MXPA02007995A - Derivados de tetrahidrofurilo sustituidos por oxy y amino con actividad antitumoral. - Google Patents
Derivados de tetrahidrofurilo sustituidos por oxy y amino con actividad antitumoral.Info
- Publication number
- MXPA02007995A MXPA02007995A MXPA02007995A MXPA02007995A MXPA02007995A MX PA02007995 A MXPA02007995 A MX PA02007995A MX PA02007995 A MXPA02007995 A MX PA02007995A MX PA02007995 A MXPA02007995 A MX PA02007995A MX PA02007995 A MXPA02007995 A MX PA02007995A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- alkynyl
- alkenyl
- Prior art date
Links
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- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 1
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- VSEAAEQOQBMPQF-UHFFFAOYSA-N morpholin-3-one Chemical compound O=C1COCCN1 VSEAAEQOQBMPQF-UHFFFAOYSA-N 0.000 description 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
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- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- VYOQBYCIIJYKJA-VORKOXQSSA-N palau'amine Chemical compound N([C@@]12[C@@H](Cl)[C@@H]([C@@H]3[C@@H]2[C@]24N=C(N)N[C@H]2N2C=CC=C2C(=O)N4C3)CN)C(N)=N[C@H]1O VYOQBYCIIJYKJA-VORKOXQSSA-N 0.000 description 1
- FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 description 1
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- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000006413 ring segment Chemical group 0.000 description 1
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- 230000035945 sensitivity Effects 0.000 description 1
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- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
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- 239000012730 sustained-release form Substances 0.000 description 1
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- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 1
- 229940063683 taxotere Drugs 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 description 1
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- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0003629A GB0003629D0 (en) | 2000-02-16 | 2000-02-16 | Antitumour agent |
| GB0021774A GB0021774D0 (en) | 2000-09-05 | 2000-09-05 | Anti-tumour compound |
| PCT/GB2001/000655 WO2001060810A1 (en) | 2000-02-16 | 2001-02-16 | Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA02007995A true MXPA02007995A (es) | 2003-05-23 |
Family
ID=26243662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02007995A MXPA02007995A (es) | 2000-02-16 | 2001-02-16 | Derivados de tetrahidrofurilo sustituidos por oxy y amino con actividad antitumoral. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6864283B2 (enExample) |
| EP (1) | EP1255746B1 (enExample) |
| JP (1) | JP2003523338A (enExample) |
| KR (1) | KR20020092958A (enExample) |
| CN (1) | CN1318409C (enExample) |
| AT (1) | ATE316524T1 (enExample) |
| AU (2) | AU2001233873B2 (enExample) |
| BR (1) | BR0108448A (enExample) |
| CA (1) | CA2400612C (enExample) |
| CZ (1) | CZ20022791A3 (enExample) |
| DE (1) | DE60116855T2 (enExample) |
| ES (1) | ES2256199T3 (enExample) |
| IL (1) | IL151241A (enExample) |
| MX (1) | MXPA02007995A (enExample) |
| PL (1) | PL357193A1 (enExample) |
| RU (1) | RU2002124591A (enExample) |
| WO (1) | WO2001060810A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001233873B2 (en) | 2000-02-16 | 2006-03-02 | Pharma Mar, S.A. | Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity |
| CN102229585A (zh) * | 2011-04-26 | 2011-11-02 | 中国人民解放军第二军医大学 | 具有抗肿瘤活性的γ-丁内酯聚酮类化合物 |
| LT3615544T (lt) | 2017-04-27 | 2023-05-10 | Pharma Mar S.A. | Priešnavikiniai junginiai |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5583160A (en) * | 1989-02-03 | 1996-12-10 | The Biomembrane Institute | Methylsphingosine used to treat apoptosis |
| CA2007507C (en) * | 1989-02-03 | 1998-05-19 | Yasuyuki Igarashi | Sphingosine and n-methyl-sphingosine as inhibitor of cell growth |
| US6107520A (en) * | 1997-04-15 | 2000-08-22 | The Board Of Trustees Of The University Of Illinois | Spisulosine compounds |
| AU2001233873B2 (en) | 2000-02-16 | 2006-03-02 | Pharma Mar, S.A. | Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity |
-
2001
- 2001-02-16 AU AU2001233873A patent/AU2001233873B2/en not_active Ceased
- 2001-02-16 JP JP2001560195A patent/JP2003523338A/ja active Pending
- 2001-02-16 RU RU2002124591/04A patent/RU2002124591A/ru not_active Application Discontinuation
- 2001-02-16 PL PL01357193A patent/PL357193A1/xx not_active Application Discontinuation
- 2001-02-16 CA CA2400612A patent/CA2400612C/en not_active Expired - Fee Related
- 2001-02-16 WO PCT/GB2001/000655 patent/WO2001060810A1/en not_active Ceased
- 2001-02-16 DE DE60116855T patent/DE60116855T2/de not_active Expired - Lifetime
- 2001-02-16 CN CNB018080421A patent/CN1318409C/zh not_active Expired - Fee Related
- 2001-02-16 AU AU3387301A patent/AU3387301A/xx active Pending
- 2001-02-16 EP EP01905903A patent/EP1255746B1/en not_active Expired - Lifetime
- 2001-02-16 MX MXPA02007995A patent/MXPA02007995A/es active IP Right Grant
- 2001-02-16 ES ES01905903T patent/ES2256199T3/es not_active Expired - Lifetime
- 2001-02-16 CZ CZ20022791A patent/CZ20022791A3/cs unknown
- 2001-02-16 AT AT01905903T patent/ATE316524T1/de not_active IP Right Cessation
- 2001-02-16 BR BR0108448-8A patent/BR0108448A/pt not_active IP Right Cessation
- 2001-02-16 US US10/203,918 patent/US6864283B2/en not_active Expired - Fee Related
- 2001-02-16 KR KR1020027010697A patent/KR20020092958A/ko not_active Ceased
-
2002
- 2002-08-13 IL IL151241A patent/IL151241A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1255746A1 (en) | 2002-11-13 |
| WO2001060810A1 (en) | 2001-08-23 |
| US20030092738A1 (en) | 2003-05-15 |
| ES2256199T3 (es) | 2006-07-16 |
| AU3387301A (en) | 2001-08-27 |
| AU2001233873B2 (en) | 2006-03-02 |
| RU2002124591A (ru) | 2004-01-10 |
| DE60116855D1 (de) | 2006-04-13 |
| CA2400612A1 (en) | 2001-08-23 |
| CA2400612C (en) | 2010-05-11 |
| CN1423642A (zh) | 2003-06-11 |
| US6864283B2 (en) | 2005-03-08 |
| KR20020092958A (ko) | 2002-12-12 |
| DE60116855T2 (de) | 2006-09-14 |
| JP2003523338A (ja) | 2003-08-05 |
| BR0108448A (pt) | 2003-04-01 |
| CZ20022791A3 (cs) | 2003-02-12 |
| WO2001060810B1 (en) | 2001-11-29 |
| EP1255746B1 (en) | 2006-01-25 |
| PL357193A1 (en) | 2004-07-26 |
| CN1318409C (zh) | 2007-05-30 |
| ATE316524T1 (de) | 2006-02-15 |
| IL151241A (en) | 2006-10-31 |
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