DE602005026378D1 - Neues verfahren zur herstellung von für die synthese von vitamin-d-analoga geeigneten zwischenprodukten - Google Patents

Neues verfahren zur herstellung von für die synthese von vitamin-d-analoga geeigneten zwischenprodukten

Info

Publication number
DE602005026378D1
DE602005026378D1 DE602005026378T DE602005026378T DE602005026378D1 DE 602005026378 D1 DE602005026378 D1 DE 602005026378D1 DE 602005026378 T DE602005026378 T DE 602005026378T DE 602005026378 T DE602005026378 T DE 602005026378T DE 602005026378 D1 DE602005026378 D1 DE 602005026378D1
Authority
DE
Germany
Prior art keywords
analogue
vitamin
synthesis
new method
intermediates suitable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602005026378T
Other languages
German (de)
English (en)
Inventor
Erik Torngaard Hansen
Thomas Peter Sabroe
Martin John Calverley
Henrik Pedersen
Heinz-Josef Wilhelm Deussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharma AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma AS filed Critical Leo Pharma AS
Publication of DE602005026378D1 publication Critical patent/DE602005026378D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602005026378T 2004-04-02 2005-03-23 Neues verfahren zur herstellung von für die synthese von vitamin-d-analoga geeigneten zwischenprodukten Expired - Lifetime DE602005026378D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55854604P 2004-04-02 2004-04-02
PCT/DK2005/000203 WO2005095336A2 (en) 2004-04-02 2005-03-23 Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues

Publications (1)

Publication Number Publication Date
DE602005026378D1 true DE602005026378D1 (de) 2011-03-31

Family

ID=34961754

Family Applications (2)

Application Number Title Priority Date Filing Date
DE602005026378T Expired - Lifetime DE602005026378D1 (de) 2004-04-02 2005-03-23 Neues verfahren zur herstellung von für die synthese von vitamin-d-analoga geeigneten zwischenprodukten
DE05715124T Pending DE05715124T1 (de) 2004-04-02 2005-03-23 Neues verfahren zur herstellung von für die synthese von vitamin-d-analoga geeigneten zwischenprodukten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE05715124T Pending DE05715124T1 (de) 2004-04-02 2005-03-23 Neues verfahren zur herstellung von für die synthese von vitamin-d-analoga geeigneten zwischenprodukten

Country Status (18)

