DE60027272D1 - Stabile nicht wässerige einphasige visköse vehikeln und formulierungen die diese vehikeln verwenden - Google Patents

Stabile nicht wässerige einphasige visköse vehikeln und formulierungen die diese vehikeln verwenden

Info

Publication number
DE60027272D1
DE60027272D1 DE60027272T DE60027272T DE60027272D1 DE 60027272 D1 DE60027272 D1 DE 60027272D1 DE 60027272 T DE60027272 T DE 60027272T DE 60027272 T DE60027272 T DE 60027272T DE 60027272 D1 DE60027272 D1 DE 60027272D1
Authority
DE
Germany
Prior art keywords
vehicles
unphase
formulations
aqueous
viscous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60027272T
Other languages
English (en)
Other versions
DE60027272T2 (de
Inventor
A Berry
J Fereira
Houdin Dehnad
Anna Muchnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intarcia Therapeutics Inc
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22382917&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60027272(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Publication of DE60027272D1 publication Critical patent/DE60027272D1/de
Application granted granted Critical
Publication of DE60027272T2 publication Critical patent/DE60027272T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Dispersion Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60027272T 1999-02-08 2000-02-02 Stabile, nichtwässrige, einphasige, biokompatible, viskose Träger und Formulierungen, die diese Träger verwenden Expired - Lifetime DE60027272T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11917099P 1999-02-08 1999-02-08
US119170P 1999-02-08
PCT/US2000/002772 WO2000045790A2 (en) 1999-02-08 2000-02-02 Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles

Publications (2)

Publication Number Publication Date
DE60027272D1 true DE60027272D1 (de) 2006-05-24
DE60027272T2 DE60027272T2 (de) 2007-01-25

Family

ID=22382917

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60027272T Expired - Lifetime DE60027272T2 (de) 1999-02-08 2000-02-02 Stabile, nichtwässrige, einphasige, biokompatible, viskose Träger und Formulierungen, die diese Träger verwenden

Country Status (22)

Country Link
EP (2) EP1152749B1 (de)
JP (1) JP4861551B2 (de)
KR (2) KR100858856B1 (de)
CN (1) CN1232244C (de)
AR (1) AR029613A1 (de)
AT (2) ATE322889T1 (de)
AU (1) AU775904B2 (de)
CA (1) CA2361424C (de)
CO (1) CO5140096A1 (de)
CY (1) CY1119950T1 (de)
DE (1) DE60027272T2 (de)
DK (1) DK1666026T4 (de)
ES (2) ES2379471T5 (de)
HK (2) HK1041451B (de)
HU (1) HUP0200202A3 (de)
IL (1) IL144755A0 (de)
NO (1) NO20013861L (de)
NZ (1) NZ513441A (de)
PT (2) PT1152749E (de)
TW (2) TWI292716B (de)
WO (1) WO2000045790A2 (de)
ZA (1) ZA200106443B (de)

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Also Published As

Publication number Publication date
DK1666026T4 (da) 2015-05-04
HK1041451A1 (en) 2002-07-12
EP1152749A2 (de) 2001-11-14
KR20080045300A (ko) 2008-05-22
IL144755A0 (en) 2002-06-30
HUP0200202A3 (en) 2009-08-28
AU775904B2 (en) 2004-08-19
EP1152749B1 (de) 2006-04-12
DE60027272T2 (de) 2007-01-25
NZ513441A (en) 2004-01-30
EP1666026A2 (de) 2006-06-07
CA2361424C (en) 2009-04-28
CO5140096A1 (es) 2002-03-22
TW200730199A (en) 2007-08-16
CN1339962A (zh) 2002-03-13
ES2261190T3 (es) 2006-11-16
KR20010101842A (ko) 2001-11-14
EP1666026A3 (de) 2007-08-08
NO20013861D0 (no) 2001-08-08
ZA200106443B (en) 2002-08-06
HK1094528A1 (en) 2007-04-04
ATE537811T1 (de) 2012-01-15
AU3481600A (en) 2000-08-25
TWI292716B (en) 2008-01-21
ATE322889T1 (de) 2006-04-15
EP1666026B2 (de) 2015-02-25
CN1232244C (zh) 2005-12-21
WO2000045790A2 (en) 2000-08-10
WO2000045790A3 (en) 2000-12-07
PT1152749E (pt) 2006-08-31
PT1666026E (pt) 2012-03-15
CA2361424A1 (en) 2000-08-10
JP2002536315A (ja) 2002-10-29
CY1119950T1 (el) 2018-12-12
AR029613A1 (es) 2003-07-10
EP1666026B1 (de) 2011-12-21
JP4861551B2 (ja) 2012-01-25
NO20013861L (no) 2001-09-20
ES2379471T5 (es) 2015-05-26
DK1666026T3 (da) 2012-04-10
HUP0200202A2 (hu) 2002-05-29
ES2379471T3 (es) 2012-04-26
KR100858856B1 (ko) 2008-09-17
HK1041451B (zh) 2006-12-01

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