DE602004002275D1 - Verfahren zur herstellung rekombinanterpolyklonaler proteine - Google Patents
Verfahren zur herstellung rekombinanterpolyklonaler proteineInfo
- Publication number
- DE602004002275D1 DE602004002275D1 DE602004002275T DE602004002275T DE602004002275D1 DE 602004002275 D1 DE602004002275 D1 DE 602004002275D1 DE 602004002275 T DE602004002275 T DE 602004002275T DE 602004002275 T DE602004002275 T DE 602004002275T DE 602004002275 D1 DE602004002275 D1 DE 602004002275D1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- collection
- library
- nucleic acid
- recombinant polyclonal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 150000007523 nucleic acids Chemical group 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012228 culture supernatant Substances 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000001890 transfection Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43840303P | 2003-01-07 | 2003-01-07 | |
DKPA200300008 | 2003-01-07 | ||
US438403P | 2003-01-07 | ||
DK200300008 | 2003-01-07 | ||
US47601803P | 2003-06-05 | 2003-06-05 | |
US476018P | 2003-06-05 | ||
PCT/DK2004/000001 WO2004061104A2 (en) | 2003-01-07 | 2004-01-07 | Method for manufacturing recombinant polyclonal proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
DE602004002275D1 true DE602004002275D1 (de) | 2006-10-19 |
DE602004002275T2 DE602004002275T2 (de) | 2007-09-06 |
Family
ID=32718469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004002275T Expired - Lifetime DE602004002275T2 (de) | 2003-01-07 | 2004-01-07 | Verfahren zur herstellung rekombinanterpolyklonaler proteine |
Country Status (19)
Country | Link |
---|---|
US (1) | US9163232B2 (de) |
EP (2) | EP1762617A1 (de) |
JP (2) | JP4589914B2 (de) |
KR (1) | KR101024443B1 (de) |
AT (1) | ATE338816T1 (de) |
AU (1) | AU2004203727C1 (de) |
BR (1) | BRPI0406678A (de) |
CA (1) | CA2512647C (de) |
DE (1) | DE602004002275T2 (de) |
DK (1) | DK1583830T3 (de) |
EA (1) | EA013225B1 (de) |
ES (1) | ES2273202T3 (de) |
HK (1) | HK1078896A1 (de) |
IL (1) | IL169101A (de) |
MX (1) | MXPA05006724A (de) |
NZ (1) | NZ541458A (de) |
PT (1) | PT1583830E (de) |
SI (1) | SI1583830T1 (de) |
WO (1) | WO2004061104A2 (de) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2872136C (en) | 2002-07-18 | 2017-06-20 | Merus B.V. | Recombinant production of mixtures of antibodies |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
CA2512647C (en) | 2003-01-07 | 2013-10-08 | Symphogen A/S | Method for manufacturing recombinant polyclonal proteins |
TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
EP1771483A1 (de) | 2004-07-20 | 2007-04-11 | Symphogen A/S | Rekombinanter polyklonaler anti-rhesus-d-antikörper und herstellungsverfahren |
ATE548657T1 (de) * | 2004-07-20 | 2012-03-15 | Symphogen As | Prozedur zur strukturellen charakterisierung rekombinanter polyclonaler proteine oder einer polyclonalen zelllinie |
EP1907561B1 (de) | 2005-06-24 | 2013-08-28 | Unigene Laboratories, Inc. | Zellinien zur expression eines bei der herstellung amidierter produkte geeigneten enzyms |
JP2009518320A (ja) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
KR20080113223A (ko) * | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
US7504106B2 (en) | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
FR2910490B1 (fr) * | 2006-12-20 | 2012-10-26 | Lab Francais Du Fractionnement | Lignee cellulaire a forte activite transcriptionnelle pour la production de proteines, notamment therapeutiques |
