DE60036940T2 - Verbessertes verfahren zur phosphorylierung - Google Patents

Verbessertes verfahren zur phosphorylierung Download PDF

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Publication number
DE60036940T2
DE60036940T2 DE60036940T DE60036940T DE60036940T2 DE 60036940 T2 DE60036940 T2 DE 60036940T2 DE 60036940 T DE60036940 T DE 60036940T DE 60036940 T DE60036940 T DE 60036940T DE 60036940 T2 DE60036940 T2 DE 60036940T2
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DE
Germany
Prior art keywords
alcohols
complex
temperature
intimate mixture
steps
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60036940T
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German (de)
English (en)
Other versions
DE60036940D1 (de
Inventor
Simon Michael Williamstown WEST
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vital Health Sciences Pty Ltd
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Vital Health Sciences Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/AU2000/000038 external-priority patent/WO2000043380A1/en
Application filed by Vital Health Sciences Pty Ltd filed Critical Vital Health Sciences Pty Ltd
Priority claimed from PCT/AU2000/000452 external-priority patent/WO2000069865A1/en
Application granted granted Critical
Publication of DE60036940D1 publication Critical patent/DE60036940D1/de
Publication of DE60036940T2 publication Critical patent/DE60036940T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/11—Esters of phosphoric acids with hydroxyalkyl compounds without further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60036940T 1999-05-14 2000-05-12 Verbessertes verfahren zur phosphorylierung Expired - Lifetime DE60036940T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPQ037499 1999-05-14
AUPQ0374A AUPQ037499A0 (en) 1999-05-14 1999-05-14 Improved process for phosphorylation and compounds produced by this method
WOPCT/AU00/00038 2000-01-25
PCT/AU2000/000038 WO2000043380A1 (en) 1999-01-25 2000-01-25 Recovery of chroman derivatives
PCT/AU2000/000452 WO2000069865A1 (en) 1999-05-14 2000-05-12 Improved process for phosphorylation and compounds produced by this process

Publications (2)

Publication Number Publication Date
DE60036940D1 DE60036940D1 (de) 2007-12-13
DE60036940T2 true DE60036940T2 (de) 2008-08-14

Family

ID=3814578

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60036940T Expired - Lifetime DE60036940T2 (de) 1999-05-14 2000-05-12 Verbessertes verfahren zur phosphorylierung

Country Status (7)

Country Link
US (1) US6579995B1 (enExample)
JP (1) JP4932995B2 (enExample)
KR (1) KR20020013876A (enExample)
AT (1) ATE377015T1 (enExample)
AU (1) AUPQ037499A0 (enExample)
BR (1) BR0011523B1 (enExample)
DE (1) DE60036940T2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040097472A1 (en) * 2000-11-14 2004-05-20 West Simon Michael Complexes of phosphate derivatives
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
MXPA04000654A (es) * 2001-07-27 2004-03-19 Vital Health Sciences Pty Ltd Terapia dermica usando derivados de fosfato de agente de transferencia de electrones.
WO2003049774A1 (en) * 2001-12-13 2003-06-19 Vital Health Sciences Pty Ltd Transdermal transport of compounds
AU2002950713A0 (en) * 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
JP4690305B2 (ja) * 2003-01-17 2011-06-01 バイタル ヘルス サイエンシズ プロプライアタリー リミティド 抗増殖性質を有する化合物
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
RU2477136C2 (ru) * 2004-03-03 2013-03-10 Вайтал Хэлф Сайнсис Пти Лтд Алкалоидные составы
WO2006012692A1 (en) * 2004-08-03 2006-02-09 Vital Health Sciences Pty Ltd Carrier for enteral administration
JP2008531602A (ja) * 2005-03-03 2008-08-14 バイタル ヘルス サイエンシズ プロプライアタリー リミティド 抗癌特性を有する化合物
US9168216B2 (en) * 2005-06-17 2015-10-27 Vital Health Sciences Pty. Ltd. Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
US20090005348A1 (en) * 2005-12-23 2009-01-01 Vital Health Sciences Pty Ltd Compounds Having Cytokine Modulating Properties
US8728990B2 (en) 2009-12-04 2014-05-20 Elementis Specialties, Inc. Phosphate ester oil gellant
WO2011094814A1 (en) 2010-02-05 2011-08-11 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
CA2794734C (en) 2010-03-30 2017-12-12 Phosphagenics Limited Transdermal delivery patch
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
US10973761B2 (en) 2015-12-09 2021-04-13 Phosphagenics Limited Pharmaceutical formulation
JP7198754B2 (ja) * 2016-12-21 2023-01-04 アベーチョ バイオテクノロジー リミテッド 方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5022535B1 (enExample) * 1970-05-12 1975-07-31
JPS5239013B1 (enExample) * 1970-05-21 1977-10-03
US4141938A (en) 1976-10-07 1979-02-27 Hoechst Aktiengesellschaft Production of acid orthophosphoric acid ester mixtures
JPH0247997B2 (ja) 1983-02-25 1990-10-23 Sanyo Chemical Ind Ltd Rinsanesuterunoseizoho
JPS62195393A (ja) 1986-02-21 1987-08-28 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造方法
JPS6393791A (ja) * 1986-10-08 1988-04-25 Nippon Shokubai Kagaku Kogyo Co Ltd リン酸エステルおよびその製法
DE3702766A1 (de) 1987-01-30 1988-08-11 Henkel Kgaa Verfahren zur herstellung und isolierung von monoalkylphosphorsaeureestern
IT1236843B (it) * 1989-11-22 1993-04-21 Simes Processo per la preparazione di 4-0-fosfati di dopamina o suoi derivati
US5741518A (en) * 1992-08-03 1998-04-21 L'oreal Composition composed of an aqueous dispersion of stabilized vesicles of nonionic amphiphilic lipids
US5554781A (en) * 1994-03-30 1996-09-10 Reierson; Robert L. Monoalkyl phosphonic acid ester production process
JPH07316170A (ja) 1994-05-24 1995-12-05 Kao Corp リン酸モノエステルの製造法
JP3526940B2 (ja) 1995-01-11 2004-05-17 花王株式会社 リン酸エステルの製造法
FR2730928B1 (fr) * 1995-02-23 1997-04-04 Oreal Composition a base de vesicules lipidiques a ph acide et son utilisation en application topique
JPH08231564A (ja) * 1995-02-28 1996-09-10 Nippon Shokubai Co Ltd リン酸エステルおよびその製造方法並びにリン酸エステル重合体
JP3197787B2 (ja) 1995-05-17 2001-08-13 花王株式会社 分岐二量化アルキルリン酸塩基性アミノ酸塩の製造方法
FR2741263B1 (fr) * 1995-11-22 1997-12-26 Oreal Composition comprenant une dispersion aqueuse de vesicules lipidiques encapsulant un filtre uv a fonction acide et utilisations en application topique
JPH1045783A (ja) * 1996-07-29 1998-02-17 Showa Denko Kk ヒドロキシクロマン誘導体リン酸エステルの製造方法

Also Published As

Publication number Publication date
US6579995B1 (en) 2003-06-17
JP4932995B2 (ja) 2012-05-16
DE60036940D1 (de) 2007-12-13
KR20020013876A (ko) 2002-02-21
ATE377015T1 (de) 2007-11-15
JP2003526623A (ja) 2003-09-09
AUPQ037499A0 (en) 1999-06-10
BR0011523B1 (pt) 2014-09-30
BR0011523A (pt) 2002-03-26

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