DE602005023492D1 - 2-arylmethylazetidincarbapenemderivate und deren herstellung - Google Patents

2-arylmethylazetidincarbapenemderivate und deren herstellung

Info

Publication number
DE602005023492D1
DE602005023492D1 DE602005023492T DE602005023492T DE602005023492D1 DE 602005023492 D1 DE602005023492 D1 DE 602005023492D1 DE 602005023492 T DE602005023492 T DE 602005023492T DE 602005023492 T DE602005023492 T DE 602005023492T DE 602005023492 D1 DE602005023492 D1 DE 602005023492D1
Authority
DE
Germany
Prior art keywords
arylmethylazetidincarbapene
derivatives
preparation
gram
activities against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005023492T
Other languages
English (en)
Inventor
Bong-Jin Kim
Jae-Hak Kim
Jae-Yang Kong
Heeyeong Cho
Young-Ro Choi
Chang-Seob Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Research Institute of Chemical Technology KRICT
Original Assignee
Korea Research Institute of Chemical Technology KRICT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Research Institute of Chemical Technology KRICT filed Critical Korea Research Institute of Chemical Technology KRICT
Publication of DE602005023492D1 publication Critical patent/DE602005023492D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602005023492T 2004-08-31 2005-02-24 2-arylmethylazetidincarbapenemderivate und deren herstellung Active DE602005023492D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020040068821A KR100599876B1 (ko) 2004-08-31 2004-08-31 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법
PCT/KR2005/000509 WO2006025634A1 (en) 2004-08-31 2005-02-24 2-arylmethylazetidine carbapenem derivatives and preparation thereof

Publications (1)

Publication Number Publication Date
DE602005023492D1 true DE602005023492D1 (de) 2010-10-21

Family

ID=36000255

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005023492T Active DE602005023492D1 (de) 2004-08-31 2005-02-24 2-arylmethylazetidincarbapenemderivate und deren herstellung

Country Status (8)

Country Link
US (1) US7662810B2 (de)
EP (1) EP1784407B1 (de)
JP (1) JP4801049B2 (de)
KR (1) KR100599876B1 (de)
CN (1) CN100494200C (de)
AT (1) ATE480538T1 (de)
DE (1) DE602005023492D1 (de)
WO (1) WO2006025634A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1580191A4 (de) * 2002-11-13 2011-03-02 Kaneka Corp Verfahren zur herstellungvon carbapenemverbindung zur oralen verabreichung
CN103275081A (zh) * 2007-09-12 2013-09-04 黄振华 培南类抗菌素
KR101050976B1 (ko) * 2007-09-20 2011-07-21 국제약품공업주식회사 카바페넴계 항생제의 합성 중간체의 산부가염 및 그의 제조방법
CN101848911A (zh) * 2007-09-20 2010-09-29 国际药品工业株式会社 碳青霉烯类抗生素的合成中间体的酸加成盐及其制备方法
KR101044559B1 (ko) * 2007-09-20 2011-06-28 국제약품공업주식회사 티올 화합물의 산부가염 및 그의 제조방법
KR100950699B1 (ko) * 2008-03-28 2010-03-31 국제약품공업주식회사 2-아릴메틸아제티딘-카바페넴-3-카복실산 에스테르유도체의 산부가염, 이의 제조방법 및 이를 포함하는 약학조성물
KR100930586B1 (ko) * 2007-11-23 2009-12-09 한국화학연구원 2-아릴메틸아제티딘-카바페넴-3-카복실산 에스테르 유도체,이의 제조방법 및 이를 포함하는 약학 조성물
CN101868460A (zh) * 2007-11-23 2010-10-20 国际药品工业株式会社 2-芳基甲基吖丁啶-碳青霉烯-3-羧酸酯衍生物或其盐、其制备方法以及包含上述的药物组合物
EP2407468B1 (de) * 2009-03-13 2014-04-16 Daewoong Pharmaceutical Co., Ltd. Verbessertes verfahren zur herstellung von meropenem anhand von zinkpulver
CA3235475A1 (en) * 2021-10-20 2023-04-27 Assembly Biosciences, Inc. Process

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
JPS5916892A (ja) * 1982-07-19 1984-01-28 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体およびその製法
US4698339A (en) * 1983-09-28 1987-10-06 Takeda Chemical Industries, Ltd. Carbapenems, their production and use
JPS60233076A (ja) * 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
DE3617626A1 (de) * 1986-05-26 1987-12-03 Bayer Ag Substituierte 6-hydroxymethyl-carbapenem-antibiotika, verfahren zu ihrer herstellung und ihre verwendung
AU644008B2 (en) 1990-08-10 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production and use
JP3242677B2 (ja) * 1990-08-10 2001-12-25 住友製薬株式会社 新規なβ−ラクタム化合物及びその製造法
AU682510B2 (en) 1993-07-01 1997-10-09 Pfizer Japan Inc. 2-(1-(1,3-thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives
JP4182545B2 (ja) * 1994-02-25 2008-11-19 萬有製薬株式会社 カルバペネム誘導体
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
JP3209675B2 (ja) * 1994-12-12 2001-09-17 日本ワイスレダリー株式会社 チオール化合物
JPH09202789A (ja) * 1995-11-20 1997-08-05 Suntory Ltd ペネム誘導体およびこれを含有する抗菌剤
TW420681B (en) * 1995-12-08 2001-02-01 Lederle Japan Ltd Carbapenem-3-carboxylic acid ester derivatives
JPH1059970A (ja) * 1996-08-16 1998-03-03 Suntory Ltd カルバペネム誘導体およびこれを含有する抗菌剤
DE69810651T2 (de) * 1997-10-07 2003-08-21 Boehringer Ingelheim Ca Ltd Azetidinonderivate zur behandlung von hcmv entzündungen
EP1113016A4 (de) * 1998-09-10 2001-12-12 Wyeth Lederle Japan Ltd Carbapenemderivate
JP4260941B2 (ja) * 1998-11-09 2009-04-30 株式会社片山製薬所 アゼチジン−３−オール
JP2002212182A (ja) * 2000-11-16 2002-07-31 Sankyo Co Ltd １−メチルカルバペネム誘導体
PT1340757E (pt) * 2000-11-16 2006-12-29 Sankyo Co Derivados 1-metilcarbapenem
JP2003183282A (ja) * 2001-12-21 2003-07-03 Wyeth Lederle Japan Ltd カルバペネム化合物

Also Published As

Publication number Publication date
WO2006025634A8 (en) 2006-08-24
CN1946724A (zh) 2007-04-11
WO2006025634A1 (en) 2006-03-09
CN100494200C (zh) 2009-06-03
ATE480538T1 (de) 2010-09-15
US20070244089A1 (en) 2007-10-18
EP1784407B1 (de) 2010-09-08
EP1784407A1 (de) 2007-05-16
EP1784407A4 (de) 2009-02-11
US7662810B2 (en) 2010-02-16
JP2007532693A (ja) 2007-11-15
KR20060020081A (ko) 2006-03-06
KR100599876B1 (ko) 2006-07-13
JP4801049B2 (ja) 2011-10-26

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