US10155038B2 (en) | 2007-02-02 | 2018-12-18 | Yale University | Cells prepared by transient transfection and methods of use thereof |
US8859229B2 (en) * | 2007-02-02 | 2014-10-14 | Yale University | Transient transfection with RNA |
US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
TW200846362A (en) * | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
ES2369946T3 (es) | 2007-03-01 | 2011-12-09 | Symphogen A/S | Procedimiento para clonación de anticuerpos análogos. |
DK2132229T3 (en) | 2007-03-01 | 2016-06-20 | Symphogen As | Recombinant anti-epidermal growth factor receptor-ANTIBODY COMPOSITIONS |
CA2678628A1 (en) | 2007-03-06 | 2008-09-12 | Symphogen A/S | Recombinant antibodies for treatment of respiratory syncytial virus infections |
BRPI0812091A2 (pt) | 2007-05-25 | 2014-10-14 | Symphogen As | Método para fabricar uma proteína policlonal recombinante |
HUE032301T2 (en) | 2007-08-30 | 2017-09-28 | Daiichi Sankyo Co Ltd | Anti-EPHA2 antibody |
EP2725035A1 (de) | 2007-10-02 | 2014-04-30 | Avaxia Biologics, Inc. | Antikörpertherapie zur Verwendung im Verdauungstrakt |
SI2206727T1 (sl) | 2007-10-11 | 2015-06-30 | Daiichi Sankyo Company, Limited | Protitelo, ki cilja osteoklast - soroden protein Siglec-15 |
CA2722348A1 (en) * | 2008-04-23 | 2009-10-29 | Symphogen A/S | Methods for manufacturing a polyclonal protein |
KR20110058861A (ko) * | 2008-08-29 | 2011-06-01 | 심포젠 에이/에스 | 조류 유래 항체의 클로닝 방법 |
KR101706255B1 (ko) | 2008-08-29 | 2017-02-14 | 심포젠 에이/에스 | 재조합 항-표피 성장 인자 수용체 항체 조성물 |
US8575316B2 (en) | 2009-04-09 | 2013-11-05 | Daiichi Sankyo Company, Limited | Anti-Siglec-15 antibody |
KR20120098664A (ko) | 2009-10-15 | 2012-09-05 | 아바시아 바이오로직스, 인크. | 소화 기관에서 국소 활성을 가진 항체 치료법 |
KR101814852B1 (ko) | 2010-10-29 | 2018-01-04 | 다이이찌 산쿄 가부시키가이샤 | 신규 항 dr5 항체 |
EP2635604B1 (de) | 2010-11-01 | 2016-11-30 | Symphogen A/S | Pan-her-antikörperzusammensetzung |
WO2012068317A2 (en) | 2010-11-16 | 2012-05-24 | Excelimmune, Inc. | Methods for producing recombinant proteins |
DK2703486T3 (en) | 2011-04-25 | 2018-05-28 | Daiichi Sankyo Co Ltd | ANTI-B7-H3 ANTIBODY |
SG10201601882PA (en) | 2011-12-22 | 2016-04-28 | Hoffmann La Roche | Expression Vector Organization, Novel Production Cell Generation Methods And Their Use For The Recombinant Production Of Polypeptides |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
EP2832855A4 (de) | 2012-03-30 | 2016-02-24 | Daiichi Sankyo Co Ltd | Neuartiger anti-siglec-15-antikörper |
ES2660472T3 (es) | 2012-03-30 | 2018-03-22 | Daiichi Sankyo Company, Limited | Anticuerpo anti-Siglec-15 modificado con CDR |
JP6188681B2 (ja) | 2012-04-09 | 2017-08-30 | 第一三共株式会社 | 抗fgfr2抗体 |
ES2743399T3 (es) | 2012-04-20 | 2020-02-19 | Merus Nv | Métodos y medios para la producción de moléculas heterodiméricas similares a Ig |
AU2013254313B2 (en) | 2012-04-27 | 2017-03-30 | Daiichi Sankyo Company, Limited | Anti-ROBO4-antibody |
AU2013255537B2 (en) | 2012-05-02 | 2018-02-15 | Symphogen A/S | Humanized pan-her antibody compositions |
JP2015163047A (ja) * | 2012-06-20 | 2015-09-10 | 国立大学法人 東京大学 | タンパク質の迅速改良法 |
CN104736174B (zh) | 2012-07-06 | 2019-06-14 | 根马布私人有限公司 | 具有三重突变的二聚体蛋白质 |
EP3470431A1 (de) | 2012-09-27 | 2019-04-17 | Merus N.V. | Bispezifische igg-antikörper als t-zell-engager |
JP2016514091A (ja) | 2013-02-08 | 2016-05-19 | ミスフォールディング ダイアグノスティクス, インコーポレイテッド | トランスサイレチン抗体およびその使用 |
MX2016003643A (es) | 2013-09-30 | 2016-12-20 | Daiichi Sankyo Co Ltd | Anticuerpo anti-lps o11. |
TWI664977B (zh) | 2013-10-08 | 2019-07-11 | 第一三共股份有限公司 | 抗fgfr2抗體及其與其他藥劑之組合 |
