BRPI0414581B8 - composto, composição farmacêutica compreendendo o referido composto e uso do referido composto - Google Patents

composto, composição farmacêutica compreendendo o referido composto e uso do referido composto Download PDF

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Publication number
BRPI0414581B8
BRPI0414581B8 BRPI0414581A BRPI0414581A BRPI0414581B8 BR PI0414581 B8 BRPI0414581 B8 BR PI0414581B8 BR PI0414581 A BRPI0414581 A BR PI0414581A BR PI0414581 A BRPI0414581 A BR PI0414581A BR PI0414581 B8 BRPI0414581 B8 BR PI0414581B8
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BR
Brazil
Prior art keywords
compound
pharmaceutical composition
compounds
disruption
preparation
Prior art date
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BRPI0414581A
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English (en)
Inventor
Chen Dizhong
T Sun Eric
Yan Song Hong
Sangthongpitag Kanda
Yu Niefang
Deng Weiping
Zou Yong
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Mei Pharma Inc
Sstarbio Pte Ltd
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Application filed by Mei Pharma Inc, Sstarbio Pte Ltd filed Critical Mei Pharma Inc
Publication of BRPI0414581A publication Critical patent/BRPI0414581A/pt
Publication of BRPI0414581B1 publication Critical patent/BRPI0414581B1/pt
Publication of BRPI0414581B8 publication Critical patent/BRPI0414581B8/pt
Publication of BRPI0414581C1 publication Critical patent/BRPI0414581C1/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

"derivados de benzimidazol: preparação e aplicações farmacêuticas". a presente invenção se refere a compostos de hidroxamato que são inibidores de histona desacetilase. mais especificamente, a presente invenção se refere a compostos contendo benzimidazol a métodos para a usa preparação. estes compostos podem ser úteis como medicamentos para o tratamento de distúrbios proliferativos, assim como de outras doenças abrangendo a desregulação de histona desacetilase (hdac) , ou são relacionadas ou associadas com tal desregulação.
BRPI0414581A 2003-09-22 2004-09-21 composto, composição farmacêutica compreendendo o referido composto e uso do referido composto BRPI0414581C1 (pt)

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US20100256138A1 (en) 2010-10-07
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TWI349664B (en) 2011-10-01
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US20170360757A1 (en) 2017-12-21
WO2005028447A1 (en) 2005-03-31
JP5042626B2 (ja) 2012-10-03
BRPI0414581A (pt) 2006-11-07
ATE472534T1 (de) 2010-07-15
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US10736881B2 (en) 2020-08-11
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US20140005194A1 (en) 2014-01-02
NZ545864A (en) 2009-12-24
US7781595B2 (en) 2010-08-24
DE602004027932D1 (de) 2010-08-12
KR20070030162A (ko) 2007-03-15
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