DE602004027932D1 - Benzimidazolderivate: herstellung und pharmazeutische anwendungen - Google Patents

Benzimidazolderivate: herstellung und pharmazeutische anwendungen

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Publication number
DE602004027932D1
DE602004027932D1 DE200460027932 DE602004027932T DE602004027932D1 DE 602004027932 D1 DE602004027932 D1 DE 602004027932D1 DE 200460027932 DE200460027932 DE 200460027932 DE 602004027932 T DE602004027932 T DE 602004027932T DE 602004027932 D1 DE602004027932 D1 DE 602004027932D1
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Germany
Prior art keywords
preparation
pharmaceutical applications
benzimidazole derivatives
benzimidazole
derivatives
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DE200460027932
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English (en)
Inventor
Dizhong Chen
Hong Yan Song
Eric T Sun
Niefang Yu
Yong Blk Hong L Zou
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SBio Pte Ltd
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SBio Pte Ltd
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Publication of DE602004027932D1 publication Critical patent/DE602004027932D1/de
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Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0308081A (pt) 2002-03-13 2004-12-21 Janssen Pharmaceutica Nv Inibidores de histona desacetilase
WO2003076395A1 (en) 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
EA007270B1 (ru) 2002-03-13 2006-08-25 Янссен Фармацевтика Н.В. Пиперазинил-, пиперидинил- и морфолинилпроизводные как новые ингибиторы гистондеацетилазы
CN1305850C (zh) 2002-03-13 2007-03-21 詹森药业有限公司 作为组蛋白脱乙酰酶新颖抑制剂的磺酰基氨基衍生物
TWI349664B (en) 2003-09-22 2011-10-01 S Bio Pte Ltd Benzimidazole derivatives: preparation and pharmaceutical applications
WO2006010750A1 (en) 2004-07-28 2006-02-02 Janssen Pharmaceutica N.V. Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
ME01058B (me) 2004-07-28 2012-10-20 Janssen Pharmaceutica Nv Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze
US7666880B2 (en) 2005-03-21 2010-02-23 S*Bio Pte Ltd. Imidazo[1,2-A]pyridine derivatives: preparation and pharmaceutical applications
GB0509223D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Enzyme inhibitors
GB0509225D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of enzymatic activity
CA2605272C (en) 2005-05-18 2013-12-10 Janssen Pharmaceutica N.V. Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
GB0510204D0 (en) 2005-05-19 2005-06-22 Chroma Therapeutics Ltd Enzyme inhibitors
JP2009501236A (ja) 2005-07-14 2009-01-15 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
US8143282B2 (en) * 2005-09-08 2012-03-27 S*Bio Pte Ltd. Heterocyclic compounds
CA2540459C (en) * 2005-09-08 2014-02-18 S*Bio Pte Ltd Benzimidazole compounds and uses in treating proliferative disorders
JP2007077085A (ja) * 2005-09-15 2007-03-29 Univ Of Tokyo Hdac阻害活性を有する新規置換ヒドロキサム酸誘導体
DK1943232T3 (da) 2005-10-27 2011-08-29 Janssen Pharmaceutica Nv Kvadratsyrederivater som inhibitorer af histondeacetylase
AU2006327892B2 (en) * 2005-12-19 2011-12-22 Methylgene Inc. Histone deacetylase inhibitors for enhancing activity of antifungal agents
CA2633100C (en) 2006-01-19 2014-12-09 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
CN101370790B (zh) 2006-01-19 2015-10-21 詹森药业有限公司 作为组蛋白去乙酰化酶抑制剂的吡啶和嘧啶衍生物
JP5137849B2 (ja) 2006-01-19 2013-02-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼのインヒビターとしての置換インドリル−アルキル−アミノ−誘導体
CA2631876C (en) 2006-01-19 2014-05-27 Janssen Pharmaceutica N.V. Aminophenyl derivatives as inhibitors of histone deacetylase
EP1979327A1 (de) 2006-01-19 2008-10-15 Janssen Pharmaceutica, N.V. Pyridin- und pyrimidinderivate als inhibitoren von histondeacetylase
ATE539073T1 (de) 2006-01-19 2012-01-15 Janssen Pharmaceutica Nv Heterocyclylalkylderivate als neue inhibitoren von histondeacetylase
