BR0108448A - Derivados de tetraidrofuril óxi-e amino-substituìdos com atividade antitumor - Google Patents
Derivados de tetraidrofuril óxi-e amino-substituìdos com atividade antitumorInfo
- Publication number
- BR0108448A BR0108448A BR0108448-8A BR0108448A BR0108448A BR 0108448 A BR0108448 A BR 0108448A BR 0108448 A BR0108448 A BR 0108448A BR 0108448 A BR0108448 A BR 0108448A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- unsubstituted
- amino
- antitumor activity
- alkenyl
- Prior art date
Links
- -1 Amino-substituted tetrahydrofuryl Chemical group 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 125000006702 (C1-C18) alkyl group Chemical group 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 5
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0003629A GB0003629D0 (en) | 2000-02-16 | 2000-02-16 | Antitumour agent |
| GB0021774A GB0021774D0 (en) | 2000-09-05 | 2000-09-05 | Anti-tumour compound |
| PCT/GB2001/000655 WO2001060810A1 (en) | 2000-02-16 | 2001-02-16 | Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0108448A true BR0108448A (pt) | 2003-04-01 |
Family
ID=26243662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0108448-8A BR0108448A (pt) | 2000-02-16 | 2001-02-16 | Derivados de tetraidrofuril óxi-e amino-substituìdos com atividade antitumor |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6864283B2 (enExample) |
| EP (1) | EP1255746B1 (enExample) |
| JP (1) | JP2003523338A (enExample) |
| KR (1) | KR20020092958A (enExample) |
| CN (1) | CN1318409C (enExample) |
| AT (1) | ATE316524T1 (enExample) |
| AU (2) | AU2001233873B2 (enExample) |
| BR (1) | BR0108448A (enExample) |
| CA (1) | CA2400612C (enExample) |
| CZ (1) | CZ20022791A3 (enExample) |
| DE (1) | DE60116855T2 (enExample) |
| ES (1) | ES2256199T3 (enExample) |
| IL (1) | IL151241A (enExample) |
| MX (1) | MXPA02007995A (enExample) |
| PL (1) | PL357193A1 (enExample) |
| RU (1) | RU2002124591A (enExample) |
| WO (1) | WO2001060810A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001233873B2 (en) | 2000-02-16 | 2006-03-02 | Pharma Mar, S.A. | Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity |
| CN102229585A (zh) * | 2011-04-26 | 2011-11-02 | 中国人民解放军第二军医大学 | 具有抗肿瘤活性的γ-丁内酯聚酮类化合物 |
| LT3615544T (lt) | 2017-04-27 | 2023-05-10 | Pharma Mar S.A. | Priešnavikiniai junginiai |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5583160A (en) * | 1989-02-03 | 1996-12-10 | The Biomembrane Institute | Methylsphingosine used to treat apoptosis |
| CA2007507C (en) * | 1989-02-03 | 1998-05-19 | Yasuyuki Igarashi | Sphingosine and n-methyl-sphingosine as inhibitor of cell growth |
| US6107520A (en) * | 1997-04-15 | 2000-08-22 | The Board Of Trustees Of The University Of Illinois | Spisulosine compounds |
| AU2001233873B2 (en) | 2000-02-16 | 2006-03-02 | Pharma Mar, S.A. | Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity |
-
2001
- 2001-02-16 AU AU2001233873A patent/AU2001233873B2/en not_active Ceased
- 2001-02-16 JP JP2001560195A patent/JP2003523338A/ja active Pending
- 2001-02-16 RU RU2002124591/04A patent/RU2002124591A/ru not_active Application Discontinuation
- 2001-02-16 PL PL01357193A patent/PL357193A1/xx not_active Application Discontinuation
- 2001-02-16 CA CA2400612A patent/CA2400612C/en not_active Expired - Fee Related
- 2001-02-16 WO PCT/GB2001/000655 patent/WO2001060810A1/en not_active Ceased
- 2001-02-16 DE DE60116855T patent/DE60116855T2/de not_active Expired - Lifetime
- 2001-02-16 CN CNB018080421A patent/CN1318409C/zh not_active Expired - Fee Related
- 2001-02-16 AU AU3387301A patent/AU3387301A/xx active Pending
- 2001-02-16 EP EP01905903A patent/EP1255746B1/en not_active Expired - Lifetime
- 2001-02-16 MX MXPA02007995A patent/MXPA02007995A/es active IP Right Grant
- 2001-02-16 ES ES01905903T patent/ES2256199T3/es not_active Expired - Lifetime
- 2001-02-16 CZ CZ20022791A patent/CZ20022791A3/cs unknown
- 2001-02-16 AT AT01905903T patent/ATE316524T1/de not_active IP Right Cessation
- 2001-02-16 BR BR0108448-8A patent/BR0108448A/pt not_active IP Right Cessation
- 2001-02-16 US US10/203,918 patent/US6864283B2/en not_active Expired - Fee Related
- 2001-02-16 KR KR1020027010697A patent/KR20020092958A/ko not_active Ceased
-
2002
- 2002-08-13 IL IL151241A patent/IL151241A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1255746A1 (en) | 2002-11-13 |
| WO2001060810A1 (en) | 2001-08-23 |
| US20030092738A1 (en) | 2003-05-15 |
| ES2256199T3 (es) | 2006-07-16 |
| AU3387301A (en) | 2001-08-27 |
| AU2001233873B2 (en) | 2006-03-02 |
| RU2002124591A (ru) | 2004-01-10 |
| DE60116855D1 (de) | 2006-04-13 |
| CA2400612A1 (en) | 2001-08-23 |
| CA2400612C (en) | 2010-05-11 |
| CN1423642A (zh) | 2003-06-11 |
| US6864283B2 (en) | 2005-03-08 |
| KR20020092958A (ko) | 2002-12-12 |
| DE60116855T2 (de) | 2006-09-14 |
| JP2003523338A (ja) | 2003-08-05 |
| MXPA02007995A (es) | 2003-05-23 |
| CZ20022791A3 (cs) | 2003-02-12 |
| WO2001060810B1 (en) | 2001-11-29 |
| EP1255746B1 (en) | 2006-01-25 |
| PL357193A1 (en) | 2004-07-26 |
| CN1318409C (zh) | 2007-05-30 |
| ATE316524T1 (de) | 2006-02-15 |
| IL151241A (en) | 2006-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7O E 8O ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009 |