WO2005007665A8 - Lincomycin derivatives possessing antibacterial activity - Google Patents

Lincomycin derivatives possessing antibacterial activity

Info

Publication number
WO2005007665A8
WO2005007665A8 PCT/US2004/019497 US2004019497W WO2005007665A8 WO 2005007665 A8 WO2005007665 A8 WO 2005007665A8 US 2004019497 W US2004019497 W US 2004019497W WO 2005007665 A8 WO2005007665 A8 WO 2005007665A8
Authority
WO
WIPO (PCT)
Prior art keywords
antibacterial activity
lincomycin derivatives
derivatives possessing
possessing antibacterial
compounds
Prior art date
Application number
PCT/US2004/019497
Other languages
French (fr)
Other versions
WO2005007665A2 (en
WO2005007665A3 (en
Inventor
Jason G Lewis
Dinesh V Patel
Sampath K Anandan
Mikhail F Gordeev
Original Assignee
Vicuron Pharm Inc
Jason G Lewis
Dinesh V Patel
Sampath K Anandan
Mikhail F Gordeev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2003/025820 external-priority patent/WO2004016632A2/en
Priority claimed from US10/777,455 external-priority patent/US7199105B2/en
Application filed by Vicuron Pharm Inc, Jason G Lewis, Dinesh V Patel, Sampath K Anandan, Mikhail F Gordeev filed Critical Vicuron Pharm Inc
Priority to EP04785949A priority Critical patent/EP1654268A2/en
Priority to BRPI0411537-6A priority patent/BRPI0411537A/en
Priority to CA002528596A priority patent/CA2528596A1/en
Priority to JP2006517386A priority patent/JP2007528360A/en
Publication of WO2005007665A2 publication Critical patent/WO2005007665A2/en
Publication of WO2005007665A8 publication Critical patent/WO2005007665A8/en
Publication of WO2005007665A3 publication Critical patent/WO2005007665A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
PCT/US2004/019497 2003-06-17 2004-06-17 Lincomycin derivatives possessing antibacterial activity WO2005007665A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04785949A EP1654268A2 (en) 2003-06-17 2004-06-17 Lincomycin derivatives possessing antibacterial activity
BRPI0411537-6A BRPI0411537A (en) 2003-06-17 2004-06-17 lincomycin derivatives that have antibacterial activity
CA002528596A CA2528596A1 (en) 2003-06-17 2004-06-17 Lincomycin derivatives possessing antibacterial activity
JP2006517386A JP2007528360A (en) 2003-06-17 2004-06-17 Lincomycin derivatives with antibacterial activity

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US47950203P 2003-06-17 2003-06-17
US60/479,502 2003-06-17
PCT/US2003/025820 WO2004016632A2 (en) 2002-08-15 2003-08-15 Lincomycin derivatives possessing antibacterial activity
US10/642,807 US7164011B2 (en) 2002-08-15 2003-08-15 Lincomycin derivatives possessing antibacterial activity
USPCT/US03/25820 2003-08-15
US10/642,807 2003-08-15
US10/777,455 US7199105B2 (en) 2002-08-15 2004-02-11 Lincomycin derivatives possessing antibacterial activity
US10/777,455 2004-02-11

Publications (3)

Publication Number Publication Date
WO2005007665A2 WO2005007665A2 (en) 2005-01-27
WO2005007665A8 true WO2005007665A8 (en) 2005-04-14
WO2005007665A3 WO2005007665A3 (en) 2005-08-18

Family

ID=34084654

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/019497 WO2005007665A2 (en) 2003-06-17 2004-06-17 Lincomycin derivatives possessing antibacterial activity

Country Status (3)

Country Link
EP (1) EP1654268A2 (en)
CA (1) CA2528596A1 (en)
WO (1) WO2005007665A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05001689A (en) 2002-08-15 2005-05-27 Vicuron Pharm Inc Lincomycin derivatives possessing antibacterial activity.
US7199105B2 (en) 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7361743B2 (en) * 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
JP5290166B2 (en) * 2007-05-31 2013-09-18 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Lincosamide derivative and antibacterial agent comprising the same
JP5356223B2 (en) * 2007-05-31 2013-12-04 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Lincomycin derivatives and antibacterial agents containing the same as active ingredients
CN109627299B (en) * 2018-11-03 2022-02-18 北京工商大学 Bacteriocin Gr17 with broad-spectrum antibacterial activity and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3282917A (en) * 1964-08-17 1966-11-01 Upjohn Co Methyl n-(1-alkyl-4-alkoxy-prolyl)-alpha-thiolincosaminide compounds and process therefor
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3555007A (en) * 1968-07-22 1971-01-12 Upjohn Co 7-deoxy-7-halo lincomycin d derivatives
MXPA05001689A (en) * 2002-08-15 2005-05-27 Vicuron Pharm Inc Lincomycin derivatives possessing antibacterial activity.
EP1644393A2 (en) * 2003-06-17 2006-04-12 Vicuron Pharmaceuticals, Inc. Novel lincomycin derivatives possessing antimicrobial activity

Also Published As

Publication number Publication date
CA2528596A1 (en) 2005-01-27
WO2005007665A2 (en) 2005-01-27
EP1654268A2 (en) 2006-05-10
WO2005007665A3 (en) 2005-08-18

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