DK1979328T3 - Pyridin- og pyrimidinderivater i deres egenskab af histondeacetylasehæmmere - Google Patents
Pyridin- og pyrimidinderivater i deres egenskab af histondeacetylasehæmmereInfo
- Publication number
- DK1979328T3 DK1979328T3 DK07703894.1T DK07703894T DK1979328T3 DK 1979328 T3 DK1979328 T3 DK 1979328T3 DK 07703894 T DK07703894 T DK 07703894T DK 1979328 T3 DK1979328 T3 DK 1979328T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyridine
- histone deacetylase
- pyrimidine derivatives
- deacetylase inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06100571 | 2006-01-19 | ||
| PCT/EP2007/050379 WO2007082880A1 (en) | 2006-01-19 | 2007-01-16 | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1979328T3 true DK1979328T3 (da) | 2013-03-25 |
Family
ID=36499299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07703894.1T DK1979328T3 (da) | 2006-01-19 | 2007-01-16 | Pyridin- og pyrimidinderivater i deres egenskab af histondeacetylasehæmmere |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7888360B2 (da) |
| EP (1) | EP1979328B1 (da) |
| JP (1) | JP5261192B2 (da) |
| CN (1) | CN101370791B (da) |
| AU (1) | AU2007206948B2 (da) |
| CA (1) | CA2633100C (da) |
| DK (1) | DK1979328T3 (da) |
| ES (1) | ES2402213T3 (da) |
| HK (1) | HK1128284A1 (da) |
| WO (1) | WO2007082880A1 (da) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL214279B1 (pl) | 2002-03-13 | 2013-07-31 | Janssen Pharmaceutica Nv | Pochodna sulfonyloaminowa, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania |
| EP1485099B1 (en) | 2002-03-13 | 2010-07-07 | Janssen Pharmaceutica N.V. | Inhibitors of histone deacetylase |
| US7592450B2 (en) * | 2002-03-13 | 2009-09-22 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as inhibitors of histone deacetylase |
| OA12789A (en) | 2002-03-13 | 2006-07-10 | Janssen Pharmaceutica Nv | Carbonylamino-derivatives as novel inhibitors of histone deacetylase. |
| PL1781639T3 (pl) | 2004-07-28 | 2012-07-31 | Janssen Pharmaceutica Nv | Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej |
| RS51189B (sr) * | 2004-07-28 | 2010-10-31 | Janssen Pharmaceutica N.V. | Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
| JP5055268B2 (ja) | 2005-05-18 | 2012-10-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としての置換されたアミノプロペニルピペリジンまたはモルホリン誘導体 |
| EP1943232B1 (en) * | 2005-10-27 | 2011-05-18 | Janssen Pharmaceutica NV | Squaric acid derivatives as inhibitors of histone deacetylase |
| CN101370803B (zh) | 2006-01-19 | 2012-12-12 | 詹森药业有限公司 | 作为组蛋白脱乙酰酶抑制剂的取代的吲哚基-烷基-氨基衍生物 |
| JP5247470B2 (ja) | 2006-01-19 | 2013-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体 |
| PL1981874T3 (pl) | 2006-01-19 | 2009-10-30 | Janssen Pharmaceutica Nv | Pochodne aminofenylowe jako nowe inhibitory deacetylazy histonowej |
| ES2402213T3 (es) | 2006-01-19 | 2013-04-29 | Janssen Pharmaceutica N.V. | Derivados de piridina y pirimidina como inhibidores de histona desacetilasa |
| US8101616B2 (en) | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| KR20100095430A (ko) * | 2007-11-02 | 2010-08-30 | 메틸진 인크. | 히스톤 탈아세틸화효소의 저해물질 |
| WO2009118370A1 (en) | 2008-03-27 | 2009-10-01 | Janssen Pharmaceutica Nv | Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
| MX2011007326A (es) | 2009-01-08 | 2011-10-19 | Curis Inc | Inhibidores de fosfoinositida 3-quinasa con una porcion de enlace de cinc. |
| US8609672B2 (en) | 2010-08-27 | 2013-12-17 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| CN102153606B (zh) * | 2011-02-25 | 2013-07-17 | 连云港笃翔化工有限公司 | 核苷衍生物与其立体异构体及药学上可接受的盐与用途 |
| EP2683371B1 (en) | 2011-03-09 | 2020-10-21 | Cereno Scientific AB | Compounds and methods for improving impaired endogenous fibrinolysis using histone deacetylase inhibitors |
| PL2694075T3 (pl) | 2011-04-01 | 2016-09-30 | Inhibitor 3-kinazy fosfoinozytydowej z grupą wiążącą cynk | |
| EA202190748A1 (ru) | 2018-09-11 | 2021-07-22 | Кьюрис Инк. | Комбинированная терапия ингибитором фосфоинозитид-3-киназы с цинк-связывающей группировкой |
