DE602005003369T2 - Neue sequenz um die expression einer nukleinsäure zu erhöhen - Google Patents

Neue sequenz um die expression einer nukleinsäure zu erhöhen Download PDF

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Publication number
DE602005003369T2
DE602005003369T2 DE602005003369T DE602005003369T DE602005003369T2 DE 602005003369 T2 DE602005003369 T2 DE 602005003369T2 DE 602005003369 T DE602005003369 T DE 602005003369T DE 602005003369 T DE602005003369 T DE 602005003369T DE 602005003369 T2 DE602005003369 T2 DE 602005003369T2
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Prior art keywords
sequences
repressor
nucleic acid
sequence
expression
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Expired - Lifetime
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DE602005003369T
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German (de)
English (en)
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DE602005003369D1 (de
Inventor
Arie Pieter Otte
Theodorus Hendrikus Kwaks
Richard George Antonius Bernardus Sewalt
Henricus Johannes Maria Van Blokland
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Chromagenics BV
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Chromagenics BV
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Application filed by Chromagenics BV filed Critical Chromagenics BV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602005003369T 2004-07-08 2005-07-07 Neue sequenz um die expression einer nukleinsäure zu erhöhen Expired - Lifetime DE602005003369T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US58700704P 2004-07-08 2004-07-08
EP2004051405 2004-07-08
US587007P 2004-07-08
EP04051405 2004-07-08
PCT/EP2005/053251 WO2006005718A2 (en) 2004-07-08 2005-07-07 Novel sequence for improving expression of nucleic acid

Publications (2)

Publication Number Publication Date
DE602005003369D1 DE602005003369D1 (de) 2007-12-27
DE602005003369T2 true DE602005003369T2 (de) 2009-03-05

Family

ID=34971366

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005003369T Expired - Lifetime DE602005003369T2 (de) 2004-07-08 2005-07-07 Neue sequenz um die expression einer nukleinsäure zu erhöhen

Country Status (19)

Country Link
US (1) US7825232B2 (https=)
JP (1) JP4805262B2 (https=)
KR (1) KR101188013B1 (https=)
CN (1) CN1981057B (https=)
AT (1) ATE378426T1 (https=)
AU (1) AU2005261699B2 (https=)
BR (1) BRPI0512798A (https=)
CA (1) CA2573022C (https=)
DE (1) DE602005003369T2 (https=)
DK (1) DK1763586T3 (https=)
EA (1) EA011747B1 (https=)
ES (1) ES2296201T3 (https=)
IL (1) IL180531A (https=)
MX (1) MXPA06014553A (https=)
NO (1) NO341862B1 (https=)
NZ (1) NZ551510A (https=)
PT (1) PT1763586E (https=)
WO (1) WO2006005718A2 (https=)
ZA (1) ZA200610470B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE354645T1 (de) * 2002-12-20 2007-03-15 Chromagenics Bv Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können
US20100136616A1 (en) * 2004-11-08 2010-06-03 Chromagenics B.V. Selection of Host Cells Expressing Protein at High Levels
US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20060195935A1 (en) 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
ES2384391T3 (es) 2004-11-08 2012-07-04 Chromagenics B.V. Selección de células hospedantes que expresan proteína a altos niveles
KR101271884B1 (ko) * 2004-11-08 2013-06-05 크로마제닉스 비.브이. 고수준으로 단백질을 발현하는 숙주세포의 선택
US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
EP2443239B1 (en) 2009-06-15 2015-11-25 Cellagenics B.V. Novel stringent selectable markers
WO2011159157A1 (en) 2010-06-15 2011-12-22 Cellagenics B.V. Novel intergenic elements for enhancing gene expression
DK2611915T3 (da) 2010-09-01 2015-06-22 Cellagenics B V Nukleinsyrefragmenter fra en ribosomal proteinpromoter til forstærkning af genekspression
CN110484563B (zh) * 2019-07-25 2023-04-07 新乡医学院 哺乳动物细胞组合表达载体、表达系统、制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1600510E (pt) * 2001-07-04 2007-06-25 Chromagenics Bv Sequências de adn com actividade anti-repressora.
CA2489475C (en) 2002-06-14 2011-03-29 Chromagenics B.V. A method for simultaneous production of multiple proteins; vectors and cells for use therein
ATE354645T1 (de) * 2002-12-20 2007-03-15 Chromagenics Bv Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können

Also Published As

Publication number Publication date
AU2005261699B2 (en) 2009-07-23
MXPA06014553A (es) 2007-03-12
HK1097004A1 (en) 2007-06-15
ATE378426T1 (de) 2007-11-15
CA2573022C (en) 2012-03-06
PT1763586E (pt) 2008-02-25
JP2008505626A (ja) 2008-02-28
KR20070042122A (ko) 2007-04-20
BRPI0512798A (pt) 2008-04-08
DE602005003369D1 (de) 2007-12-27
CN1981057A (zh) 2007-06-13
EA011747B1 (ru) 2009-06-30
AU2005261699A1 (en) 2006-01-19
EA200700233A1 (ru) 2007-06-29
CN1981057B (zh) 2012-07-04
NO341862B1 (no) 2018-02-12
US20070212755A1 (en) 2007-09-13
ES2296201T3 (es) 2008-04-16
US7825232B2 (en) 2010-11-02
DK1763586T3 (da) 2008-03-17
KR101188013B1 (ko) 2012-10-08
CA2573022A1 (en) 2006-01-19
IL180531A0 (en) 2007-06-03
WO2006005718A3 (en) 2006-08-17
NZ551510A (en) 2009-10-30
WO2006005718A2 (en) 2006-01-19
IL180531A (en) 2011-04-28
JP4805262B2 (ja) 2011-11-02
NO20070757L (no) 2007-02-08
ZA200610470B (en) 2008-09-25

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