DE602006010676D1 - Fermentationsverfahren zur herstellung von diphterietoxin - Google Patents

Fermentationsverfahren zur herstellung von diphterietoxin

Info

Publication number
DE602006010676D1
DE602006010676D1 DE602006010676T DE602006010676T DE602006010676D1 DE 602006010676 D1 DE602006010676 D1 DE 602006010676D1 DE 602006010676 T DE602006010676 T DE 602006010676T DE 602006010676 T DE602006010676 T DE 602006010676T DE 602006010676 D1 DE602006010676 D1 DE 602006010676D1
Authority
DE
Germany
Prior art keywords
diphterietoxin
production
fermentation method
culture
fermentation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006010676T
Other languages
English (en)
Inventor
Phillippe Marc Dehottay
Sandrine Dessoy
Olivier Marc Laloux
Marc Roger Orval
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Biologicals SA
Original Assignee
GlaxoSmithKline Biologicals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Biologicals SA filed Critical GlaxoSmithKline Biologicals SA
Publication of DE602006010676D1 publication Critical patent/DE602006010676D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DE602006010676T 2005-03-23 2006-03-21 Fermentationsverfahren zur herstellung von diphterietoxin Active DE602006010676D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0505996.9A GB0505996D0 (en) 2005-03-23 2005-03-23 Fermentation process
PCT/EP2006/002835 WO2006100108A1 (en) 2005-03-23 2006-03-21 Fermentation process for the production of diphtheria toxin

Publications (1)

Publication Number Publication Date
DE602006010676D1 true DE602006010676D1 (de) 2010-01-07

Family

ID=34531759

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006010676T Active DE602006010676D1 (de) 2005-03-23 2006-03-21 Fermentationsverfahren zur herstellung von diphterietoxin

Country Status (14)

Country Link
US (2) US20080193475A1 (de)
EP (2) EP1861420B1 (de)
JP (1) JP4917087B2 (de)
KR (1) KR101341121B1 (de)
CN (1) CN101180313B (de)
AT (2) ATE540053T1 (de)
AU (1) AU2006226542B2 (de)
BR (1) BRPI0609692C1 (de)
CA (1) CA2602143C (de)
DE (1) DE602006010676D1 (de)
ES (2) ES2378193T3 (de)
GB (1) GB0505996D0 (de)
RU (1) RU2394914C2 (de)
WO (1) WO2006100108A1 (de)

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WO2013191225A1 (ja) 2012-06-20 2013-12-27 国立大学法人 東京大学 粘膜免疫賦活化剤及びｈｐｖ感染症治療用経口医薬組成物
CN103627758B (zh) * 2012-08-28 2018-04-27 天士力医药集团股份有限公司 一种crm197蛋白的生产方法
US20140193451A1 (en) * 2012-10-17 2014-07-10 Glaxosmithkline Biologicals Sa Immunogenic composition
UY35418A (es) 2013-03-15 2014-10-31 Glaxosmithkline Biolog Sa Vacuna que proporciona protección frente a diferentes Picornavirus humanos.
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
WO2018156465A1 (en) * 2017-02-24 2018-08-30 Merck Sharp & Dohme Corp. Polysaccharide-protein conjugates utilizing diphtheria toxin fragment b as a carrier
UA127497C2 (uk) * 2017-04-22 2023-09-13 Байолоджикал Е Лімітед СПОСІБ ВЕЛИКОМАСШТАБНОГО ВИРОБНИЦТВА CRM<sub>197</sub>
EP3699263A1 (de) 2019-02-22 2020-08-26 GlaxoSmithKline Biologicals S.A. Gärungsprozess
CN110452838B (zh) * 2019-07-18 2020-12-29 艾美卫信生物药业（浙江）有限公司 一种crm197菌种培养基、配制方法及发酵培养方法
WO2021176409A1 (en) 2020-03-05 2021-09-10 Sanofi Healthcare India Private Limited Preservative combination for vaccine composition
CN114806973B (zh) * 2022-06-08 2024-02-23 艾美坚持生物制药有限公司 一种提高crm197蛋白产量的生长因子及其制备方法和应用

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Also Published As

Publication number Publication date
CN101180313A (zh) 2008-05-14
US20140242635A1 (en) 2014-08-28
CN101180313B (zh) 2012-10-03
RU2394914C2 (ru) 2010-07-20
ATE540053T1 (de) 2012-01-15
US20080193475A1 (en) 2008-08-14
JP4917087B2 (ja) 2012-04-18
JP2008533980A (ja) 2008-08-28
BRPI0609692A2 (pt) 2010-04-20
EP1861420B1 (de) 2009-11-25
WO2006100108A1 (en) 2006-09-28
BRPI0609692B1 (pt) 2019-02-12
EP1861420A1 (de) 2007-12-05
ATE449788T1 (de) 2009-12-15
CA2602143A1 (en) 2006-09-28
KR20070116132A (ko) 2007-12-06
EP2174950B1 (de) 2012-01-04
EP2174950A1 (de) 2010-04-14
GB0505996D0 (en) 2005-04-27
CA2602143C (en) 2016-08-09
BRPI0609692C1 (pt) 2021-05-25
BRPI0609692B8 (pt) 2020-01-21
KR101341121B1 (ko) 2013-12-12
AU2006226542A1 (en) 2006-09-28
ES2335133T3 (es) 2010-03-22
AU2006226542B2 (en) 2012-02-09
RU2007135122A (ru) 2009-04-27
ES2378193T3 (es) 2012-04-09

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