WO2015093925A1 (es) * | 2013-12-19 | 2015-06-25 | CASTRO ALDRETE, Jorge Isaac | Método de producción de anticuerpos específicos |
WO2015130172A1 (en) | 2014-02-28 | 2015-09-03 | Merus B.V. | Antibodies that bind egfr and erbb3 |
US11279770B2 (en) | 2014-02-28 | 2022-03-22 | Merus N.V. | Antibody that binds ErbB-2 and ErbB-3 |
CA2961323C (en) | 2014-09-16 | 2021-11-30 | Symphogen A/S | Anti-met antibodies and compositions |
ES2904573T3 (es) | 2015-03-27 | 2022-04-05 | Univ Southern California | Terapia con células T dirigida a LHR para el tratamiento de tumores sólidos |
CN107847601A (zh) | 2015-06-04 | 2018-03-27 | 南加利福尼亚大学 | Lym‑1和lym‑2靶向的car细胞免疫疗法 |
DK3115376T3 (en) | 2015-07-10 | 2018-11-26 | Merus Nv | HUMANT CD3 BINDING ANTIBODY |
WO2017053889A2 (en) | 2015-09-23 | 2017-03-30 | Precision Immunotherapy, Inc. | Flt3 directed car cells for immunotherapy |
TWI836305B (zh) | 2015-09-24 | 2024-03-21 | 日商第一三共股份有限公司 | 抗garp抗體及其製造方法及用途 |
CN108602888B (zh) | 2015-10-23 | 2022-10-04 | 美勒斯公司 | 抑制癌症生长的结合分子 |
CN109475627B (zh) * | 2016-05-26 | 2023-01-06 | 齐鲁普吉湾生物治疗公司 | 抗体混合物 |
US11618785B2 (en) | 2016-12-22 | 2023-04-04 | Daiichi Sankyo Company, Limited | Anti-CD3 antibody and molecules comprising the antibody |
AU2018218753A1 (en) | 2017-02-07 | 2019-09-26 | Daiichi Sankyo Company, Limited | Anti-GPRC5D antibody and molecule containing same |
TWI782000B (zh) | 2017-03-30 | 2022-11-01 | 日商第一三共股份有限公司 | 抗gpr20抗體、其製造方法及其應用 |
AU2018246873B2 (en) | 2017-03-31 | 2021-05-06 | Merus N.V. | ErbB-2 and ErbB3 binding bispecific antibodies for use in the treatment f cells that have an NRG1 fusion gene |
PE20191741A1 (es) | 2017-04-05 | 2019-12-12 | Symphogen As | Terapias combinadas dirigidas a pd-1, tim-3, y lag-3 |
JP7181535B2 (ja) | 2017-06-30 | 2022-12-01 | 国立大学法人北海道大学 | 成長障害を生じない小児骨粗鬆症治療薬 |
SG11202000759XA (en) | 2017-07-27 | 2020-02-27 | Daiichi Sankyo Co Ltd | Anti-cd147 antibody |
SG11202001050PA (en) | 2017-08-09 | 2020-03-30 | Merus Nv | Antibodies that bind egfr and cmet |
TW201927336A (zh) | 2017-10-05 | 2019-07-16 | 日商第一三共股份有限公司 | 細胞毒性t細胞耗竭用組成物 |
JP7419248B2 (ja) | 2017-12-11 | 2024-01-22 | アバローニー バイオ,インコーポレーテッド | ペリプラズム空間中におけるタンパク質の酵母ディスプレイ |
CA3093205A1 (en) | 2018-03-05 | 2019-09-12 | Saitama Medical University | Pharmaceutical composition for treating or preventing heterotopic ossification |
KR20210018192A (ko) | 2018-05-31 | 2021-02-17 | 다이이찌 산쿄 가부시키가이샤 | 항인간 tlr7 항체 |
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AU2004203727A1 (en) | 2004-07-22 |
EP1583830A2 (de) | 2005-10-12 |
NZ541458A (en) | 2006-04-28 |
AU2004203727C1 (en) | 2008-08-21 |
KR101024443B1 (ko) | 2011-03-23 |
KR20050101538A (ko) | 2005-10-24 |
CA2512647A1 (en) | 2004-07-22 |
US20090136498A1 (en) | 2009-05-28 |
IL169101A (en) | 2009-02-11 |
EP1762617A1 (de) | 2007-03-14 |
HK1078896A1 (en) | 2006-03-24 |
WO2004061104A2 (en) | 2004-07-22 |
AU2004203727B2 (en) | 2008-01-31 |
ES2273202T3 (es) | 2007-05-01 |
DK1583830T3 (da) | 2007-01-15 |
EA013225B1 (ru) | 2010-04-30 |
JP2006515520A (ja) | 2006-06-01 |
BRPI0406678A (pt) | 2005-12-20 |
CA2512647C (en) | 2013-10-08 |
EA200501101A1 (ru) | 2006-02-24 |
PT1583830E (pt) | 2006-11-30 |
EP1583830B1 (de) | 2006-09-06 |
ATE338816T1 (de) | 2006-09-15 |
MXPA05006724A (es) | 2005-09-08 |
SI1583830T1 (sl) | 2006-12-31 |
JP4589914B2 (ja) | 2010-12-01 |
US9163232B2 (en) | 2015-10-20 |
JP2010268806A (ja) | 2010-12-02 |
DE602004002275T2 (de) | 2007-09-06 |
WO2004061104A3 (en) | 2004-11-04 |
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