| CA3113819A1 (en) * | 2018-10-10 | 2020-04-16 | Regenacy Pharmaceuticals, Llc | Pyrimidine and pyrazine hdac1,2 inhibitors |
| WO2023044364A1 (en) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0827742A1 (en) | 1996-09-04 | 1998-03-11 | Vrije Universiteit Brussel | Use of histone deacetylase inhibitors for treating fribosis or cirrhosis |
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| AU2003215112A1 (en) | 2002-02-07 | 2003-09-02 | Axys Pharmaceuticals | Novel bicyclic hydroxamates as inhibitors of histone deacetylase |
| NZ534830A (en) | 2002-03-13 | 2005-08-26 | Janssen Pharmaceutica Nv | Compounds with histone deacetylase HDAC inhibiting activity and oral bioavailability useful for treating proliferative diseases |
| OA12789A (en) | 2002-03-13 | 2006-07-10 | Janssen Pharmaceutica Nv | Carbonylamino-derivatives as novel inhibitors of histone deacetylase. |
| US7592450B2 (en) | 2002-03-13 | 2009-09-22 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as inhibitors of histone deacetylase |
| EP1485099B1 (en) * | 2002-03-13 | 2010-07-07 | Janssen Pharmaceutica N.V. | Inhibitors of histone deacetylase |
| PL214279B1 (pl) * | 2002-03-13 | 2013-07-31 | Janssen Pharmaceutica Nv | Pochodna sulfonyloaminowa, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania |
| EP1485378B1 (en) | 2002-03-13 | 2008-06-18 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
| AU2003229883B2 (en) | 2002-04-03 | 2009-06-11 | Topotarget Uk Limited | Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors |
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| GB0209715D0 (en) * | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| DE10233412A1 (de) | 2002-07-23 | 2004-02-12 | 4Sc Ag | Neue Verbindungen als Histondeacetylase-Inhibitoren |
| PL374970A1 (en) | 2002-08-02 | 2005-11-14 | Argenta Discovery Limited | Substituted thienyl-hydroxamic acids as histone deacetylase inhibitors |
| ITMI20030025A1 (it) | 2003-01-10 | 2004-07-11 | Italfarmaco Spa | Derivati dell'acido idrossammico ad attivita' antinfiammatoria. |
| TW200418806A (en) | 2003-01-13 | 2004-10-01 | Fujisawa Pharmaceutical Co | HDAC inhibitor |
| TW200424174A (en) | 2003-02-06 | 2004-11-16 | Hoffmann La Roche | New TP diamide |
| AU2003900608A0 (en) | 2003-02-11 | 2003-02-27 | Fujisawa Pharmaceutical Co., Ltd. | Hdac inhibitor |
| US7244751B2 (en) | 2003-02-14 | 2007-07-17 | Shenzhen Chipscreen Biosciences Ltd. | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity |
| WO2004082638A2 (en) | 2003-03-17 | 2004-09-30 | Syrrx, Inc. | Histone deacetylase inhibitors |
| TW200424187A (en) | 2003-04-04 | 2004-11-16 | Hoffmann La Roche | New oxime derivatives and their use as pharmaceutically active agents |
| EA200501570A1 (ru) | 2003-04-07 | 2006-06-30 | Аксис Фармасьютикалз, Инк. | Новые гидроксаматы как лечебные средства |
| NZ545864A (en) | 2003-09-22 | 2009-12-24 | S Bio Pte Ltd | Benzimidazole derivates: preparation and pharmaceutical applications |
| EP1663953A1 (en) | 2003-09-24 | 2006-06-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US20070167499A1 (en) | 2003-10-27 | 2007-07-19 | A*Bio Pte Ltd. | Biaryl linked hydroxamates: preparation and pharmaceutical applications |
| EP1685094A4 (en) | 2003-10-27 | 2007-08-22 | S Bio Pte Ltd | HYDROXAMATES CONNECTED TO ACYLUREE AND SULFONYLUREE |
| GB0402496D0 (en) | 2004-02-04 | 2004-03-10 | Argenta Discovery Ltd | Novel compounds |
| US20050197336A1 (en) | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
| KR101258504B1 (ko) | 2004-03-26 | 2013-04-26 | 메틸진 인코포레이티드 | 히스톤 데아세틸라제의 억제제 |
| RS51189B (sr) | 2004-07-28 | 2010-10-31 | Janssen Pharmaceutica N.V. | Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
| JP5055268B2 (ja) | 2005-05-18 | 2012-10-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としての置換されたアミノプロペニルピペリジンまたはモルホリン誘導体 |
| AU2006260961B2 (en) | 2005-06-23 | 2011-08-11 | Janssen Pharmaceutica N.V. | Imidazolinone and hydantoine derivatives as novel inhibitors of histone deacetylase |
