DE60116855T2 - Oxy- und aminosubstituierte tetrahydrofurylderivate mit antitumoraktivität - Google Patents

Oxy- und aminosubstituierte tetrahydrofurylderivate mit antitumoraktivität Download PDF

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Publication number
DE60116855T2
DE60116855T2 DE60116855T DE60116855T DE60116855T2 DE 60116855 T2 DE60116855 T2 DE 60116855T2 DE 60116855 T DE60116855 T DE 60116855T DE 60116855 T DE60116855 T DE 60116855T DE 60116855 T2 DE60116855 T2 DE 60116855T2
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DE
Germany
Prior art keywords
substituted
unsubstituted
compound
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60116855T
Other languages
German (de)
English (en)
Other versions
DE60116855D1 (de
Inventor
Tatsuo Higa
Junichi Tanaka
Dolores Garcia Gravalos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0003629A external-priority patent/GB0003629D0/en
Priority claimed from GB0021774A external-priority patent/GB0021774D0/en
Application filed by Pharmamar SA filed Critical Pharmamar SA
Publication of DE60116855D1 publication Critical patent/DE60116855D1/de
Application granted granted Critical
Publication of DE60116855T2 publication Critical patent/DE60116855T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Furan Compounds (AREA)
DE60116855T 2000-02-16 2001-02-16 Oxy- und aminosubstituierte tetrahydrofurylderivate mit antitumoraktivität Expired - Lifetime DE60116855T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0003629A GB0003629D0 (en) 2000-02-16 2000-02-16 Antitumour agent
GB0003629 2000-02-16
GB0021774 2000-09-05
GB0021774A GB0021774D0 (en) 2000-09-05 2000-09-05 Anti-tumour compound
PCT/GB2001/000655 WO2001060810A1 (en) 2000-02-16 2001-02-16 Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity

Publications (2)

Publication Number Publication Date
DE60116855D1 DE60116855D1 (de) 2006-04-13
DE60116855T2 true DE60116855T2 (de) 2006-09-14

Family

ID=26243662

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60116855T Expired - Lifetime DE60116855T2 (de) 2000-02-16 2001-02-16 Oxy- und aminosubstituierte tetrahydrofurylderivate mit antitumoraktivität

Country Status (17)

Country Link
US (1) US6864283B2 (enExample)
EP (1) EP1255746B1 (enExample)
JP (1) JP2003523338A (enExample)
KR (1) KR20020092958A (enExample)
CN (1) CN1318409C (enExample)
AT (1) ATE316524T1 (enExample)
AU (2) AU2001233873B2 (enExample)
BR (1) BR0108448A (enExample)
CA (1) CA2400612C (enExample)
CZ (1) CZ20022791A3 (enExample)
DE (1) DE60116855T2 (enExample)
ES (1) ES2256199T3 (enExample)
IL (1) IL151241A (enExample)
MX (1) MXPA02007995A (enExample)
PL (1) PL357193A1 (enExample)
RU (1) RU2002124591A (enExample)
WO (1) WO2001060810A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001233873B2 (en) 2000-02-16 2006-03-02 Pharma Mar, S.A. Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity
CN102229585A (zh) * 2011-04-26 2011-11-02 中国人民解放军第二军医大学 具有抗肿瘤活性的γ-丁内酯聚酮类化合物
LT3615544T (lt) 2017-04-27 2023-05-10 Pharma Mar S.A. Priešnavikiniai junginiai

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583160A (en) * 1989-02-03 1996-12-10 The Biomembrane Institute Methylsphingosine used to treat apoptosis
CA2007507C (en) * 1989-02-03 1998-05-19 Yasuyuki Igarashi Sphingosine and n-methyl-sphingosine as inhibitor of cell growth
US6107520A (en) * 1997-04-15 2000-08-22 The Board Of Trustees Of The University Of Illinois Spisulosine compounds
AU2001233873B2 (en) 2000-02-16 2006-03-02 Pharma Mar, S.A. Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity

Also Published As

Publication number Publication date
EP1255746A1 (en) 2002-11-13
WO2001060810A1 (en) 2001-08-23
US20030092738A1 (en) 2003-05-15
ES2256199T3 (es) 2006-07-16
AU3387301A (en) 2001-08-27
AU2001233873B2 (en) 2006-03-02
RU2002124591A (ru) 2004-01-10
DE60116855D1 (de) 2006-04-13
CA2400612A1 (en) 2001-08-23
CA2400612C (en) 2010-05-11
CN1423642A (zh) 2003-06-11
US6864283B2 (en) 2005-03-08
KR20020092958A (ko) 2002-12-12
JP2003523338A (ja) 2003-08-05
BR0108448A (pt) 2003-04-01
MXPA02007995A (es) 2003-05-23
CZ20022791A3 (cs) 2003-02-12
WO2001060810B1 (en) 2001-11-29
EP1255746B1 (en) 2006-01-25
PL357193A1 (en) 2004-07-26
CN1318409C (zh) 2007-05-30
ATE316524T1 (de) 2006-02-15
IL151241A (en) 2006-10-31

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