WO2007109178A2 (en) 2006-03-16 2007-09-27 Pharmacyclics, Inc. Indole derivatives as inhibitors of histone deacetylase
CN101460168B (zh) * 2006-03-31 2013-07-17 詹森药业有限公司 作为组胺h4受体调节剂的苯并咪唑-2-基吡啶
SI2007752T1 (sl) 2006-03-31 2010-12-31 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidini in pirazini kot modulatorji histamin H4 receptorja
ES2561835T3 (es) 2006-09-20 2016-03-01 Mei Pharma, Inc. Compuestos hidroxamato de imidazo[1,2-a]piridina que son inhibidores de la histona desacetilasa
GB0619753D0 (en) 2006-10-06 2006-11-15 Chroma Therapeutics Ltd Enzyme inhibitors
WO2008053131A1 (en) 2006-10-30 2008-05-08 Chroma Therapeutics Ltd. Hydroxamates as inhibitors of histone deacetylase
RU2009126739A (ru) * 2006-12-15 2011-01-20 Новартис АГ (CH) Гетероциклические соединения и способы их применения
JP2010513326A (ja) * 2006-12-19 2010-04-30 メシルジーン インコーポレイテッド ヒストンデアセチラーゼの阻害薬及びそのプロドラッグ
EP3449923A1 (de) * 2007-03-07 2019-03-06 MEI Pharma, Inc. Kombination eines benzimidazol-anti-krebs-mittels mit einem zweiten anti-krebs-mittel
DE102007037579B4 (de) 2007-08-09 2012-05-16 Emc Microcollections Gmbh Neue Benzimidazol-2-yl-alkylamine und ihre Anwendung als mikrobizide Wirkstoffe
US8084466B2 (en) * 2007-12-18 2011-12-27 Janssen Pharmaceutica Nv Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor
WO2009100045A1 (en) * 2008-02-04 2009-08-13 Translational Genomics Research Institute Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives
CN101990433B (zh) 2008-02-07 2014-11-05 马萨诸塞眼科耳科诊所 提高Atoh1表达的化合物
EP2265590B8 (de) 2008-04-15 2016-07-27 Pharmacyclics LLC Selektive histondeacetylase-hemmer
US20110288070A1 (en) * 2008-05-05 2011-11-24 ROGERS Kathryn Methods for treating cognitive disorders using inhibitors of histone deacetylase
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
WO2010039697A2 (en) * 2008-09-30 2010-04-08 Gilead Sciences, Inc. Selective inhibition of histone deacetylases 1 and 2 as a treatment for cardiac hypertrophy
GB0903480D0 (en) 2009-02-27 2009-04-08 Chroma Therapeutics Ltd Enzyme Inhibitors
EP2305643A1 (de) 2009-10-02 2011-04-06 Ikerchem, S.L. Neue Histondeacetylase-Inhibitoren, die zugleich auf trisubstituierten 1H-Pyrrolen und aromatischen und heteroaromatischen Spacern basieren
WO2011056635A1 (en) * 2009-10-27 2011-05-12 Glaxosmithkline Llc Benzimidazoles as fatty acid synthase inhibitors
CN101881735B (zh) * 2010-06-11 2011-11-16 赵永秀 尿液中百草枯的检测方法
JP5782234B2 (ja) * 2010-06-16 2015-09-24 チャイナ メディカル ユニヴァーシティーChina Medical University ベンゾイミダゾール化合物およびその使用
EP2397471A1 (de) * 2010-06-16 2011-12-21 China Medical University Benzimidazolverbindungen und deren Verwendung
BR112013008259A2 (pt) 2010-10-06 2017-12-12 Glaxosmithkline Llc composto, composição farmacêutica, e, uso de um composto
TW201245115A (en) 2011-01-24 2012-11-16 Chdi Foundation Inc Histone deacetylase inhibitors and compositions and methods of use thereof
WO2013066832A1 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods
TW201408628A (zh) 2012-07-16 2014-03-01 Chdi Foundation Inc 組蛋白去乙醯酶抑制劑及組成物,暨其使用之方法
CN103755595A (zh) * 2012-12-25 2014-04-30 中南大学 异羟肟酸类衍生物及其应用
TWI617554B (zh) 2013-03-06 2018-03-11 健生藥品公司 組織胺h受體之苯并咪唑-2-基嘧啶調控劑
EP3054952B1 (de) 2013-10-08 2022-10-26 Acetylon Pharmaceuticals, Inc. Kombinationen von histondeacetylase 6 inhibitoren und dem her2-inhibitor lapatinib zur behandlung von brustkrebs
ES2862126T3 (es) 2013-10-10 2021-10-07 Acetylon Pharmaceuticals Inc Compuestos de pirimidín-hidroxiamida como inhibidores de histona desacetilasa
ES2918673T3 (es) 2013-10-24 2022-07-19 Mayo Found Medical Education & Res Tratamiento de enfermedades poliquísticas con un inhibidor de HDAC6
MX2016007251A (es) 2013-12-03 2016-09-07 Acetylon Pharmaceuticals Inc Combinaciones de inhibidores de histona deacetilasa y farmacos inmunomoduladores.