| EP1943232B1 (en) | 2005-10-27 | 2011-05-18 | Janssen Pharmaceutica NV | Squaric acid derivatives as inhibitors of histone deacetylase |
| ATE539073T1 (de) | 2006-01-19 | 2012-01-15 | Janssen Pharmaceutica Nv | Heterocyclylalkylderivate als neue inhibitoren von histondeacetylase |
| JP5247470B2 (ja) | 2006-01-19 | 2013-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体 |
| PL1981874T3 (pl) | 2006-01-19 | 2009-10-30 | Janssen Pharmaceutica Nv | Pochodne aminofenylowe jako nowe inhibitory deacetylazy histonowej |
| US8101616B2 (en) | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| ES2402213T3 (es) | 2006-01-19 | 2013-04-29 | Janssen Pharmaceutica N.V. | Derivados de piridina y pirimidina como inhibidores de histona desacetilasa |
| CN101370803B (zh) | 2006-01-19 | 2012-12-12 | 詹森药业有限公司 | 作为组蛋白脱乙酰酶抑制剂的取代的吲哚基-烷基-氨基衍生物 |
-
2007
- 2007-01-16 ES ES07703894T patent/ES2402213T3/es active Active
- 2007-01-16 AU AU2007206948A patent/AU2007206948B2/en not_active Ceased
- 2007-01-16 DK DK07703894.1T patent/DK1979328T3/da active
- 2007-01-16 EP EP07703894A patent/EP1979328B1/en active Active
- 2007-01-16 CN CN2007800030166A patent/CN101370791B/zh active Active
- 2007-01-16 US US12/160,156 patent/US7888360B2/en active Active
- 2007-01-16 WO PCT/EP2007/050379 patent/WO2007082880A1/en active Application Filing
- 2007-01-16 JP JP2008550743A patent/JP5261192B2/ja active Active
- 2007-01-16 CA CA2633100A patent/CA2633100C/en active Active
-
2009
- 2009-06-26 HK HK09105786.8A patent/HK1128284A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009525959A (ja) | 2009-07-16 |
| CN101370791B (zh) | 2012-05-02 |
| JP5261192B2 (ja) | 2013-08-14 |
| AU2007206948B2 (en) | 2012-08-23 |
| EP1979328A1 (en) | 2008-10-15 |
| ES2402213T3 (es) | 2013-04-29 |
| CA2633100C (en) | 2014-12-09 |
| EP1979328B1 (en) | 2012-12-26 |
| CA2633100A1 (en) | 2007-07-26 |
| HK1128284A1 (en) | 2009-10-23 |
| US20090036463A1 (en) | 2009-02-05 |
| AU2007206948A1 (en) | 2007-07-26 |
| US7888360B2 (en) | 2011-02-15 |
| WO2007082880A1 (en) | 2007-07-26 |
| CN101370791A (zh) | 2009-02-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1979328T3 (da) | Pyridin- og pyrimidinderivater i deres egenskab af histondeacetylasehæmmere | |
| DK1979326T3 (da) | Pyridin- og pyrimidinderivater som inhibitorer af histondeacetylase | |
| HK1128282A1 (en) | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase | |
| NO20091423L (no) | Pyrimidinderivater og deres anvendelse som kinaseinhibitorer | |
| DK1981875T3 (da) | Substituerede indolylalkylaminoderivater som inhibitorer af histondeacetylase | |
| DK2848610T3 (da) | Hæmmere af kinaseaktivitet | |
| CR10369A (es) | Pyrimidine derivatives as pi3k inhibitors | |
| DK2015754T3 (da) | Anvendelse af dpp-iv-inhibitorer | |
| DK2332909T3 (da) | Hydroxybenzamidderivater og deres anvendelse som inhibitorer af hsp90 | |
| EP2170339A4 (en) | PYRIDYL AND PYRIMIDINYL DERIVATIVES AS HISTONDEACETYLASE INHIBITORS | |
| DK2121614T3 (da) | Aminonikotin og isonikotinsyrederivater som dhodh-inhibitorer | |
| DK2117523T3 (da) | Inhibitorer af AKT-aktivitet | |
| DK2089361T5 (da) | Inhibitorer af natriumglucose-cotransportør 2 og fremgangsmåder til deres anvendelse | |
| DK1989206T3 (da) | E1-aktiveringsenzymhæmmere | |
| NO20084764L (no) | Tioksantinderivater og deres anvendelse som MPO inhibitorer | |
| SMP200800048B (it) | Derivati pirimidinici utilizzati come inibitori dip13-chinasi | |
| DK1981892T3 (da) | Thienopyridinderivater som mek-inhibitorer | |
| BRPI0817860A2 (pt) | inibidores de histona deacetilase | |
| CY2014011I1 (el) | Χορηγηση αναστολεων διπεπτιδυλοπεπτιδασης | |
| DK1898903T3 (da) | Inhibitorer af Akt-aktivitet | |
| BRPI0908906A2 (pt) | compostos heterocíclicos e usos dos mesmos | |
| DK2099447T3 (da) | Imidazotriaziner og imidazopyrimidiner som kinaseinhibitorer | |
| DK2252597T3 (da) | Pyrazinderivater og deres anvendelse som proteinkinaseinhibitorer | |
| DK2439205T3 (da) | Carboxamidforbindelser og deres anvendelse som calpaininhibitorer | |
| DK2091945T3 (da) | Nye inhibitorer af glutaminylcyclase |