Country Link
US (1) US20070135395A1 (https=)
EP (1) EP1735276B1 (https=)
JP (1) JP4744507B2 (https=)
KR (1) KR20070056001A (https=)
CN (1) CN1938268B (https=)
AR (1) AR048462A1 (https=)
AT (1) ATE498609T1 (https=)
BR (1) BRPI0508704A (https=)
CA (1) CA2561590C (https=)
DE (2) DE602005026378D1 (https=)
ES (1) ES2361389T3 (https=)
IL (1) IL177357A (https=)
MX (1) MXPA06010824A (https=)
MY (1) MY146099A (https=)
RU (1) RU2378252C2 (https=)
TW (1) TWI322800B (https=)
UA (1) UA94568C2 (https=)
WO (1) WO2005095336A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1948283B (zh) * 2005-10-14 2010-12-29 台耀化学股份有限公司 维生素d衍生物的制备方法
CN101400649B (zh) * 2006-03-17 2012-07-04 利奥制药有限公司 药物中间体的异构化
WO2009057136A2 (en) * 2007-08-03 2009-05-07 Glenmark Generics Limited Epimerization by stereoselective synthesis of vitamin d analogues
EP2299809B1 (en) * 2008-06-17 2018-10-17 Ben Gurion University Of The Negev R&D Authority Substituted cyclohexylidene-ethylidene-octahydro-indene compounds
WO2011002756A2 (en) * 2009-07-01 2011-01-06 Vitamin Derivatives, Inc. Vitamin d compounds and methods for preparing same
CN101607932B (zh) * 2009-07-23 2012-05-09 青岛正大海尔制药有限公司 一种光化学反应制备骨化三醇的方法及其装置
CN103980172A (zh) * 2014-04-26 2014-08-13 湖南华腾制药有限公司 一种1α,25-二羟基维生素D2的制备方法
CN103980173A (zh) * 2014-04-26 2014-08-13 湖南华腾制药有限公司 一种帕立骨化醇中间体的制备方法
CN105624215B (zh) * 2014-10-27 2020-10-27 天津金耀集团有限公司 一种卡泊三醇合成新方法
CN104447211A (zh) * 2014-12-12 2015-03-25 重庆华邦制药有限公司 维生素d类药物的中间体化合物及制备方法
CN105777665B (zh) * 2014-12-17 2018-11-06 上虞京新药业有限公司 卡泊三醇的中间体化合物及其制备方法
ES2575744B1 (es) * 2014-12-30 2017-02-09 Laboratorios Viñas S.A. Procedimiento para proteger derivados de vitamina D con SO2 y uso correspondiente
CN106905358B (zh) * 2015-12-23 2020-12-01 重庆华邦胜凯制药有限公司 一种制备维生素d3类似物中间体的方法
CN105717206B (zh) * 2016-01-27 2018-02-06 重庆华邦制药有限公司 分离测定卡泊三醇中间体f及其杂质的方法
CN107643354B (zh) * 2016-07-22 2022-02-01 重庆华邦胜凯制药有限公司 卡泊三醇起始原料a及相关杂质的分离与测定方法
ES2674336B1 (es) * 2016-12-28 2019-04-11 Laboratorios Vinas S A Procedimiento para reducir derivados carbonilicos de vitamina d y uso correspondiente
CN113845541B (zh) * 2021-10-19 2023-11-07 重庆华邦胜凯制药有限公司 一种制备维生素d3类似物的方法
CN116396268A (zh) * 2021-12-27 2023-07-07 上海信谊万象药业股份有限公司 一种阿法骨化醇中间体合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866048A (en) * 1985-08-02 1989-09-12 Leo Pharmaceutical Products Ltd. Novel vitamin D analogues
US5244104A (en) * 1992-01-02 1993-09-14 Sias Equipment Company Drying rack and spacer
US5247104A (en) * 1992-11-04 1993-09-21 Wisconsin Alumni Research Foundation Preparation of 1α, 24-dihydroxyvitamin D analogs
JPH08325226A (ja) * 1995-05-30 1996-12-10 Teijin Ltd ビタミンｄ３ 誘導体の製造法
BR0315553A (pt) * 2002-10-23 2005-08-23 Leo Pharma As Composto, composição farmacêutica, método de tratamento ou profilaxia de doenças, método de tratamento ou profilaxia de hiperparatireoidismo secundário, e, uso de um composto, opcionalmente em conjunto com outro composto terapeuticamente ativo
ES2233209B1 (es) * 2003-11-28 2006-04-01 Laboratorios Viñas S.A. Compuestos monohalogenovinilderivados de vitamina d.
CA2555260C (en) * 2004-03-18 2011-12-06 Leo Pharma A/S Stereoselective synthesis of vitamin d analogues

Also Published As

Publication number Publication date
EP1735276B1 (en) 2011-02-16
EP1735276A2 (en) 2006-12-27
ATE498609T1 (de) 2011-03-15
JP4744507B2 (ja) 2011-08-10
RU2378252C2 (ru) 2010-01-10
BRPI0508704A (pt) 2007-08-07
WO2005095336A2 (en) 2005-10-13
MY146099A (en) 2012-06-29
JP2007530602A (ja) 2007-11-01
CN1938268B (zh) 2010-06-02
DE05715124T1 (de) 2008-02-21
AR048462A1 (es) 2006-04-26
HK1098124A1 (en) 2007-07-13
CN1938268A (zh) 2007-03-28
WO2005095336A3 (en) 2005-11-10
TW200613257A (en) 2006-05-01
RU2006138613A (ru) 2008-05-10
UA94568C2 (ru) 2011-05-25
CA2561590A1 (en) 2005-10-13
CA2561590C (en) 2008-11-18
ES2361389T3 (es) 2011-06-16
MXPA06010824A (es) 2007-01-17
US20070135395A1 (en) 2007-06-14
KR20070056001A (ko) 2007-05-31
IL177357A (en) 2008-04-13
TWI322800B (en) 2010-04-01

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