CN107205988A (zh) 2014-07-07 2017-09-26 埃斯泰隆制药公司 利用组蛋白脱乙酰酶抑制剂治疗白血病
WO2016068099A1 (ja) * 2014-10-28 2016-05-06 塩野義製薬株式会社 Ampk活性化作用を有する複素環誘導体
WO2016087950A1 (en) 2014-12-05 2016-06-09 University of Modena and Reggio Emilia Combinations of histone deacetylase inhibitors and bendamustine for use in the treatment of lymphoma
MA41677A (fr) 2015-03-13 2021-06-02 Forma Therapeutics Inc Composés alpha-cinnamide et compositions comme inhibiteurs de hdac8
EP3294715B1 (de) 2015-05-11 2020-05-06 Kancera AB Benzimidazolderivate als inhibitoren von histon-deacetylase-aktivität bei säugetieren
US10272084B2 (en) 2015-06-01 2019-04-30 Regenacy Pharmaceuticals, Llc Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy
KR20170049279A (ko) * 2015-10-28 2017-05-10 엘지전자 주식회사 이동 단말기
ES2893099T3 (es) * 2015-12-22 2022-02-08 Kancera Ab Acidos hidroxámicos bicíclicos útiles como inhibidores de la actividad de histona desacetilasa de mamíferos
WO2017184774A1 (en) 2016-04-19 2017-10-26 Acetylon Pharmaceuticals, Inc. Hdac inhibitors, alone or in combination with btk inhibitors, for treating chronic lymphocytic leukemia
AR108257A1 (es) 2016-05-02 2018-08-01 Mei Pharma Inc Formas polimórficas de 3-[2-butil-1-(2-dietilamino-etil)-1h-bencimidazol-5-il]-n-hidroxi-acrilamida y usos de las mismas
TWI659949B (zh) * 2016-05-16 2019-05-21 臺北醫學大學 組蛋白去乙醯酶6抑制劑及其用途
CN108976139B (zh) * 2017-06-02 2021-03-16 沈阳化工研究院有限公司 一种芳乙烯衍生物及其应用
CN110950848B (zh) * 2018-09-27 2024-03-26 徐诺药业 新型氨基吡唑类衍生物的合成与应用
WO2021217180A1 (en) 2020-04-22 2021-10-28 Johnson Matthey Public Limited Company Novel forms of pracinostat dihydrochloride
WO2021226261A1 (en) 2020-05-06 2021-11-11 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
US20230248703A1 (en) * 2020-06-12 2023-08-10 Hk Inno.N Corporation Pharmaceutical composition comprising benzimidazole derivative compound
MX2022016546A (es) * 2020-07-03 2023-02-01 Nihon Nohyaku Co Ltd Agente anticoccidio y metodo para su uso.
WO2022140527A1 (en) 2020-12-23 2022-06-30 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
AU2022388555A1 (en) 2021-11-09 2024-05-02 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
CN115368239B (zh) * 2022-09-01 2024-04-26 南开大学 一种肉桂酸酯衍生物的合成及其制药应用
CA3213748A1 (en) 2022-10-21 2023-12-08 Bongyong Lee Pharmaceutical composition for preventing or treating alopecia areata acting as a functional antagonist for s1pr1 and s1pr4
KR102541577B1 (ko) * 2022-10-21 2023-06-13 주식회사 넥스트젠바이오사이언스 S1pr1과 s1pr4에 대한 기능적 저해제로 작용하는 원형 탈모증의 예방 또는 치료용 약학적 조성물

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2291749A1 (fr) * 1974-11-20 1976-06-18 Delalande Sa Nouveaux benzimidazoles acetiques, leur procede de preparation et leur application en therapeutique
EP0649306B1 (de) 1992-05-20 2001-01-10 Merck & Co. Inc. Ester derivate von 4-aza-steroiden
SE9804212D0 (sv) 1998-12-04 1998-12-04 Astra Pharma Prod Compounds
OA11746A (en) 1999-01-13 2005-05-13 Warner Lambert Co Benzoheterocycles and their use as MEK inhibitors.
