07-31 JP JP2007529263A patent/JP5131457B2/ja active Active
-
2008
- 2008-02-04 US US12/025,138 patent/US8329448B2/en active Active
-
2010
- 2010-06-10 JP JP2010132749A patent/JP5131493B2/ja active Active
-
2012
- 2012-11-01 US US13/666,116 patent/US20130122547A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2182060A1 (de) | 2010-05-05 |
EP2182060B1 (de) | 2012-10-24 |
US20130122547A1 (en) | 2013-05-16 |
JP5131457B2 (ja) | 2013-01-30 |
EP1930428B1 (de) | 2010-12-01 |
JPWO2007015470A1 (ja) | 2009-02-19 |
US8329448B2 (en) | 2012-12-11 |
WO2007015470A1 (ja) | 2007-02-08 |
JP2010220626A (ja) | 2010-10-07 |
CA2617832A1 (en) | 2007-02-08 |
US20080206816A1 (en) | 2008-08-28 |
EP1930428A1 (de) | 2008-06-11 |
EP1930428A4 (de) | 2008-11-26 |
JP5131493B2 (ja) | 2013-01-30 |
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