CA2383546A1 (en) * 1999-06-30 2001-01-04 William H. Parsons Src kinase inhibitor compounds
EP1206260A4 (de) 1999-06-30 2002-10-30 Merck & Co Inc Src-kinase hemmende verbindungen
DE60005688T2 (de) 1999-07-16 2004-04-29 Warner-Lambert Co. Llc Verfahren zur behandlung von chronischem schmerz durch verabreichung von einem mek hemmer
KR20020015376A (ko) * 1999-07-16 2002-02-27 로즈 암스트롱, 크리스틴 에이. 트러트웨인 Mek 억제제를 사용한 만성 통증의 치료 방법
GB9919558D0 (en) 1999-08-18 1999-10-20 Hoechst Schering Agrevo Gmbh Fungicidal compounds
KR20020070285A (ko) * 1999-11-23 2002-09-05 메틸진, 인크. 히스톤 디아세틸라제의 억제제
CA2363274A1 (en) * 1999-12-27 2001-07-05 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs for hepatitis c
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
US7569724B2 (en) * 2000-09-29 2009-08-04 Topotarget Uk Limited Carbamic acid compounds comprising an amide linkage as HDAC inhibitors
US6642252B2 (en) 2000-11-07 2003-11-04 Bristol-Myers Squibb Company Acid derivatives useful as serine protease inhibitors
PA8535601A1 (es) * 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
US7196095B2 (en) * 2001-06-25 2007-03-27 Merck & Co., Inc. (Pyrimidinyl) (phenyl) substituted fused heteroaryl p38 inhibiting and PKG kinase inhibiting compounds
AR035543A1 (es) * 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
AU2003215112A1 (en) * 2002-02-07 2003-09-02 Axys Pharmaceuticals Novel bicyclic hydroxamates as inhibitors of histone deacetylase
KR100984573B1 (ko) 2002-03-13 2010-09-30 어레이 바이오파마 인크. Mek 억제제로서의 n3 알킬화 벤즈이미다졸 유도체
PA8569201A1 (es) * 2002-03-13 2004-05-21 Array Biopharma Inc "derivados de bencimidazol n3 alquilado como inhibidores de mek" "n3 alkylated benzimimidazole derivatives as mek inhibitors"
KR20040101520A (ko) * 2002-04-16 2004-12-02 데이진 가부시키가이샤 Ccr3 길항작용을 갖는 피페리딘 유도체
DE10239042A1 (de) 2002-08-21 2004-03-04 Schering Ag Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
WO2004078682A2 (en) 2003-03-05 2004-09-16 Irm Llc Cyclic compounds and compositions as protein kinase inhibitors
US7375228B2 (en) * 2003-03-17 2008-05-20 Takeda San Diego, Inc. Histone deacetylase inhibitors
TWI349664B (en) 2003-09-22 2011-10-01 S Bio Pte Ltd Benzimidazole derivatives: preparation and pharmaceutical applications
WO2005065681A1 (en) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer
US20050137234A1 (en) * 2003-12-19 2005-06-23 Syrrx, Inc. Histone deacetylase inhibitors
WO2006101456A1 (en) 2005-03-21 2006-09-28 S*Bio Pte Ltd Bicyclic heterocycles hydroxamate compounds useful as histone deacetylase (hdac) inhibitors
US8143282B2 (en) 2005-09-08 2012-03-27 S*Bio Pte Ltd. Heterocyclic compounds
EP3449923A1 (de) 2007-03-07 2019-03-06 MEI Pharma, Inc. Kombination eines benzimidazol-anti-krebs-mittels mit einem zweiten anti-krebs-mittel
RS60122B1 (sr) 2012-10-30 2020-05-29 Mei Pharma Inc Kombinovane terapije za lečenje hemorezistentnih kancera

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